#hOGG1
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prcatstronaut.bsky.social
Oh.. in another academic life, my thesis was on 8oxoG and hOGG1. I left with a masters, but you never forget your first project
biorxiv-genetic.bsky.social bioRxiv Genetics @biorxiv-genetic.bsky.social · Oct 9
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1. https://www.biorxiv.org/content/10.1101/2025.10.08.681224v1
October 9, 2025 at 2:55 AM
c0nc0rdance.bsky.social
On all levels except physical, I am this graph with "T" instead of error bars today.
Text from Josemari Felici... "Wait a second, these are not real error bars... the author literally just put the letter "T" above the bar graphs", and it shows a bar graph labeled blank, pink, lysozyme, hOGG1, and Endo IV vs. Current in microamps.
October 18, 2024 at 4:58 PM
iucrj.iucr.org
M​ichihiro Suga: Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex ##XRayFreeElectronLasers##XFELs##TimeResolvedCrystallography@okayama_uni...##IUCrhttps://journals.iucr.org/paper?S2052252525007353
Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex
Structural analysis of the co-crystal between human DNA glycosylase hOGG1 and a light-sensitive substrate analog highlights its utility as a platform for real-time observation of catalytic dynamics.
journals.iucr.org
August 29, 2025 at 12:00 AM
iucrj.iucr.org
Tomoki Imura et al.: Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target? ##DNARepair##PhotocagedSubstrateAnaloga##HOgg1@osaka_univ_e...##IUCrhttps://journals.iucr.org/paper?S2052252525006062
Revisiting the co-crystal structure of a DNA glycosylase with photocaged substrate: a suitable time-resolved crystallography target?
Engineered in crystallo photosensitivity in a DNA-repair enzyme is carefully assessed for its suitability as a target for time-resolved crystallographic studies.
journals.iucr.org
July 15, 2025 at 12:01 AM
narjournal.bsky.social
⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes
Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant
Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A
doi.org
August 4, 2025 at 9:09 AM
cbm-csic-uam.bsky.social
Miguel de Vega (@devega_M, @CBMSO_CSIC_UAM) has participated in a study published in Science (@Sciencemagazine) showing how a small molecule endows hOGG1 with new activity, improving oxidative DNA damage repair.

science.org/doi/10.1126/sc…
November 27, 2024 at 3:33 PM