Abstract. Plasmids are major drivers of bacterial horizontal gene transfer, including transfer of antimicrobial resistance. Plasmid dissemination extends b

Plasmids are small DNA molecules that can move between bacterial cells. When a plasmid carries an antibiotic resistance gene, that gene can spread quickly through a bacterial population. We study what...

PhD Project - (MRC NW-DMS) Uncovering plasmid-driven metabolic vulnerabilities to tackle multidrug resistant pathogens at The University of Manchester, listed on FindAPhD.com

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Published in Nucleic acids research

Many bacteria carry conjugative plasmids, mobile DNA molecules that spread traits such as antibiotic resistance. Some conjugative plasmids encode proteins related to the bacterial DNA-binding protein H-NS. We show that an H-NS-like protein from the IncX4 plasmid pCROD2 binds almost exclusively to the plasmid from which it originates, while largely ignoring the host chromosome. Our findings reveal a previously unrecognized mechanism that allows plasmids to regulate their own genes with high specificity while minimizing interference with host gene expression.

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Bacterial conjugation spreads antibiotic resistance among pathogens via plasmid transfer. Here, the authors determine cryo-EM structures of the TraI helicase bound to DNA. These findings reveal the molecular mechanism of DNA processing during conjugation.

Inovio Pharma's plasmid DNA-based Voceryq has become the second drug approved in the US for adults with recurrent respiratory papillomatosis.

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