Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
October 5, 2026 at 4:15 PM
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
October 5, 2026 at 4:10 PM
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
October 4, 2026 at 12:15 PM
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
October 4, 2026 at 12:10 PM
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
October 3, 2026 at 8:15 AM
Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5
🧪 #AcademicSky #virus
plos.io/4rNWkD5
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
October 3, 2026 at 8:10 AM
How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG
🧪 #AcademicSky
plos.io/4y9KgxG
🗞️Vacinas contra covid podem ajudar a barrar coronavírus de morcegos, diz estudo
A equipe descobriu que sarbecovírus capazes de usar receptores ACE2 de muitas espécies diferentes estavam, em grande parte, confinados ao mesmo grupo evolutivo que o Sars-CoV-2.
A equipe descobriu que sarbecovírus capazes de usar receptores ACE2 de muitas espécies diferentes estavam, em grande parte, confinados ao mesmo grupo evolutivo que o Sars-CoV-2.
Vacinas contra covid podem ajudar a barrar coronavírus de morcegos, diz estudo
A equipe descobriu que sarbecovírus capazes de usar receptores ACE2 de muitas espécies diferentes estavam, em grande parte, confinados ao mesmo grupo evolutivo que o Sars-CoV-2
www.correiobraziliense.com.br
October 2, 2026 at 10:40 AM
🗞️Vacinas contra covid podem ajudar a barrar coronavírus de morcegos, diz estudo
A equipe descobriu que sarbecovírus capazes de usar receptores ACE2 de muitas espécies diferentes estavam, em grande parte, confinados ao mesmo grupo evolutivo que o Sars-CoV-2.
A equipe descobriu que sarbecovírus capazes de usar receptores ACE2 de muitas espécies diferentes estavam, em grande parte, confinados ao mesmo grupo evolutivo que o Sars-CoV-2.
Here’s the paper, I couldn’t really find details of AI used with quick read.
www.journalofinfection.com/article/S016...
But can’t really figure out how predictive AI alone could work for that. Predictive AIs tend to be better for sales than science or serious engineering. Useful for cyber though.
www.journalofinfection.com/article/S016...
But can’t really figure out how predictive AI alone could work for that. Predictive AIs tend to be better for sales than science or serious engineering. Useful for cyber though.
A phase I, needle free, dose escalation clinical trial of pEVAC-PS, a candidate pan-Sarbecovirus Vaccine
Needle-free intradermal delivery of this novel computationally designed PanSarbeco
vaccine was safe and well tolerated. Although immunogenicity was modest in the context
of substantial pre-existing im...
www.journalofinfection.com
September 20, 2026 at 7:12 PM
Here’s the paper, I couldn’t really find details of AI used with quick read.
www.journalofinfection.com/article/S016...
But can’t really figure out how predictive AI alone could work for that. Predictive AIs tend to be better for sales than science or serious engineering. Useful for cyber though.
www.journalofinfection.com/article/S016...
But can’t really figure out how predictive AI alone could work for that. Predictive AIs tend to be better for sales than science or serious engineering. Useful for cyber though.
Anyway, the point is that totally unexpected factors (like ORF3a) can have major effects on S1/S2 cleavage.
It may be, for example, that the effect of ORF3a or some other sarbecovirus protein partially explains why an FCS is not tolerated in the GI tract of bats, but generally favored in merbecos.
It may be, for example, that the effect of ORF3a or some other sarbecovirus protein partially explains why an FCS is not tolerated in the GI tract of bats, but generally favored in merbecos.
September 9, 2026 at 9:57 AM
Anyway, the point is that totally unexpected factors (like ORF3a) can have major effects on S1/S2 cleavage.
It may be, for example, that the effect of ORF3a or some other sarbecovirus protein partially explains why an FCS is not tolerated in the GI tract of bats, but generally favored in merbecos.
It may be, for example, that the effect of ORF3a or some other sarbecovirus protein partially explains why an FCS is not tolerated in the GI tract of bats, but generally favored in merbecos.
As of yet I know of no sarbecovirus other than SARS-CoV-2 that had it, but we recently discovered a furin cleavage site in a hibecovirus, the sister subgenus of sarbecovirus.
September 9, 2026 at 5:13 AM
As of yet I know of no sarbecovirus other than SARS-CoV-2 that had it, but we recently discovered a furin cleavage site in a hibecovirus, the sister subgenus of sarbecovirus.
Linfa identified what was needed but overstated what it would prove. An FCS in another sarbecovirus would show natural acquisition in that subgenus. SARS-CoV-2 still aligns with the unusual research underway, lacks an identified animal host, and hints at contained evolution such work might produce.
September 8, 2026 at 1:40 PM
Linfa identified what was needed but overstated what it would prove. An FCS in another sarbecovirus would show natural acquisition in that subgenus. SARS-CoV-2 still aligns with the unusual research underway, lacks an identified animal host, and hints at contained evolution such work might produce.
I am sure the Coal Baron is magically gonna reverse his position on lab leak when a Sarbecovirus with a functional FCS at S1/S2 is found, right?
Of course not, he will double down and claim that when nature created it, isn´t it so much more likely the lab found it secretly and used it as template?
Of course not, he will double down and claim that when nature created it, isn´t it so much more likely the lab found it secretly and used it as template?
September 8, 2026 at 12:06 PM
I am sure the Coal Baron is magically gonna reverse his position on lab leak when a Sarbecovirus with a functional FCS at S1/S2 is found, right?
Of course not, he will double down and claim that when nature created it, isn´t it so much more likely the lab found it secretly and used it as template?
Of course not, he will double down and claim that when nature created it, isn´t it so much more likely the lab found it secretly and used it as template?
More here from Ryan Hisner –
(I’m seeing many of the more, uh, "committed" 'lab leak' proponents insisting that it’s not a sarbecovirus matters.)
bsky.app/profile/ryan...
(I’m seeing many of the more, uh, "committed" 'lab leak' proponents insisting that it’s not a sarbecovirus matters.)
bsky.app/profile/ryan...
There are already plenty of bat BetaCoVs with FCS's. There's an alignment in the paper that shows several of them.
The "no FCS in sarbecoviruses" was never the slam dunk some presumed it to be. Now all or most of 3/5 BetaCoV bat subgenera have FCS's.
Furthermore...
The "no FCS in sarbecoviruses" was never the slam dunk some presumed it to be. Now all or most of 3/5 BetaCoV bat subgenera have FCS's.
Furthermore...
September 8, 2026 at 10:44 AM
More here from Ryan Hisner –
(I’m seeing many of the more, uh, "committed" 'lab leak' proponents insisting that it’s not a sarbecovirus matters.)
bsky.app/profile/ryan...
(I’m seeing many of the more, uh, "committed" 'lab leak' proponents insisting that it’s not a sarbecovirus matters.)
bsky.app/profile/ryan...
Il y a déjà plein de bétacoronavirus avec des sites polybasiques. L'argument des leakers porte sur les sarbécovirus spécifiquement -- comme si c'était impossible d'en avoir naturellement dans ce sous-genre
September 8, 2026 at 10:20 AM
Il y a déjà plein de bétacoronavirus avec des sites polybasiques. L'argument des leakers porte sur les sarbécovirus spécifiquement -- comme si c'était impossible d'en avoir naturellement dans ce sous-genre
They all seem to be crying, "but it’s not a sarbecovirus" 😐
September 8, 2026 at 7:24 AM
They all seem to be crying, "but it’s not a sarbecovirus" 😐
Online now: Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection
Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection
Our understanding of long-term sarbecovirus immune imprinting remains limited. Zhang et al. reveal persistent imprinting in individuals sequentially infected with SARS-CoV-1 and SARS-CoV-2 over two decades, characterized by redirected antibody targeting from the variable receptor-binding motif to conserved receptor-binding domain (RBD) core regions after breakthrough infection. These findings define the durability and molecular basis of antibody imprinting and inform pan-sarbecovirus vaccine design.
dlvr.it
September 7, 2026 at 7:55 PM
Online now: Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection
I don't think anyone seriously entertains the notion that WIV engineered >1000 nuc changes into the SARS-2 genome. But the only way around proposing this is to suppose that WIV secretly had a much more closely related sarbecovirus.
But in that case, why haven't we found it? Not to say...
But in that case, why haven't we found it? Not to say...
September 5, 2026 at 5:03 PM
I don't think anyone seriously entertains the notion that WIV engineered >1000 nuc changes into the SARS-2 genome. But the only way around proposing this is to suppose that WIV secretly had a much more closely related sarbecovirus.
But in that case, why haven't we found it? Not to say...
But in that case, why haven't we found it? Not to say...
Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection https://www.biorxiv.org/content/10.64898/2026.09.01.748598v1
September 4, 2026 at 2:19 AM
Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection https://www.biorxiv.org/content/10.64898/2026.09.01.748598v1
Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection https://www.biorxiv.org/content/10.64898/2026.09.01.748598v1
September 4, 2026 at 2:19 AM
Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection https://www.biorxiv.org/content/10.64898/2026.09.01.748598v1
Yeah. There was a lot of French; and a lot of newer words unaccepted, like "sarbecovirus". It felt like "scanned rando book corpus."
September 1, 2026 at 8:28 PM
Yeah. There was a lot of French; and a lot of newer words unaccepted, like "sarbecovirus". It felt like "scanned rando book corpus."
You wrote: “That the pandemic started in Wuhan is the only circumstantial evidence favoring a lab leak.”
Not true.
Some other circumstantial facts:
In 2018 the Wuhan–EcoHealth–Baric team proposed inserting an FCS at S1/S2 in a sarbecovirus. In 2019 a sarbecovirus appeared there with...
Not true.
Some other circumstantial facts:
In 2018 the Wuhan–EcoHealth–Baric team proposed inserting an FCS at S1/S2 in a sarbecovirus. In 2019 a sarbecovirus appeared there with...
August 31, 2026 at 8:44 AM
You wrote: “That the pandemic started in Wuhan is the only circumstantial evidence favoring a lab leak.”
Not true.
Some other circumstantial facts:
In 2018 the Wuhan–EcoHealth–Baric team proposed inserting an FCS at S1/S2 in a sarbecovirus. In 2019 a sarbecovirus appeared there with...
Not true.
Some other circumstantial facts:
In 2018 the Wuhan–EcoHealth–Baric team proposed inserting an FCS at S1/S2 in a sarbecovirus. In 2019 a sarbecovirus appeared there with...
Why would respiratory adaptation point to a natural origin?
DEFUSE proposed an FCS at S1/S2 in a sarbecovirus, then tests in human cells and humanized mice. Grow a virus in airway tissue and you get airway adaptation. That is not evidence against a lab.
DEFUSE proposed an FCS at S1/S2 in a sarbecovirus, then tests in human cells and humanized mice. Grow a virus in airway tissue and you get airway adaptation. That is not evidence against a lab.
August 31, 2026 at 8:18 AM
Why would respiratory adaptation point to a natural origin?
DEFUSE proposed an FCS at S1/S2 in a sarbecovirus, then tests in human cells and humanized mice. Grow a virus in airway tissue and you get airway adaptation. That is not evidence against a lab.
DEFUSE proposed an FCS at S1/S2 in a sarbecovirus, then tests in human cells and humanized mice. Grow a virus in airway tissue and you get airway adaptation. That is not evidence against a lab.
If an FCS is deleterious in bat sarbecos, the natural route gets harder, not easier.
Then the first S1/S2 FCS in a sarbecovirus still appears in Wuhan, a year after they proposed putting one there.
That coincidence does not go away because the spike also needed longer NTD loops.
Then the first S1/S2 FCS in a sarbecovirus still appears in Wuhan, a year after they proposed putting one there.
That coincidence does not go away because the spike also needed longer NTD loops.
August 29, 2026 at 5:59 AM
If an FCS is deleterious in bat sarbecos, the natural route gets harder, not easier.
Then the first S1/S2 FCS in a sarbecovirus still appears in Wuhan, a year after they proposed putting one there.
That coincidence does not go away because the spike also needed longer NTD loops.
Then the first S1/S2 FCS in a sarbecovirus still appears in Wuhan, a year after they proposed putting one there.
That coincidence does not go away because the spike also needed longer NTD loops.
“I think you should be more explicit here in step two: how an FCS appeared for the first time in a sarbecovirus, at S1/S2, in Wuhan — a year after the Wuhan–EcoHealth–Baric team proposed putting an FCS at S1/S2 in a sarbecovirus, in Wuhan, including at BSL-2.”
August 27, 2026 at 1:44 PM
“I think you should be more explicit here in step two: how an FCS appeared for the first time in a sarbecovirus, at S1/S2, in Wuhan — a year after the Wuhan–EcoHealth–Baric team proposed putting an FCS at S1/S2 in a sarbecovirus, in Wuhan, including at BSL-2.”
I note that it does not explain why a FCS suddenly appeared in a sarbecovirus, at S1/S2, in Wuhan, a year after the Wuhan–EcoHealth–Baric team proposed putting exactly that feature in exactly that place.
August 27, 2026 at 1:33 PM
I note that it does not explain why a FCS suddenly appeared in a sarbecovirus, at S1/S2, in Wuhan, a year after the Wuhan–EcoHealth–Baric team proposed putting exactly that feature in exactly that place.