Read our #pQTL study using the SEER
#proteomics platform in @naturecomms.bsky.social
The full raw MS spectral data is available on PRIDE:
ebi.ac.uk/pride/archiv...
The paper is here:
link.springer.com/article/10.1...
#proteomics platform in @naturecomms.bsky.social
The full raw MS spectral data is available on PRIDE:
ebi.ac.uk/pride/archiv...
The paper is here:
link.springer.com/article/10.1...
December 10, 2024 at 12:35 PM
Read our #pQTL study using the SEER
#proteomics platform in @naturecomms.bsky.social
The full raw MS spectral data is available on PRIDE:
ebi.ac.uk/pride/archiv...
The paper is here:
link.springer.com/article/10.1...
#proteomics platform in @naturecomms.bsky.social
The full raw MS spectral data is available on PRIDE:
ebi.ac.uk/pride/archiv...
The paper is here:
link.springer.com/article/10.1...
From DNA to RNA to protein: pQTL mapping and Proteome-Wide Association Study reveal protein-level drivers of soybean traits #correspondence #MolecularPlant cell.com/molecular-pl...
September 24, 2026 at 2:52 AM
From DNA to RNA to protein: pQTL mapping and Proteome-Wide Association Study reveal protein-level drivers of soybean traits #correspondence #MolecularPlant cell.com/molecular-pl...
Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture https://www.medrxiv.org/content/10.64898/2026.09.08.26362390v1
September 10, 2026 at 10:40 PM
Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture https://www.medrxiv.org/content/10.64898/2026.09.08.26362390v1
It would be interesting to revisit these specific analyses with eQTL sample sizes in 1000s like in @mikelove.bsky.social 's recent work. IMO it's very plausible that while typical cis-eQTL sample sizes find lots of eQTLs, the relevant ones with enough power for colocalization need a bigger N.
March 4, 2026 at 4:39 PM
We used a similar design in this paper:
www.sciencedirect.com/science/arti...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals colocalise between eQTL and pQTL traits) sign concordance was around 95%:
www.sciencedirect.com/science/arti...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals colocalise between eQTL and pQTL traits) sign concordance was around 95%:
January 7, 2026 at 9:20 AM
We used a similar design in this paper:
www.sciencedirect.com/science/arti...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals colocalise between eQTL and pQTL traits) sign concordance was around 95%:
www.sciencedirect.com/science/arti...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals colocalise between eQTL and pQTL traits) sign concordance was around 95%:
Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism www.nature.com/articles/s41... @ksusztak.bsky.social #TranslationalScience
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine
Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.
www.nature.com
August 14, 2025 at 7:41 PM
Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism www.nature.com/articles/s41... @ksusztak.bsky.social #TranslationalScience
Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics
This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.
nature.com
February 19, 2025 at 10:44 AM
Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
GWAS #Glaucoma
Multitrait analysis of GWAS #PrimaryOpenAngleGlaucoma #IntraocularPressure #VeticalCuptoDiscRatio N>600k
Multiancestry meta-analysis
Validation 23andMe N>2.8M➡️
240 loci 😁
+TWAS pQTL PWAS tp prioritize causal variants & drug targets
#NatureGenet 2023
www.nature.com/articles/s41...
Multitrait analysis of GWAS #PrimaryOpenAngleGlaucoma #IntraocularPressure #VeticalCuptoDiscRatio N>600k
Multiancestry meta-analysis
Validation 23andMe N>2.8M➡️
240 loci 😁
+TWAS pQTL PWAS tp prioritize causal variants & drug targets
#NatureGenet 2023
www.nature.com/articles/s41...
November 23, 2024 at 1:30 PM
GWAS #Glaucoma
Multitrait analysis of GWAS #PrimaryOpenAngleGlaucoma #IntraocularPressure #VeticalCuptoDiscRatio N>600k
Multiancestry meta-analysis
Validation 23andMe N>2.8M➡️
240 loci 😁
+TWAS pQTL PWAS tp prioritize causal variants & drug targets
#NatureGenet 2023
www.nature.com/articles/s41...
Multitrait analysis of GWAS #PrimaryOpenAngleGlaucoma #IntraocularPressure #VeticalCuptoDiscRatio N>600k
Multiancestry meta-analysis
Validation 23andMe N>2.8M➡️
240 loci 😁
+TWAS pQTL PWAS tp prioritize causal variants & drug targets
#NatureGenet 2023
www.nature.com/articles/s41...
One of those truly multiomic studies. Get to see sQTL, eQTL, pQTL, mQTL connect genetic etiology across molecular traits and health outcomes
📣 New from the lab: The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes www.nature.com/articles/s41...
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
Check out the INTERVAL RNAseq portal www.intervalrna.org.uk
Led by @alextokolyi.bsky.social & Elodie Persyn!
March 5, 2025 at 6:15 AM
One of those truly multiomic studies. Get to see sQTL, eQTL, pQTL, mQTL connect genetic etiology across molecular traits and health outcomes
www.youtube.com/watch?v=pQtl...
Eu nunca li ambos os autores fora Kakushigoto e isso aqui está explodindo minha cabeça
Eu nunca li ambos os autores fora Kakushigoto e isso aqui está explodindo minha cabeça
Two Mangaka and a 20+ Years Long "Rivalry"
YouTube video by KYDB
www.youtube.com
December 31, 2025 at 3:08 AM
www.youtube.com/watch?v=pQtl...
Eu nunca li ambos os autores fora Kakushigoto e isso aqui está explodindo minha cabeça
Eu nunca li ambos os autores fora Kakushigoto e isso aqui está explodindo minha cabeça
📢OUT @natgenet.nature.com
📰Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
By Aliza P. Wingo, Thomas S. Wingo and colleagues.
⬇️
www.nature.com/articles/s41...
📰Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
By Aliza P. Wingo, Thomas S. Wingo and colleagues.
⬇️
www.nature.com/articles/s41...
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions - Nature Genetics
Multiancestry fine-mapping of brain protein quantitative trait loci coupled with Mendelian randomization analyses identifies protein–trait pairs consistent with causal effects across neurological and ...
www.nature.com
September 15, 2025 at 11:51 AM
📢OUT @natgenet.nature.com
📰Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
By Aliza P. Wingo, Thomas S. Wingo and colleagues.
⬇️
www.nature.com/articles/s41...
📰Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
By Aliza P. Wingo, Thomas S. Wingo and colleagues.
⬇️
www.nature.com/articles/s41...
No new instruments, no splitting scarce sample — just collect what you'd have thrown out. Opens the door to intra-tissue pQTL analyses linking somatic mutations to their protein-level consequences.
July 10, 2026 at 10:15 AM
No new instruments, no splitting scarce sample — just collect what you'd have thrown out. Opens the door to intra-tissue pQTL analyses linking somatic mutations to their protein-level consequences.
I would also highlight the ProGeM paper which I think was the first one to use this clever eQTL-pQTL design to evaluate gene prioritisation strategies:
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
January 7, 2026 at 9:33 AM
I would also highlight the ProGeM paper which I think was the first one to use this clever eQTL-pQTL design to evaluate gene prioritisation strategies:
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
We used a similar design in this paper together with @mikelove.bsky.social:
doi.org/10.1016/j.xh...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals that colocalise between matched eQTL and pQTL genes) sign concordance was around 95%:
doi.org/10.1016/j.xh...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals that colocalise between matched eQTL and pQTL genes) sign concordance was around 95%:
January 7, 2026 at 9:30 AM
We used a similar design in this paper together with @mikelove.bsky.social:
doi.org/10.1016/j.xh...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals that colocalise between matched eQTL and pQTL genes) sign concordance was around 95%:
doi.org/10.1016/j.xh...
Found that in cis-MR with multiple colocalising instruments (i.e. multiple indepdent signals that colocalise between matched eQTL and pQTL genes) sign concordance was around 95%:
Used to have a simple talk about what to do with eQTL and GWAS when there are multiple, distinct signals in either or both. Now I try to also talk about pQTL, splicing, context/cell type, response QTL, allelic effects, multiplex assays of variant effect… it’s too much, bad for storytelling 😅
October 4, 2023 at 2:30 PM
Used to have a simple talk about what to do with eQTL and GWAS when there are multiple, distinct signals in either or both. Now I try to also talk about pQTL, splicing, context/cell type, response QTL, allelic effects, multiplex assays of variant effect… it’s too much, bad for storytelling 😅
ICYMI: New online! Proteogenomics in human populations
Proteogenomics in human populations
Nature Reviews Genetics, Published online: 20 August 2026; doi:10.1038/s41576-026-00998-4Proteogenomics integrates genomic and proteomic data to reveal how genetic variation influences protein abundance and contributes to human disease. In this Review, the authors focus on protein quantitative trait loci (pQTL), highlighting advances in pQTL mapping, biological interpretation and emerging applications.
dlvr.it
August 27, 2026 at 11:37 AM
ICYMI: New online! Proteogenomics in human populations
Kidney proteomics uncovers 89 targetable proteins linked to cardio-kidney-metabolic diseases, revealing potential new therapeutic pathways.
by Hirohama D, Fadista J (...) Susztak K et 15 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
by Hirohama D, Fadista J (...) Susztak K et 15 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine
Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.
www.nature.com
August 21, 2025 at 10:35 AM
A large-scale kidney proteomics study uncovers proteins and targetable mechanisms prioritized for CKM diseases www.nature.com/articles/s41...
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine
Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.
www.nature.com
August 12, 2025 at 10:35 AM
A large-scale kidney proteomics study uncovers proteins and targetable mechanisms prioritized for CKM diseases www.nature.com/articles/s41...
Exciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social
We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease.
Check it out here: academic.oup.com/brain/advanc...
We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease.
Check it out here: academic.oup.com/brain/advanc...
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes
Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creu
academic.oup.com
February 13, 2025 at 1:23 PM
Exciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social
We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease.
Check it out here: academic.oup.com/brain/advanc...
We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease.
Check it out here: academic.oup.com/brain/advanc...
Epitope Effect Prevalence in Affinity-based pQTL studies https://www.biorxiv.org/content/10.1101/2025.06.20.660695v1
June 24, 2025 at 8:33 AM
Epitope Effect Prevalence in Affinity-based pQTL studies https://www.biorxiv.org/content/10.1101/2025.06.20.660695v1
Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10956233/latest
https://www.researchsquare.com/article/rs-10956233/latest
September 21, 2026 at 4:02 PM
Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10956233/latest
https://www.researchsquare.com/article/rs-10956233/latest
Slavé Petrovski from @astrazeneca.bsky.social security on the proteomics stage giving a great talk on the amazing work coming from the centre for genomics research and UK biobank. Check out astrazeneca-cgr-publications.github.io/pqtl-browser/
January 29, 2025 at 12:02 PM
Slavé Petrovski from @astrazeneca.bsky.social security on the proteomics stage giving a great talk on the amazing work coming from the centre for genomics research and UK biobank. Check out astrazeneca-cgr-publications.github.io/pqtl-browser/
