Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

YouTube video by the bumbling biochemist

Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...

Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...

Here, the authors show that the oral microbe Streptococcus mutans, elevated in the gut microbiome of Parkinson’s patients, produces imidazole propionate via UrdA that in mice reaches the brain and tri...

The gut microbiome modulates metabolic and neurovascular processes implicated in Alzheimer’s disease and related dementias (ADRD), but the underlying mechanisms remain unclear. Here, we identify the bacterial metabolite imidazole propionate (ImP) as a modifier of ADRD pathology. In a cohort of 1196 cognitively unimpaired adults, higher plasma ImP levels were associated with lower preclinical cognitive scores and biomarkers of ADRD, both cross-sectionally and longitudinally. Fecal metagenomic analysis linked putative ImP producers to ADRD phenotypes. Genome-wide integrative analysis revealed a locus on chromosome 12 associated with both plasma ImP levels and AD risk in humans, supporting a host genetic contribution to ImP regulation and a causal role of this metabolite in AD. In mice, chronic ImP administration exacerbated AD-like pathology. ImP impaired brain endothelial barrier and promoted tau hyperphosphorylation in primary neurons, an effect blocked by glycogen synthase kinase-3β i

Gut bacteria produce a common compound called imidazole propionate. Higher levels of it contribute to dementia-related changes in the brain, a study reveals.

Cryo-EM structures of M. tuberculosis imidazole glycerol phosphate dehydratase suggest that the enzyme exhibits a 24-mer assembly with 432 symmetry in both apo and small-molecule-bound states.

Agirman et al. find that imidazole propionate, a microbiome-derived metabolite, reaches the brain, dampens hypothalamic activity, and promotes stress-related behaviors. Human data show that higher ImP...

Gut bacteria produce a common compound called imidazole propionate. Higher levels of it contribute to dementia-related changes in the brain, a study reveals.

The formation of metal-mediated base pairs comprised of HQIm (3H-imidazo[4,5-f]quinolin-5-ol) and/or CaIm (imidazole-4-carboxylate) induces a significant thermal stabilization of DNA with the 3d meta....

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...