If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
April 3, 2025 at 4:27 PM
If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
Medchem heterocycles:
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
December 20, 2024 at 4:48 AM
Medchem heterocycles:
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Dislike: oxetane (closely followed by oxazole)
Overrated: BCP (yes I know it’s not a heterocycle)
Underrated: THF
Like: Pyrazole
Trust: Piperidine
#Chemsky
(Disclaimer: post is copied from the other place but a fun way to start…something)
Hmm could have sworn it was about pyrazole alkylation regioisomers
September 30, 2025 at 1:01 AM
Hmm could have sworn it was about pyrazole alkylation regioisomers
Why wasn't the deprotonated pyrazole hungry? Because Pyrazolate.
November 21, 2024 at 5:39 PM
Why wasn't the deprotonated pyrazole hungry? Because Pyrazolate.
I'm sorry, but I must let you know that as a chemist I thought that was a structural formula for some kind of dipyrazole at first, lmao
January 4, 2025 at 4:35 PM
I'm sorry, but I must let you know that as a chemist I thought that was a structural formula for some kind of dipyrazole at first, lmao
May 14, 2025 at 8:52 PM
Just in time for the new year - we show that you can make either isomer of N-aryl pyrazole selectively from a single TDSO. We really believe in the power of these wacky heterocycles.
chemrxiv.org/engage/chemr...
Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
chemrxiv.org/engage/chemr...
Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
December 30, 2025 at 2:26 PM
Just in time for the new year - we show that you can make either isomer of N-aryl pyrazole selectively from a single TDSO. We really believe in the power of these wacky heterocycles.
chemrxiv.org/engage/chemr...
Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
chemrxiv.org/engage/chemr...
Excellent work by superstar Alex Fanourakis, in collab with Osvaldo Gutierrez and J&J
IMHO, for flavor, you cannot beat a pyrazole.
May 17, 2026 at 12:09 AM
IMHO, for flavor, you cannot beat a pyrazole.
@gricechemistry.bsky.social post about pyrazole made me look up my industrial career stats for my 39 years. Compounds with multi heterocycles may reappear
14000 compounds
10700 with benzene
4200 with pyrazole or pyrazoline
3270 with pyridine
1530 with pyridazinone
1400 with pyrimidine
600 triazole
14000 compounds
10700 with benzene
4200 with pyrazole or pyrazoline
3270 with pyridine
1530 with pyridazinone
1400 with pyrimidine
600 triazole
November 15, 2024 at 11:28 PM
@gricechemistry.bsky.social post about pyrazole made me look up my industrial career stats for my 39 years. Compounds with multi heterocycles may reappear
14000 compounds
10700 with benzene
4200 with pyrazole or pyrazoline
3270 with pyridine
1530 with pyridazinone
1400 with pyrimidine
600 triazole
14000 compounds
10700 with benzene
4200 with pyrazole or pyrazoline
3270 with pyridine
1530 with pyridazinone
1400 with pyrimidine
600 triazole
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
June 4, 2025 at 12:47 AM
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
This is why I always love pyrazole-derived MOFs, beautiful structures too
March 30, 2026 at 7:42 PM
This is why I always love pyrazole-derived MOFs, beautiful structures too
Check out 'Iminobispyrazole (IBP) photoswitches: two pyrazole rings can be better than one' 🔥
From Jake Greenfield (@jakeylg.bsky.social), first author @jiarongwu.bsky.social and colleagues.
From Jake Greenfield (@jakeylg.bsky.social), first author @jiarongwu.bsky.social and colleagues.
Iminobispyrazole (IBP) photoswitches: two pyrazole rings can be better than one
We recently demonstrated that suitably functionalised aryliminopyrazoles can exhibit useful photoswitching properties. This study investigates the photoswitching potential of iminobispyrazoles…
buff.ly
March 8, 2025 at 1:00 PM
Check out 'Iminobispyrazole (IBP) photoswitches: two pyrazole rings can be better than one' 🔥
From Jake Greenfield (@jakeylg.bsky.social), first author @jiarongwu.bsky.social and colleagues.
From Jake Greenfield (@jakeylg.bsky.social), first author @jiarongwu.bsky.social and colleagues.
The trend for heterocyclic surgery continues…
This one is neat and easy to understand.
www.nature.com/articles/s41... #chemsky
This one is neat and easy to understand.
www.nature.com/articles/s41... #chemsky
Strategic atom replacement enables regiocontrol in pyrazole alkylation - Nature
Nature - Strategic atom replacement enables regiocontrol in pyrazole alkylation
www.nature.com
April 7, 2025 at 1:38 PM
The trend for heterocyclic surgery continues…
This one is neat and easy to understand.
www.nature.com/articles/s41... #chemsky
This one is neat and easy to understand.
www.nature.com/articles/s41... #chemsky
New paper out in #BJOC @beilstein-institut.bsky.social
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
![Bimanes, a class of molecules based on the 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione scaffold, were first introduced by E. M. Kosower in 1978. In this study, we report the topochemical cycloaddition of diethyl 2,6-dichloro-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazole-3,5-dicarboxylate (Cl2B), initiated by visible light. Crystal structure analysis confirmed that the reactive double bonds are parallel and coplanar, in line with the Schmidt criteria for topochemical cycloaddition. Additionally, two other bimane derivatives with different substitution patterns were synthesized and investigated. Our findings suggest that functionalizing bimanes to redshift their absorption maxima into the visible-light spectrum provides a promising strategy for synthesizing substituted cyclobutanes without the need for ultraviolet irradiation.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ls54voiihm3bxde2dkgrxbm3/bafkreidduymtzhb44xcfbfd46fwrtmmzmgmj7u6dbks42otca4k5xfa37i)
March 5, 2025 at 8:34 PM
New paper out in #BJOC @beilstein-institut.bsky.social
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
As a pyrazole-stan, random hydrazine mentions always perk up the ears
a man wearing a san antonio spurs t-shirt is holding a baby .
ALT: a man wearing a san antonio spurs t-shirt is holding a baby .
media.tenor.com
April 11, 2026 at 2:05 AM
As a pyrazole-stan, random hydrazine mentions always perk up the ears
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
June 4, 2025 at 12:45 AM
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
A greenhouse gas molecule such as CO₂ is small and elusive... few CO₂ complexes with heterocycles are known experimentally!
pubs.aip.org/aip/jcp/arti...
#weakinteractions #NCI #tetrelbond #hydrogenbond
pubs.aip.org/aip/jcp/arti...
#weakinteractions #NCI #tetrelbond #hydrogenbond
Rotational spectrum and theoretical calculations of pyrazole⋯CO2 complex: Tetrel and hydrogen bond interactions
The complex between pyrazole and carbon dioxide has been generated in a supersonic jet and characterized using Fourier transform microwave spectroscopy and stat
pubs.aip.org
January 26, 2026 at 2:56 PM
A greenhouse gas molecule such as CO₂ is small and elusive... few CO₂ complexes with heterocycles are known experimentally!
pubs.aip.org/aip/jcp/arti...
#weakinteractions #NCI #tetrelbond #hydrogenbond
pubs.aip.org/aip/jcp/arti...
#weakinteractions #NCI #tetrelbond #hydrogenbond
Enhanced Anticancer Selectivity of Cyclometalated Imidazole/Pyrazole-Imine IridiumIII Complexes Through the Switch from Cationic to Zwitterionic Forms | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Liu, Guo, and co-workers @InorgChem #iridium #imidazole #pyrazole #zwitterionic
February 4, 2025 at 1:17 AM
Enhanced Anticancer Selectivity of Cyclometalated Imidazole/Pyrazole-Imine IridiumIII Complexes Through the Switch from Cationic to Zwitterionic Forms | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Liu, Guo, and co-workers @InorgChem #iridium #imidazole #pyrazole #zwitterionic
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
June 4, 2025 at 12:33 AM
Pyrazole-thermal-assisted assembly of the largest N-rich tin-oxo clusters with tunable broadband nonlinear optical limiting effect
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Online NOW | Beilstein J. Org. Chem. "Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane" by Z. Noori @miquelsola.bsky.social C. Viñas F. Teixidor
J. Poater @icmabcsic.bsky.social @iqccudg.bsky.social #OpenAccess www.beilstein-journals.org/bjoc/article...
J. Poater @icmabcsic.bsky.social @iqccudg.bsky.social #OpenAccess www.beilstein-journals.org/bjoc/article...
February 21, 2025 at 11:16 AM
Online NOW | Beilstein J. Org. Chem. "Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane" by Z. Noori @miquelsola.bsky.social C. Viñas F. Teixidor
J. Poater @icmabcsic.bsky.social @iqccudg.bsky.social #OpenAccess www.beilstein-journals.org/bjoc/article...
J. Poater @icmabcsic.bsky.social @iqccudg.bsky.social #OpenAccess www.beilstein-journals.org/bjoc/article...
Found an old post on Twix that sums up my chemistry
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
September 16, 2023 at 6:36 PM
Found an old post on Twix that sums up my chemistry
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
About me:
Favourite element: carbon, duh
Favourite reaction: a photochemical reaction
Favourite het: pyrazole (of course)
Favourite functional group: anything conjugated
Favourite piece of glassware: Soxhlet extractor
Favourite natural product: ATP
Chemsky
Favourite element: carbon, duh
Favourite reaction: a photochemical reaction
Favourite het: pyrazole (of course)
Favourite functional group: anything conjugated
Favourite piece of glassware: Soxhlet extractor
Favourite natural product: ATP
Chemsky
Found an old post on Twix that sums up my chemistry
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
About me:
Favourite element: gold
Favourite reaction: Bargellini
Favourite het: pyrazole
Favourite functional group: sulfonamide
Favourite piece of glassware: clean 125 ml sep funnel Favourite natural product: sucrose
Chemsky
September 17, 2023 at 2:52 PM
About me:
Favourite element: carbon, duh
Favourite reaction: a photochemical reaction
Favourite het: pyrazole (of course)
Favourite functional group: anything conjugated
Favourite piece of glassware: Soxhlet extractor
Favourite natural product: ATP
Chemsky
Favourite element: carbon, duh
Favourite reaction: a photochemical reaction
Favourite het: pyrazole (of course)
Favourite functional group: anything conjugated
Favourite piece of glassware: Soxhlet extractor
Favourite natural product: ATP
Chemsky
🚀New advance toward asymmetric α‑Alkylation of Aldehydes.
✨Lead by Kezhi, we report a branched-selective α-alkylation of aldehydes with unactivated olefins — enabled by a pyrazole mediator and a chiral Ir catalyst. Congrats!
pubs.acs.org/doi/full/10....
✨Lead by Kezhi, we report a branched-selective α-alkylation of aldehydes with unactivated olefins — enabled by a pyrazole mediator and a chiral Ir catalyst. Congrats!
pubs.acs.org/doi/full/10....
Toward Iridium-Catalyzed Asymmetric Branched-Selective α-Alkylation of Aldehydes with Unactivated Alkenes Enabled by a Pyrazole Mediator
Aldehyde α-alkylation remains a challenging transformation. On the other hand, given the wide availability of alkenes, it has been an attractive objective to use unactivated alkenes as alkylating agen...
pubs.acs.org
June 25, 2025 at 6:49 PM
🚀New advance toward asymmetric α‑Alkylation of Aldehydes.
✨Lead by Kezhi, we report a branched-selective α-alkylation of aldehydes with unactivated olefins — enabled by a pyrazole mediator and a chiral Ir catalyst. Congrats!
pubs.acs.org/doi/full/10....
✨Lead by Kezhi, we report a branched-selective α-alkylation of aldehydes with unactivated olefins — enabled by a pyrazole mediator and a chiral Ir catalyst. Congrats!
pubs.acs.org/doi/full/10....
A search for fragments was carried out using STD-NMR, WaterLogsy and NOESY experiments. The best fragments were: indole, biphenyl and pyrazole. The authors therefore made several derivatives of these fragments, using an amide linker between the fragments and the hydroxamic acid.
November 30, 2024 at 3:43 PM
A search for fragments was carried out using STD-NMR, WaterLogsy and NOESY experiments. The best fragments were: indole, biphenyl and pyrazole. The authors therefore made several derivatives of these fragments, using an amide linker between the fragments and the hydroxamic acid.
📢Our latest issue is now online!
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
December 3, 2025 at 2:30 PM
📢Our latest issue is now online!
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...
🔓Check out the #OpenAccess paper by Saeedreza Emamian, @tonifrontera.bsky.social & co. @dquimicauib.bsky.social decoding ortho regiospecificity & high endo stereoselectivity in pyrazole synthesis via the activation/strain model #orgchem
pubs.rsc.org/en/content/a...