Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
May 21, 2025 at 11:50 PM
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
In our first paper of 2026, @aliceieong.bsky.social puts NHC organocatalyst in action with mechanical force in ACS Catalysis!
🔨 NHC generated by milling a new betaine mechanophore to catalyse transesterification and polymerisation reactions.
#chemsky @pubs.acs.org
pubs.acs.org/doi/10.1021/...
🔨 NHC generated by milling a new betaine mechanophore to catalyse transesterification and polymerisation reactions.
#chemsky @pubs.acs.org
pubs.acs.org/doi/10.1021/...
Force-Generated N-Heterocyclic Carbene Organocatalyst
Controlling the life cycle of polymer materials, for example, by extending their useful lifetime and by accelerating their recycling, is crucial to ensure a better future. Such properties can be intro...
pubs.acs.org
January 14, 2026 at 7:10 PM
In our first paper of 2026, @aliceieong.bsky.social puts NHC organocatalyst in action with mechanical force in ACS Catalysis!
🔨 NHC generated by milling a new betaine mechanophore to catalyse transesterification and polymerisation reactions.
#chemsky @pubs.acs.org
pubs.acs.org/doi/10.1021/...
🔨 NHC generated by milling a new betaine mechanophore to catalyse transesterification and polymerisation reactions.
#chemsky @pubs.acs.org
pubs.acs.org/doi/10.1021/...
My favorite 2025 #PfizerChemistry publications #12daysOfPapers 8/n:
Room temp catalytic amide formation with this ingenious bifunctional B-P reagent from our process chem in collab with the Sandford Lab @ UTSA
#ChemSky #ChemChat
Room temp catalytic amide formation with this ingenious bifunctional B-P reagent from our process chem in collab with the Sandford Lab @ UTSA
#ChemSky #ChemChat
A bifunctional boronic acid/phosphorus(V) organocatalyst for the direct room-temperature amidation of carboxylic acids
An organocatalyst containing boronic acid and phosphine oxide groups enables the coupling
of carboxylic acids and amines at room temperature to achieve a sustainable route
to the amide bonds present i...
www.cell.com
December 20, 2025 at 4:57 PM
My favorite 2025 #PfizerChemistry publications #12daysOfPapers 8/n:
Room temp catalytic amide formation with this ingenious bifunctional B-P reagent from our process chem in collab with the Sandford Lab @ UTSA
#ChemSky #ChemChat
Room temp catalytic amide formation with this ingenious bifunctional B-P reagent from our process chem in collab with the Sandford Lab @ UTSA
#ChemSky #ChemChat
if I'm cynical, "organocatalyst"?
August 7, 2026 at 11:22 PM
if I'm cynical, "organocatalyst"?
In @science.org for chemsky this week, @wennemersgroup.bsky.social asymmetrically clasp macrocycles using a peptide catalyst
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Organocatalyst-controlled stereoselective head-to-tail macrocyclizations
Chiral macrocycles are key to the discovery of new medicines. Their synthesis is, however, challenging and typically requires the often-cumbersome installation of stereochemical features in a linear p...
www.science.org
February 26, 2026 at 8:19 PM
In @science.org for chemsky this week, @wennemersgroup.bsky.social asymmetrically clasp macrocycles using a peptide catalyst
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
It’s the organocatalyst alternative
June 30, 2026 at 4:48 AM
It’s the organocatalyst alternative
Organocatalyst for Electrochemical Hydrogen Evolution
Metal-free, N-heterocyclic phosphine (NHP)-type organocatalyst provides high activity
www.chemistryviews.org/organocataly...
Metal-free, N-heterocyclic phosphine (NHP)-type organocatalyst provides high activity
www.chemistryviews.org/organocataly...
Organocatalyst for Electrochemical Hydrogen Evolution - ChemistryViews
Metal-free, N-heterocyclic phosphine (NHP)-type organocatalyst provides high activity
www.chemistryviews.org
September 17, 2024 at 4:37 AM
Organocatalyst for Electrochemical Hydrogen Evolution
Metal-free, N-heterocyclic phosphine (NHP)-type organocatalyst provides high activity
www.chemistryviews.org/organocataly...
Metal-free, N-heterocyclic phosphine (NHP)-type organocatalyst provides high activity
www.chemistryviews.org/organocataly...
Confinement in a nanohoop 💍 organocatalyst enables outstanding enantioselectivity: 95% vs. 50% ee in non-cyclic reference catalysts!!! Check out our latest preprint, just out for #ISNA20, P-164 today! SC-XRD by @apoethig.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
August 13, 2024 at 3:07 PM
Confinement in a nanohoop 💍 organocatalyst enables outstanding enantioselectivity: 95% vs. 50% ee in non-cyclic reference catalysts!!! Check out our latest preprint, just out for #ISNA20, P-164 today! SC-XRD by @apoethig.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
May 21, 2025 at 11:32 PM
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Said opus magnum (see below) is now in its final layout: highly enantioselective organocatalysis with bidentate halogen bond donors! A breakthrough that we had been hunting fir many, many years: onlinelibrary.wiley.com/doi/10.1002/...
Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors
In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)-based halogen bonding organocatalyst. The crucial role of halo...
onlinelibrary.wiley.com
July 7, 2025 at 3:08 PM
Said opus magnum (see below) is now in its final layout: highly enantioselective organocatalysis with bidentate halogen bond donors! A breakthrough that we had been hunting fir many, many years: onlinelibrary.wiley.com/doi/10.1002/...
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
May 21, 2025 at 11:55 PM
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
www.organic-chemistry.org/abstracts/li...
The organic dye gallocyanine can act as an organocatalyst for the halogenation of a variety of functionalized pyrazoles, indazoles, and aromatics.
The organic dye gallocyanine can act as an organocatalyst for the halogenation of a variety of functionalized pyrazoles, indazoles, and aromatics.
September 29, 2026 at 5:15 PM
www.organic-chemistry.org/abstracts/li...
The organic dye gallocyanine can act as an organocatalyst for the halogenation of a variety of functionalized pyrazoles, indazoles, and aromatics.
The organic dye gallocyanine can act as an organocatalyst for the halogenation of a variety of functionalized pyrazoles, indazoles, and aromatics.
After a thourough peer-review (as it should be), we are proud to say that our review on Supramolecular Self-Association of Organocatalysts has now been published in Nat. Rev. Chem.! Great work by Shounak @shounakhinge.bsky.social and Sohom @sohomkundu.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The impact of supramolecular self-association of organocatalysts on catalytic performance - Nature Reviews Chemistry
Non-covalent interactions between organocatalyst molecules can change catalytic behaviour, leading to changes in reaction rates and selectivities. This Review discusses how to identify such interactio...
www.nature.com
September 22, 2025 at 2:26 PM
After a thourough peer-review (as it should be), we are proud to say that our review on Supramolecular Self-Association of Organocatalysts has now been published in Nat. Rev. Chem.! Great work by Shounak @shounakhinge.bsky.social and Sohom @sohomkundu.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The catalyst temporarily holds both the phosphorous reagents and a nucleoside in the correct orientation through a network of hydrogen bonds, enabling stereochemical control.
www.chemistryworld.com/news/organoc...
www.chemistryworld.com/news/organoc...
Organocatalyst streamlines oligonucleotide drug synthesis
New reaction controls phosphorus stereochemistry during the synthesis of phosphorothioate oligonucleotides
www.chemistryworld.com
August 25, 2026 at 3:23 PM
The catalyst temporarily holds both the phosphorous reagents and a nucleoside in the correct orientation through a network of hydrogen bonds, enabling stereochemical control.
www.chemistryworld.com/news/organoc...
www.chemistryworld.com/news/organoc...
www.organic-chemistry.org/abstracts/li...
The use of tetrahydroxydiboron as reductant and 4,4′-bipyridine as organocatalyst for a metal-free and highly chemoselective reduction of aromatic nitro compounds
The use of tetrahydroxydiboron as reductant and 4,4′-bipyridine as organocatalyst for a metal-free and highly chemoselective reduction of aromatic nitro compounds
November 16, 2024 at 10:03 AM
www.organic-chemistry.org/abstracts/li...
The use of tetrahydroxydiboron as reductant and 4,4′-bipyridine as organocatalyst for a metal-free and highly chemoselective reduction of aromatic nitro compounds
The use of tetrahydroxydiboron as reductant and 4,4′-bipyridine as organocatalyst for a metal-free and highly chemoselective reduction of aromatic nitro compounds
organic-chemistry.org/abstracts/li...
An organocatalyst delivers nitroalkanes from β,β-disubstituted nitroalkenes
An organocatalyst delivers nitroalkanes from β,β-disubstituted nitroalkenes
January 9, 2025 at 6:22 PM
organic-chemistry.org/abstracts/li...
An organocatalyst delivers nitroalkanes from β,β-disubstituted nitroalkenes
An organocatalyst delivers nitroalkanes from β,β-disubstituted nitroalkenes
Thread: Meet TBD, a powerful organocatalyst suitable under mild conditions.
Its legal name is 1,5,7-Triazabicyclo[4.4.0]dec-5-ene.
Blue from the Auclair Lab has investigated this catalyst thoroughly - check out this thread to see his work 🧵
#chemsky
Its legal name is 1,5,7-Triazabicyclo[4.4.0]dec-5-ene.
Blue from the Auclair Lab has investigated this catalyst thoroughly - check out this thread to see his work 🧵
#chemsky
![Chemical structure of 1,5,7-triazabicyclo[4.4.0]dec-5-ene or TBD. Structure is similar to guanidine but bicyclic. SMILES: N\2=C1/NCCCN1CCC/2](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:uwej4kil46vaemx4oerfjght/bafkreibggnk462w47xs5e2hbo6yl3mhhx2lyisq255ocxbdn6x7umepenu)
December 20, 2024 at 2:57 PM
Thread: Meet TBD, a powerful organocatalyst suitable under mild conditions.
Its legal name is 1,5,7-Triazabicyclo[4.4.0]dec-5-ene.
Blue from the Auclair Lab has investigated this catalyst thoroughly - check out this thread to see his work 🧵
#chemsky
Its legal name is 1,5,7-Triazabicyclo[4.4.0]dec-5-ene.
Blue from the Auclair Lab has investigated this catalyst thoroughly - check out this thread to see his work 🧵
#chemsky
Researchers have demonstrated the new synthesis across more than 20 nucleoside combinations and used it to form phosphorus–oxygen, phosphorus–sulfur, phosphorus–carbon and phosphorus–nitrogen bonds.
www.chemistryworld.com/news/organoc...
www.chemistryworld.com/news/organoc...
Organocatalyst streamlines oligonucleotide drug synthesis
New reaction controls phosphorus stereochemistry during the synthesis of phosphorothioate oligonucleotides
www.chemistryworld.com
August 27, 2026 at 8:55 AM
Researchers have demonstrated the new synthesis across more than 20 nucleoside combinations and used it to form phosphorus–oxygen, phosphorus–sulfur, phosphorus–carbon and phosphorus–nitrogen bonds.
www.chemistryworld.com/news/organoc...
www.chemistryworld.com/news/organoc...
Congratulations to Ava Trask F22 whose presentation, "Complete Synthesis of a Novel Organocatalyst for CO2 Incorporation into Organic Compounds," won two awards at the American Chemical Society: Connecticut Valley Section's Undergraduate Research Symposium! Ava is graduating in June. 🐸🔔💚
May 4, 2026 at 3:40 PM
Congratulations to Ava Trask F22 whose presentation, "Complete Synthesis of a Novel Organocatalyst for CO2 Incorporation into Organic Compounds," won two awards at the American Chemical Society: Connecticut Valley Section's Undergraduate Research Symposium! Ava is graduating in June. 🐸🔔💚
www.organic-chemistry.org/abstracts/li...
The use of a bifunctional organocatalyst and Cs2CO3 for a direct carboxylation of terminal alkynes with CO2
The use of a bifunctional organocatalyst and Cs2CO3 for a direct carboxylation of terminal alkynes with CO2
June 30, 2025 at 10:04 AM
www.organic-chemistry.org/abstracts/li...
The use of a bifunctional organocatalyst and Cs2CO3 for a direct carboxylation of terminal alkynes with CO2
The use of a bifunctional organocatalyst and Cs2CO3 for a direct carboxylation of terminal alkynes with CO2
I am happy to share my latest publication from my PhD in the Melchiorre group, published in @jacs.acspublications.org, in which we present a simple organocatalyst to realize the Birch reductions of electron-rich benzenes under mild photocatalytic conditions.
#ChemSky
pubs.acs.org/doi/10.1021/...
#ChemSky
pubs.acs.org/doi/10.1021/...
Light-Driven Organocatalytic Birch Reduction for Late-Stage Drug Modification and sp3-Rich Spirocycle Synthesis
The Birch reduction is a cornerstone transformation in synthetic chemistry, yet its widespread application is limited by harsh conditions, poor functional group tolerance, and safety concerns. Recent ...
pubs.acs.org
January 29, 2026 at 8:51 PM
I am happy to share my latest publication from my PhD in the Melchiorre group, published in @jacs.acspublications.org, in which we present a simple organocatalyst to realize the Birch reductions of electron-rich benzenes under mild photocatalytic conditions.
#ChemSky
pubs.acs.org/doi/10.1021/...
#ChemSky
pubs.acs.org/doi/10.1021/...
The temporary molecular guides currently needed to control phosphorus stereochemistry during synthesis of phosphorothioate oligonucleotides used in several approved RNA therapies can be eliminated with the new chiral catalyst.
Rupali Dabas reports:
#ChemSky
www.chemistryworld.com/news/organoc...
Rupali Dabas reports:
#ChemSky
www.chemistryworld.com/news/organoc...
Organocatalyst streamlines oligonucleotide drug synthesis
New reaction controls phosphorus stereochemistry during the synthesis of phosphorothioate oligonucleotides
www.chemistryworld.com
August 20, 2026 at 12:46 PM
The temporary molecular guides currently needed to control phosphorus stereochemistry during synthesis of phosphorothioate oligonucleotides used in several approved RNA therapies can be eliminated with the new chiral catalyst.
Rupali Dabas reports:
#ChemSky
www.chemistryworld.com/news/organoc...
Rupali Dabas reports:
#ChemSky
www.chemistryworld.com/news/organoc...
In this study, we show that a simple organocatalyst (TrBF4) can catalyze the fluoroacylation of alkynes (and alkenes) through a dual activation pathway.
January 28, 2025 at 2:52 PM
In this study, we show that a simple organocatalyst (TrBF4) can catalyze the fluoroacylation of alkynes (and alkenes) through a dual activation pathway.
I’m highlighting this paper simply because I’ve always liked the name Hofmann–Löffler–Freytag which sounds grand. www.nature.com/articles/s41...
Asymmetric Hofmann–Löffler–Freytag-type reaction via a transient carbenium ion complex merging organocatalysis and photocatalysis - Nature Catalysis
Enantiocontrolled transformation of carbenium ions is challenging due to their instability and high reactivity. Now, combining a chiral organocatalyst with a photocatalyst enables enantioselective int...
www.nature.com
April 29, 2025 at 7:09 PM
I’m highlighting this paper simply because I’ve always liked the name Hofmann–Löffler–Freytag which sounds grand. www.nature.com/articles/s41...