Here's the un-janky final version of LIPASES, a beefy 60-page art zine I'm debuting this weekend at @smallpressexpo.bsky.social
Come by Table I-4 and say hi
Come by Table I-4 and say hi
September 12, 2025 at 7:02 PM
Here's the un-janky final version of LIPASES, a beefy 60-page art zine I'm debuting this weekend at @smallpressexpo.bsky.social
Come by Table I-4 and say hi
Come by Table I-4 and say hi
Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al
@cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...
@cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...
September 24, 2026 at 9:24 AM
Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al
@cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...
@cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...
The end of high cholesterol / triglycerides, tested in humans. CRISPR/CAS can fix genetic illnesses.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | NEJM
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases.
ANGPTL3 loss-of-function genetic variants are associated with decreased levels of
low-density lipoprotein cholest...
www.nejm.org
November 15, 2025 at 12:19 AM
The end of high cholesterol / triglycerides, tested in humans. CRISPR/CAS can fix genetic illnesses.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
What if bacteria were using wax esters to shape skin microbiomes? Staphylococcal lipases convert skin antimicrobial fatty acids into harmless wax esters.
This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.
This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.
Extracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competition
Abstract. To maintain its barrier function, human skin requires lipids, including cholesterol, ceramides, free fatty acids, and wax esters. In contrast to
track.smtpsendmail.com
June 11, 2026 at 8:49 PM
What if bacteria were using wax esters to shape skin microbiomes? Staphylococcal lipases convert skin antimicrobial fatty acids into harmless wax esters.
This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.
This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.
It might be enough to try grating the bar soap for laundry detergent with baking soda or borax. Enzymatic cleaners that specialize in degrading fats (lipases) could also help.
April 4, 2025 at 5:12 AM
It might be enough to try grating the bar soap for laundry detergent with baking soda or borax. Enzymatic cleaners that specialize in degrading fats (lipases) could also help.
So what does this protist do to its surroundings?
Fig. 2 gives the answer: it exports enzymes into the environment.
#CAZymes, #proteases, #lipases and oxidoreductases break extracellular polymers into sugars, amino acids and lipids that the cell can import.
Fig. 2 gives the answer: it exports enzymes into the environment.
#CAZymes, #proteases, #lipases and oxidoreductases break extracellular polymers into sugars, amino acids and lipids that the cell can import.
July 22, 2026 at 7:51 AM
So what does this protist do to its surroundings?
Fig. 2 gives the answer: it exports enzymes into the environment.
#CAZymes, #proteases, #lipases and oxidoreductases break extracellular polymers into sugars, amino acids and lipids that the cell can import.
Fig. 2 gives the answer: it exports enzymes into the environment.
#CAZymes, #proteases, #lipases and oxidoreductases break extracellular polymers into sugars, amino acids and lipids that the cell can import.
Reading this made my day! Elegant experiments, convincing data and a crazy mechanism: Fuel switch and adrenergic stimulation converge on intra-mitochondrial calcium that induces mito swelling to physically release mitos from LDs. This enhances lipolysis by increasing LD accessibility to lipases 🤯
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - facilitating lipolysis during thermogenesis
Israel Sekler, Orian Shirihai and collaborators
link.springer.com/article/10.1...
Israel Sekler, Orian Shirihai and collaborators
link.springer.com/article/10.1...
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - The EMBO Journal
Adrenergic stimulation of brown adipocytes induces a robust detachment of mitochondria from lipid droplets (LD), which is followed by lipolysis and lipid catabolism. However, the signals inducing mito...
link.springer.com
July 24, 2026 at 11:22 AM
Reading this made my day! Elegant experiments, convincing data and a crazy mechanism: Fuel switch and adrenergic stimulation converge on intra-mitochondrial calcium that induces mito swelling to physically release mitos from LDs. This enhances lipolysis by increasing LD accessibility to lipases 🤯
It is also known as a psychrotroph, meaning it can grow in cold temperatures and is commonly found in raw milk, where it produces spoilage enzymes like proteases and lipases. While often harmless, it can be an opportunistic pathogen that causes infections
October 29, 2025 at 7:14 AM
It is also known as a psychrotroph, meaning it can grow in cold temperatures and is commonly found in raw milk, where it produces spoilage enzymes like proteases and lipases. While often harmless, it can be an opportunistic pathogen that causes infections
Scientists identified two unique domains in Bacillus licheniformis Est2 inhibiting its activity. When removed, the enzyme becomes highly active, revealing it as an esterase with structural ties to lipases (PDB id 6WPX, 6WPY)
Rendering made using #ProteinImager
3dproteinimaging.com/protein-imag...
Rendering made using #ProteinImager
3dproteinimaging.com/protein-imag...
November 21, 2024 at 2:47 PM
Scientists identified two unique domains in Bacillus licheniformis Est2 inhibiting its activity. When removed, the enzyme becomes highly active, revealing it as an esterase with structural ties to lipases (PDB id 6WPX, 6WPY)
Rendering made using #ProteinImager
3dproteinimaging.com/protein-imag...
Rendering made using #ProteinImager
3dproteinimaging.com/protein-imag...
Evaluating Pre-Immobilization and Post-Immobilization Bioimprinting Strategies for the Activation of Lipases: A Case Study of LipC12 🧫🔬
www.ftb.com.hr/archives/194...
#bioimprinting #lipases #immobilization #SDG9 #SDG12 #SDG13 #ftbjournal #DiamondOpenAccess
www.ftb.com.hr/archives/194...
#bioimprinting #lipases #immobilization #SDG9 #SDG12 #SDG13 #ftbjournal #DiamondOpenAccess
September 29, 2025 at 9:16 AM
Evaluating Pre-Immobilization and Post-Immobilization Bioimprinting Strategies for the Activation of Lipases: A Case Study of LipC12 🧫🔬
www.ftb.com.hr/archives/194...
#bioimprinting #lipases #immobilization #SDG9 #SDG12 #SDG13 #ftbjournal #DiamondOpenAccess
www.ftb.com.hr/archives/194...
#bioimprinting #lipases #immobilization #SDG9 #SDG12 #SDG13 #ftbjournal #DiamondOpenAccess
The mucosal redox gateway for dietary iron absorption: integrating gastrointestinal mucus, Fe(II)/Fe(III) speciation and ligand-centred valence tautomerism
The mucosal redox gateway for dietary iron absorption: integrating gastrointestinal mucus, Fe(II)/Fe(III) speciation and ligand-centred valence tautomerism - PubMed
Non-haem dietary iron reaches the duodenum as a dynamic mixture of Fe(III) and Fe(II) complexes whose solubility and exchange kinetics are strongly influenced by pH, reductants, proteases, lipases, carbohydrases,...
ift.tt
September 24, 2026 at 4:12 PM
The mucosal redox gateway for dietary iron absorption: integrating gastrointestinal mucus, Fe(II)/Fe(III) speciation and ligand-centred valence tautomerism
Visceral fat lipolysis by pancreatic lipases worsens heart failure @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
June 2, 2025 at 7:12 PM
Visceral fat lipolysis by pancreatic lipases worsens heart failure @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Bioinformatic, cell localization and phylogenetic analyses reveal a novel family of putative lipases in Tetrahymena thermophila https://pubmed.ncbi.nlm.nih.gov/42068160/
May 3, 2026 at 4:40 AM
Bioinformatic, cell localization and phylogenetic analyses reveal a novel family of putative lipases in Tetrahymena thermophila https://pubmed.ncbi.nlm.nih.gov/42068160/
🐁 Mice lacking key lipases in brown adipose tissue (BAT) struggle to maintain body temperature when fasting in the cold.
🥶 By deleting lipolytic enzymes in brown adipocytes, the researchers found that these mice had impaired oxidative activity and cold tolerance.
2/4
🥶 By deleting lipolytic enzymes in brown adipocytes, the researchers found that these mice had impaired oxidative activity and cold tolerance.
2/4
February 6, 2025 at 11:41 AM
🐁 Mice lacking key lipases in brown adipose tissue (BAT) struggle to maintain body temperature when fasting in the cold.
🥶 By deleting lipolytic enzymes in brown adipocytes, the researchers found that these mice had impaired oxidative activity and cold tolerance.
2/4
🥶 By deleting lipolytic enzymes in brown adipocytes, the researchers found that these mice had impaired oxidative activity and cold tolerance.
2/4
Hope y'all enjoyed our talks at #Candida2025! Theresa presented yesterday one of her PhD projects about the C. glabrata-macrophage interaction. Tim presented today his work about the antibacterial mechanisms of candidalysin, and Sascha presented Osama's work on C. albicans' lipases.
@leibniz-hki.de
@leibniz-hki.de
October 8, 2025 at 10:37 AM
Hope y'all enjoyed our talks at #Candida2025! Theresa presented yesterday one of her PhD projects about the C. glabrata-macrophage interaction. Tim presented today his work about the antibacterial mechanisms of candidalysin, and Sascha presented Osama's work on C. albicans' lipases.
@leibniz-hki.de
@leibniz-hki.de
Our new publication on the characterisation of hyperthermal lipases with polyesterase activity and a strange, unstructured N-terminus that improves thermostability
doi.org/10.1002/pro....
doi.org/10.1002/pro....
doi.org
December 23, 2025 at 1:12 AM
Our new publication on the characterisation of hyperthermal lipases with polyesterase activity and a strange, unstructured N-terminus that improves thermostability
doi.org/10.1002/pro....
doi.org/10.1002/pro....
Extracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competition
Extracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competition - PubMed
To maintain its barrier function, human skin requires lipids, including cholesterol, ceramides, free fatty acids, and wax esters. In contrast to other skin lipids, wax esters remain largely unexplored...
t.co
June 12, 2026 at 9:05 AM
Extracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competition
New in #G3journal: Bioinformatic, cell localization, and phylogenetic analyses reveal a unique gene family of lipases associated with lipid droplets in freshwater ciliate Tetrahymena thermophila.
🔗 buff.ly/f8MlsjD
🔗 buff.ly/f8MlsjD
July 8, 2026 at 1:03 PM
New in #G3journal: Bioinformatic, cell localization, and phylogenetic analyses reveal a unique gene family of lipases associated with lipid droplets in freshwater ciliate Tetrahymena thermophila.
🔗 buff.ly/f8MlsjD
🔗 buff.ly/f8MlsjD
probably could be modernised by directly using proteases and amylases, and can probably directly use normal coconut if you avoid lipases
August 1, 2024 at 5:59 PM
probably could be modernised by directly using proteases and amylases, and can probably directly use normal coconut if you avoid lipases
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #methodsmatter #ReproducibleResearch
LIPL-1 and LIPL-2 are TCER-1-regulated Lysosomal Lipases with Distinct Roles in Immunity and Fertility
doi.org
December 4, 2025 at 8:00 AM
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #methodsmatter #ReproducibleResearch
I am excited to share this new work published with collaborators Gyanu Lamichhane, Vivian Lin, and Aaron Wright:
pubs.acs.org/doi/full/10....
Beta-lactams don't just bind PBPs!! In Mtb they also bind L,D-transpeptidases, MurI, DapE, lipases, and other targets. See results at the link.
pubs.acs.org/doi/full/10....
Beta-lactams don't just bind PBPs!! In Mtb they also bind L,D-transpeptidases, MurI, DapE, lipases, and other targets. See results at the link.
Comprehensive Identification of β-Lactam Antibiotic Polypharmacology in Mycobacterium tuberculosis
Infections with Mycobacterium tuberculosis (Mtb) cause tuberculosis (TB), which requires at least 6 months of treatment with multiple antibiotics. There is emergent interest in using β-lactam antibiotics to improve treatment outcomes for patients. These drugs target cell wall biosynthesis, but a comprehensive list of enzymes inhibited by β-lactams in Mtb is lacking. In the current study, we sought to identify and characterize Mtb enzymes inhibited by β-lactam antibiotics using physiological conditions representative of both acute and chronic TB disease. We used new activity-based probes based on the β-lactam antibiotic meropenem due to its approval by the World Health Organization for TB treatment. Activity-based probes label enzymes based on both substrate specificity and catalytic mechanism, enabling precise identification of drug targets. We identified previously undiscovered targets of meropenem in addition to known cell wall biosynthetic enzymes. We validated β-lactam binding and hydrolysis for six newly identified targets: Rv1723, Rv2257c, Rv0309, DapE (Rv1202), MurI (Rv1338), and LipD (Rv1923). Our results demonstrate that there are at least 30 enzymes in Mtb vulnerable to inhibition by meropenem. This is many more β-lactam targets than historically described, suggesting that efficacy in Mtb is a direct result of polypharmacology.
pubs.acs.org
August 18, 2025 at 4:39 PM
I am excited to share this new work published with collaborators Gyanu Lamichhane, Vivian Lin, and Aaron Wright:
pubs.acs.org/doi/full/10....
Beta-lactams don't just bind PBPs!! In Mtb they also bind L,D-transpeptidases, MurI, DapE, lipases, and other targets. See results at the link.
pubs.acs.org/doi/full/10....
Beta-lactams don't just bind PBPs!! In Mtb they also bind L,D-transpeptidases, MurI, DapE, lipases, and other targets. See results at the link.
People know proteases/lipases are for breaking down a prey's body, but forget the enzymes that break down the mind.
Some preds only secrete them in the large intestine, leaving prey with no ability to lose consciousness while or even after they turn to slop. Release has to wait.
Some preds only secrete them in the large intestine, leaving prey with no ability to lose consciousness while or even after they turn to slop. Release has to wait.
September 16, 2024 at 10:19 PM
People know proteases/lipases are for breaking down a prey's body, but forget the enzymes that break down the mind.
Some preds only secrete them in the large intestine, leaving prey with no ability to lose consciousness while or even after they turn to slop. Release has to wait.
Some preds only secrete them in the large intestine, leaving prey with no ability to lose consciousness while or even after they turn to slop. Release has to wait.
Nice proof of concept! Almost 50% LDL reduction… with one injection.
www.nejm.org/doi/full/10....
@fzores.bsky.social what do you think? Still we need long term effects, and to demonstrate better suitability than the conventional treatment… but CRISPR is starting to show nice real potential?
www.nejm.org/doi/full/10....
@fzores.bsky.social what do you think? Still we need long term effects, and to demonstrate better suitability than the conventional treatment… but CRISPR is starting to show nice real potential?
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | NEJM
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases.
ANGPTL3 loss-of-function genetic variants are associated with decreased levels of
low-density lipoprotein cholest...
www.nejm.org
January 26, 2026 at 5:23 PM
Nice proof of concept! Almost 50% LDL reduction… with one injection.
www.nejm.org/doi/full/10....
@fzores.bsky.social what do you think? Still we need long term effects, and to demonstrate better suitability than the conventional treatment… but CRISPR is starting to show nice real potential?
www.nejm.org/doi/full/10....
@fzores.bsky.social what do you think? Still we need long term effects, and to demonstrate better suitability than the conventional treatment… but CRISPR is starting to show nice real potential?
Our Enzymes & Digestion paper model look at the organs of the #digestivesystem, where #enzymes are produced & what different enzymes do. Covers: digestive system, proteases, carbohydrases, lipases. Learn more here: https://bit.ly/2ULLS00
#EduSky #iteachbio #biologyteacher
#EduSky #iteachbio #biologyteacher
February 5, 2025 at 7:00 AM
Our Enzymes & Digestion paper model look at the organs of the #digestivesystem, where #enzymes are produced & what different enzymes do. Covers: digestive system, proteases, carbohydrases, lipases. Learn more here: https://bit.ly/2ULLS00
#EduSky #iteachbio #biologyteacher
#EduSky #iteachbio #biologyteacher