⭐ #NARBreakthrough ⭐
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
October 26, 2026 at 2:57 PM
⭐ #NARBreakthrough ⭐
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates
A single-tube protocol for enzymatic synthesis of DNA containing 1–3 site-specific nucleobase modifications was developed based on repeated single nucleotide extension, primer extension, and exchange...
chemistry-europe.onlinelibrary.wiley.com
October 23, 2026 at 5:15 PM
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates
Genes to Cells
Volume 31, Issue 5 , 2026.
"Characterization of Nucleobase Cation Symporter 1 (NCS1) Localized to the Plastids of Nicotiana tabacum"
doi.org/10.1111/gtc....
Author's Comment ➡️
Volume 31, Issue 5 , 2026.
"Characterization of Nucleobase Cation Symporter 1 (NCS1) Localized to the Plastids of Nicotiana tabacum"
doi.org/10.1111/gtc....
Author's Comment ➡️
Characterization of Nucleobase Cation Symporter 1 (<fc>NCS1</fc>) Localized to the Plastids of <fc><fi>Nicotiana tabacum</fi></fc>
The organ-specific role of the plastidial NtNCS1 in resource allocation. JA differentially regulates NtNCS1: comprehensive repression in leaves, but mRNA induction with sustained protein levels in ro...
doi.org
October 20, 2026 at 1:16 AM
Genes to Cells
Volume 31, Issue 5 , 2026.
"Characterization of Nucleobase Cation Symporter 1 (NCS1) Localized to the Plastids of Nicotiana tabacum"
doi.org/10.1111/gtc....
Author's Comment ➡️
Volume 31, Issue 5 , 2026.
"Characterization of Nucleobase Cation Symporter 1 (NCS1) Localized to the Plastids of Nicotiana tabacum"
doi.org/10.1111/gtc....
Author's Comment ➡️
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenResearch #accelerateopenscience #methodsmatter
Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY
Read the full paper: Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY
doi.org
October 9, 2026 at 7:05 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenResearch #accelerateopenscience #methodsmatter
The authors included RRIDs in their in ChemBioChem paper! RRIDs improve reproducibility in scientific research. #STMpublishing #BetterScience #methodsmatter
Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY
Read the full paper: Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY
doi.org
October 9, 2026 at 7:12 AM
The authors included RRIDs in their in ChemBioChem paper! RRIDs improve reproducibility in scientific research. #STMpublishing #BetterScience #methodsmatter
New online! Enzymatic skeletal editing reaction forming the 1,3,5-triazine core during biosynthesis of the anticancer nucleoside analogue 5-azacytidine: Nature Catalysis, Published online: 07 September 2026; doi:10.1038/s41929-026-01611-xDespite decades of clinical use, the biosynthetic origin of…
Enzymatic skeletal editing reaction forming the 1,3,5-triazine core during biosynthesis of the anticancer nucleoside analogue 5-azacytidine
Nature Catalysis, Published online: 07 September 2026; doi:10.1038/s41929-026-01611-xDespite decades of clinical use, the biosynthetic origin of 5-azacytidine remained unknown. Now the responsible gene cluster is identified, revealing enzymes that convert guanosine triphosphate into a triazine nucleobase through rare skeletal editing and unconventional thiamine-dependent chemistry.
go.nature.com
September 7, 2026 at 1:37 PM
New online! Enzymatic skeletal editing reaction forming the 1,3,5-triazine core during biosynthesis of the anticancer nucleoside analogue 5-azacytidine: Nature Catalysis, Published online: 07 September 2026; doi:10.1038/s41929-026-01611-xDespite decades of clinical use, the biosynthetic origin of…
@garagemtribal
⚡ IRA! NA VEIA, SEM FILTRO. ⚡
(...)
🔥 Nasi, Edgard Scandurra, Ricardo Gaspa e André Jung, uma formação que deixou o som da banda ainda mais afiado e intenso.
(...)
🎸 Garagem Tribal - mantendo vivo o som que marcou gerações. 🤘⚡
#RockNacional #IRA #NucleoBase #Anos80 #GaragemTribal
⚡ IRA! NA VEIA, SEM FILTRO. ⚡
(...)
🔥 Nasi, Edgard Scandurra, Ricardo Gaspa e André Jung, uma formação que deixou o som da banda ainda mais afiado e intenso.
(...)
🎸 Garagem Tribal - mantendo vivo o som que marcou gerações. 🤘⚡
#RockNacional #IRA #NucleoBase #Anos80 #GaragemTribal
September 5, 2026 at 8:33 AM
@garagemtribal
⚡ IRA! NA VEIA, SEM FILTRO. ⚡
(...)
🔥 Nasi, Edgard Scandurra, Ricardo Gaspa e André Jung, uma formação que deixou o som da banda ainda mais afiado e intenso.
(...)
🎸 Garagem Tribal - mantendo vivo o som que marcou gerações. 🤘⚡
#RockNacional #IRA #NucleoBase #Anos80 #GaragemTribal
⚡ IRA! NA VEIA, SEM FILTRO. ⚡
(...)
🔥 Nasi, Edgard Scandurra, Ricardo Gaspa e André Jung, uma formação que deixou o som da banda ainda mais afiado e intenso.
(...)
🎸 Garagem Tribal - mantendo vivo o som que marcou gerações. 🤘⚡
#RockNacional #IRA #NucleoBase #Anos80 #GaragemTribal
RiPP peptide–nucleobase hybrid natural products with a pyrimidone motif
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides - Nature Chemical Biology
Naturally occurring peptide–nucleobase hybrids are rare. Here Pei et al. report the discovery and biosynthetic studies of the first peptide–nucleobase hybrid catalyzed by an RRE–YcaO–dehydrogenase com...
www.nature.com
September 19, 2024 at 8:54 AM
RiPP peptide–nucleobase hybrid natural products with a pyrimidone motif
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📣New from @byronpurse.bsky.social et al at @sdsuresearch.bsky.social
A nucleobase analogue that lights up only when it pairs right: DEAtC turns on fluorescence through G-templated tautomerism, switching from a dark T-like form to an emissive C-like tautomer.
Read it here
A nucleobase analogue that lights up only when it pairs right: DEAtC turns on fluorescence through G-templated tautomerism, switching from a dark T-like form to an emissive C-like tautomer.
Read it here
Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEAtC
Fluorescent probes for measuring the structure, dynamics, cellular localization, and biochemistry of DNA and RNA are useful for determining the regulatory mechanisms of gene expression. Intrinsically fluorescent, Watson–Crick-capable nucleobase analogues are especially powerful because they can precisely probe desi
doi.org
December 18, 2025 at 4:15 PM
📣New from @byronpurse.bsky.social et al at @sdsuresearch.bsky.social
A nucleobase analogue that lights up only when it pairs right: DEAtC turns on fluorescence through G-templated tautomerism, switching from a dark T-like form to an emissive C-like tautomer.
Read it here
A nucleobase analogue that lights up only when it pairs right: DEAtC turns on fluorescence through G-templated tautomerism, switching from a dark T-like form to an emissive C-like tautomer.
Read it here
📢Latest article out now!
M Michel et al. used synthetic purine analogues to profile the nucleobase landscape of OGG1 looking for catalysts of the Schiff base cleavage, identifying two series that increased enzyme turnover and enhanced DNA damage repair.
👉Full story here:
M Michel et al. used synthetic purine analogues to profile the nucleobase landscape of OGG1 looking for catalysts of the Schiff base cleavage, identifying two series that increased enzyme turnover and enhanced DNA damage repair.
👉Full story here:
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with an abasic (AP) site base excision repair intermediate. For 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining step in the initiation of 8-oxoguanine (8-oxoG) repair
doi.org
December 5, 2025 at 8:09 AM
📢Latest article out now!
M Michel et al. used synthetic purine analogues to profile the nucleobase landscape of OGG1 looking for catalysts of the Schiff base cleavage, identifying two series that increased enzyme turnover and enhanced DNA damage repair.
👉Full story here:
M Michel et al. used synthetic purine analogues to profile the nucleobase landscape of OGG1 looking for catalysts of the Schiff base cleavage, identifying two series that increased enzyme turnover and enhanced DNA damage repair.
👉Full story here:
Distribution of purine and pyrimidine bases in Antarctic carbonaceous meteorites #stableisotopes www.sciencedirect.com/science/arti...
Distribution of purine and pyrimidine bases in Antarctic carbonaceous meteorites
Carbonaceous meteorites preserve organic records of early Solar System chemistry, yet nucleobase inventories remain difficult to interpret owing to po…
www.sciencedirect.com
August 2, 2026 at 6:56 AM
Distribution of purine and pyrimidine bases in Antarctic carbonaceous meteorites #stableisotopes www.sciencedirect.com/science/arti...
Fresh off the lab press! New ACS Chem Bio paper from Benner and colleagues reveals improved Z nucleosides for AEGIS DNA, reducing deprotonation, Z:G mismatches, and boosting fidelity.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Improving the Fidelity of Replication of a Six-Letter DNA Alphabet
The Watson–Crick-Franklin (WCF) rules describing nucleobase pairing in antiparallel strands of DNA and RNA can be exploited to create artificially expanded genetic information systems (AEGIS) with as ...
pubs.acs.org
November 12, 2025 at 3:16 PM
Fresh off the lab press! New ACS Chem Bio paper from Benner and colleagues reveals improved Z nucleosides for AEGIS DNA, reducing deprotonation, Z:G mismatches, and boosting fidelity.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Professors Purse and Lee's groups collaborated to produced the manuscript "Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN" that was recently accepted for publication by the RCS's Chemical Sciences journal! Read about their work here: buff.ly/3WOpG5M
Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN
Fluorescent nucleobase analogues (FBAs) have emerged as powerful tools for understanding nucleic acid systems at the molecular level. However, their application at the single-molecule level has been l...
buff.ly
February 5, 2025 at 5:58 PM
Professors Purse and Lee's groups collaborated to produced the manuscript "Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN" that was recently accepted for publication by the RCS's Chemical Sciences journal! Read about their work here: buff.ly/3WOpG5M
May I suggest "Gobboline" as the name of the last nucleobase, to keep the theming.
August 18, 2025 at 1:57 AM
May I suggest "Gobboline" as the name of the last nucleobase, to keep the theming.