INDEPENDENT CONTRACTOR LOCKHEED MARTIN Celtic Author Winter Breshna form #Delftholland NLD RUSSIAN. Civil Engineer Penn Valley, CA SINGLE. tumblr.com

Background: Falls are a major cause of morbidity among older adults, yet fall risk may begin to emerge during midlife. Physical performance measures may identify early functional vulnerability associated with later-life health outcomes. Objective: This study examined whether midlife gait speed and muscle performance were associated with recurrent falls later in life. Methods: This study was a secondary analysis of prospectively collected data from the Midlife in the United States (MIDUS) cohort. Independent adults (n=309) aged 45 to 64 years at wave 2 (2004-2009) who completed physical performance assessments were followed to wave 3 (2013-2021). Baseline measures included gait speed from a 50-foot walk test, grip strength, sit-to-stand time, and calculated lower-extremity power. The primary analysis examined associations between baseline physical performance and recurrent falls at follow-up (≥2 falls in the previous 12 months). A sensitivity analysis repeated the primary models but was restricted to participants without a baseline history of recurrent falls. Results: At follow-up, 20.4% (63/309) of participants reported recurrent falls. Slower midlife gait speed was associated with higher odds of recurrent falls (odds ratio 1.43, 95% CI 1.05-1.95; P=.02), whereas muscle performance measures were not associated with falls in the primary analysis. The association between slower gait speed and recurrent falls remained significant in the sensitivity analysis. Over follow-up, muscle performance declined, whereas gait speed remained stable. Conclusions: Slower midlife gait speed was associated with higher odds of recurrent falls, suggesting that fall vulnerability may be detectable as early as midlife. Given the exploratory nature of this study, further studies are warranted to confirm these findings.

Individuals with intellectual disabilities (ID) often experience poor balance, leading to a higher risk of falls. Exercise can help, but adherence is low because accessible and suitable exercise opportunities are often perceived as lacking. This study qualitatively analysed the user experience design preferences of adults with ID during the co-creation of a digital exercise application focused on balance and muscle strength. Two groups, comprising four and five adults with ID, participated in five co-creation workshops over 15 months, alongside two academic facilitators.

NDRG1 protein accumulation in aging stem cells slows muscle repair activation, explaining delayed healing in older adults—despite higher cell survival. The aging paradox.