Background/Purpose: Idiopathic inflammatory myopathies (IIM) are associated with increased atherosclerotic cardiovascular disease risk and reduced cardiorespiratory fitness despite disease control.…

IMPORTANCE: Preliminary evidence suggests that intravenous immune globulin (IVIG) may be valuable as an add-on treatment in newly diagnosed idiopathic inflammatory myopathies (IIMs), but a randomized ...

Soutenez le Téléthon en faisant un don sur la page de En mémoire de Françoise Helmbacher via https://mapage.telethon.fr/collecte-hommages/En-memoire-de-Francoise-Helmbacher

Pierre Birambeau, l’un des fondateurs du Téléthon français, est décédé hier à l’âge de 84 ans, a annoncé ce jeudi l’Association française contre les myopathies (AFM-Téléthon). Sa...

Pierre Birambeau, l’un des fondateurs du Téléthon français, est décédé hier à l’âge de 84 ans, a annoncé ce jeudi l’Association française contre les myopathies (AFM-Téléthon). Sa...

RYR1-related diseases (RYR1-RDs) encompass a wide spectrum of disease manifestations with limited available disease-modifying therapies. The RYR1-RD phenotypes include congenital myopathies of different histotypes often with early-onset muscle weakness, feeding difficulties, and respiratory insufficiency of varying severity. RYR1-RDs also include a group of episodic diseases such as exercise intolerance, exertional rhabdomyolysis, periodic paralysis, and malignant hyperthermia susceptibility....

Loss of skeletal muscle mass and strength is a debilitating consequence of various chronic diseases, inflammatory myopathies, and neuromuscular disorders. Inflammation plays a major role in the perpetuation of myopathy in degenerative muscle diseases. TGF-β-activated kinase 1 (TAK1) is a major signaling protein that mediates the activation of multiple signaling pathways in response to inflammatory cytokines and microbial products. Recent studies have demonstrated that TAK1 is essential for th...

Reported Monday, Oct 19 - 11:05am EDT (TheFly subscription required to read more.)

Reported Monday, Oct 19 - 10:59am EDT (TheFly subscription required to read more.)

In this Journal Club episode, we discuss the publication by Iannibelli, Ruggieri and colleagues investigating the role of aggrephagy - the cellular…

Congenital myopathies are a group of rare, inherited muscle diseases that often cause muscle weakness in childhood. This weakness can affect, among other things, the ability to walk, stand up and use one's arms and hands, and in some cases, it can also affect the respiratory muscles.

Congenital myopathies are a group of rare, inherited muscle diseases that often cause muscle weakness in childhood. This weakness can affect, among other things, the ability to walk, stand up and use one's arms and hands, and in some cases, it can also affect the respiratory muscles.

Le diagnostic des myopathies peut être complexe en raison de leur grande diversité génétique. Une étude coordonnée par le Dr Svetlana GOROKHOVA, sous l’égide de la Commission Génétique moléculaire de la Filière Nationale des Maladies Rares Neuromusculaires FILNEMUS (coordination Pr Mire...

The juvenile idiopathic inflammatory myopathies (JIIM) are rare serious, multisystem autoimmune diseases affecting children and young people. Fifty years ago the prognosis for these conditions was poo...