📢 New publication 'microRNA-mediated control of cell fate specification and patterning in #Marchantia polymorpha' by Adolfo Aguilar-Cruz et al. in @newphyt.bsky.social 🧪
doi.org/10.1111/nph....
#auxin #microRNA
doi.org/10.1111/nph....
#auxin #microRNA
microRNA‐mediated control of cell fate specification and patterning in <fi>Marchantia polymorpha</fi>
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166-mediated repression of MpC3HDZ and auxin homeostasis.
doi.org
August 27, 2026 at 12:28 AM
📢 New publication 'microRNA-mediated control of cell fate specification and patterning in #Marchantia polymorpha' by Adolfo Aguilar-Cruz et al. in @newphyt.bsky.social 🧪
doi.org/10.1111/nph....
#auxin #microRNA
doi.org/10.1111/nph....
#auxin #microRNA
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
December 20, 2024 at 5:14 PM
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Happy to see this out! We describe a patterning mechanism underlying rhizoid specification in Marchantia. Contrary to classic patterning mechanisms (e.g., Turing), rhizoid specification depends on both randomness and lateral inhibition, involves subcritical bifurcations, and occurs at criticality!
Cell-type specification at criticality underlies rhizoid patterning in the liverwort Marchantia polymorpha
Rhizoid specification in Marchantia polymorpha gemmae involves lateral inhibition mediated by the microRNA FRH1, which represses the rhizoid-specific …
www.sciencedirect.com
December 23, 2025 at 6:07 PM
Happy to see this out! We describe a patterning mechanism underlying rhizoid specification in Marchantia. Contrary to classic patterning mechanisms (e.g., Turing), rhizoid specification depends on both randomness and lateral inhibition, involves subcritical bifurcations, and occurs at criticality!
In the battle between #plant and #pathogen, new work reports a fungal RNA decoy strategy that interferes with plant microRNA-mediated immune regulation, impacting disease susceptibility in #rice.
#FreeAccess review here⬇️🆓
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB
#FreeAccess review here⬇️🆓
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB
Cross‐kingdom RNA decoy redefines fungal virulence strategies
This commentary highlights a new study revealing a fungal RNA decoy strategy that interferes with plant microRNA-mediated immune regulation. By blocking key microRNA activity, fungal RNAs reprogram h....
doi.org
August 15, 2026 at 1:25 PM
In the battle between #plant and #pathogen, new work reports a fungal RNA decoy strategy that interferes with plant microRNA-mediated immune regulation, impacting disease susceptibility in #rice.
#FreeAccess review here⬇️🆓
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB
#FreeAccess review here⬇️🆓
doi.org/10.1111/jipb...
@wileylifesci.bsky.social
#PlantSci #JIPB
Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers?
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD...
www.biorxiv.org
December 4, 2024 at 4:10 PM
Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers?
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
New preprint from the lab!
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
www.biorxiv.org/content/10.1...
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 4, 2024 at 2:08 AM
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
2024 Nobel laureate Victor Ambros visited IBMB-CSIC!
He gave the seminar "MicroRNA-mediated gene regulation and developmental robustness", met with our research teams, and spent time with PhD students.
📖 Full story: ibmb.csic.es/en/news/vict...
He gave the seminar "MicroRNA-mediated gene regulation and developmental robustness", met with our research teams, and spent time with PhD students.
📖 Full story: ibmb.csic.es/en/news/vict...
September 21, 2026 at 1:51 PM
2024 Nobel laureate Victor Ambros visited IBMB-CSIC!
He gave the seminar "MicroRNA-mediated gene regulation and developmental robustness", met with our research teams, and spent time with PhD students.
📖 Full story: ibmb.csic.es/en/news/vict...
He gave the seminar "MicroRNA-mediated gene regulation and developmental robustness", met with our research teams, and spent time with PhD students.
📖 Full story: ibmb.csic.es/en/news/vict...
circRNAs as tools for gene silencing, similar to microRNA-mediated gene silencing. Do we also need circRNA target prediction software? Circular RNAs trigger nonsense-mediated mRNA decay: Molecular Cell
Circular RNAs trigger nonsense-mediated mRNA decay
Boo and Shin et al. uncover that the EJC deposited onto circRNAs after back-splicing is spatially located near the 3′ UTR of mRNA through circRNA-mRNA interaction. The EJC on circRNA triggers NMD of the mRNA. Mechanistic studies reveal the roles of circNMD in apoptosis and its therapeutic potential for mRNA downregulation.
www.cell.com
December 12, 2024 at 2:30 PM
circRNAs as tools for gene silencing, similar to microRNA-mediated gene silencing. Do we also need circRNA target prediction software? Circular RNAs trigger nonsense-mediated mRNA decay: Molecular Cell
New #MolTherapy paper: Development of an AAV-delivered microRNA gene therapy for Myotonic Dystrophy Type 1. #Myoblue tinyurl.com/mrjrue3f
Development of an AAV-delivered microRNA gene therapy for Myotonic Dystrophy Type 1
An AAV-mediated gene therapy for myotonic dystrophy type 1 using a novel muscle-tropic
capsid and promoter to express a DMPK-targeting miRNA effectively reduces DMPK expression
and nuclear RNA foci, a...
tinyurl.com
September 4, 2025 at 4:25 PM
New #MolTherapy paper: Development of an AAV-delivered microRNA gene therapy for Myotonic Dystrophy Type 1. #Myoblue tinyurl.com/mrjrue3f
🚨Just published - Multiplex engineering using microRNA-mediated gene silencing in CAR T cells #celltherapy #genetherapy #immunotherapy www.frontiersin.org/journals/imm...
August 21, 2025 at 1:23 PM
🚨Just published - Multiplex engineering using microRNA-mediated gene silencing in CAR T cells #celltherapy #genetherapy #immunotherapy www.frontiersin.org/journals/imm...
🚨Coming soon! Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. In a single lentiviral vector- multiplex silencing & expression of a CAR, better expansion & viability than gene editing by electroporation www.frontiersin.org/journals/imm...
Frontiers | Multiplex engineering using microRNA-mediated gene silencing in CAR T cells
Multiplex gene edited CAR T cell therapies face challenges, including potential oncogenic risks from double-strand breaks. Targeted microRNAs (miRNAs) may of...
www.frontiersin.org
August 5, 2025 at 1:05 PM
🚨Coming soon! Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. In a single lentiviral vector- multiplex silencing & expression of a CAR, better expansion & viability than gene editing by electroporation www.frontiersin.org/journals/imm...
A #parasitic wasp suppresses host pupation by #microRNA-mediated transcriptional silencing of OfE93
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
A parasitic wasp suppresses host pupation by microRNA‐mediated transcriptional silencing of OfE93
Parasitism by Macrocentrus cingulum induces miR-281a-5p upregulation in the host Ostrinia furnacalis larvae, which suppresses OfE93 expression and arrests pupation. This finding reveals a miRNA-media...
onlinelibrary.wiley.com
January 27, 2026 at 1:14 PM
A #parasitic wasp suppresses host pupation by #microRNA-mediated transcriptional silencing of OfE93
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
Argonaute proteins regulate the timing of the spermatogenic transcriptional program
Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3 and AGO4, but not AGO2, localize to the sex chromatin of pachytene sp...
biorxiv.org
January 1, 2025 at 10:54 PM
Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
ICYMI: New Online! Precise protein expression through microRNA-mediated gene dosage compensation
Precise protein expression through microRNA-mediated gene dosage compensation
Nature Reviews Molecular Cell Biology, Published online: 27 February 2026; doi:10.1038/s41580-026-00959-zBased on microRNAs, DIMMERs is a modular tool for dampening expression fluctuations of multiple proteins in a cell owing to transgene copy number variations.
dlvr.it
March 2, 2026 at 6:15 PM
ICYMI: New Online! Precise protein expression through microRNA-mediated gene dosage compensation
MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery Br&Beh
MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery
Brain and Behavior, Volume 16, Issue 5, May 2026.
dlvr.it
May 14, 2026 at 9:19 AM
MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery Br&Beh
MicroRNA-mediated transgenerational plasticity reveals pathways for ocean warming resilience https://www.biorxiv.org/content/10.64898/2026.05.21.727062v1
May 26, 2026 at 4:33 PM
MicroRNA-mediated transgenerational plasticity reveals pathways for ocean warming resilience https://www.biorxiv.org/content/10.64898/2026.05.21.727062v1
Using biochemistry 🧪, cryo-EM 🔬 and cell biology 🧫, we show how pairing of trigger RNAs to microRNAs induces a unique AGO-microRNA-trigger RNA conformation. Dimeric ZSWIM8 engulfs this complex recognizing both RNA- and protein conformation that specify AGO for ubiquitin-mediated degradation (2/5).
January 6, 2026 at 8:05 AM
Using biochemistry 🧪, cryo-EM 🔬 and cell biology 🧫, we show how pairing of trigger RNAs to microRNAs induces a unique AGO-microRNA-trigger RNA conformation. Dimeric ZSWIM8 engulfs this complex recognizing both RNA- and protein conformation that specify AGO for ubiquitin-mediated degradation (2/5).
Researchers showed promising results using unique acute cellular rejection and antibody-mediated rejection microRNA panels to identify rejection after heart transplantation.
https://www.medpagetoday.com/transplantation/hearttransplantation/119412
https://www.medpagetoday.com/transplantation/hearttransplantation/119412
MicroRNA Tests Eyed for Flagging Heart Transplant Rejection
Panels designed to identify acute cellular rejection, antibody-mediated rejection without biopsy
www.medpagetoday.com
January 15, 2026 at 2:09 PM
Researchers showed promising results using unique acute cellular rejection and antibody-mediated rejection microRNA panels to identify rejection after heart transplantation.
https://www.medpagetoday.com/transplantation/hearttransplantation/119412
https://www.medpagetoday.com/transplantation/hearttransplantation/119412
New genetic circuits developed at MIT allow more precise control of gene therapy, keeping gene expression levels within a target range. The research could help scientists develop treatments for fragile X syndrome and other diseases caused by mutations of a single gene.
Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells
Using a model to explore the design space, Love et al. developed ComMAND, a single-transcript,
microRNA-mediated incoherent feedforward loop that mitigates variance due to gene
dosage and tightly regu...
www.cell.com
May 10, 2025 at 10:33 PM
New genetic circuits developed at MIT allow more precise control of gene therapy, keeping gene expression levels within a target range. The research could help scientists develop treatments for fragile X syndrome and other diseases caused by mutations of a single gene.
Graph neural network-based prediction of direct reprogramming factors using gene regulatory networks with microRNA-mediated regulation https://www.biorxiv.org/content/10.64898/2026.01.28.702229v1
February 2, 2026 at 6:46 AM
Graph neural network-based prediction of direct reprogramming factors using gene regulatory networks with microRNA-mediated regulation https://www.biorxiv.org/content/10.64898/2026.01.28.702229v1
Now we're cooking !!!
#Drosophila folks never disappoint - I love it that they called it MIMOSAS 🍸
@narjournal.bsky.social
#RNA #splicing
#Drosophila folks never disappoint - I love it that they called it MIMOSAS 🍸
@narjournal.bsky.social
#RNA #splicing
MicroRNA-Mediated Obstruction of Stem–loop Alternative Splicing (MIMOSAS) regulates long-range alternative splicing in Drosophila
Abstract. RNA secondary structures are key regulators of long-range pre-messenger RNA (mRNA) alternative splicing, yet the rules governing these structures
academic.oup.com
April 24, 2026 at 3:42 PM
Now we're cooking !!!
#Drosophila folks never disappoint - I love it that they called it MIMOSAS 🍸
@narjournal.bsky.social
#RNA #splicing
#Drosophila folks never disappoint - I love it that they called it MIMOSAS 🍸
@narjournal.bsky.social
#RNA #splicing
@nature, researchers describe an RNA-RNA-mediated arm-race between fungal pathogens and their plant hosts. Specifically, they show that a fungal lncRNA weakens host immunity by sequestering a protective rice miRNA.
shorturl.at/mIuvy
shorturl.at/mIuvy
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence - Nature
A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.
shorturl.at
May 21, 2026 at 5:52 PM
@nature, researchers describe an RNA-RNA-mediated arm-race between fungal pathogens and their plant hosts. Specifically, they show that a fungal lncRNA weakens host immunity by sequestering a protective rice miRNA.
shorturl.at/mIuvy
shorturl.at/mIuvy
Our latest @acspublications.bsky.social JCIM study unveils new insights into pre-miR21 conformational dynamics using innovative computational techniques. Potential game-changer for RNA processing inhibition.
#MicroRNA #ComputationalChemistry #DrugDiscovery
pubs.acs.org/doi/10.1021/...
#MicroRNA #ComputationalChemistry #DrugDiscovery
pubs.acs.org/doi/10.1021/...
Investigating Ligand-Mediated Conformational Dynamics of Pre-miR21: A Machine-Learning-Aided Enhanced Sampling Study
MicroRNAs (miRs) are short, noncoding RNA strands that regulate the activity of mRNAs by affecting the repression of protein translation, and their dysregulation has been implicated in several patholo...
pubs.acs.org
November 28, 2024 at 2:28 PM
Our latest @acspublications.bsky.social JCIM study unveils new insights into pre-miR21 conformational dynamics using innovative computational techniques. Potential game-changer for RNA processing inhibition.
#MicroRNA #ComputationalChemistry #DrugDiscovery
pubs.acs.org/doi/10.1021/...
#MicroRNA #ComputationalChemistry #DrugDiscovery
pubs.acs.org/doi/10.1021/...
An interesting work which used enhanced sampling (OneOPES MD simulations) to investigate the effect of a peptide binder (L50) on the conformational dynamics of a precursor of a microRNA, pre-miR21.
miR21 is involved in anticancer drug resistance.
#compchem
pubs.acs.org/doi/10.1021/...
miR21 is involved in anticancer drug resistance.
#compchem
pubs.acs.org/doi/10.1021/...
Investigating Ligand-Mediated Conformational Dynamics of Pre-miR21: A Machine-Learning-Aided Enhanced Sampling Study
MicroRNAs (miRs) are short, noncoding RNA strands that regulate the activity of mRNAs by affecting the repression of protein translation, and their dysregulation has been implicated in several patholo...
pubs.acs.org
November 29, 2024 at 7:04 PM
An interesting work which used enhanced sampling (OneOPES MD simulations) to investigate the effect of a peptide binder (L50) on the conformational dynamics of a precursor of a microRNA, pre-miR21.
miR21 is involved in anticancer drug resistance.
#compchem
pubs.acs.org/doi/10.1021/...
miR21 is involved in anticancer drug resistance.
#compchem
pubs.acs.org/doi/10.1021/...
Curious new preprint on tdmd of microRNAs in Drosophila. www.biorxiv.org/content/10.1...
An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families
While much is known about miRNA biogenesis and canonical miRNA targeting, relatively less is understood about miRNA decay. The major miRNA decay pathway in metazoans is mediated through target-directe...
www.biorxiv.org
December 17, 2024 at 12:47 PM
Curious new preprint on tdmd of microRNAs in Drosophila. www.biorxiv.org/content/10.1...