Last lecture of summer popgen:"Evolutionary QuantGen: why (almost) everything we learned is (kinda) wrong". how selection on traits affects alleles. Architecture, stabilizing selection, popgen on gene sets, corn example & a shiny app from @mgstetter.bsky.social mgstetter.shinyapps.io/quantgensimA...
August 25, 2025 at 2:20 AM
Last lecture of summer popgen:"Evolutionary QuantGen: why (almost) everything we learned is (kinda) wrong". how selection on traits affects alleles. Architecture, stabilizing selection, popgen on gene sets, corn example & a shiny app from @mgstetter.bsky.social mgstetter.shinyapps.io/quantgensimA...
I just had the most wonderful time at the Quantgen GRC in Italy with these lovely and brilliant people :) hope to see everyone again in Ventura for the next Quantgen GRC in 2 years time, and sooner on other occasions!
February 21, 2025 at 10:26 AM
I just had the most wonderful time at the Quantgen GRC in Italy with these lovely and brilliant people :) hope to see everyone again in Ventura for the next Quantgen GRC in 2 years time, and sooner on other occasions!
Excited to share the news that our article on the partition of variance of reaction norm with @lmchev.bsky.social has been recommended by @peercommunityin.bsky.social Evolutionary Biology: 👇🧵
ecoevorxiv.org/repository/v...
evolbiol.peercommunityin.org/articles/rec...
#phenplas #quantgen
ecoevorxiv.org/repository/v...
evolbiol.peercommunityin.org/articles/rec...
#phenplas #quantgen
Partitioning the phenotypic and genetic variances of reaction norms
ecoevorxiv.org
January 21, 2025 at 7:57 AM
Excited to share the news that our article on the partition of variance of reaction norm with @lmchev.bsky.social has been recommended by @peercommunityin.bsky.social Evolutionary Biology: 👇🧵
ecoevorxiv.org/repository/v...
evolbiol.peercommunityin.org/articles/rec...
#phenplas #quantgen
ecoevorxiv.org/repository/v...
evolbiol.peercommunityin.org/articles/rec...
#phenplas #quantgen
Great to see so many new people here 👋
We are the #SocietyJournal of @geneticssocietyuk.bsky.social
Heredity covers a broad range of topics within the field of genetics #population #genetics #genomics #evolution #phylogenetics #epigenetics #quantgen
www.nature.com/hdy/
We are the #SocietyJournal of @geneticssocietyuk.bsky.social
Heredity covers a broad range of topics within the field of genetics #population #genetics #genomics #evolution #phylogenetics #epigenetics #quantgen
www.nature.com/hdy/
November 18, 2024 at 9:40 AM
Great to see so many new people here 👋
We are the #SocietyJournal of @geneticssocietyuk.bsky.social
Heredity covers a broad range of topics within the field of genetics #population #genetics #genomics #evolution #phylogenetics #epigenetics #quantgen
www.nature.com/hdy/
We are the #SocietyJournal of @geneticssocietyuk.bsky.social
Heredity covers a broad range of topics within the field of genetics #population #genetics #genomics #evolution #phylogenetics #epigenetics #quantgen
www.nature.com/hdy/
Took me a year (😱), but I finally published a blog post about our article on the #quantgen variance partition of phenitypic plasticity with @lmchev.bsky.social, published in @peercomjournal.bsky.social.
🇬🇧 devillemereuil.legtux.org/quantitative...
🇫🇷 devillemereuil.legtux.org/fr/genetique...
🇬🇧 devillemereuil.legtux.org/quantitative...
🇫🇷 devillemereuil.legtux.org/fr/genetique...
Quantitative genetics of reaction norms: an onion partitionning – Pierre de Villemereuil
devillemereuil.legtux.org
December 10, 2025 at 10:48 AM
Took me a year (😱), but I finally published a blog post about our article on the #quantgen variance partition of phenitypic plasticity with @lmchev.bsky.social, published in @peercomjournal.bsky.social.
🇬🇧 devillemereuil.legtux.org/quantitative...
🇫🇷 devillemereuil.legtux.org/fr/genetique...
🇬🇧 devillemereuil.legtux.org/quantitative...
🇫🇷 devillemereuil.legtux.org/fr/genetique...
Question for evolutionary biologists. Am I missing something or are Fisher's geometric model and Simpson's adaptive landscape model exactly the same thing? And why has nobody said so? If you know a paper that makes this point even tangentially, pls let me know.
#evolution #popgen #quantgen
#evolution #popgen #quantgen
September 1, 2026 at 5:26 AM
Question for evolutionary biologists. Am I missing something or are Fisher's geometric model and Simpson's adaptive landscape model exactly the same thing? And why has nobody said so? If you know a paper that makes this point even tangentially, pls let me know.
#evolution #popgen #quantgen
#evolution #popgen #quantgen
Our paper with @lmchev.bsky.social on the partitioning of variance of reaction norm for plastic traits has now been published in @peercomjournal.bsky.social.
#evolbiol #phenplas #quantgen 🧪
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 🧪
peercommunityjournal.org/articles/10....
Partitioning the phenotypic and genetic variances of reaction norms
peercommunityjournal.org
January 28, 2025 at 8:42 AM
Our paper with @lmchev.bsky.social on the partitioning of variance of reaction norm for plastic traits has now been published in @peercomjournal.bsky.social.
#evolbiol #phenplas #quantgen 🧪
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 🧪
peercommunityjournal.org/articles/10....
Have any #QuantGen folk tried fitting an animal model with the new covariance structure in glmmTMB? Intrigued at the prospect of fitting big models in seconds/minutes rather than days/weeks...
Fast phylogenetic generalised linear mixed-effects modelling using the glmmTMB R package https://www.biorxiv.org/content/10.64898/2025.12.20.695312v1
December 29, 2025 at 9:45 AM
Have any #QuantGen folk tried fitting an animal model with the new covariance structure in glmmTMB? Intrigued at the prospect of fitting big models in seconds/minutes rather than days/weeks...
#editorbio Craig Walling #quantgen #lifehistory #evolutionofaging #tradeoffs
@edinburgh-uni.bsky.social @edinburghbiology.bsky.social
@edinburgh-uni.bsky.social @edinburghbiology.bsky.social
July 9, 2025 at 10:57 AM
Today's Quan Gen Journal Club : a paper by @pdevillemereuil.bsky.social & @lmchev.bsky.social that presents the new #Rpackage Reacnorm to partition phenotypic & genetic var in reaction norms - it was tough but worth it !
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 📈📉
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 📈📉
Partitioning the phenotypic and genetic variances of reaction norms
peercommunityjournal.org
March 7, 2025 at 3:38 PM
Today's Quan Gen Journal Club : a paper by @pdevillemereuil.bsky.social & @lmchev.bsky.social that presents the new #Rpackage Reacnorm to partition phenotypic & genetic var in reaction norms - it was tough but worth it !
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 📈📉
peercommunityjournal.org/articles/10....
#evolbiol #phenplas #quantgen 📈📉
Less than a week to #wcpg2023, looking forward to seeing everyone there!
My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please email me, also happy to chat during the conference!
www.nacailab.com
My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please email me, also happy to chat during the conference!
www.nacailab.com
www.nacailab.com
October 4, 2023 at 12:03 PM
Less than a week to #wcpg2023, looking forward to seeing everyone there!
My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please email me, also happy to chat during the conference!
www.nacailab.com
My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please email me, also happy to chat during the conference!
www.nacailab.com
Our paper addresses a central question in quantgen: whether all genetic variants associated with a complex disease contribute additively to its liability as commonly assumed, or there exists sets of them that co-occur more in certain cases than expected under additivity. 2/n
July 24, 2025 at 5:24 AM
Our paper addresses a central question in quantgen: whether all genetic variants associated with a complex disease contribute additively to its liability as commonly assumed, or there exists sets of them that co-occur more in certain cases than expected under additivity. 2/n
@uchicagopress.bsky.social's gives a good overview: press.uchicago.edu/ucp/books/bo...
Central arguments use roles of #popgen, #quantgen, modeling, statistics in empirical research & theory, but provide context for #evodevo, #nicheconstruction, and organisms. 2/9
Central arguments use roles of #popgen, #quantgen, modeling, statistics in empirical research & theory, but provide context for #evodevo, #nicheconstruction, and organisms. 2/9
Evolution and the Machinery of Chance
An innovative view of the role of fitness concepts in evolutionary theory. Natural selection is one of the factors responsible for changes in biological populations. Some traits or organisms are fit...
press.uchicago.edu
June 13, 2025 at 6:13 PM
@uchicagopress.bsky.social's gives a good overview: press.uchicago.edu/ucp/books/bo...
Central arguments use roles of #popgen, #quantgen, modeling, statistics in empirical research & theory, but provide context for #evodevo, #nicheconstruction, and organisms. 2/9
Central arguments use roles of #popgen, #quantgen, modeling, statistics in empirical research & theory, but provide context for #evodevo, #nicheconstruction, and organisms. 2/9
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 3:35 PM
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
For example, here's an old twitter thread dissecting how Cremieux/Lasker completely misunderstands a basic simulation I wrote on heritability & selection, which he uses to try and illustrate some inane argument about eugenics.
old link x.com/Graham_Coop/...
old link x.com/Graham_Coop/...
March 6, 2025 at 4:56 AM
For example, here's an old twitter thread dissecting how Cremieux/Lasker completely misunderstands a basic simulation I wrote on heritability & selection, which he uses to try and illustrate some inane argument about eugenics.
old link x.com/Graham_Coop/...
old link x.com/Graham_Coop/...
I say:
1) DNA as hereditary material was validated 80 yrs later hence knowledge about DNA was not required for Mendel
2) Occam's Razor suggests single causal mechanism of inheritance in 7 traits
3) Treat Mendelian genetics as special case of Hardy-Weinberg Eq and Fisher's 1918 model of quantgen.
1) DNA as hereditary material was validated 80 yrs later hence knowledge about DNA was not required for Mendel
2) Occam's Razor suggests single causal mechanism of inheritance in 7 traits
3) Treat Mendelian genetics as special case of Hardy-Weinberg Eq and Fisher's 1918 model of quantgen.
November 8, 2025 at 1:41 PM
I say:
1) DNA as hereditary material was validated 80 yrs later hence knowledge about DNA was not required for Mendel
2) Occam's Razor suggests single causal mechanism of inheritance in 7 traits
3) Treat Mendelian genetics as special case of Hardy-Weinberg Eq and Fisher's 1918 model of quantgen.
1) DNA as hereditary material was validated 80 yrs later hence knowledge about DNA was not required for Mendel
2) Occam's Razor suggests single causal mechanism of inheritance in 7 traits
3) Treat Mendelian genetics as special case of Hardy-Weinberg Eq and Fisher's 1918 model of quantgen.
Deep Quantgen philosophical question. Why not pronounce BLUPs “bloops” and BLUEs as “blueys”. Much more fun.
March 28, 2024 at 4:25 PM
Deep Quantgen philosophical question. Why not pronounce BLUPs “bloops” and BLUEs as “blueys”. Much more fun.
Quantgen GRC (16-21 Feb 2025) updates: we are now 75% subscribed!
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
December 5, 2024 at 9:47 AM
Quantgen GRC (16-21 Feb 2025) updates: we are now 75% subscribed!
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
Deadline: 19 Jan 2025
BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!
www.grc.org/quantitative...
Reminds me that I need expand the animal model section of quantgen notes somewhat.
September 11, 2023 at 1:46 AM
Reminds me that I need expand the animal model section of quantgen notes somewhat.
Using #quantgen, #commongarden, and #GWAS approaches, we find that urban and forest great tits do not differ (phenotypically or genetically) in their cognitive abilities related to inhibitory control, but show that cognitive variation may have a genetic basis.
July 4, 2025 at 3:53 PM
Using #quantgen, #commongarden, and #GWAS approaches, we find that urban and forest great tits do not differ (phenotypically or genetically) in their cognitive abilities related to inhibitory control, but show that cognitive variation may have a genetic basis.
Quantgen GRC (16-21 Feb 2025) in Lucca, Italy: we are still accepting applications and poster abstracts!
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 9, 2025 at 3:43 PM
Quantgen GRC (16-21 Feb 2025) in Lucca, Italy: we are still accepting applications and poster abstracts!
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Deadline: 19 Jan 2025
Apply now - we have a great selection of invited speakers and the posters abstracts are amazing. It’s going to be a blast 💥
www.grc.org/quantitative...
Yes! I got into quantgen relatively recently (thanks to chandra jack’s talk) and was for separate reasons digging deeper into regressions and geometry. that combined learning somehow made popgen click in ways it didn’t earlier
December 18, 2024 at 5:35 AM
Yes! I got into quantgen relatively recently (thanks to chandra jack’s talk) and was for separate reasons digging deeper into regressions and geometry. that combined learning somehow made popgen click in ways it didn’t earlier
I recently realized that some widely adopted assumptions & models in human quantgen can be deduced from the infinite-sites assumption + ARG. I guess it's time to update an old preprint.
December 25, 2023 at 12:14 AM
I recently realized that some widely adopted assumptions & models in human quantgen can be deduced from the infinite-sites assumption + ARG. I guess it's time to update an old preprint.