“You see, nephritic people pee like this, but nephrotic people pee like THIS.”
August 20, 2023 at 6:37 PM
“You see, nephritic people pee like this, but nephrotic people pee like THIS.”
Nephrotic 🆚Nephritic syndrome
From Curbsiders
From Curbsiders
November 13, 2024 at 4:44 PM
Nephrotic 🆚Nephritic syndrome
From Curbsiders
From Curbsiders
oh no. oh no no no. not again.
November 30, 2024 at 5:04 AM
oh no. oh no no no. not again.
Post-infectious GN that didn't read the textbook. Young adult with nephritic syndrome + recent step throat. +ASO. Low C3/C4. UA with 2+ blood and 1+ protein. DPGN with full house staining and massive subendo deposits. Serologic w/u (-). Resolved with supportive care. #nephsky #pathsky #renapath
January 11, 2025 at 4:11 PM
I don’t think C3 nephritic factor has been checked in lupus? @alhkim.bsky.social knows I have mentioned this to him a few times.
January 17, 2025 at 7:47 PM
I don’t think C3 nephritic factor has been checked in lupus? @alhkim.bsky.social knows I have mentioned this to him a few times.
As a diabetic (well-controlled, and close to remission), keeping nephritic function has been a big focus of my docs and me.
I wish you luck….
I wish you luck….
January 7, 2026 at 5:20 AM
As a diabetic (well-controlled, and close to remission), keeping nephritic function has been a big focus of my docs and me.
I wish you luck….
I wish you luck….
Yesterday I was in ER because I had a nephritic colic and despite they gave me medication for a week my biggest issue is that i wont be able to consume coffee, life has no meaning without coffee
April 13, 2025 at 5:13 AM
Yesterday I was in ER because I had a nephritic colic and despite they gave me medication for a week my biggest issue is that i wont be able to consume coffee, life has no meaning without coffee
Trying to isolate this RBC cast from a sea of normocytic RBCs.
78/F with nephrotic-nephritic syndrome. Labs pending.
78/F with nephrotic-nephritic syndrome. Labs pending.
January 18, 2025 at 5:49 AM
Trying to isolate this RBC cast from a sea of normocytic RBCs.
78/F with nephrotic-nephritic syndrome. Labs pending.
78/F with nephrotic-nephritic syndrome. Labs pending.
Nephritic and nephrotic #UrinarySediment in a case of GPA PR3+ AKI. 1000x bright field: RBC cast (SM-stained). 500x polarized light: oval fat body cast with Maltese cross signs @OchsnerNephro @GlomConILA #ANCA
December 10, 2024 at 12:22 AM
Nephritic and nephrotic #UrinarySediment in a case of GPA PR3+ AKI. 1000x bright field: RBC cast (SM-stained). 500x polarized light: oval fat body cast with Maltese cross signs @OchsnerNephro @GlomConILA #ANCA
T1c
Inclusion criteria:
⭕adolescents (ages 12–17)
⭕adults (> 18 years)
⭕biopsy proven C3 GN or primary IC-MPGN
⭕evidence of 🤸🏽♀️active disease: 2+ or higher on C3 IF staining
⭕➕biomarkers if adolescent
‼️⬆️Plasma sC5-9
‼️⬇️serum C3
‼️hematuria
‼️C3 nephritic factor
#NephJC
Inclusion criteria:
⭕adolescents (ages 12–17)
⭕adults (> 18 years)
⭕biopsy proven C3 GN or primary IC-MPGN
⭕evidence of 🤸🏽♀️active disease: 2+ or higher on C3 IF staining
⭕➕biomarkers if adolescent
‼️⬆️Plasma sC5-9
‼️⬇️serum C3
‼️hematuria
‼️C3 nephritic factor
#NephJC
January 14, 2026 at 2:18 AM
T1c
Inclusion criteria:
⭕adolescents (ages 12–17)
⭕adults (> 18 years)
⭕biopsy proven C3 GN or primary IC-MPGN
⭕evidence of 🤸🏽♀️active disease: 2+ or higher on C3 IF staining
⭕➕biomarkers if adolescent
‼️⬆️Plasma sC5-9
‼️⬇️serum C3
‼️hematuria
‼️C3 nephritic factor
#NephJC
Inclusion criteria:
⭕adolescents (ages 12–17)
⭕adults (> 18 years)
⭕biopsy proven C3 GN or primary IC-MPGN
⭕evidence of 🤸🏽♀️active disease: 2+ or higher on C3 IF staining
⭕➕biomarkers if adolescent
‼️⬆️Plasma sC5-9
‼️⬇️serum C3
‼️hematuria
‼️C3 nephritic factor
#NephJC
unmistakable leak through those nephritic filters
March 3, 2026 at 3:25 PM
unmistakable leak through those nephritic filters
Acquired factors matter equally: C3 nephritic factors (present in 50–80% of patients) stabilize C3 convertase and drive uncontrolled activation. Highly stabilizing activity correlates with rapid disease progression.
April 10, 2026 at 1:51 PM
Acquired factors matter equally: C3 nephritic factors (present in 50–80% of patients) stabilize C3 convertase and drive uncontrolled activation. Highly stabilizing activity correlates with rapid disease progression.
This is an interesting question! This is how I see it. First, it’s important to define what we call a nephritic factor - which is an autoab to the neoepitope on C3 convertase that stabilizes the convertase & allows complement activation to keep going and prevents regulation by complement regulators.
January 18, 2025 at 6:44 PM
This is an interesting question! This is how I see it. First, it’s important to define what we call a nephritic factor - which is an autoab to the neoepitope on C3 convertase that stabilizes the convertase & allows complement activation to keep going and prevents regulation by complement regulators.
Management starts with a comprehensive complement workup: C3, C3c, Bb, C4, nephritic factors, soluble C5b-9, properdin, factor H, CH50/APH50, and genotyping. Treatment is activity-guided: supportive care → MMF/steroids → anti-complement therapy.
April 10, 2026 at 1:51 PM
Management starts with a comprehensive complement workup: C3, C3c, Bb, C4, nephritic factors, soluble C5b-9, properdin, factor H, CH50/APH50, and genotyping. Treatment is activity-guided: supportive care → MMF/steroids → anti-complement therapy.
Case report: A nephritic puzzle: C3-dominant glomerulonephritis as a sentinel of hidden autoinflammatory disease
#openaccess
#nephsky
#openaccess
#nephsky
A nephritic puzzle: C3-dominant glomerulonephritis as a sentinel of hidden autoinflammatory disease - Pediatric Nephrology
Membranoproliferative glomerulonephritis (MPGN) is among the most challenging glomerulonephritides to diagnose and manage, given its clinico-immunopathologic heterogeneity. Although recent advances…
buff.ly
February 28, 2026 at 6:03 PM
Case report: A nephritic puzzle: C3-dominant glomerulonephritis as a sentinel of hidden autoinflammatory disease
#openaccess
#nephsky
#openaccess
#nephsky
So RTX does not deplete B cells from lymph nodes & likely inflamed organs.
Curious in the non-responders what the C3 nephritic factor levels are. If high, they are coming from long-lived plasma cells (I’d hypothesize). If they drop, then it argues that tissue B cells are contributing to pathology.
Curious in the non-responders what the C3 nephritic factor levels are. If high, they are coming from long-lived plasma cells (I’d hypothesize). If they drop, then it argues that tissue B cells are contributing to pathology.
January 18, 2025 at 3:43 AM
So RTX does not deplete B cells from lymph nodes & likely inflamed organs.
Curious in the non-responders what the C3 nephritic factor levels are. If high, they are coming from long-lived plasma cells (I’d hypothesize). If they drop, then it argues that tissue B cells are contributing to pathology.
Curious in the non-responders what the C3 nephritic factor levels are. If high, they are coming from long-lived plasma cells (I’d hypothesize). If they drop, then it argues that tissue B cells are contributing to pathology.
A Case Report and Literature Review of ANCA-Associated Vasculitis and #Lupus Nephritis Overlap: Lessons in Management
karger.com/gdz/article/...
karger.com/gdz/article/...
A Case Report and Literature Review of ANCA-Associated Vasculitis and Lupus Nephritis Overlap: Lessons in Management
Abstract. Introduction: ANCA-associated vasculitis (AAV) and lupus nephritis (LN) are distinct disease processes that both cause a nephritic picture with acute renal failure, but have different pathop...
karger.com
March 18, 2025 at 8:57 AM
A Case Report and Literature Review of ANCA-Associated Vasculitis and #Lupus Nephritis Overlap: Lessons in Management
karger.com/gdz/article/...
karger.com/gdz/article/...
Daily Pearl(s):
Signs of GPA
The combination of an acute kidney injury with a nephritic sediment and any upper respiratory symptoms (sinusitis, otitis, nasal deformity) should immediately raise suspicion for GPA.
Signs of GPA
The combination of an acute kidney injury with a nephritic sediment and any upper respiratory symptoms (sinusitis, otitis, nasal deformity) should immediately raise suspicion for GPA.
April 11, 2026 at 9:00 PM
Daily Pearl(s):
Signs of GPA
The combination of an acute kidney injury with a nephritic sediment and any upper respiratory symptoms (sinusitis, otitis, nasal deformity) should immediately raise suspicion for GPA.
Signs of GPA
The combination of an acute kidney injury with a nephritic sediment and any upper respiratory symptoms (sinusitis, otitis, nasal deformity) should immediately raise suspicion for GPA.
8/10
Consensus:
The indications can guide you for the biopsy:
🔬Age <30 or >60
🔬Active urine sediment
🔬AKI/Acute Nephritic presentation/RPRF
🔬Atypical symptoms: arthritis / rash
🔬Better to avoid in DM pts with CKD & proteinuria without atypical features
Consensus:
The indications can guide you for the biopsy:
🔬Age <30 or >60
🔬Active urine sediment
🔬AKI/Acute Nephritic presentation/RPRF
🔬Atypical symptoms: arthritis / rash
🔬Better to avoid in DM pts with CKD & proteinuria without atypical features
June 3, 2026 at 12:10 PM
8/10
Consensus:
The indications can guide you for the biopsy:
🔬Age <30 or >60
🔬Active urine sediment
🔬AKI/Acute Nephritic presentation/RPRF
🔬Atypical symptoms: arthritis / rash
🔬Better to avoid in DM pts with CKD & proteinuria without atypical features
Consensus:
The indications can guide you for the biopsy:
🔬Age <30 or >60
🔬Active urine sediment
🔬AKI/Acute Nephritic presentation/RPRF
🔬Atypical symptoms: arthritis / rash
🔬Better to avoid in DM pts with CKD & proteinuria without atypical features
Addressing Risk Factors That Drive CKD Risk in Lupus Nephritis - Physician's Weekly - goo.gl/alerts/TdXMgN #GoogleAlerts
Addressing Risk Factors That Drive CKD Risk in Lupus Nephritis - Physician's Weekly
Research shows multiple factors drive CKD risk in lupus nephritis, including nephritic flares, baseline hypertension, renal impairment, and proteinuria.
goo.gl
March 14, 2025 at 1:00 PM
Addressing Risk Factors That Drive CKD Risk in Lupus Nephritis - Physician's Weekly - goo.gl/alerts/TdXMgN #GoogleAlerts
A Case Report and Literature Review of ANCA-Associated Vasculitis and Lupus Nephritis Overlap: Lessons in Management karger.com/gdz/article/...
A Case Report and Literature Review of ANCA-Associated Vasculitis and Lupus Nephritis Overlap: Lessons in Management
Abstract. Introduction: ANCA-associated vasculitis (AAV) and lupus nephritis (LN) are distinct disease processes that both cause a nephritic picture with acute renal failure, but have different pathop...
karger.com
March 29, 2025 at 7:23 PM
A Case Report and Literature Review of ANCA-Associated Vasculitis and Lupus Nephritis Overlap: Lessons in Management karger.com/gdz/article/...
The combination of hematuria, proteinuria, and casts on a UA is considered “nephritic sediment”. The presence of the sediment helps to localize the pathology to the glomerulus.
August 25, 2026 at 9:00 PM
The combination of hematuria, proteinuria, and casts on a UA is considered “nephritic sediment”. The presence of the sediment helps to localize the pathology to the glomerulus.
Lecture 10: Glomerular Diseases — Renal
Glomerular diseases produce recognizable clinical patterns that guide differential diagnosis and management.
https://hibbertmed.com/lectures/year2/unit2.1_renal/lecture_10_glomerular_diseases
Glomerular diseases produce recognizable clinical patterns that guide differential diagnosis and management.
https://hibbertmed.com/lectures/year2/unit2.1_renal/lecture_10_glomerular_diseases
February 20, 2026 at 5:34 PM
Lecture 10: Glomerular Diseases — Renal
Glomerular diseases produce recognizable clinical patterns that guide differential diagnosis and management.
https://hibbertmed.com/lectures/year2/unit2.1_renal/lecture_10_glomerular_diseases
Glomerular diseases produce recognizable clinical patterns that guide differential diagnosis and management.
https://hibbertmed.com/lectures/year2/unit2.1_renal/lecture_10_glomerular_diseases