Here the authors show that circulating tumor cells shed migrasomes that carry tumor antigens, which in turn can activate CD8+ T cells through cross-presentation to restrict metastasis.

Nature Reviews Immunology, Published online: 09 October 2026; doi:10.1038/s41577-026-01366-3Metastasizing cancer cells release migrasomes containing tumour-specific antigens that can promote T cell responses.

Nature Reviews Immunology, Published online: 09 October 2026; doi:10.1038/s41577-026-01366-3Metastasizing cancer cells release migrasomes containing tumour-specific antigens that can promote T cell responses.

Here the authors show that circulating tumor cells shed migrasomes that carry tumor antigens, which in turn can activate CD8+ T cells through cross-presentation to restrict metastasis.

Published in Journal of the National Cancer Center

Published in Cell discovery

Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Re...

Hu et al. identify border-associated macrophages as early targets of brain aging. These cells acquire senescence-associated properties, which are transmittable via migrasomes carrying the apoptosis…

【J Nanobiotechnology】<AbstractText>The regulatory role of migrasomes (Migs) has attracted growing attentions recently. However,...

Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy associated with dismal prognosis. Migrasomes, a unique class of migration-dependent extracellular vesicles, have emerged as pivotal mediators of intercellular crosstalk within the tumor microenvironment. However, the clinical implications and regulatory mechanisms of migrasome-related long non-coding RNAs (MRLs) in HNSCC remain largely unexplored. Herein, we retrieved transcriptomic and clinical data of HNSCC from The Cancer Genome Atlas (TCGA) and established a prognostic signature using LASSO-Cox regression analysis, which was further internally validated in a randomly split subset of the TCGA cohort as internal validation. We systematically characterized the immune microenvironment and drug sensitivity profiles stratified by this signature, and identified the cellular distribution of core MRLs via single-cell RNA sequencing. Functional experiments were performed in clinical specimens and HNSCC cell lines using