#osteocyte
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shahfa.bsky.social
🧪🔬🦴 This is an #Osteocyte

It lives in #bone and reaches out to #implants and #biomaterials through cellular extensions [ * ]

It frequently talks to other osteocytes and orchestrates bone remodelling

Be like the Osteocyte =)

* Scanning electron microscopy
** Horizontal field width = 27 µm
This is an Osteocyte. It lives in bone and reaches out to implants and biomaterials through cellular extensions [ * ]. It frequently talks to other osteocytes and orchestrates bone remodelling. Be like the Osteocyte!
December 10, 2024 at 3:59 PM
www.nature.com/articles/s41...
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 - Nature Neuroscience
Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...
www.nature.com
September 26, 2026 at 7:37 PM
pacheco-torgal.bsky.social
A surprising bone-brain connection. Squeezing a Leg Bone Helped Animals Recover From Brain Injury. www.nature.com/articles/s41...
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 - Nature Neuroscience
Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...
www.nature.com
September 27, 2026 at 2:13 PM
shahfa.bsky.social
🧪 #Bone meets the scanning electron microscope 🦴🔬

Detailed description in Alt text

#MicroscopyMonday #science #biology #biomineralization #biomaterials #imaging #bioimaging #electronmicroscopy #mineral #collagen #apatite

www.nature.com/articles/s41...
(a) BSE-SEM photomontage of a human rib viewed in cross-section. Local variations in mineralisation density, Haversian canals, resorption spaces, and osteocyte lacunae can be detected. (b) Osteocyte lacunar density determined using BSE imaging. (c) A cement line between osteonal bone and interstitial bone. (d) The intertrabecular spaces in antler bone are occupied by primary osteons. Trabeculae (asterisks) and unremodelled islands of calcified cartilage (arrow) can be identified. (e) Topographical BSE-SEM. For each 90° sector of an annular BSE detector, a separate image is recorded containing information sensitive to the direction of apparent illumination (arrows). (f) Osteon pull-out under cyclic mechanical loading observed using SE imaging. (g) Cell surface detail of osteoblasts on the surface of parietal bone. (h) Osteoblasts appear to organise collagen fibrils through flat basal processes. (i) Hypermineralised osteocyte lacuna containing mineralised apoptotic debris. (j) Severely disorganised bone microstructure in melorheostosis. (k) Bone with (right) and without (left) osteocytes. (l) An osteocyte and associated canalicular network exposed by resin cast etching. (m) Howship’s lacunae: longitudinally extended resorption (LER; left) and reticulate patch resorption (RPR; right) lacunae. (n) Cryo-SEM. The combination of SE (above) and BSE (below) imaging provides morphological and compositional information. SE = secondary electron mode; BSE = backscattered electron mode
December 2, 2024 at 10:07 AM
healthcare-global.bsky.social
www.nature.com/articles/s41...
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1 - Nature Neuroscience
Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...
www.nature.com
September 21, 2026 at 7:36 PM
elisaperego78.bsky.social
A review analyses the "evidence linking COVID-19 to skeletal deterioration, ranging from changes in bone mineral density, trabecular microarchitecture, and mechanical competence to osteocyte lacunar remodeling and altered bone-cell activity"

#LongCovid

www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
www.frontiersin.org
August 6, 2026 at 3:26 PM
docbruggsbunny.bsky.social
An early Christmas gift to have @karljlewis.bsky.social visit us to round out our @cornelluniversity.bsky.social - @qmul.ac.uk Global Hub collaboration! Exciting early data and much more osteocyte mechanobiology fun to come!
December 20, 2024 at 8:17 AM
albertonykus.bsky.social
#2025SVP @gruiformabi.bsky.social: Can avian medullary bone be distinguished from osteopetrosis in micro-CT scans? Yes! Differ in distribution, isotropy, trabecular thickness, orientation of osteocyte lacunae, etc. However, there’s variation in medullary bone structure as well.
November 15, 2025 at 8:11 AM
biomechannika.bsky.social
Interested in osteocyte imaging?
In the summer, we published a review where we discuss common approaches and pitfalls for 2D and 3D imaging:

#bone #osteocytes #imaging
@ects.bsky.social (Hoping this is the correct ECTS)

doi.org/10.1007/s119...
2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS) - Current Osteoporosis...
Purpose of Review Quantification of the morphology of osteocyte lacunae has become a powerful tool to investigate bone metabolism, pathologies and aging. This review will provide a brief overview of 2...
doi.org
December 9, 2024 at 11:39 AM
biorxivpreprint.bsky.social
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
September 23, 2026 at 2:46 PM
camillamussoni.bsky.social
Check out this brand new interesting paper I am happy to have contributed to: A 3D #bioreactor model to study #osteocyte differentiation and #mechanobiology under perfusion and compressive mechanical loading
www.sciencedirect.com/science/arti...
A 3D bioreactor model to study osteocyte differentiation and mechanobiology under perfusion and compressive mechanical loading
Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in bone. As a result, they secrete signaling molecules that media…
www.sciencedirect.com
July 16, 2024 at 4:44 PM
biorxiv-bioeng.bsky.social
hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels https://www.biorxiv.org/content/10.64898/2026.09.22.753603v1
September 23, 2026 at 2:46 PM
brjournal.bsky.social
Osteogenesis imperfecta is shown to be driven by osteocyte dysfunction in new research, highlighting a specific gene mutation's impact！👇
#Osteogenesis #gene #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
July 24, 2025 at 6:43 AM
shahfa.bsky.social
🦴🔬#Osteocyte – the master orchestrator of #bone #remodeling. ~42 billion in the average adult human skeleton, #osteocytes make up ~90–95% of all #cells within bone, interconnected by ~3.7 trillion dendritic projections with an estimated, total end-to-end length of 175,000 km 🔍
December 28, 2023 at 11:55 PM
bigearthdata.ai
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1
->Nature | More on "Bone compression therapy brain injury" at BigEarthData.ai
Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1
a, Schematic illustrating mild TBI (mTBI), DCTAL, and behavioral tests. This figure was created using FigDraw. b, c, Return time (b) and total time (c) in the pole test of the mTBI mice treated with DCTAL (4 N, 300 cycles, 2 Hz, five times per week, 1 week). n = 10 biologically independent mice per group. Return time: SHAM versus mTBI, P = 0.0143; mTBI versus mTBI + LOAD, P = 0.0143. Total time, SHAM versus mTBI, P = 0.0007; mTBI versus mTBI + LOAD, P = 0.0213. X axis: Experimental groups (SHAM, mTBI, mTBI + LOAD). d, Representative images of the swim paths of TBI mice in each group after removal of the platform (memory phase). Groups: SHAM, mTBI and mTBI + LOAD. e, f, Spatial memory was assessed on day 6 of MWM testing during a probe trial (platform was removed). The number of platform crossings (e) and time spent in the target quadrant (f) were quantified in the mTBI mice treated with DCTAL n = 10 biologically independent mice per group. The number of platform crossings: SHAM versus mTBI, P = 0.0004; mTBI versus mTBI + LOAD, P = 0.0021. Time spent in the target quadrant: SHAM...
www.nature.com
September 21, 2026 at 11:47 PM
isph2027.bsky.social
Marcos Ramon Fritzen won joint 2nd place of our palaeohistology image competition with his image titled "A Deep Time Genomic Window: 3D Visualization of Fossil Lungfish Osteocyte Lacunae" #isph2025
June 21, 2025 at 12:15 PM
atranscendedman.bsky.social
Politecnico di Milano review finds COVID-19 may reshape bone itself.

Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair.

www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
www.frontiersin.org
August 5, 2026 at 12:33 PM
shahfa.bsky.social
🔥Hot off the press🔥 "Revisiting the physical and chemical nature of the mineral component of bone" 🦴🔬
doi.org/10.1016/j.ac...
🧪

#bone #biomaterials #apatite #mineral #biomineralization #collagen #calcium #phosphate #hydroxyapatite #osteocyte #biology #medicine #osteology #osteoarchaeology
The physico-chemical characteristics of bone mineral remain heavily debated. On the nanoscale, bone mineral resides both inside and outside the collagen fibril as distinct compartments fused together into a cohesive continuum. On the micrometre level, larger aggregates are arranged in a staggered pattern described as crossfibrillar tessellation. Unlike geological and synthetic hydroxy(l)apatite, bone mineral is a unique form of apatite deficient in calcium and hydroxyl ions with distinctive carbonate and acid phosphate substitutions (CHAp), together with a minor contribution of amorphous calcium phosphate as a surface layer around a crystalline core of CHAp. In mammalian bone, an amorphous solid phase has not been observed, though an age-dependent shift in the amorphous-to-crystalline character is observed. Although octacalcium phosphate has been postulated as a bone mineral precursor, there is inconsistent evidence of calcium phosphate phases other than CHAp in the extracellular matrix. In association with micropetrosis, magnesium whitlockite is occasionally detected, indicating pathological calcification rather than a true extracellular matrix component. Therefore, the terms ‘biomimetic’ or ‘bone-like’ should be used cautiously in descriptions of synthetic biomaterials. The practice of reporting the calcium-to-phosphorus ratio (Ca/P) as proxy for bone mineral maturity oversimplifies the chemistry since both Ca2+ and PO43- ions are partially substituted. Moreover, non-mineral sources of phosphorus are ignored. Alternative compositional metrics should be considered. In the context of bone tissue and bone mineral, the term ‘mature’ must be used carefully, with clear criteria that consider both compositional and structural parameters and the potential impact on mechanical properties.
February 1, 2025 at 3:12 AM
phil-donoghue.bsky.social
Our latest: Dermoskeletal histology of Moythomasia and the evolution of the vertebrate dermal skeleton, led by Xianren Shan and Edine Pape, with a little help from Martin Rucklin @evopalaeo.bsky.social and Davide Pisani @bristolpalaeo.bsky.social
The Dermal Skeleton of Stem‐Actinopterygian Moythomasia durgaringa and Its Implications for the Nature of the Ancestral Osteichthyan
The figure presents a model of Moythomasia and a schematic histological model illustrating the internal structure and features of the cranial bones. These include bone (brown), osteocyte spaces (red)...
onlinelibrary.wiley.com
March 20, 2026 at 7:58 AM
shahfa.bsky.social
2/3; Introduction 🕰️ - My scholarly interests [‼️] include #bone repair #biomaterials, the #osteocyte (a remarkable cell in bone), #osseointegration of implants, #biomineralization. I think #bacteria are fascinating! #electronmicroscopy and #Ramanspectroscopy ftw! #academicsky #science #fungifriends 🧪
Our in-house confocal Raman microscope! 😍 My best mate at work - Donatello. Osteocytes in bone!
January 18, 2024 at 9:15 AM
osteoporosis-nl.bsky.social
Bone quality in pycnodysostosis: micropetrosis, locally distorted osteocyte lacuno-canalicular network, and heterogenous mineralization pattern in an adult female patient with multiple fractures. N Fratzl-Zelman et al. JBMR Plus 2025 Jan 23 tinyurl.com/bdcbthvy
April 4, 2025 at 7:37 AM
uwumichi.bsky.social
They change every decade more or less. Lol, oh my god. Trigger mass osteocyte apoptosis? 😭 Idk at all.
February 13, 2025 at 11:54 PM
biorxivpreprint.bsky.social
Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival https://www.biorxiv.org/content/10.64898/2026.04.27.721119v1
April 30, 2026 at 5:30 PM
dmmjournal.bsky.social
@jtrendbio.bsky.social, @clarkinbonebiol.bsky.social & co used synchrotron X-ray computed tomography to characterise the distribution and structure of intracortical canals and #osteocyte lacunae, helping identify molecular drivers of age-related cortical porosity.
Read: doi.org/10.1242/dmm....
The figure shows the results of regionalisation of murine cortical bone, which reveals region-specific microstructural properties. Panels A-C show images of regional microstructure quantification, namely intracortical canals and osteocyte lacunae mapped by size. Panels D-G show graphs of regionalised and quantified cortical porosity, canal number density, lacunar number density and average lacunar volume.
February 12, 2026 at 12:01 PM
shahfa.bsky.social
🧪🔬🦴💠 A Review of the Impact of Implant Biomaterials on Osteocytes

journals.sagepub.com/doi/full/10....

#bone #biomaterials #osteocytes #microscopy #histology #electronmicroscopy #imaging #biology #science #aging #biomechanics #osteoporosis #bonehealth #pathology
The proximity of osteocytes (Ot) to implant surfaces observed with (a) histology and (b) BSE-SEM. (c) Resin cast etching allows visualization of osteocyte attachment to implant surfaces. (d) Osteocyte attachment to an acid-etched surface. (e) Interdigitation of canaliculi with the implant surface (arrowheads). (f, g) Canaliculi (Ot.Ca) adherent to the surface of a laser-ablated implant. (h) Cross-sectional view of canaliculi (*) in close association with surface TiO2 layer of a laser-ablated implant (HAADF-STEM). (i) Osteocytes align parallel to the lamellar direction, which closely follows the microcontour of the laser-ablated implant surface. (j) Adjacent to the implant surface, osteocytes form an interconnected network. (k) Canaliculi (arrowheads) can be identified within the first several micrometers from the implant surface (HAADF-STEM). (l) Mineralized collagen fibrils appear to “wrap around” the canaliculus (*).
May 12, 2024 at 3:01 PM