Run out there and give it your 25%…four times over!
February 13, 2026 at 9:12 PM
Run out there and give it your 25%…four times over!
🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 16, 2025 at 5:36 AM
🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 6, 2025 at 9:30 PM
How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 13, 2025 at 9:33 AM
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
@science.org G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation | Science www.science.org/doi/10.1126/... @sahilbatra.bsky.social @benallwein.bsky.social @dirkremus.bsky.social www.mskcc.org/research/ski...
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 7, 2025 at 4:24 PM
@science.org G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation | Science www.science.org/doi/10.1126/... @sahilbatra.bsky.social @benallwein.bsky.social @dirkremus.bsky.social www.mskcc.org/research/ski...
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
April 21, 2026 at 4:13 PM
@alison-harrod.bsky.social has her wonderful project on SMARCA4 and G quadruplex stability out now in Genome Biology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Tyler has a quadruplex orgasm every time dronez or the potential for dronez are mentioned. Hell, he probably does form of BDSM involving quadcopters...
October 5, 2026 at 11:24 PM
Tyler has a quadruplex orgasm every time dronez or the potential for dronez are mentioned. Hell, he probably does form of BDSM involving quadcopters...
🧬@science.org Structural basis for nucleolin recognition of MYC promoter G-quadruplex | Science www.science.org/doi/10.1126/...
@cancer-inst-purdue.bsky.social danzhou-yang.com #DNA #StructuralBiology
@cancer-inst-purdue.bsky.social danzhou-yang.com #DNA #StructuralBiology
Structural basis for nucleolin recognition of MYC promoter G-quadruplex
The MYC oncogene promoter G-quadruplex (MycG4) regulates transcription and is a prevalent G4 locus in immortal cells. Nucleolin, a major MycG4-binding protein, exhibits greater affinity for MycG4 than...
www.science.org
April 17, 2025 at 6:25 PM
🧬@science.org Structural basis for nucleolin recognition of MYC promoter G-quadruplex | Science www.science.org/doi/10.1126/...
@cancer-inst-purdue.bsky.social danzhou-yang.com #DNA #StructuralBiology
@cancer-inst-purdue.bsky.social danzhou-yang.com #DNA #StructuralBiology
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers - Genome Biology
Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex...
doi.org
June 4, 2025 at 9:00 PM
How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function?
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9
doi.org/10.1186/s130...
someone sell me and my friends a cute quadruplex to live in. fuck you.
September 12, 2026 at 7:37 PM
someone sell me and my friends a cute quadruplex to live in. fuck you.
Interested in G-quadruplexes, check out "Early events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering" #DNA #Quadruplex 👉 Read the full article here: https://buff.ly/3Q2whFW
January 31, 2025 at 12:11 PM
Interested in G-quadruplexes, check out "Early events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering" #DNA #Quadruplex 👉 Read the full article here: https://buff.ly/3Q2whFW
Want to learn more about water-soluble luminescent platinum(II) complexes for guanine quadruplex binding? Check out the full paper of this collaborative Müller/Strassert work @daltontrans.rsc.org (doi.org/10.1039/D4DT...)
Congrats to Simon, Marian, Alex, Marcus, Joschua and Ali 🎉
Congrats to Simon, Marian, Alex, Marcus, Joschua and Ali 🎉
Water-soluble luminescent platinum(II) complexes for guanine quadruplex binding
A family of 16 platinum(ii) complexes was synthesized with the aim of obtaining water-soluble luminescent coordination compounds for guanine quadruplex (G4) binding. The complexes share a common tride...
pubs.rsc.org
March 26, 2025 at 10:56 AM
Want to learn more about water-soluble luminescent platinum(II) complexes for guanine quadruplex binding? Check out the full paper of this collaborative Müller/Strassert work @daltontrans.rsc.org (doi.org/10.1039/D4DT...)
Congrats to Simon, Marian, Alex, Marcus, Joschua and Ali 🎉
Congrats to Simon, Marian, Alex, Marcus, Joschua and Ali 🎉
Everyone in the apartment quadruplex is home today and they're all being LOUD. Only I'M allowed to be home and be loud on a weekday!
August 11, 2026 at 4:19 PM
Everyone in the apartment quadruplex is home today and they're all being LOUD. Only I'M allowed to be home and be loud on a weekday!
Yes. Nuance: F-16’s quadruplex FBW was designed to survive individual channel failures, so “computer failure = eject” is a bit strong. But lose the flight-control system badly enough - no mechanical fallback. The F-15 remained conventionally stable – demonstrated by the Israeli one wing landing.
October 2, 2026 at 6:35 PM
Yes. Nuance: F-16’s quadruplex FBW was designed to survive individual channel failures, so “computer failure = eject” is a bit strong. But lose the flight-control system badly enough - no mechanical fallback. The F-15 remained conventionally stable – demonstrated by the Israeli one wing landing.
Quadruplex works on U-Matic right?
February 17, 2025 at 10:20 PM
Quadruplex works on U-Matic right?
Happy to take you behind the scenes of the discovery of 7 alternative #DNA structures: 𝘁𝗿𝗶𝗽𝗹𝗲𝘅, G-quadruplex (𝗚𝟰), 𝗶-𝗺𝗼𝘁𝗶𝗳, both 3- and 4-way 𝗗𝗡𝗔 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀, 𝗥-𝗹𝗼𝗼𝗽 and the left-handed duplex 𝗭-𝗗𝗡𝗔.
Hope you'll enjoy this journey back in time!
In @narjournal.bsky.social
👉 doi.org/10.1093/nar/...
Hope you'll enjoy this journey back in time!
In @narjournal.bsky.social
👉 doi.org/10.1093/nar/...
April 29, 2026 at 9:36 AM
Happy to take you behind the scenes of the discovery of 7 alternative #DNA structures: 𝘁𝗿𝗶𝗽𝗹𝗲𝘅, G-quadruplex (𝗚𝟰), 𝗶-𝗺𝗼𝘁𝗶𝗳, both 3- and 4-way 𝗗𝗡𝗔 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀, 𝗥-𝗹𝗼𝗼𝗽 and the left-handed duplex 𝗭-𝗗𝗡𝗔.
Hope you'll enjoy this journey back in time!
In @narjournal.bsky.social
👉 doi.org/10.1093/nar/...
Hope you'll enjoy this journey back in time!
In @narjournal.bsky.social
👉 doi.org/10.1093/nar/...
It's a happy Monday when you realise a compound you discovered during your PhD is now commercially available!
TAP1 (forever etched into my mind) can disrupt G-quadruplex DNA structures and is now available from MedChemExpress
#chemsky
TAP1 (forever etched into my mind) can disrupt G-quadruplex DNA structures and is now available from MedChemExpress
#chemsky
July 7, 2025 at 8:15 AM
It's a happy Monday when you realise a compound you discovered during your PhD is now commercially available!
TAP1 (forever etched into my mind) can disrupt G-quadruplex DNA structures and is now available from MedChemExpress
#chemsky
TAP1 (forever etched into my mind) can disrupt G-quadruplex DNA structures and is now available from MedChemExpress
#chemsky
fall in love with Lily again, on quadruplex videotape...?
June 20, 2026 at 4:41 PM
fall in love with Lily again, on quadruplex videotape...?
Congrats to Koichi Sato and @puckknipscheer.bsky.social on this beautiful paper! The biochemistry is 🤯 Happy to help with scEdUseq to pinpoint the DNA replication defects! 🎉🧬
RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...
RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 13, 2025 at 7:04 AM
Congrats to Koichi Sato and @puckknipscheer.bsky.social on this beautiful paper! The biochemistry is 🤯 Happy to help with scEdUseq to pinpoint the DNA replication defects! 🎉🧬
RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...
RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
December 11, 2024 at 9:14 AM
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
Visualizing TERRA RNA G-quadruplex unfolding in FUS biomolecular condensates
RNA G-quadruplexes (rG4s) are remarkably stable secondary structures with critical regulatory roles in gene expression, RNA metabolism, and telomere maintenance. However, their behavior within cells r...
www.biorxiv.org
October 30, 2025 at 7:35 PM
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
ugh. A:T, G:C pairing. G:G is seen in weird G quadruplex structures that do exist but don't explain inheritance.
November 9, 2025 at 7:04 PM
ugh. A:T, G:C pairing. G:G is seen in weird G quadruplex structures that do exist but don't explain inheritance.
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
December 22, 2025 at 3:48 PM
⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...
#NARBreaktrhough #RNA #StructuralBiology
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
January 22, 2025 at 7:56 AM
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
"But, I Prayed for Blue Wings!" Original Film Captures 📷 .tiff Stack w/Ink Drawing/Mineral/DigaPaint into a Digital Artifact Quadruplex - © Brad Michael Moore #Art #Abstract #DigitalArtifact #MixedMedia #Humor #CandlerMineralCollection #Pen&Ink #Consequences #Vanity #Confession #WhoAmIIfIAmNotWhoIAm
February 19, 2025 at 10:50 PM
"But, I Prayed for Blue Wings!" Original Film Captures 📷 .tiff Stack w/Ink Drawing/Mineral/DigaPaint into a Digital Artifact Quadruplex - © Brad Michael Moore #Art #Abstract #DigitalArtifact #MixedMedia #Humor #CandlerMineralCollection #Pen&Ink #Consequences #Vanity #Confession #WhoAmIIfIAmNotWhoIAm