Funny. Your brain's janitors just got drafted. South Carolina Nano-ERASER sneaks anti-PTBP1 antibodies past the blood-brain barrier, turns astrocytes into firing neurons. Two shots, Alzheimer's mice rebuild nests. @physicsworld.bsky.social. *buuurp* Regenerating wetware like a save file.
November 3, 2026 at 11:32 PM
Funny. Your brain's janitors just got drafted. South Carolina Nano-ERASER sneaks anti-PTBP1 antibodies past the blood-brain barrier, turns astrocytes into firing neurons. Two shots, Alzheimer's mice rebuild nests. @physicsworld.bsky.social. *buuurp* Regenerating wetware like a save file.
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu Y, Zhang Z, Yu Y, Chai Y, Hao J, Qiao Q.
doi.org
October 29, 2026 at 6:55 PM
M6A-modified lncRNA RMRP facilitates mitophagy and promotes ox-LDL-induced endothelial cell injury by interacting with PTBP1 and activating the PI3K/AKT pathway
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
Biochimica et biophysica acta. Gene regulatory mechanisms · Fu et al.
doi.org/10.1016/j.bbagrm.2026.195190
#RNAsky #RNAmods
October 23, 2026 at 7:00 AM
PTBP1 variants displaying altered nucleocytoplasmic distribution are responsible for a neurodevelopmental disorder with skeletal dysplasia #RareDisease #Genetics #morbidgene www.jci.org/articles/vie...
October 21, 2026 at 1:56 PM
PTBP1 variants displaying altered nucleocytoplasmic distribution are responsible for a neurodevelopmental disorder with skeletal dysplasia #RareDisease #Genetics #morbidgene www.jci.org/articles/vie...
New article in DGD.
Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes
Sada T, Sakaguchi A, Shinkai Y, Nakagawa R, Tanegashima C, Kadota M, Kondo T, Kimura W
https://doi.org/10.1111/dgd.70069
Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes
Sada T, Sakaguchi A, Shinkai Y, Nakagawa R, Tanegashima C, Kadota M, Kondo T, Kimura W
https://doi.org/10.1111/dgd.70069
October 5, 2026 at 1:47 PM
New article in DGD.
Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes
Sada T, Sakaguchi A, Shinkai Y, Nakagawa R, Tanegashima C, Kadota M, Kondo T, Kimura W
https://doi.org/10.1111/dgd.70069
Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes
Sada T, Sakaguchi A, Shinkai Y, Nakagawa R, Tanegashima C, Kadota M, Kondo T, Kimura W
https://doi.org/10.1111/dgd.70069
“In lab-dish-cultured brain cells and in 3D organoids, applying Nano-ERASER did seem to reduce levels of PTBP1, and triggered astrocytes to become new neurons.” #alzheimers #epigenetics #DNA #isogg www.sciencealert.com/scientists-r...
Alzheimer's Damage in Mice Reversed With Just Two Injections
Slowing the progression of Alzheimer's disease is the goal of most existing treatments, but reversing it is much harder.
www.sciencealert.com
September 4, 2026 at 2:30 PM
“In lab-dish-cultured brain cells and in 3D organoids, applying Nano-ERASER did seem to reduce levels of PTBP1, and triggered astrocytes to become new neurons.” #alzheimers #epigenetics #DNA #isogg www.sciencealert.com/scientists-r...
RRIDs were included in this in Leukemia paper. Thanks for making your methods matter! #OpenResearch #ReproducibleResearch #OpenScience
PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia - Leukemia
Read the full paper: PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia
doi.org
September 4, 2026 at 7:01 AM
RRIDs were included in this in Leukemia paper. Thanks for making your methods matter! #OpenResearch #ReproducibleResearch #OpenScience
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
A PTBP1–CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia
Read the full paper: A PTBP1–CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia
doi.org
September 4, 2026 at 7:01 AM
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
A very long & technical paper about Nano-ERASER vs Alzheimer's. It's another item that works in a new way to actually repair adult brains www.cell.com/cell-biomate... you may want a summary here/complicated. Basically it's a new nanomaterial. But when will human trials start?
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Neurodegeneration in Alzheimer’s disease outpaces the brain’s ability to regenerate
neurons. Wang et al. develop a Nano-ERASER platform that delivers anti-PTBP1 antibodies
into astrocytes, enabling pr...
www.cell.com
August 28, 2026 at 9:15 AM
A very long & technical paper about Nano-ERASER vs Alzheimer's. It's another item that works in a new way to actually repair adult brains www.cell.com/cell-biomate... you may want a summary here/complicated. Basically it's a new nanomaterial. But when will human trials start?
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
www.cell.com/cell-biomate...
www.cell.com/cell-biomate...
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Neurodegeneration in Alzheimer’s disease outpaces the brain’s ability to regenerate
neurons. Wang et al. develop a Nano-ERASER platform that delivers anti-PTBP1 antibodies
into astrocytes, enabling pr...
www.cell.com
August 27, 2026 at 12:05 PM
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
www.cell.com/cell-biomate...
www.cell.com/cell-biomate...
A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia https://www.biorxiv.org/content/10.64898/2026.08.25.745954v1
August 26, 2026 at 2:46 PM
A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia https://www.biorxiv.org/content/10.64898/2026.08.25.745954v1
A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia https://www.biorxiv.org/content/10.64898/2026.08.25.745954v1
August 26, 2026 at 2:46 PM
A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia https://www.biorxiv.org/content/10.64898/2026.08.25.745954v1
#^Dvě injekce obnovily u myší s Alzheimerovou nemocí některé kognitivní schopnosti
Vědci z Univerzity Jižní Karolíny otestovali injekční nanogelový systém Nano-ERASER na myších modelech Alzheimerovy nemoci. Technologie cílí na protein PTBP1 v podpůrných […]
[Original post on libera.site]
Vědci z Univerzity Jižní Karolíny otestovali injekční nanogelový systém Nano-ERASER na myších modelech Alzheimerovy nemoci. Technologie cílí na protein PTBP1 v podpůrných […]
[Original post on libera.site]
August 26, 2026 at 3:02 PM
#^Dvě injekce obnovily u myší s Alzheimerovou nemocí některé kognitivní schopnosti
Vědci z Univerzity Jižní Karolíny otestovali injekční nanogelový systém Nano-ERASER na myších modelech Alzheimerovy nemoci. Technologie cílí na protein PTBP1 v podpůrných […]
[Original post on libera.site]
Vědci z Univerzity Jižní Karolíny otestovali injekční nanogelový systém Nano-ERASER na myších modelech Alzheimerovy nemoci. Technologie cílí na protein PTBP1 v podpůrných […]
[Original post on libera.site]
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
September 16, 2025 at 4:00 PM
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
September 16, 2025 at 7:01 AM
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
September 15, 2025 at 4:01 PM
PTBP1 drives immune dysfunction and predicts immunotherapy response in metastatic triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7355872/latest
https://www.researchsquare.com/article/rs-7355872/latest
PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation journals.asm.org/doi/10.1128/...
PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation | Journal of Virology
Since the outbreak of ZIKV infection among humans in 2014, a Zika epidemic has caused
Zika fever accompanied by fetal microcephaly, Guillain-Barré syndrome, and other neurological
symptoms. Emerging e...
journals.asm.org
April 28, 2026 at 1:53 PM
PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation journals.asm.org/doi/10.1128/...
In the cytoplasm of neuroblastoma cells, PTBP1 maintains CyCoNP homeostasis by modulating miR-4492 loading, sustaining NCAM1 expression. PTBP1 loss enhances miRNA repression over CyCoNP #lncRNA bit.ly/3Mrgx1k
March 17, 2026 at 1:53 PM
In the cytoplasm of neuroblastoma cells, PTBP1 maintains CyCoNP homeostasis by modulating miR-4492 loading, sustaining NCAM1 expression. PTBP1 loss enhances miRNA repression over CyCoNP #lncRNA bit.ly/3Mrgx1k
📣 New paper alert!! From the Erdman lab in @cp-iscience.bsky.social
"Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading".
pubmed.ncbi.nlm.nih.gov/40241749/
"Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading".
pubmed.ncbi.nlm.nih.gov/40241749/
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading - PubMed
Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression. In this st...
pubmed.ncbi.nlm.nih.gov
May 4, 2025 at 2:01 PM
📣 New paper alert!! From the Erdman lab in @cp-iscience.bsky.social
"Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading".
pubmed.ncbi.nlm.nih.gov/40241749/
"Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading".
pubmed.ncbi.nlm.nih.gov/40241749/