#nDNA
The Role of Nuclear and Mitochondrial DNA in Myalgic Encephalomyelitis: Molecular Insights into Susceptibility and Dysfunction
by Wesam Elremaly, Mohamed Elbakry, Yasaman Vahdani, Anita Franco and Alain Moreau
7 November, 2025

#ME/CFS #nDNA #mtDNA
www.mdpi.com
November 3, 2026 at 2:19 PM
Mitochondrial dysfunction can be caused by maternal mDNA inheritance OR
paternal / maternal nDNA cellular process influences 💥 !!
So now “don’t blame just your Mother &why GWAS studies of nuclear DNA insufficient to show patterns related to complex diagnosis lmetabolic syndrome& mental ill health
Buhuu 👻 You absolutely cannot miss this week's edition of @biomednews.bsky.social Mitochondria in Health & Disease! Full collection available here: biomed.news/bims-mitdis/...

As always thanks to @gavinmcstay.bsky.social, @mitoscientist.bsky.social, @mitoworld.bsky.social and all mitoscientists!
November 1, 2026 at 4:21 PM
True that other ministers would stay in post (a NDNA measure aimed at improving stability of the institutions) but this would be in a caretaker capacity overseeing work already in progress, with no new or cross-cutting decisions. It's not intended to be pursued as an alternative form of governance
Diane Forsythe joins Carla Lockhart in calling for the DUP leader to take the dFM Emma Little-Pengelly out of The Executive Office - to remove Michelle O'Neill from the First Minister position

She says other ministers would remain in post without a FM/dFM in office
October 27, 2026 at 10:55 AM
Safe Work Australia's model fatigue Code gives at least 12 hours between shifts as one example of a control. NSW approved the Code from February 2026.

Image description: Blue card reading At least 12 hours between shifts, with a clock and moon.

#ndnurses #neurodivergentnurses #nursingworkforce
November 4, 2026 at 1:01 AM
More to do to get Ofsted inspections right despite positive signs | NDNA
More to do to get Ofsted inspections right despite positive signs - NDNA
Early years providers are generally giving the new Ofsted inspection framework the thumbs up, although they question the consistency and collaborative approach.
ndna.org.uk
October 15, 2026 at 10:03 AM
🌟 Become a Maths Champion! 🌟

The National Day Nurseries Association (NDNA) are working to create Maths Champions!

Join the session session on 13 October at 15:45 on Zoom. Register now! ➕

🔢 #EarlyYears #MathsChampions #SouthYorkshireMathsHub
October 8, 2026 at 11:32 AM
Conservative Party proposes to remove earnings limit on funded childcare places | NDNA
Conservative Party Proposes to Remove Earnings Limit on Funded Childcare Places  - NDNA
Conservative leader Kemi Badenoch has said a Conservative government would scrap the "cliff edge" that means parents in England are no longer eligible for funded childcare hours once they earn more than £100,000 a year.
ndna.org.uk
October 7, 2026 at 6:38 AM
Autumn maths for early years: pumpkins, patterns and plenty of play | NDNA
Autumn maths for early years: pumpkins, patterns and plenty of play - NDNA
Discover how autumn provides everyday opportunities for early years maths. Explore Maths Champions and build confidence in supporting children’s mathematical development.
ndna.org.uk
September 30, 2026 at 10:01 AM
The rewriting of NI's post-1998 governance arrangements has happened repeatedly from St Andrews to NDNA (often at the behest of the parties and never, since 1998, with direct popular input). St Andrews itself demonstrates how far such changes can go if the UK and Irish Govts accept them.
September 30, 2026 at 9:59 AM
New vocational GCSEs unveiled | NDNA
New Vocational GCSEs Unveiled - NDNA
New Vocational GCSEs have been unveiled to be introduced from 2029 and could include child development as one of the subjects.
ndna.org.uk
September 28, 2026 at 3:55 PM
With NDNA changes, the Executive Ministers would stay in post until March, so there is an argument for not going early and leaving it until May.
September 27, 2026 at 7:53 PM
However, operations will not completely cease should this happen - it will put things into a type of care-taker mode. Arrangements agreed in NDNA mean Exec ministers will continue in post for 24 weeks and committees will continue to function
Don’t be at all surprised if Stormont collapses one way or another this week – SF because the present-day structures don’t serve the interest of nationalists; DUP because the First Minister participated in an unlawful protest gathering – and for another stalemate that last for *years*.
September 27, 2026 at 2:58 PM
Improving children's outcomes is the top priority in Wales-Scotland agreement | NDNA
Improving children’s outcomes is the top priority in Wales-Scotland agreement - NDNA
Tackling child poverty and improving outcomes for children and families is the top area for co-operation as agreed by the Welsh and Scottish governments.
ndna.org.uk
September 16, 2026 at 4:15 PM
Calls growing to raise the earnings threshold for funded childcare | NDNA
Calls growing to raise the earnings threshold for funded childcare - NDNA
Noise is increasing around the proposal to raise the higher earnings threshold for funded places in England which has been fixed at £100,000 per parent since 2017
ndna.org.uk
September 16, 2026 at 4:16 PM
NDNA urges support for PVIs ahead of Budget | Nursery World
September 16, 2026 at 5:35 AM
タテジマフジツボ属 Amphibalanusっぽいけどぜんぜんわかんねえな、とフジツボ好きおじさんに「これわかる?」と写真を送ったところ、「これたぶん1989年に新種記載されて以来誰にも言及されてない例のクソマイナーフジツボですよ」と教えてもらいました。で、原記載論文を確認してみたところまさにそれ、ということで世界で数例目の記録として形態の詳細な再記載とmtDNA COI配列、nDNA H3配列を合わせて記録しました。
September 7, 2026 at 2:35 PM
Re the Boorman connection they were supposed to shoot NDNA and Tel Young's Caine Philbysploitation the Jigsaw Man at Ardmore but Fianna Fail incompetence involving the sale and closure of Ardmore forced both very dreary films to stay in England
Both look same budget. Cept nsna cost 35m and Jigsaw 6
August 29, 2026 at 4:55 PM
Mitochondrial cardiomyopathy arises from defects in oxidative phosphorylation due to nDNA or mtDNA variants, differing in inheritance from sarcomere cardiomyopathies. Understanding these molecular… PMID:42315930, Nat Rev Cardiol 2026, @NatRevCardiol https://doi.org/10.1038/s41569-026-01301-y #RNA 🧪
Mitochondrial cardiomyopathy: bridging molecular mechanisms and clinical frontiers | Nature Reviews Cardiology
Genetic cardiomyopathies caused by pathogenic variants in nuclear DNA (nDNA) that encodes contractile sarcomere proteins are among the best understood of all the cardiomyopathies. By contrast, mitochondrial cardiomyopathy is caused by a dysfunction in mitochondrial oxidative phosphorylation due to pathogenic variants in either nDNA or the maternal mitochondrial DNA (mtDNA). Unlike contractile protein defects, which generally follow predictable Mendelian inheritance patterns, mitochondrial cardiomyopathy is genetically complex as a result of the distinctive characteristics of the mitochondrial genome, which influence patterns of maternal inheritance, heteroplasmy and tissue-specific variations in mtDNA variant load. Both single-gene nDNA and mtDNA variants can impair cardiac energetics, resulting in a wide clinical spectrum ranging from severe, childhood-onset to milder, adult-onset cardiomyopathy. Furthermore, the intricate metabolic demands of the heart mean that mitochondrial dysfunc
doi.org
August 21, 2026 at 5:00 PM
Give your views on how EY funding formula is distributed | NDNA
Give your views on how EY funding formula is distributed - NDNA
The Government has launched a consultation into the EY funding formula, proposing among other measures that they remove the pass-through rate. Please give your views over the coming weeks, deadline is 14 September.
ndna.org.uk
July 7, 2026 at 6:00 AM