#proinflammatory
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liddelowsa.bsky.social
UPDATE!

Now published in @cp-cellreports.bsky.social here - www.cell.com/cell-reports...

With a fantastic Preview from Daniel Shapiro, @krishnagajjar.bsky.social, and @fchrisbennett.bsky.social here - www.cell.com/cell-reports...
November 14, 2026 at 12:18 PM
science.org
The drug spesolimab for generalized pustular psoriasis targets the IL-36 receptor in skin cells. But how exactly does it work?

Read more in #ScienceImmunology: https://scim.ag/4zzrHV4
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37
Structural insights reveal how IL-36R is activated by distinct cytokines and antagonized by spesolimab.
scim.ag
November 10, 2026 at 4:00 PM
labtakei.bsky.social
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37 | Science Immunology www.science.org/doi/10.1126/...
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37
Structural insights reveal how IL-36R is activated by distinct cytokines and antagonized by spesolimab.
www.science.org
November 14, 2026 at 6:08 AM
pacheco-torgal.bsky.social
Ketogenic Diets May Increase Inflammation And Mitochondrial Stress www.science.org/doi/10.1126/...
Ketogenic diets induce proinflammatory macrophage accumulation through long-chain saturated fatty acids driving cGAS-STING signaling
Ketogenic diets (KDs) have demonstrated both pro- and anti-inflammatory effects; however, the mechanisms underlying divergent outcomes on a KD are unclear. Here, we show that a KD promotes the accumul...
www.science.org
November 14, 2026 at 1:19 PM
neurotherapytdy.bsky.social
New research links proinflammatory diets and elevated BMI to a higher risk of sleep disorders, underscoring the role of lifestyle factors in sleep health. #SleepResearch #Nutrition #Obesity
www.docwirenews.com/post/proinfl...
Proinflammatory Diets and Elevated BMI Tied to Greater Sleep Disorder Risk | Neuro Therapy Today
A high BMI, age, and dietary inflammatory index were positively related to sleep disorder risk.
www.docwirenews.com
November 11, 2026 at 7:06 PM
labtakei.bsky.social
Subunit engineering enables the generation of human interleukin-39 as a proinflammatory cytokine | Science Signaling www.science.org/doi/10.1126/...
Subunit engineering enables the generation of human interleukin-39 as a proinflammatory cytokine
Rational design enables human cells to produce an inflammatory cytokine that may not be made naturally.
www.science.org
November 11, 2026 at 12:57 AM
cryoempapers.bsky.social
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37 pubmed.ncbi.nlm.nih.gov/42993810/ #cryoem
November 7, 2026 at 4:36 PM
biorxivpreprint.bsky.social
Single-nucleus analysis reveals renal STAT1/CEBPB signaling as a modifiable relay of proinflammatory FGF23 effects in diabetic kidney disease https://www.biorxiv.org/content/10.64898/2026.11.10.765607v1
November 11, 2026 at 1:00 PM
biorxiv-physio.bsky.social
Single-nucleus analysis reveals renal STAT1/CEBPB signaling as a modifiable relay of proinflammatory FGF23 effects in diabetic kidney disease https://www.biorxiv.org/content/10.64898/2026.11.10.765607v1
November 11, 2026 at 1:00 PM
cp-cellreports.bsky.social
Meningeal inflammation and arachnoid barrier breakdown in a mouse model of neonatal bacterial meningitis
Meningeal inflammation and arachnoid barrier breakdown in a mouse model of neonatal bacterial meningitis
Kim et al. show the neonatal arachnoid barrier is compromised after GBS infection, causing increased permeability and proinflammatory signaling in most meningeal cell types including meningeal fibroblasts. A systemic injection of TNF-α alone is sufficient to break down the arachnoid barrier, suggesting its potential contribution in in vivo meningitis model.
dlvr.it
November 14, 2026 at 12:23 AM
primrlab.bsky.social
(2) EN: It also shifted macrophages from the proinflammatory M1 phenotype toward the repair-oriented M2 phenotype. However, there are important limitations: the findings come from an animal model, the follow-up was short, and a higher dose caused harm.
November 12, 2026 at 6:19 PM
cp-cellrepmed.bsky.social
Online now: The CD39/CD73 adenosinergic pathway is increased by proinflammatory states and modified by chemo-radiation in human non-small cell lung cancer
The CD39/CD73 adenosinergic pathway is increased by proinflammatory states and modified by chemo-radiation in human non-small cell lung cancer
Ashley et al. report local expression of adenosine-producing enzymes CD39 and CD73 as an inducible and inflammation-driven immunosuppressive pathway present in >85% of NSCLCs. This pathway displays preferential expression in lung adenocarcinomas with elevated TILs and PD-L1 or in tumors lacking STK11/KEAP1 mutations and is suppressed by radio-chemotherapy.
dlvr.it
November 11, 2026 at 1:27 PM
labwaggoner.bsky.social
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37
www.science.org/doi/10.1126/... @savvideslab.bsky.social
November 6, 2026 at 8:28 PM
scentificreports.bsky.social
Not all keto diets affect inflammation the same way.
A new Science Advances study finds that long-chain saturated fats trigger inflammatory immune responses.
doi.org/10.1126/scia...
@kcklatt.bsky.social @kevinh-phd.bsky.social @marionnestle.bsky.social @juliabelluz.bsky.social @met-hsph.bsky.social
Ketogenic diets induce proinflammatory macrophage accumulation through long-chain saturated fatty acids driving cGAS-STING signaling
Ketogenic diets (KDs) have demonstrated both pro- and anti-inflammatory effects; however, the mechanisms underlying divergent outcomes on a KD are unclear. Here, we show that a KD promotes the accumul...
doi.org
November 15, 2026 at 12:21 AM
topladave.bsky.social
The drug spesolimab for generalized pustular psoriasis targets the IL-36 receptor in skin cells. But how exactly does it work?

Read more in Science Immunology: scim.ag/4BRJtEE
The structural basis of IL-36R proinflammatory signaling mediated by IL-36γ and IL-37
Structural insights reveal how IL-36R is activated by distinct cytokines and antagonized by spesolimab.
scim.ag
November 10, 2026 at 6:15 PM
rheumatologyadv.bsky.social
Immunostimulatory herbs — such as #spirulina and #ashwagandha — produce proinflammatory cytokines, leading to new onset cases or flares of autoimmune disease.

— Research presented by Dr. Victoria Werth at #ACR26

https://www.rheumatologyadvisor.com/reports/herbal-supplements-dermatomyositis-flares/
New Onset Disease, Flare Risk, and Other Safety Concerns Surround Supplement Use in Autoimmune Disease
Herbal supplement use is linked to disease onset or flares in dermatomyositis, especially in patients with family autoimmune history.
www.rheumatologyadvisor.com
November 10, 2026 at 5:56 PM
science.org
New experiments in #ScienceSignaling present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in immunology. https://scim.ag/3V8FhQ9
Subunit engineering enables the generation of human interleukin-39 as a proinflammatory cytokine
Rational design enables human cells to produce an inflammatory cytokine that may not be made naturally.
scim.ag
November 4, 2026 at 4:00 PM
scienceartnews.bsky.social
The participants of the study:

David Ma
Anthony Rodrigues
Jennifer Massey
Rasha Cosman
Venessa Chin
@lailagirgis.bsky.social
James Lynam
Peter Lau
Barbara Withers
@anthonymjoshua.bsky.social
Ben Tran
Jayesh Desai
Simon J. Harrison,
John Moore
@jiajennyliu.bsky.social
Classes of adoptive cellular therapies. (A) TIL therapy involves surgical excision of a tumour to isolate naturally occurring tumour-reactive T cells, which are expanded ex vivo. Patients then receive LD chemotherapy followed by re-infusion of expanded TILs and administration of IL-2 to support in vivo proliferation and persistence. TILs recognise tumour-specific antigens presented via MHC molecules and mediate anti-tumour activity through cytotoxicity and secretion of proinflammatory cytokines, including TNF-α and IFN-γ. (B) TCR-T therapy involves apheresis and isolation of autologous or allogeneic T cells, which are genetically modified using viral vectors to express a tumour-specific TCR. Modified T cells are expanded ex vivo and administered following LD chemotherapy and recognise intracellular tumour antigens presented by MHC molecules. (C) CAR-T therapy involves genetic modification of autologous or allogeneic T cells to express a synthetic CAR that recognises cell-surface antigens independent of MHC. CAR-T cell activation results in robust cytokine secretion, including TNF-α and IFN-γ, with secondary activation of monocytes and macrophages that release IL-6 and IL-1, driving systemic inflammation and characteristic toxicities such as CRS and ICANS. CAR, chimeric antigen receptor; CAR-T, chimeric antigen receptor T cell; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity; IFN-γ, interferon-γ; IL, interleukin; LD, lymphodepleting, MHC, major histocompatibility complex; TCR-T, T-cell receptor-engineered T cell; TCR, T-cell receptor; TIL, tumour-infiltrating lymphocyte; TNF-α, tumour necrosis factor-α. Schematic timeline outlining major toxicities associated with adoptive cellular therapies.a ACT, adoptive cellular therapies; CAR-T, chimeric antigen receptor T cell; CRS, cytokine release syndrome; HLH, haemophagocytic lymphohistiocytosis; ICANS, immune effector cell-associated neurotoxicity syndrome; ICE, immune effector cell-associated encephalopathy; IL, interleukin; IV, intravenous; IVF, intravenous fluid; LD, lymphodepleting; LICATS, local immune effector cell-associated toxicity syndrome; MAS, macrophage-activation syndrome; TCR-T, T-cell receptor-engineered T-cell therapy; TIL, tumour-infiltrating lymphocyte. aPre-infusion toxicities primarily attributable to LD chemotherapy and include cytopaenias with and associated risk of infection, which may necessitate growth factor support, transfusions and antimicrobial prophylaxis. Early post-infusion toxicities include IL-2-related acute toxicity (TIL therapy) [14], CRS and ICANS [16]. Late or less common toxicities include on-target/off-tumour effects and emerging syndromes such as HLH/MAS, CAR-T cell-associated neurological toxicities, cerebellar toxicity, LICATS and secondary T-cell lymphomas. Barriers to efficacy of adoptive cellular therapies (ACT) in solid tumours. (A) Identification of a tumour-specific antigen is challenging, as most solid organ tumours express tumour-associated antigens that are shared with normal tissue, creating a risk of ‘on-target/off-tumour’ toxicity. (B) Tumour heterogeneity contributes to variable responses and resistance through antigen downregulation or loss. (C) The solid tumour micro-environment restricts immune trafficking, infiltration and persistence through physical barriers and immunosuppressive cells, including Tregs, TAMs, MDSCs and CAFs, which secrete inhibitory cytokines such as TGF-β, IL-10 and IL-4. (D) Treatment-limiting toxicities, including CRS and ICANS, are driven by monocyte and macrophage activation with IL-6 release, resulting in systemic inflammation, neurotoxicity and end-organ dysfunction. CAFs, cancer-associated fibroblasts; CAR-T, chimeric antigen receptor T cell; CRS, cytokine release syndrome; IL, interleukin; ICANS, immune effector cell-associated neurotoxicity; MDSCs, myeloid-derived suppressor cells; TAMs, tumour-associated macrophages; TCR-T, T-cell receptor-engineered T-cell therapy; TIL, tumour-infiltrating lymphocyte; TGF-β, transforming growth factor-β; Treg, regulator T cells. Integrated care pathway and shared-care model for adoptive cellular therapies (ACT).a aSchematic representation of the four key phases of ACT delivery: (panel 1) referral and patient selection; (panel 2) multidisciplinary assessment and care planning; (panel 3) ACT delivery, including leukapheresis, lymphodepleting chemotherapy and cellular infusion; and (panel 4) toxicity management and survivorship. The model highlights the central role of tertiary ACT centres in treatment coordination and toxicity management, supported by bidirectional shared-care pathways with primary care physicians, regional hospitals and community services. Effective implementation requires integrated communication across settings to enable timely referral, safe delivery of therapy, early recognition of toxicities and long-term survivorship care. ACT, adoptive cellular therapies; CRS, cytokine release syndrome; GP, general practitioner; ICANS, immune effector cell-associated neurotoxicity syndrome; ICU, intensive care unit; IL, interleukin; MDT, multidisciplinary team.
November 14, 2026 at 4:33 AM
viennaairwaylab.bsky.social
SIRT3 deficiency worsens olfactory dysfunction in chronic rhinosinusitis by driving proinflammatory, glycolysis-heavy macrophage activity and OSN loss in a murine model, identifying SIRT3 as a potential therapeutic target for #CRS with olfactory dysfunction
#Immunology #Rhinology
🔗 ino.to/e8lnwtc
November 3, 2026 at 5:35 AM
biorxivpreprint.bsky.social
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
November 3, 2026 at 2:18 PM
prepub-neurodegen.bsky.social
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
November 3, 2026 at 5:02 PM
biorxiv-neursci.bsky.social
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
November 3, 2026 at 2:18 PM
topladave.bsky.social
New experiments present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in immunology.

See more in Science Signaling: scim.ag/4zhP8RX
Subunit engineering enables the generation of human interleukin-39 as a proinflammatory cytokine
Rational design enables human cells to produce an inflammatory cytokine that may not be made naturally.
scim.ag
November 4, 2026 at 4:23 PM
phypapers.bsky.social
Proinflammatory strains of Mediterraneibacter gnavus are enriched during spondyloarthritis and bolster disease severity in animal model https://pubmed.ncbi.nlm.nih.gov/42966666/
November 2, 2026 at 1:59 PM
collectormask.bsky.social
An intervention against inflammation: "intranasal hiPSC-NSC-EVs therapy in late middle age can effectively diminish proinflammatory microglial transcriptome and signalling cascades that drive neuroinflammaging in the hippocampus" isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Intranasal Human NSC‐Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS‐STING Signalling, in Aged Hippocampus
Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age-related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide-binding...
isevjournals.onlinelibrary.wiley.com
November 3, 2026 at 2:50 AM