"Altogether, we establish a bone–brain axis in which bone endocrine function can be modulated by mechanical forces to enhance brain repair after injury." This is incredible. www.nature.com/articles/s41...
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 - Nature Neuroscience
Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...
www.nature.com
September 28, 2026 at 1:08 AM
"Altogether, we establish a bone–brain axis in which bone endocrine function can be modulated by mechanical forces to enhance brain repair after injury." This is incredible. www.nature.com/articles/s41...
A surprising bone-brain connection. Squeezing a Leg Bone Helped Animals Recover From Brain Injury. www.nature.com/articles/s41...
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 - Nature Neuroscience
Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...
www.nature.com
September 27, 2026 at 2:13 PM
A surprising bone-brain connection. Squeezing a Leg Bone Helped Animals Recover From Brain Injury. www.nature.com/articles/s41...
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
September 23, 2026 at 2:46 PM
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
September 23, 2026 at 2:46 PM
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1
->Nature | More on "Bone compression therapy brain injury" at BigEarthData.ai
->Nature | More on "Bone compression therapy brain injury" at BigEarthData.ai
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1
a, Schematic illustrating mild TBI (mTBI), DCTAL, and behavioral tests. This figure was created using FigDraw. b, c, Return time (b) and total time (c) in the pole test of the mTBI mice treated with DCTAL (4 N, 300 cycles, 2 Hz, five times per week, 1 week). n = 10 biologically independent mice per group. Return time: SHAM versus mTBI, P = 0.0143; mTBI versus mTBI + LOAD, P = 0.0143. Total time, SHAM versus mTBI, P = 0.0007; mTBI versus mTBI + LOAD, P = 0.0213. X axis: Experimental groups (SHAM, mTBI, mTBI + LOAD). d, Representative images of the swim paths of TBI mice in each group after removal of the platform (memory phase). Groups: SHAM, mTBI and mTBI + LOAD. e, f, Spatial memory was assessed on day 6 of MWM testing during a probe trial (platform was removed). The number of platform crossings (e) and time spent in the target quadrant (f) were quantified in the mTBI mice treated with DCTAL n = 10 biologically independent mice per group. The number of platform crossings: SHAM versus mTBI, P = 0.0004; mTBI versus mTBI + LOAD, P = 0.0021. Time spent in the target quadrant: SHAM...
www.nature.com
September 21, 2026 at 11:47 PM
Osteocyte lacunar and cellular characteristics in the subchondral bone plate and trabecular bone of human knee osteoarthritis. K Huynh et al. Bone Dec 2026 shorturl.at/GeRoP ...compartment-specific structural and cellular heterogeneity within osteoarthritic subchondral bone
September 10, 2026 at 7:01 AM
Osteocyte lacunar and cellular characteristics in the subchondral bone plate and trabecular bone of human knee osteoarthritis. K Huynh et al. Bone Dec 2026 shorturl.at/GeRoP ...compartment-specific structural and cellular heterogeneity within osteoarthritic subchondral bone
Integrated analysis of human osteocyte lacunar ultrastructure and bone proteome profiling reveals coupling between immune and osteogenic signaling pathways. S Reppe et al. Bone 2026 Sep 3 shorturl.at/a0Xlk ... lacunar density and total lacunar volume are associated with BMD
September 7, 2026 at 7:11 AM
Integrated analysis of human osteocyte lacunar ultrastructure and bone proteome profiling reveals coupling between immune and osteogenic signaling pathways. S Reppe et al. Bone 2026 Sep 3 shorturl.at/a0Xlk ... lacunar density and total lacunar volume are associated with BMD
Oxygen-dependent osteocyte transcriptomic adaptations occur without modulation of endothelial gene expression via osteocyte paracrine signaling
Léa Gellée, Frédéric Martins, Alexandre Brochard, Katharina Jähn-Rickert, Delphine B Maurel
Published: 19 August
academic.oup.com/jbmrplus/adv...
Léa Gellée, Frédéric Martins, Alexandre Brochard, Katharina Jähn-Rickert, Delphine B Maurel
Published: 19 August
academic.oup.com/jbmrplus/adv...
August 27, 2026 at 2:43 PM
Oxygen-dependent osteocyte transcriptomic adaptations occur without modulation of endothelial gene expression via osteocyte paracrine signaling
Léa Gellée, Frédéric Martins, Alexandre Brochard, Katharina Jähn-Rickert, Delphine B Maurel
Published: 19 August
academic.oup.com/jbmrplus/adv...
Léa Gellée, Frédéric Martins, Alexandre Brochard, Katharina Jähn-Rickert, Delphine B Maurel
Published: 19 August
academic.oup.com/jbmrplus/adv...
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
August 13, 2026 at 10:00 PM
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
August 13, 2026 at 8:17 PM
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
August 13, 2026 at 8:17 PM
Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging https://www.biorxiv.org/content/10.64898/2026.08.07.743422v1
Visualizing the Osteocyte Lacuno-Canalicular System via a Rapid 10-Minute Silver Nitrate Staining Method
Work by Jinlian Wu, Weiwei Dai and Libo Wang at Shanghai University of Traditional Chinese Medicine.
#LifeSciences #Reproducibility #CellBiology
Work by Jinlian Wu, Weiwei Dai and Libo Wang at Shanghai University of Traditional Chinese Medicine.
#LifeSciences #Reproducibility #CellBiology
August 11, 2026 at 2:06 AM
Visualizing the Osteocyte Lacuno-Canalicular System via a Rapid 10-Minute Silver Nitrate Staining Method
Work by Jinlian Wu, Weiwei Dai and Libo Wang at Shanghai University of Traditional Chinese Medicine.
#LifeSciences #Reproducibility #CellBiology
Work by Jinlian Wu, Weiwei Dai and Libo Wang at Shanghai University of Traditional Chinese Medicine.
#LifeSciences #Reproducibility #CellBiology
A review analyses the "evidence linking COVID-19 to skeletal deterioration, ranging from changes in bone mineral density, trabecular microarchitecture, and mechanical competence to osteocyte lacunar remodeling and altered bone-cell activity"
#LongCovid
www.frontiersin.org/journals/bio...
#LongCovid
www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
www.frontiersin.org
August 6, 2026 at 3:26 PM
A review analyses the "evidence linking COVID-19 to skeletal deterioration, ranging from changes in bone mineral density, trabecular microarchitecture, and mechanical competence to osteocyte lacunar remodeling and altered bone-cell activity"
#LongCovid
www.frontiersin.org/journals/bio...
#LongCovid
www.frontiersin.org/journals/bio...
Politecnico di Milano review finds COVID-19 may reshape bone itself.
Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair.
www.frontiersin.org/journals/bio...
Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair.
www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
www.frontiersin.org
August 5, 2026 at 12:33 PM
Politecnico di Milano review finds COVID-19 may reshape bone itself.
Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair.
www.frontiersin.org/journals/bio...
Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair.
www.frontiersin.org/journals/bio...
A Modular Synthetic Hydrogel with Cell-scale Micropores Modulates Osteocyte-like Morphogenesis and Osteogenic Differentiation In Vitro https://www.biorxiv.org/content/10.64898/2026.08.04.742693v1
August 4, 2026 at 3:49 PM
A Modular Synthetic Hydrogel with Cell-scale Micropores Modulates Osteocyte-like Morphogenesis and Osteogenic Differentiation In Vitro https://www.biorxiv.org/content/10.64898/2026.08.04.742693v1
A Modular Synthetic Hydrogel with Cell-scale Micropores Modulates Osteocyte-like Morphogenesis and Osteogenic Differentiation In Vitro https://www.biorxiv.org/content/10.64898/2026.08.04.742693v1
August 4, 2026 at 3:49 PM
A Modular Synthetic Hydrogel with Cell-scale Micropores Modulates Osteocyte-like Morphogenesis and Osteogenic Differentiation In Vitro https://www.biorxiv.org/content/10.64898/2026.08.04.742693v1
Some of the most exciting sessions at #ASBMR2026 won't just share new findings. They'll challenge how we think.
Join #ASBMR2026 as experts tackle questions across rare bone disease through our keynotes, debates, and more.
See the full program: meeting.asbmr.org/Program
youtu.be/iGktX4DUkXQ
Join #ASBMR2026 as experts tackle questions across rare bone disease through our keynotes, debates, and more.
See the full program: meeting.asbmr.org/Program
youtu.be/iGktX4DUkXQ
#ASBMR2026: Emma Duncan, MBBS, PhD, FRACP, and Joe Stains, PhD, Share 3 New Updates
Will a T-score threshold of -2.5 remain the standard for managing osteoporosis? Is the osteocyte the primary mediator of bone's response to mechanical loading?
These are just two of the…
youtu.be
July 24, 2026 at 7:02 PM
Some of the most exciting sessions at #ASBMR2026 won't just share new findings. They'll challenge how we think.
Join #ASBMR2026 as experts tackle questions across rare bone disease through our keynotes, debates, and more.
See the full program: meeting.asbmr.org/Program
youtu.be/iGktX4DUkXQ
Join #ASBMR2026 as experts tackle questions across rare bone disease through our keynotes, debates, and more.
See the full program: meeting.asbmr.org/Program
youtu.be/iGktX4DUkXQ
A paper using RRID:AB_2762848 from @thermofishersci.bsky.social was just published in Biofabrication. We value the author's support of reproducibility. #methodsmatter #RRID #STMpublishing
Bioprinted bonoid-on-a-chip model for studying drug effects on human osteocyte differentiation
Read the full paper: Bioprinted bonoid-on-a-chip model for studying drug effects on human osteocyte differentiation
doi.org
July 23, 2026 at 7:01 AM
A paper using RRID:AB_2762848 from @thermofishersci.bsky.social was just published in Biofabrication. We value the author's support of reproducibility. #methodsmatter #RRID #STMpublishing
A leader in bone and musculoskeletal research, Schaffler's groundbreaking work in bone microdamage, osteocyte biology, and skeletal adaptation has had a profound impact on the field and continues to influence researchers worldwide.
July 22, 2026 at 5:01 PM
A leader in bone and musculoskeletal research, Schaffler's groundbreaking work in bone microdamage, osteocyte biology, and skeletal adaptation has had a profound impact on the field and continues to influence researchers worldwide.
Feed: "BIOENGINEER.ORG"
By: Bioengineer on Wednesday, July 15, 2026
By: Bioengineer on Wednesday, July 15, 2026
Osteocyte Parvalbumin Drives Mechanotransduction to Reduce Osteoarthritis Progression
A new study published in Nature Communications (2026) spotlights an unexpected molecular player in the battle against osteoarthritis: osteocyte parvalbumin. Osteocytes, the bone’s embedded m
bioengineer.org
July 15, 2026 at 5:32 AM
Feed: "BIOENGINEER.ORG"
By: Bioengineer on Wednesday, July 15, 2026
By: Bioengineer on Wednesday, July 15, 2026
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone. CA Schurman et al. Adv Sci (Weinh) 2026 13 Apr shorturl.at/YeWhc ... APOE4 as a molecular driver of early osteocyte dysfunction and ↓bone quality in mouse model
July 5, 2026 at 9:36 AM
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone. CA Schurman et al. Adv Sci (Weinh) 2026 13 Apr shorturl.at/YeWhc ... APOE4 as a molecular driver of early osteocyte dysfunction and ↓bone quality in mouse model
Dear phone, when I am typing “osteophyte,” DO NOT “correct” it to “osteocyte.”
Tara Maclay: This Is Different
Alt: Tara Maclay: This Is Different
static.klipy.com
June 19, 2026 at 12:05 PM
Dear phone, when I am typing “osteophyte,” DO NOT “correct” it to “osteocyte.”