We really need to buy a bunch of AEW, tankers, oilers, and MPFs
March 28, 2026 at 11:25 PM
We really need to buy a bunch of AEW, tankers, oilers, and MPFs
MPFS - Makes Per Fect Sense
November 30, 2025 at 10:01 PM
MPFS - Makes Per Fect Sense
Great news fresh from #SABCS24 RLY-2608 (mutant selective PI3Kα inhibitor):
mPFS 9.2m (all patients)
mPFS 11.4m (for kinase domain mutants H1047R)
Clinical Benefit Rate 67%
#bcsm @breastcancernow.bsky.social
mPFS 9.2m (all patients)
mPFS 11.4m (for kinase domain mutants H1047R)
Clinical Benefit Rate 67%
#bcsm @breastcancernow.bsky.social
December 11, 2024 at 1:21 PM
Great news fresh from #SABCS24 RLY-2608 (mutant selective PI3Kα inhibitor):
mPFS 9.2m (all patients)
mPFS 11.4m (for kinase domain mutants H1047R)
Clinical Benefit Rate 67%
#bcsm @breastcancernow.bsky.social
mPFS 9.2m (all patients)
mPFS 11.4m (for kinase domain mutants H1047R)
Clinical Benefit Rate 67%
#bcsm @breastcancernow.bsky.social
First Bluesky post! EMBER-3 presented by my mentor @breastcancerdoc.bsky.social demonstrating greater mPFS as single agent vs. SOC ET in ESR1mut, and impressive benefit of imlunestrant+abema with mPFS 9.4 months, 59% had prior CDK4/6i. Novel ET + CDK4/6i switch is intriguing - ELAINE3 is enrolling!
December 11, 2024 at 4:21 PM
First Bluesky post! EMBER-3 presented by my mentor @breastcancerdoc.bsky.social demonstrating greater mPFS as single agent vs. SOC ET in ESR1mut, and impressive benefit of imlunestrant+abema with mPFS 9.4 months, 59% had prior CDK4/6i. Novel ET + CDK4/6i switch is intriguing - ELAINE3 is enrolling!
@andretrig.bsky.social
Sobre crimes ambientais, Bolsonaro está "anistiado" não só pela omissão do sistema Globo, que evita citar seu nome, mas também pelos hipócritas que transitam nos MPFs e no PGR.
Com caneta ou microfone nas mãos, Bolsonaro matou milhões, inclusive, fauna e flora.
@stf.jus.br
Sobre crimes ambientais, Bolsonaro está "anistiado" não só pela omissão do sistema Globo, que evita citar seu nome, mas também pelos hipócritas que transitam nos MPFs e no PGR.
Com caneta ou microfone nas mãos, Bolsonaro matou milhões, inclusive, fauna e flora.
@stf.jus.br
November 25, 2024 at 2:41 PM
@andretrig.bsky.social
Sobre crimes ambientais, Bolsonaro está "anistiado" não só pela omissão do sistema Globo, que evita citar seu nome, mas também pelos hipócritas que transitam nos MPFs e no PGR.
Com caneta ou microfone nas mãos, Bolsonaro matou milhões, inclusive, fauna e flora.
@stf.jus.br
Sobre crimes ambientais, Bolsonaro está "anistiado" não só pela omissão do sistema Globo, que evita citar seu nome, mas também pelos hipócritas que transitam nos MPFs e no PGR.
Com caneta ou microfone nas mãos, Bolsonaro matou milhões, inclusive, fauna e flora.
@stf.jus.br
YENİDEN VE AŞKLA, BİR KERE DAHA "HİZMET"
Fikirlerin Dili'nde, İlahiyatçı-Yazar Necdet İçel Hocamızla haftalık sohbetlere yaklaşık 1 yıl aradan sonra yeniden başlıyoruz.
Türkiye:20.45 Avrupa: 18.45 İngiltere: 17.45 ABD Doğu-Kanada:12.45
www.youtube.com/watch?v=MpfS...
Fikirlerin Dili'nde, İlahiyatçı-Yazar Necdet İçel Hocamızla haftalık sohbetlere yaklaşık 1 yıl aradan sonra yeniden başlıyoruz.
Türkiye:20.45 Avrupa: 18.45 İngiltere: 17.45 ABD Doğu-Kanada:12.45
www.youtube.com/watch?v=MpfS...
December 12, 2024 at 5:27 PM
YENİDEN VE AŞKLA, BİR KERE DAHA "HİZMET"
Fikirlerin Dili'nde, İlahiyatçı-Yazar Necdet İçel Hocamızla haftalık sohbetlere yaklaşık 1 yıl aradan sonra yeniden başlıyoruz.
Türkiye:20.45 Avrupa: 18.45 İngiltere: 17.45 ABD Doğu-Kanada:12.45
www.youtube.com/watch?v=MpfS...
Fikirlerin Dili'nde, İlahiyatçı-Yazar Necdet İçel Hocamızla haftalık sohbetlere yaklaşık 1 yıl aradan sonra yeniden başlıyoruz.
Türkiye:20.45 Avrupa: 18.45 İngiltere: 17.45 ABD Doğu-Kanada:12.45
www.youtube.com/watch?v=MpfS...
#OncSky #regulatory #bcsm
📣 #FDA has approved trastuzumab deruxtecan + pertuzumab for 1st-line tx of adults w/ HER2+ unresectable or #MetastaticBreastCancer based on DB-09 trial:
🏆44% ⬇️ in risk of progression/death vs THP (mPFS: 40.7 vs 26.9 mos).
⚠️ ILD ~12%
Google drugs@FDA for current label
📣 #FDA has approved trastuzumab deruxtecan + pertuzumab for 1st-line tx of adults w/ HER2+ unresectable or #MetastaticBreastCancer based on DB-09 trial:
🏆44% ⬇️ in risk of progression/death vs THP (mPFS: 40.7 vs 26.9 mos).
⚠️ ILD ~12%
Google drugs@FDA for current label
December 15, 2025 at 5:41 PM
#OncSky #regulatory #bcsm
📣 #FDA has approved trastuzumab deruxtecan + pertuzumab for 1st-line tx of adults w/ HER2+ unresectable or #MetastaticBreastCancer based on DB-09 trial:
🏆44% ⬇️ in risk of progression/death vs THP (mPFS: 40.7 vs 26.9 mos).
⚠️ ILD ~12%
Google drugs@FDA for current label
📣 #FDA has approved trastuzumab deruxtecan + pertuzumab for 1st-line tx of adults w/ HER2+ unresectable or #MetastaticBreastCancer based on DB-09 trial:
🏆44% ⬇️ in risk of progression/death vs THP (mPFS: 40.7 vs 26.9 mos).
⚠️ ILD ~12%
Google drugs@FDA for current label
1/ 🚨 New working paper! 🚨 We investigate a novel determinant of labor market power: a firm's product scope. Do multiproduct firms (MPFs) pay lower wages than single-product firms (SPFs)? A 🧵 on our key findings.
📢 Here is the latest JKU Linz Econ Working Paper:
"Wage Setting in Multiproduct Firms"
by Chan, Irlacher (@michaelirlacher.bsky.social), Koch, and Macedoni
Link: ideas.repec.org/p/jku/econwp...
#EconSky
"Wage Setting in Multiproduct Firms"
by Chan, Irlacher (@michaelirlacher.bsky.social), Koch, and Macedoni
Link: ideas.repec.org/p/jku/econwp...
#EconSky
February 11, 2025 at 10:45 AM
1/ 🚨 New working paper! 🚨 We investigate a novel determinant of labor market power: a firm's product scope. Do multiproduct firms (MPFs) pay lower wages than single-product firms (SPFs)? A 🧵 on our key findings.
ASCENT04 changes practice w/ improved mPFS 11.2 vs. 7.8 mos; 12 mon PFS 48 vs 33 mos w/ impressive tail suggesting potential for group with durable sustained response; adverse events were not additive. Bonus points for cr up oss over design. #ASCO25 @oncoalert.bsky.social
May 31, 2025 at 8:45 PM
ASCENT04 changes practice w/ improved mPFS 11.2 vs. 7.8 mos; 12 mon PFS 48 vs 33 mos w/ impressive tail suggesting potential for group with durable sustained response; adverse events were not additive. Bonus points for cr up oss over design. #ASCO25 @oncoalert.bsky.social
#IMPROVE trial #Intermittent (I) or #Continuous (C) Panitumumab+FOLFIRI for First-Line Treatment of RAS/BRAF WT Metastatic Colorectal Cancer #oncsky #JCO
✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...
✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...
December 6, 2024 at 8:29 AM
#IMPROVE trial #Intermittent (I) or #Continuous (C) Panitumumab+FOLFIRI for First-Line Treatment of RAS/BRAF WT Metastatic Colorectal Cancer #oncsky #JCO
✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...
✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...
1) KRYSTAL-7 update on pembro+adagrasib in 1st line pdl1 >50% nsclc. Tox to navigate but mPFS >27m! Further reinforcing the view that ras orchestrates TME, not just cancer cell intrinsic pathways. Massive congrats to investigators, mirati, bms #ELCC25
March 27, 2025 at 4:03 PM
1) KRYSTAL-7 update on pembro+adagrasib in 1st line pdl1 >50% nsclc. Tox to navigate but mPFS >27m! Further reinforcing the view that ras orchestrates TME, not just cancer cell intrinsic pathways. Massive congrats to investigators, mirati, bms #ELCC25
"I sociala medier används MPFs anmälan som belägg för påståendet att TV4 har spridit desinformation."
Det här är ju särskilt intressant. Mycket konstigt drag av MPF, som nog får somliga att ifrågasätta myndighetens politiska neutralitet
Det här är ju särskilt intressant. Mycket konstigt drag av MPF, som nog får somliga att ifrågasätta myndighetens politiska neutralitet
May 17, 2024 at 2:51 PM
"I sociala medier används MPFs anmälan som belägg för påståendet att TV4 har spridit desinformation."
Det här är ju särskilt intressant. Mycket konstigt drag av MPF, som nog får somliga att ifrågasätta myndighetens politiska neutralitet
Det här är ju särskilt intressant. Mycket konstigt drag av MPF, som nog får somliga att ifrågasätta myndighetens politiska neutralitet
JIM Studie 2023 des mpfs ist veröffentlicht , Mediennutzung 12- bis 19-jährige www.mpfs.de/studien/jim-...
2023 | mpfs.de
www.mpfs.de
November 29, 2023 at 9:52 AM
JIM Studie 2023 des mpfs ist veröffentlicht , Mediennutzung 12- bis 19-jährige www.mpfs.de/studien/jim-...
#SABCS24 #bcsm #OncSky #MedEd
You must ask:
👉 What is the absolute benefit in PFS & how does it compare to imaging interval? (Note scans may get less frequent w/ time in trials so 👀 on that too dep on mPFS). If mPFS diff is < time btwn scans, hard to know if real.
@oncoalert.bsky.social
You must ask:
👉 What is the absolute benefit in PFS & how does it compare to imaging interval? (Note scans may get less frequent w/ time in trials so 👀 on that too dep on mPFS). If mPFS diff is < time btwn scans, hard to know if real.
@oncoalert.bsky.social
December 11, 2024 at 4:09 PM
#SABCS24 #bcsm #OncSky #MedEd
You must ask:
👉 What is the absolute benefit in PFS & how does it compare to imaging interval? (Note scans may get less frequent w/ time in trials so 👀 on that too dep on mPFS). If mPFS diff is < time btwn scans, hard to know if real.
@oncoalert.bsky.social
You must ask:
👉 What is the absolute benefit in PFS & how does it compare to imaging interval? (Note scans may get less frequent w/ time in trials so 👀 on that too dep on mPFS). If mPFS diff is < time btwn scans, hard to know if real.
@oncoalert.bsky.social
"Seit 1998 wird mit der JIM-Studie im jährlichen Turnus eine Basisstudie zum Medienumgang der Zwölf- bis 19-Jährigen durchgeführt."
#bluelz #medien #games #Jugendliche #JIMStudie
mpfs.de
#bluelz #medien #games #Jugendliche #JIMStudie
mpfs.de
Startseite - mpfs
mpfs -
mpfs.de
December 2, 2024 at 6:24 AM
"Seit 1998 wird mit der JIM-Studie im jährlichen Turnus eine Basisstudie zum Medienumgang der Zwölf- bis 19-Jährigen durchgeführt."
#bluelz #medien #games #Jugendliche #JIMStudie
mpfs.de
#bluelz #medien #games #Jugendliche #JIMStudie
mpfs.de
Die neue JIM-Studie ist da mit aktuellen Daten zur Mediennutzung von Jugendlichen! Nunmehr geben knapp zwei Drittel (!) der Jugendlichen an, #KI-Technologien zu verwenden. #FakeNews sind weiterhin ein ernstzunehmendes Problem. #Medienkompetenz mpfs.de/studie/jim-s...
JIM-Studie 2024 - mpfs
JIM-Studie 2024
mpfs.de
November 29, 2024 at 5:42 PM
Die neue JIM-Studie ist da mit aktuellen Daten zur Mediennutzung von Jugendlichen! Nunmehr geben knapp zwei Drittel (!) der Jugendlichen an, #KI-Technologien zu verwenden. #FakeNews sind weiterhin ein ernstzunehmendes Problem. #Medienkompetenz mpfs.de/studie/jim-s...
ORCHARD (module 10): Osi + Dato-Dxd post 1L Osi
❇️ ORR 36 - 43%
❇️ mPFS 9.5 - 11.7m
❇️ DoR longer in 6mg/kg grp
❗️ 65% Dato dose reduction
❗️ 60% Dato dose interr
💭 Active combination
💭 Toxic+
💭 Not biomarker directed
#ELCC25
❇️ ORR 36 - 43%
❇️ mPFS 9.5 - 11.7m
❇️ DoR longer in 6mg/kg grp
❗️ 65% Dato dose reduction
❗️ 60% Dato dose interr
💭 Active combination
💭 Toxic+
💭 Not biomarker directed
#ELCC25
March 26, 2025 at 4:54 PM
ORCHARD (module 10): Osi + Dato-Dxd post 1L Osi
❇️ ORR 36 - 43%
❇️ mPFS 9.5 - 11.7m
❇️ DoR longer in 6mg/kg grp
❗️ 65% Dato dose reduction
❗️ 60% Dato dose interr
💭 Active combination
💭 Toxic+
💭 Not biomarker directed
#ELCC25
❇️ ORR 36 - 43%
❇️ mPFS 9.5 - 11.7m
❇️ DoR longer in 6mg/kg grp
❗️ 65% Dato dose reduction
❗️ 60% Dato dose interr
💭 Active combination
💭 Toxic+
💭 Not biomarker directed
#ELCC25
A fun back of the envelope calculation comparing disposable magic erase sponges and polyester shirts:
www.reddit.com/r/science/s/...
www.reddit.com/r/science/s/...
PHealthy's comment on "Melamine cleaning sponges, commonly known as "magic erasers," shed microplastic fibers (MPFs) when worn down. This study pioneers the recognition of these sponges as an importan...
Explore this conversation and more from the science community
www.reddit.com
April 15, 2026 at 8:25 PM
A fun back of the envelope calculation comparing disposable magic erase sponges and polyester shirts:
www.reddit.com/r/science/s/...
www.reddit.com/r/science/s/...
2) daraxonrasib (rmc-6236) offering early phase and v impressive activity in g12d g12v 2nd line nsclc. RR 38% and mPFS >10m. V tolerable toxicity profile again. Next will be IO combos, congrats+++ to Revolution Medicines and the investigators. #ELCC25
March 27, 2025 at 4:08 PM
2) daraxonrasib (rmc-6236) offering early phase and v impressive activity in g12d g12v 2nd line nsclc. RR 38% and mPFS >10m. V tolerable toxicity profile again. Next will be IO combos, congrats+++ to Revolution Medicines and the investigators. #ELCC25
Ob die expliziten Bilder gegen den Jugendschutz verstoßen, müsse im Einzelfall geprüft werden. Sie dürften aber viele Jugendliche erreichen: Der JIM-Studie 2024 zufolge nutzt mehr als jeder Zehnte 12-19-Jährige täglich oder mehrmals die Woche die Plattform X. (5/9) mpfs.de/studie/jim-s...
JIM-Studie 2024 - mpfs
JIM-Studie 2024
mpfs.de
March 5, 2025 at 2:43 PM
Ob die expliziten Bilder gegen den Jugendschutz verstoßen, müsse im Einzelfall geprüft werden. Sie dürften aber viele Jugendliche erreichen: Der JIM-Studie 2024 zufolge nutzt mehr als jeder Zehnte 12-19-Jährige täglich oder mehrmals die Woche die Plattform X. (5/9) mpfs.de/studie/jim-s...
Du behind the scenes brut de Demolition Man (1993)
www.youtube.com/watch?v=mPfs...
www.youtube.com/watch?v=mPfs...
Demolition Man 1993 RARE Behind the Scenes Footage! General Motors Concept Cars (Sylvester Stallone)
Check out this never before seen footage taken with a camcorder on the set of the 1993 movie "Demolition Man" starring Sylvester Stallone and Wesley Snipes! ...
www.youtube.com
January 6, 2024 at 6:18 PM
Du behind the scenes brut de Demolition Man (1993)
www.youtube.com/watch?v=mPfs...
www.youtube.com/watch?v=mPfs...