Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
tinyurl.com/lambda-RIL-seq
Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…
tinyurl.com
February 26, 2026 at 1:29 PM
Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
tinyurl.com/lambda-RIL-seq
Had to look up an old paper to get the doi. It still completely boggles my mind that TWO Nobel prizes have been given for small RNAs and this work wasn't recognized by either. Abstract is literally like "yeah, we found these tiny antisense RNAs and think they're probably causing gene silencing"
September 1, 2025 at 2:51 PM
Had to look up an old paper to get the doi. It still completely boggles my mind that TWO Nobel prizes have been given for small RNAs and this work wasn't recognized by either. Abstract is literally like "yeah, we found these tiny antisense RNAs and think they're probably causing gene silencing"
𝐏𝐆𝐑𝐏𝟐𝟎𝟐𝟔 - 𝐌𝐚́𝐥𝐚𝐠𝐚
Posttranscriptional gene regulation in Plants 🌱🧬
🗺️ Beautiful city of Málaga (Spain)
🗓️ 5-7 Oct 2026
Organizers:
@manavellalab.bsky.social
@kmerchante.bsky.social
@laura-ah.bsky.social
More info: very soon!
Posttranscriptional gene regulation in Plants 🌱🧬
🗺️ Beautiful city of Málaga (Spain)
🗓️ 5-7 Oct 2026
Organizers:
@manavellalab.bsky.social
@kmerchante.bsky.social
@laura-ah.bsky.social
More info: very soon!
July 24, 2025 at 10:21 AM
𝐏𝐆𝐑𝐏𝟐𝟎𝟐𝟔 - 𝐌𝐚́𝐥𝐚𝐠𝐚
Posttranscriptional gene regulation in Plants 🌱🧬
🗺️ Beautiful city of Málaga (Spain)
🗓️ 5-7 Oct 2026
Organizers:
@manavellalab.bsky.social
@kmerchante.bsky.social
@laura-ah.bsky.social
More info: very soon!
Posttranscriptional gene regulation in Plants 🌱🧬
🗺️ Beautiful city of Málaga (Spain)
🗓️ 5-7 Oct 2026
Organizers:
@manavellalab.bsky.social
@kmerchante.bsky.social
@laura-ah.bsky.social
More info: very soon!
Looking forward to enjoying the full taste of RNA!
www.embl.org/about/info/c...
www.embl.org/about/info/c...
The expanding world of RBPs: from posttranscriptional control to riboregulation
www.embl.org
December 2, 2024 at 9:38 AM
Looking forward to enjoying the full taste of RNA!
www.embl.org/about/info/c...
www.embl.org/about/info/c...
Distinct thresholds condition sense posttranscriptional gene silencing initiation and amplification (Martin Lacroix , Nicolas Butel , Andana Barrios , Agnès Yu , Nathalie Bouteiller , Ivan Le Masson , Hervé Vaucheret) doi.org/10.1093/plce... #PlantScience @aspbofficial
Distinct thresholds condition sense posttranscriptional gene silencing initiation and amplification
Abstract. It has long been known that Pro35S-driven sense transgenes have a high propensity to undergo posttranscriptional gene silencing (S-PTGS). However
doi.org
August 24, 2026 at 6:09 PM
Distinct thresholds condition sense posttranscriptional gene silencing initiation and amplification (Martin Lacroix , Nicolas Butel , Andana Barrios , Agnès Yu , Nathalie Bouteiller , Ivan Le Masson , Hervé Vaucheret) doi.org/10.1093/plce... #PlantScience @aspbofficial
If you are into #posttranscriptional modifications, gut #inflammation, #immunology or #gutmicrobiome check out our latest work @jem.org 👇
Big team effort @miershawig.bsky.social
@connyves.bsky.social
Big thanks to @fwf-at.bsky.social for funding!
Big team effort @miershawig.bsky.social
@connyves.bsky.social
Big thanks to @fwf-at.bsky.social for funding!
.@connyves.bsky.social group shows that RNA editing of the #actin cross-linker FLNA is similarly regulated in mice & humans and that the targeted induction of edited FLNAR in myeloid cells governs resistance to DSS-induced #colitis, revealing its potential in #IBD therapy rupress.org/jem/article/...
June 6, 2025 at 4:33 PM
If you are into #posttranscriptional modifications, gut #inflammation, #immunology or #gutmicrobiome check out our latest work @jem.org 👇
Big team effort @miershawig.bsky.social
@connyves.bsky.social
Big thanks to @fwf-at.bsky.social for funding!
Big team effort @miershawig.bsky.social
@connyves.bsky.social
Big thanks to @fwf-at.bsky.social for funding!
We are pleased to be media partners at the
@embl.org Conference: The expanding world of RBPs: from posttranscriptional control to riboregulation
Registration (On-site): 28 Jan 2025
Registration (Virtual): 3 Mar 2025
embl.org/about/info/c...
#EMBLRBP
@embl.org Conference: The expanding world of RBPs: from posttranscriptional control to riboregulation
Registration (On-site): 28 Jan 2025
Registration (Virtual): 3 Mar 2025
embl.org/about/info/c...
#EMBLRBP
The expanding world of RBPs: from posttranscriptional control to riboregulation
embl.org
December 18, 2024 at 9:53 AM
We are pleased to be media partners at the
@embl.org Conference: The expanding world of RBPs: from posttranscriptional control to riboregulation
Registration (On-site): 28 Jan 2025
Registration (Virtual): 3 Mar 2025
embl.org/about/info/c...
#EMBLRBP
@embl.org Conference: The expanding world of RBPs: from posttranscriptional control to riboregulation
Registration (On-site): 28 Jan 2025
Registration (Virtual): 3 Mar 2025
embl.org/about/info/c...
#EMBLRBP
….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
July 23, 2025 at 3:20 PM
….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
Check out this new spotlight in @cp-trendsmicrobiol.bsky.social! #HIRI’s @jenshoer.bsky.social and @mvelascogomariz.bsky.social highlight a recent study from the @saharmelamed.bsky.social lab that further unravels posttranscriptional regulatory networks in phage infection. 👏👇
Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
tinyurl.com/lambda-RIL-seq
Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…
tinyurl.com
February 26, 2026 at 2:34 PM
Check out this new spotlight in @cp-trendsmicrobiol.bsky.social! #HIRI’s @jenshoer.bsky.social and @mvelascogomariz.bsky.social highlight a recent study from the @saharmelamed.bsky.social lab that further unravels posttranscriptional regulatory networks in phage infection. 👏👇
A paper using RRID:AB_2230895 from @proteintech.bsky.social was just published in Life Science Alliance. Thanks for making your methods matter! #reproducibility #OpenScience #BetterScience
Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells
Read the full paper: Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells
doi.org
October 8, 2026 at 7:05 AM
A paper using RRID:AB_2230895 from @proteintech.bsky.social was just published in Life Science Alliance. Thanks for making your methods matter! #reproducibility #OpenScience #BetterScience
you think we know all about post·transcriptional control that modulates mRNA translatability (sRNA, riboswitches,...) – then tackle yet another level: tRNA/rRNA modifications that modulate mRNA translatability under stress 👇
"everything that can be regulated will be regulated"
#RNASky #MicroSky
"everything that can be regulated will be regulated"
#RNASky #MicroSky
journals.asm.org/doi/10.1128/... comprehensive review of bacterial RNA modifications 🦠
Compendium of RNA modifications for bacterial stress adaptation | Microbiology and Molecular Biology Reviews
SUMMARYRNA modifications in the tRNA, rRNA, and mRNA constitute a widespread layer of post-transcriptional gene regulation, commonly known as the epitranscriptome. In bacteria, tRNA and rRNA modifications are well documented and play essential roles in tRNA folding, rRNA maturation, translation, and peptidyl transfer. Although mRNA modifications have been extensively characterized in eukaryotes, their functional implications for mRNA fate in prokaryotes remain uncertain, and their identities and locations are the subject of an emerging field of research. Importantly, RNA modification is a dynamic process, and variation in the presence and abundance of these modifications has significant consequences for bacterial physiology. Here, we discuss current knowledge of modified RNA nucleotides in bacteria, with a particular focus on their roles in bacterial adaptation to environmental stress.
journals.asm.org
July 30, 2026 at 3:03 PM
Proud to see our work featured in this Spotlight in @cp-trendsmicrobiol.bsky.social by @mvelascogomariz.bsky.social and @jenshoer.bsky.social!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!
Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
tinyurl.com/lambda-RIL-seq
Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…
tinyurl.com
February 27, 2026 at 2:11 PM
Proud to see our work featured in this Spotlight in @cp-trendsmicrobiol.bsky.social by @mvelascogomariz.bsky.social and @jenshoer.bsky.social!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!
Unraveling posttranscriptional regulatory networks in phage infection
Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by ligation and sequencing) to reveal an additional layer of regulation and uncovered the Hfq-mediated posttranscriptional regulon of the model phage lambda.
dlvr.it
February 27, 2026 at 12:37 AM
Unraveling posttranscriptional regulatory networks in phage infection
Yup. EMBO chose to prioritize other, 'hotter', topics. There is a new RBP meeting though - www.embl.org/about/info/c...
The expanding world of RBPs: from posttranscriptional control to riboregulation
www.embl.org
November 13, 2024 at 7:28 AM
Yup. EMBO chose to prioritize other, 'hotter', topics. There is a new RBP meeting though - www.embl.org/about/info/c...
Disabling posttranscriptional regulation of AGO2 results in enhanced viral resistance
Ludman and Fátyol
nph.onlinelibrary.wiley.com/doi/10.1111/...
Ludman and Fátyol
nph.onlinelibrary.wiley.com/doi/10.1111/...
March 25, 2026 at 12:11 AM
Disabling posttranscriptional regulation of AGO2 results in enhanced viral resistance
Ludman and Fátyol
nph.onlinelibrary.wiley.com/doi/10.1111/...
Ludman and Fátyol
nph.onlinelibrary.wiley.com/doi/10.1111/...
New paper from the lab! Spearheaded by soon-to-be doctor Athina Eleftheraki. Fantastic collaboration with Anaïs Le Rhun lab at Uni Bordeaux! academic.oup.com/nar/article/...
An RNA structural switch controlling bacterial toxin translation
Abstract. Type I toxin–antitoxin systems (T1TAs) rely on tight posttranscriptional control to prevent inadvertent toxin synthesis, yet the molecular mechan
academic.oup.com
March 19, 2026 at 9:05 PM
New paper from the lab! Spearheaded by soon-to-be doctor Athina Eleftheraki. Fantastic collaboration with Anaïs Le Rhun lab at Uni Bordeaux! academic.oup.com/nar/article/...
MDA5 surveys RNA processing fidelity and detects infections by sensing perturbations of posttranscriptional events such as splicing
www.researchsquare.com/article/rs-6...
@drnatsampaio.bsky.social
www.researchsquare.com/article/rs-6...
@drnatsampaio.bsky.social
April 26, 2025 at 2:29 AM
MDA5 surveys RNA processing fidelity and detects infections by sensing perturbations of posttranscriptional events such as splicing
www.researchsquare.com/article/rs-6...
@drnatsampaio.bsky.social
www.researchsquare.com/article/rs-6...
@drnatsampaio.bsky.social
Wei Guo works to understand the posttranscriptional process and RNA metabolism in muscle structure and function. #WARF100 @uwchancellor.bsky.social @uwmadisoncals.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_guo/
August 20, 2025 at 11:23 PM
Wei Guo works to understand the posttranscriptional process and RNA metabolism in muscle structure and function. #WARF100 @uwchancellor.bsky.social @uwmadisoncals.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_guo/
In trypanosomes (infamously causing sleeping sickness), RNA-guided RNA editing restores protein coding capacity of mitochondrial cryptogenes by massive posttranscriptional insertions/deletions of uridines. A #cryoEM study @ScienceMagazine explores structural basis of this WILD process bit.ly/adg4725
October 8, 2023 at 7:53 PM
In trypanosomes (infamously causing sleeping sickness), RNA-guided RNA editing restores protein coding capacity of mitochondrial cryptogenes by massive posttranscriptional insertions/deletions of uridines. A #cryoEM study @ScienceMagazine explores structural basis of this WILD process bit.ly/adg4725
Elated to share that this story about an unexpected and important finding is now published @pnas.org
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
May 24, 2025 at 4:36 PM
Elated to share that this story about an unexpected and important finding is now published @pnas.org
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
www.pnas.org/doi/10.1073/...
These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.
It was fun to write this review with @rcdrula.bsky.social on Dicer functions beyond the canonical RNAi roles, including discussion of its roles in the nucleus.
An evolving and sometimes complicated field, that was synthesized beautifully by Rareș, a terrific postdoc in the lab. Check it out!
An evolving and sometimes complicated field, that was synthesized beautifully by Rareș, a terrific postdoc in the lab. Check it out!
Noncanonical Functions of DICER-Mediated Pathways
Dicer has long been viewed as the RNAse III enzyme that generates small regulatory RNAs to drive RNA interference (RNAi) machinery and posttranscriptional gene silencing. However, a growing body of ev...
www.annualreviews.org
September 2, 2026 at 8:04 PM
It was fun to write this review with @rcdrula.bsky.social on Dicer functions beyond the canonical RNAi roles, including discussion of its roles in the nucleus.
An evolving and sometimes complicated field, that was synthesized beautifully by Rareș, a terrific postdoc in the lab. Check it out!
An evolving and sometimes complicated field, that was synthesized beautifully by Rareș, a terrific postdoc in the lab. Check it out!
Just sent my abstract in for the @embl.org RBP meeting. www.embl.org/about/info/c... Any other #RNAsky friends attending? Would be great to connect and kudos to EMBO for organizing!
The expanding world of RBPs: from posttranscriptional control to riboregulation
www.embl.org
December 7, 2024 at 1:02 AM
Just sent my abstract in for the @embl.org RBP meeting. www.embl.org/about/info/c... Any other #RNAsky friends attending? Would be great to connect and kudos to EMBO for organizing!
Always a pleasure to work with the @archaellum.bsky.social lab - diving into the regulation of cell motility & shape in Haloferax this time. On our side, @felixgrunberger.bsky.social was the RNAseq guru again. Shoutout also to Anita Marchfelder (giving a posttranscriptional twist to the story).
This work started as a bachelor project and @1nussi1.bsky.social and @felixgrunberger.bsky.social showed that CsmR is a very interesting regulator important for controlling motiliy and cellshape in Haloferax volcanii.
The preprint is out now: www.biorxiv.org/content/10.6...
The preprint is out now: www.biorxiv.org/content/10.6...
www.biorxiv.org
February 4, 2026 at 10:05 AM
Always a pleasure to work with the @archaellum.bsky.social lab - diving into the regulation of cell motility & shape in Haloferax this time. On our side, @felixgrunberger.bsky.social was the RNAseq guru again. Shoutout also to Anita Marchfelder (giving a posttranscriptional twist to the story).
Proud to post our first new publication on bsky!
Greatful for the very straightforward collaboratoin with the Rief lab in Munich: This is what we did together with them:
www.pnas.org/doi/10.1073/...
Congrats to everyone, especially Jan-Niklas and Andreas!
Greatful for the very straightforward collaboratoin with the Rief lab in Munich: This is what we did together with them:
www.pnas.org/doi/10.1073/...
Congrats to everyone, especially Jan-Niklas and Andreas!
Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites | PNAS
The interaction of mRNA and regulatory proteins is critical for posttranscriptional
control. For proper function, these interactions, as well as th...
www.pnas.org
April 9, 2025 at 7:15 PM
Proud to post our first new publication on bsky!
Greatful for the very straightforward collaboratoin with the Rief lab in Munich: This is what we did together with them:
www.pnas.org/doi/10.1073/...
Congrats to everyone, especially Jan-Niklas and Andreas!
Greatful for the very straightforward collaboratoin with the Rief lab in Munich: This is what we did together with them:
www.pnas.org/doi/10.1073/...
Congrats to everyone, especially Jan-Niklas and Andreas!
Mashu Bhagat is presenting our work on "Structural analysis of proteins involved in binding both DNA and RNA" at The Expanding World of RBPs: from Posttranscriptional Control to Riboregulation at EMBL Heidelberg, Germany!
📍 Visit poster #47 to discuss our findings.
#EMBL #RBPs #EMBLRBP
📍 Visit poster #47 to discuss our findings.
#EMBL #RBPs #EMBLRBP
March 12, 2025 at 6:23 PM