⭐ #NARBreakthrough ⭐
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
October 26, 2026 at 2:57 PM
⭐ #NARBreakthrough ⭐
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
🧬 Tough DNA target, big impact! Prof. Rusling's lab @daverusling.bsky.social shows that a simple #nucleobase modification enables TFOs to repress MYC #promoteractivity by ~80%, even in a challenging GC-rich DNA region. doi.org/10.1093/nar/... #triplexforming #oligonucleotides
⭐ #NARBreakthrough ⭐
What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...
What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...
September 29, 2026 at 3:10 PM
⭐ #NARBreakthrough ⭐
What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...
What if we could bring ancient proteins back to life? 🧬 Prof. Stoddard’s lab @fredhutch.org found that ~10% of homing endonucleases remain functional, and ancestral reconstruction reveals how these enzymes evolved new targets. Read the article here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐
How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...
How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...
August 28, 2026 at 2:46 PM
⭐ #NARBreakthrough ⭐
How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...
How do #IStrons juggle 3 competing functions from a single sequence? #Newstudy reveals an RNA-level #tug-of-war between #self-preservation and #hostprotection, shaped by #RNAfolding 🔬Read the article here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐
🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/...
@igmm-montpel.bsky.social
🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/...
@igmm-montpel.bsky.social
June 23, 2026 at 2:43 PM
⭐ #NARBreakthrough ⭐
🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/...
@igmm-montpel.bsky.social
🩸🔬 Unexpected role for #ZEB1 in #redbloodcell development! ZEB1 cooperates with KLF1 to regulate #erythroidmaturation and #enucleation, revealing a new regulatory axis essential for #erythropoiesis. 🧬✨ Read the article here: doi.org/10.1093/nar/...
@igmm-montpel.bsky.social
⭐ #NARBreakthrough ⭐
🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
June 22, 2026 at 2:28 PM
⭐ #NARBreakthrough ⭐
🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
🔬 How do #cyanobacteria avoid overreacting to stress? New research shows that antisense RNAs keep the #stress-response gene nblA off under normal conditions, preventing damage while enabling rapid adaptation when nutrients become limiting. 📖 Read here doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐
🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
June 19, 2026 at 5:50 PM
⭐ #NARBreakthrough ⭐
🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
🔬New research reveals that #Trypanosomabrucei CRK9 and human CDK11 share a role in #RNAsplicing through #SF3B1 phosphorylation. An unexpected link with implications for #antiparasitic drug development. 📖 Read the article here: doi.org/10.1093/nar/... @uconnhealth.bsky.social
⭐ #NARBreakthrough! ⭐
New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding.
📖 Read here: doi.org/10.1093/nar/...
New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding.
📖 Read here: doi.org/10.1093/nar/...
May 15, 2026 at 2:39 PM
⭐ #NARBreakthrough! ⭐
New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding.
📖 Read here: doi.org/10.1093/nar/...
New #cryo-EM study reveals how #transcription factor IWS1 promotes #RNApolII #elongation. Its C-terminus contains #modularmotifs that bind elongation components, stabilizing the complex. IWS1 also competes with #RECQL5 for Pol II binding.
📖 Read here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough! ⭐
🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity.
📖 Read the article: doi.org/10.1093/nar/...
🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity.
📖 Read the article: doi.org/10.1093/nar/...
May 13, 2026 at 3:23 PM
⭐ #NARBreakthrough! ⭐
🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity.
📖 Read the article: doi.org/10.1093/nar/...
🔬 New study by @magistratolab.bsky.social and @pokorna.bsky.social reveals how TAT-SF1 acts as a “molecular latch,” storing strain in #U2snRNP to drive branch-helix formation. A “loaded-spring” model for #splicingfidelity.
📖 Read the article: doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐
New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
April 29, 2026 at 3:48 PM
⭐ #NARBreakthrough ⭐
New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
New study delivers the first chromosome-level phased assemblies, uncovering >50,000 #structuralvariants and rescuing millions of #unmappable reads in BJ and IMR-90 human cell lines. 📖 Read here: doi.org/10.1093/nar/... #Genomics #CellLines #CommunityResource
⭐ #NARBreakthrough! ⭐
🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers.
📖 Read here: doi.org/10.1093/nar/...
🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers.
📖 Read here: doi.org/10.1093/nar/...
April 27, 2026 at 3:12 PM
⭐ #NARBreakthrough! ⭐
🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers.
📖 Read here: doi.org/10.1093/nar/...
🔬New study shows how the #RAD52 homolog Mgm101 anneals complementary ssDNA during single-strand annealing repair, forming an unwound #duplex intermediate. #Structural insights reveal a new #therapeutic potential in #BRCA-mutant cancers.
📖 Read here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough ⭐
🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
April 1, 2026 at 2:19 PM
⭐ #NARBreakthrough ⭐
🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...
⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
March 6, 2026 at 3:54 PM
⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
March 4, 2026 at 4:58 PM
🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
⭐ #NARBreakthrough! ⭐
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...
February 25, 2026 at 5:46 PM
⭐ #NARBreakthrough! ⭐
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...
⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
January 19, 2026 at 6:23 PM
⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis
#NARBreakthrough #RibosomeBiogenesis
December 15, 2025 at 4:25 PM
🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis
#NARBreakthrough #RibosomeBiogenesis
⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
November 24, 2025 at 6:16 PM
⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense
⭐ NAR Breakthrough! ⭐
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
November 21, 2025 at 6:18 PM
⭐ NAR Breakthrough! ⭐
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
October 15, 2025 at 1:49 PM
⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org
#NARbreakthrough #ChromosomeSegregation
⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc
doi.org
September 24, 2025 at 5:34 PM
⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social
⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
September 11, 2025 at 2:42 PM
⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...
⭐NAR Breakthrough!⭐
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
August 29, 2025 at 3:09 PM
⭐NAR Breakthrough!⭐
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823
#NARBreakthrough #RNA #RNAHelicase
⭐NAR Breakthrough!⭐
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough
Promoter-targeted small RNA duplexes increase MBNL1 transcription and mitigate myotonic dystrophy-associated spliceopathy
Abstract. Functional depletion of Muscleblind-like (MBNL) proteins is a key trigger of myotonic dystrophy (DM)-associated alternative splicing (AltS) defec
doi.org
August 20, 2025 at 3:18 PM
⭐NAR Breakthrough!⭐
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough
⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes
Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant
Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A
doi.org
August 4, 2025 at 9:09 AM
⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes
⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast
Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search
Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal
doi.org
August 1, 2025 at 7:07 AM
⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast