#lysins
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nizet.bsky.social
What do bacteriophage and James Bond have in common?

Answer: LYSINS TO KILL
November 26, 2024 at 3:17 PM
lislowe.bsky.social
PhD available with me & Paul James looking for exciting new enzymes - www.findaphd.com/phds/project...
New lysins for medically and environmentally important Mycobacteriales at Newcastle University on FindAPhD.com
PhD Project - New lysins for medically and environmentally important Mycobacteriales at Newcastle University, listed on FindAPhD.com
www.findaphd.com
February 27, 2025 at 6:12 PM
nizet.bsky.social
Blaskovich & Cooper review the pipeline of conventional antibiotics and highlight in depth numerous promising alternatives—including potentiators of antibiotic action, bacteriophage, lysins and microbiome modulation—the impact of CARB-X on innovation is patently clear

www.nature.com/articles/s44...
Antibiotics re-booted—time to kick back against drug resistance - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Antibiotics re-booted—time to kick back against drug resistance
www.nature.com
May 31, 2025 at 2:12 AM
phagepapers.bsky.social
Discovery of Antimicrobial Lysins from the "Dark Matter" of Uncharacterized Phages Using Artificial Intelligence.

DOI: 10.1002/advs.202404049

https://pubmed.ncbi.nlm.nih.gov/38899839/
Discovery of Antimicrobial Lysins from the "Dark Matter" of Uncharacterized Phages Using Artificial Intelligence - PubMed
The rapid rise of antibiotic resistance and slow discovery of new antibiotics have threatened global health. While novel phage lysins have emerged as potential antibacterial agents, experimental screening methods for novel lysins pose significant challenges due to the enormous workload. Here, the fi …
pubmed.ncbi.nlm.nih.gov
December 19, 2024 at 1:38 AM
acritschristoph.bsky.social
hmmm www.pnas.org/doi/10.1073/...
Picobirnaviruses encode proteins that are functional bacterial lysins | PNAS
Picobirnaviruses (PBVs) are double-stranded RNA viruses frequently detected in human and animal enteric viromes. Associations of PBVs with enteric ...
www.pnas.org
November 19, 2025 at 10:27 PM
phagepapers.bsky.social
You get what you test for: The killing effect of phage lysins is highly dependent on buffer tonicity and ionic strength.

DOI: 10.1111/1751-7915.14513

https://pubmed.ncbi.nlm.nih.gov/38962879/
You get what you test for: The killing effect of phage lysins is highly dependent on buffer tonicity and ionic strength - PubMed
The phage lysin field has done nothing but grow in the last decades. As a result, many different research groups around the world are contributing to the field, often with certain methodological differences that pose a challenge to the interpretation and comparison of results. In this work, we prese …
pubmed.ncbi.nlm.nih.gov
March 31, 2025 at 1:43 AM
cbcb-newcastle.bsky.social
New lysins for medically and environmentally important Mycobacteriales. Supervised by @lislowe.bsky.social and Paul James.

www.findaphd.com/phds/project...
New lysins for medically and environmentally important Mycobacteriales at Newcastle University on FindAPhD.com
PhD Project - New lysins for medically and environmentally important Mycobacteriales at Newcastle University, listed on FindAPhD.com
www.findaphd.com
March 20, 2025 at 3:24 AM
phagepapers.bsky.social
Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review.

DOI: 10.3389/fmicb.2025.1526096

https://pubmed.ncbi.nlm.nih.gov/39931378/
Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review - PubMed
Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanopartic …
pubmed.ncbi.nlm.nih.gov
March 22, 2025 at 1:43 PM
llschwartzphd.bsky.social
@iampnetwork.bsky.social does anybody in the iAMP community study lysins? I have a graduate student who needs some expert advice :)
October 24, 2025 at 12:48 PM
biorxiv-synthbio.bsky.social
Engineered lysins to modulate human gut microbiome communities https://www.biorxiv.org/content/10.1101/2024.05.14.594189v1
Engineered lysins to modulate human gut microbiome communities https://www.biorxiv.org/content/10.1101/2024.05.14.594189v1
The ability to precisely control the human gut microbiome's composition, metabolic networks, and hos
www.biorxiv.org
May 15, 2024 at 5:09 AM
phagepapers.bsky.social
DeepMineLys: Deep mining of phage lysins from human microbiome.

DOI: 10.1016/j.celrep.2024.114583

https://pubmed.ncbi.nlm.nih.gov/39110597/
DeepMineLys: Deep mining of phage lysins from human microbiome - PubMed
Vast shotgun metagenomics data remain an underutilized resource for novel enzymes. Artificial intelligence (AI) has increasingly been applied to protein mining, but its conventional performance evaluation is interpolative in nature, and these trained models often struggle to extrapolate effectively …
pubmed.ncbi.nlm.nih.gov
November 25, 2024 at 4:37 PM
aceofxandspace.bsky.social
#qatarcunt #lyingwhore #fascistbarbie 🖕🏿🖕🏾🖕🏽🖕🏼🖕🏼🖕🏻off back to the #middleeast #christianzealotbitch #7☠️lysins 🙊🙉🙈
What did you just say about that #felonpedophilesexualpredatorthief⁉️🧏🏻‍♀️🙅🏻‍♀️🤦🏻‍♀️
#eattherich

open.spotify.com/playlist/1xt...
EAT THE RICH
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open.spotify.com
May 24, 2025 at 1:18 PM
phagepapers.bsky.social
"Tear down that wall"-a critical evaluation of bioinformatic resources available for lysin researchers.

DOI: 10.1128/aem.02361-23

https://pubmed.ncbi.nlm.nih.gov/38842338/
"Tear down that wall"-a critical evaluation of bioinformatic resources available for lysin researchers - PubMed
Lytic enzymes, or lysins for short, break down peptidoglycan and interrupt the continuity of the cell wall, which, in turn, causes osmotic lysis of the bacterium. Their ability to destroy bacteria from within makes them promising antimicrobial agents that can be used as alternatives or supplements t …
pubmed.ncbi.nlm.nih.gov
January 8, 2025 at 9:38 PM
rridrobot.bsky.social
Authors used pET-28b(+)/ADK C77S from @addgene.bsky.social in their study. Including #RRIDs will make this less ambiguous.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #OpenScience
Structure-based similarity network accelerates the discovery of lysins as oral microbiome modulators targeting periodontal pathogens
www.biorxiv.org
April 17, 2026 at 12:00 PM
phagepapers.bsky.social
LHPre: Phage Host Prediction with VAE-based Class Imbalance Correction and Lyase Sequence Embedding.

DOI: 10.1109/TCBB.2024.3488059

https://pubmed.ncbi.nlm.nih.gov/39475748/
LHPre: Phage Host Prediction with VAE-based Class Imbalance Correction and Lyase Sequence Embedding - PubMed
The escalation of antibiotic resistance underscores the need for innovative approaches to combat bacterial infections. Phage therapy has emerged as a promising solution, wherein host determination plays an important role. Phage lysins, characterized by their specificity in targeting and cleaving cor …
pubmed.ncbi.nlm.nih.gov
November 21, 2024 at 9:36 AM
bffo.bsky.social
From #OUP 's #DATABASE journal | PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery | #Bioinformatics #MetaGenomics #Phage #Antimicrobials | 🧬🖥️🧪🔓
⬇️ academic.oup.com/database/art...
PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery
Abstract. As biology becomes increasingly data-driven, so does the field of phage lysins, enzymes that degrade bacterial cell walls and offer promising alt
academic.oup.com
June 6, 2026 at 2:18 PM
phagepapers.bsky.social
Heterologous expression and purification of the phage lysin-like bacteriocin LysL from Lactococcus lactis LAC460.

DOI: 10.1093/femsle/fnae065

https://pubmed.ncbi.nlm.nih.gov/39153967/
Heterologous expression and purification of the phage lysin-like bacteriocin LysL from Lactococcus lactis LAC460 - PubMed
The wild-type Lactococcus lactis strain LAC460 produces two bacteriocin-like phage lysins, LysL and LysP. This study aimed to produce and secrete LysL in various heterologous hosts and an in vitro cell-free expression system for further functional studies. Initially, the lysL gene from L. lactis LAC …
pubmed.ncbi.nlm.nih.gov
November 27, 2024 at 9:37 PM
phagepapers.bsky.social
Biological characterization of the phage lysin AVPL and its efficiency against Aerococcus viridans-induced mastitis in a murine model.

DOI: 10.1128/aem.00461-24

https://pubmed.ncbi.nlm.nih.gov/39012099/
Biological characterization of the phage lysin AVPL and its efficiency against Aerococcus viridans-induced mastitis in a murine model - PubMed
<span><i>A. viridans</i> is a zoonotic pathogen known to cause various diseases, including mastitis in dairy cows. In recent years, there has been an increase in antibiotic-resistant or multidrug-resistant strains of this pathogen. Phage lysins are an effective approach to treating infections caused by mu</span> …
pubmed.ncbi.nlm.nih.gov
December 2, 2024 at 12:37 PM
terminaltribune.bsky.social
→
Lysins Against Resistance: Apollo Forges Alliance with Precisio
Cell wall hydrolases – enzymes that precisely cleave the bacterial cell wall.
news.terminaltribune.info
August 12, 2026 at 12:20 AM
staph-papers.bsky.social
LYSG101: a potent chimeric lysin with therapeutic potential for combating Staphylococcus aureus infections
LYSG101: a potent chimeric lysin with therapeutic potential for combating Staphylococcus aureus infections - PubMed
Lysins are peptidoglycan hydrolases with great promise as novel and highly differentiated biotherapeutic agents. Here, we characterize LYSG101, a chimeric lysin active against all <i>Staphylococcus</i>...
t.co
April 30, 2026 at 5:34 PM
acronymy.net
letting your somatic intercellular nodes splat

acronymy.net/define/lysins
—submitted anonymously
September 19, 2025 at 6:38 AM
phagepapers.bsky.social
PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis.

DOI: 10.1186/s12917-025-04975-7

https://pubmed.ncbi.nlm.nih.gov/40993698/
PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis - PubMed
Our findings establish SMphage-derived lysins as a conserved, therapeutically valuable class of antimicrobials with inherent broad-spectrum potential across diverse streptococcal pathogens. Building on the previously demonstrated in vivo efficacy of PlySK1249 against S. dysgalactiae and S. agalactia …
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 3:31 AM
phagepapers.bsky.social
Domain Interactions in a Chimeric Dual-domain Lysin Lead to Broad Bactericidal Activity.

DOI: 10.1016/j.jmb.2025.169373

https://pubmed.ncbi.nlm.nih.gov/40769489/
Domain Interactions in a Chimeric Dual-domain Lysin Lead to Broad Bactericidal Activity - PubMed
Phage-derived lysins represent a novel, non-traditional therapeutic agent against multidrug-resistant bacteria. However, engineering lysins with broad host range remain poorly addressed. Previously, we reported that the chimeric lysin ClyR, which harbors the CHAP catalytic domain of PlyC lysin (PlyC …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 11:31 PM
phagepapers.bsky.social
Next-generation antimicrobials: A review of phage lysins as precision weapons against drug-resistant pathogens.

DOI: 10.1080/21505594.2025.2562634

https://pubmed.ncbi.nlm.nih.gov/40970331/
Next-generation antimicrobials: A review of phage lysins as precision weapons against drug-resistant pathogens - PubMed
The escalating misuse of antibiotics has precipitated a dramatic rise in bacterial drug resistance, rendering conventional therapies increasingly ineffective. In this post-antibiotic era, phage lysins have emerged as a novel class of antimicrobial agents, attracting significant attention for their p …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 3:30 AM
phagepapers.bsky.social
Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening.

DOI: 10.7554/eLife.98266

https://pubmed.ncbi.nlm.nih.gov/39589395/
Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening - PubMed
Phage-derived peptidoglycan hydrolases (i.e. lysins) are considered promising alternatives to conventional antibiotics due to their direct peptidoglycan degradation activity and low risk of resistance development. The discovery of these enzymes is often hampered by the limited availability of phage …
pubmed.ncbi.nlm.nih.gov
March 12, 2025 at 9:41 AM