We (@sobuelow.bsky.social & @kejohansson.bsky.social) tested AF-CALVADOS using the recently described PeptoneBench SAXS benchmark that contains SAXS data for >400 proteins with different amounts of order and disorder. The results look pretty good 😇 so we are sharing here while updating the preprint📝
December 16, 2025 at 3:01 PM
We (@sobuelow.bsky.social & @kejohansson.bsky.social) tested AF-CALVADOS using the recently described PeptoneBench SAXS benchmark that contains SAXS data for >400 proteins with different amounts of order and disorder. The results look pretty good 😇 so we are sharing here while updating the preprint📝
ari saxs: good morning #catsofbluesky! 🇬🇷kali evdomada🇬🇷 - have a great week
April 15, 2024 at 6:31 AM
ari saxs: good morning #catsofbluesky! 🇬🇷kali evdomada🇬🇷 - have a great week
göndər'ə vurduqda 3-cü çıxan
şəxs sizə üzümlü tort borclu olur
şəxs sizə üzümlü tort borclu olur
November 8, 2024 at 9:53 PM
göndər'ə vurduqda 3-cü çıxan
şəxs sizə üzümlü tort borclu olur
şəxs sizə üzümlü tort borclu olur
Rəhbər şəxs kimi
September 30, 2026 at 3:35 AM
Rəhbər şəxs kimi
Yakety Saxs is perfect for so much
September 23, 2024 at 9:27 PM
Yakety Saxs is perfect for so much
Looking forward to tomorrow’s workshop on “Advances in Molecular Modeling” organized by @drannaduncan.bsky.social & @weria-lab.bsky.social here in Copenhagen 🇩🇰
And to showing how to run MD simulations and reweight them against SAXS expts using Google Colab 🧬 🧶 🧪
indico.nbi.ku.dk/event/2076/
And to showing how to run MD simulations and reweight them against SAXS expts using Google Colab 🧬 🧶 🧪
indico.nbi.ku.dk/event/2076/
December 8, 2024 at 8:02 PM
Looking forward to tomorrow’s workshop on “Advances in Molecular Modeling” organized by @drannaduncan.bsky.social & @weria-lab.bsky.social here in Copenhagen 🇩🇰
And to showing how to run MD simulations and reweight them against SAXS expts using Google Colab 🧬 🧶 🧪
indico.nbi.ku.dk/event/2076/
And to showing how to run MD simulations and reweight them against SAXS expts using Google Colab 🧬 🧶 🧪
indico.nbi.ku.dk/event/2076/
“A Disney quer um lugar persistente onde todos os seus conteúdos possam estar lá [Fortnite], mas eles querem fazer parte de um ecossistema que construímos”, diz Saxs Persson (EVP da Epic Games).
October 6, 2024 at 7:32 PM
“A Disney quer um lugar persistente onde todos os seus conteúdos possam estar lá [Fortnite], mas eles querem fazer parte de um ecossistema que construímos”, diz Saxs Persson (EVP da Epic Games).
Really great talk here in Daejeon by @lilopozzo.bsky.social on open source, scalable self driving labs, integrating SAXS! Very cool!
February 7, 2025 at 6:46 AM
Really great talk here in Daejeon by @lilopozzo.bsky.social on open source, scalable self driving labs, integrating SAXS! Very cool!
Are you analysing hydrophobicity in disordered proteins and still using the Kyte & Doolittle scale?
Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs
doi.org/10.1021/acs....
Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs
doi.org/10.1021/acs....
May 23, 2026 at 9:22 PM
Are you analysing hydrophobicity in disordered proteins and still using the Kyte & Doolittle scale?
Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs
doi.org/10.1021/acs....
Maybe instead consider the "stickiness-scale" that Fan & Giulio derived using SAXS data for >100 IDPs
doi.org/10.1021/acs....
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
July 28, 2025 at 9:31 PM
I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.
Was Yakety Saxs playing in the background or
December 31, 2024 at 11:10 PM
Was Yakety Saxs playing in the background or
The prion-like domain from the plant thermosensory protein EARLY FLOWERING 3 was used as a model hydrogel for structural characterization by SAXS #LiquidLiquidPhaseSeparation #EARLYFLOWERING3 #SAXS doi.org/10.1107/S205...
September 30, 2026 at 12:40 PM
The prion-like domain from the plant thermosensory protein EARLY FLOWERING 3 was used as a model hydrogel for structural characterization by SAXS #LiquidLiquidPhaseSeparation #EARLYFLOWERING3 #SAXS doi.org/10.1107/S205...
This new Horizon Create app was presented today at a Meta conference by Saxs Persson, who used to run Shiny, was at Xbox, then Epic
Expect more of this kind of thing (hell, read the story's footnote)
One notable idea is Meta promoting that you can use the AI to "remix" other games on Horizon
Expect more of this kind of thing (hell, read the story's footnote)
One notable idea is Meta promoting that you can use the AI to "remix" other games on Horizon
September 25, 2026 at 3:10 AM
This new Horizon Create app was presented today at a Meta conference by Saxs Persson, who used to run Shiny, was at Xbox, then Epic
Expect more of this kind of thing (hell, read the story's footnote)
One notable idea is Meta promoting that you can use the AI to "remix" other games on Horizon
Expect more of this kind of thing (hell, read the story's footnote)
One notable idea is Meta promoting that you can use the AI to "remix" other games on Horizon
This is one of those thingss that I saw on tv as kid and it imprinted on my psyche. Like sensory heaven to me. Look at those saxs drip! Look at ‘em moosh into shape! This feels like a warm balm on my brain.
Really enjoying this classic Sesame Street segment, two minutes of freestyle jazz riffing on saxophone factory footage
March 13, 2025 at 9:32 PM
This is one of those thingss that I saw on tv as kid and it imprinted on my psyche. Like sensory heaven to me. Look at those saxs drip! Look at ‘em moosh into shape! This feels like a warm balm on my brain.
My first initial thought to dub the ship was:
Saxs
It was more for comedic purposes
Saxs
It was more for comedic purposes
October 16, 2025 at 9:26 PM
My first initial thought to dub the ship was:
Saxs
It was more for comedic purposes
Saxs
It was more for comedic purposes
Results from CASP16 on predicting conformational ensembles of 2 domain-linker-domain constructs. Happy to see that CALVADOS 3 and our two rescaled versions of Martini do well in matching SAXS data in blind tests. But the results also show that lots remain to be done in modelling domain orientations
April 29, 2025 at 8:32 PM
Results from CASP16 on predicting conformational ensembles of 2 domain-linker-domain constructs. Happy to see that CALVADOS 3 and our two rescaled versions of Martini do well in matching SAXS data in blind tests. But the results also show that lots remain to be done in modelling domain orientations
New preprint led by Fan Cao & Giulio Tesei
We present a data-driven “stickiness” scale for amino acids in intrinsically disordered proteins 🍝, learned from SAXS data on 115 proteins. The scale captures effective residue interactions without conflating size and strength
doi.org/10.64898/202...
We present a data-driven “stickiness” scale for amino acids in intrinsically disordered proteins 🍝, learned from SAXS data on 115 proteins. The scale captures effective residue interactions without conflating size and strength
doi.org/10.64898/202...
January 28, 2026 at 7:10 AM
New preprint led by Fan Cao & Giulio Tesei
We present a data-driven “stickiness” scale for amino acids in intrinsically disordered proteins 🍝, learned from SAXS data on 115 proteins. The scale captures effective residue interactions without conflating size and strength
doi.org/10.64898/202...
We present a data-driven “stickiness” scale for amino acids in intrinsically disordered proteins 🍝, learned from SAXS data on 115 proteins. The scale captures effective residue interactions without conflating size and strength
doi.org/10.64898/202...
🔬We’re live! Meet ioviso - your new partner in advanced material characterization. We offer a comprehensive portfolio of services:
🔹 SAXS/WAXS, XRF
🔹 In-operando setups
🔹 Data analysis
🔹 Proposal support
Let’s make synchrotron science more accessible.
🌐 [www.ioviso.com]
#materials #SAXS #startup
🔹 SAXS/WAXS, XRF
🔹 In-operando setups
🔹 Data analysis
🔹 Proposal support
Let’s make synchrotron science more accessible.
🌐 [www.ioviso.com]
#materials #SAXS #startup
July 1, 2025 at 9:42 AM
🔬We’re live! Meet ioviso - your new partner in advanced material characterization. We offer a comprehensive portfolio of services:
🔹 SAXS/WAXS, XRF
🔹 In-operando setups
🔹 Data analysis
🔹 Proposal support
Let’s make synchrotron science more accessible.
🌐 [www.ioviso.com]
#materials #SAXS #startup
🔹 SAXS/WAXS, XRF
🔹 In-operando setups
🔹 Data analysis
🔹 Proposal support
Let’s make synchrotron science more accessible.
🌐 [www.ioviso.com]
#materials #SAXS #startup
I keep seeing people overlaying experimental SAXS data with data calculated from simulations and stating that there is good agreement, but without actually quantifying this. Unless one actually quantifies agreement it is hard to know whether it is good.
March 2, 2025 at 4:33 PM
I keep seeing people overlaying experimental SAXS data with data calculated from simulations and stating that there is good agreement, but without actually quantifying this. Unless one actually quantifies agreement it is hard to know whether it is good.
Our SFPQ paper is out! 👌 If you're interested in disordered proteins, phase separation, SAXS/SANS, or mass spectrometry, give it a read 🧬
Heidar J. Koning et al.: Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation ##PhaseSeparation##Disorder##Flexibility@uwanews@unimelb...##IUCrhttps://journals.iucr.org/paper?S2059798325005303
Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation
SFPQ and NONO are DBHS-family proteins that are essential for transcriptional regulation and the assembly of paraspeckles, which are subnuclear structures built on the long noncoding RNA NEAT1. Through SAXS, SANS and XL-MS analyses, we reveal that the disordered regions of SFPQ surrounding its DBHS domain enable flexible interactions and that the full-length proteins are capable of dimer partner exchange, highlighting how these dynamics may contribute to phase separation and impact disease processes.
journals.iucr.org
June 28, 2025 at 1:59 AM
Our SFPQ paper is out! 👌 If you're interested in disordered proteins, phase separation, SAXS/SANS, or mass spectrometry, give it a read 🧬
Postdoc vacancy at King's College London using NMR, SAXS and cell biology to map Annexin A11 interactions and how ALS mutations drive protein aggregation. Closing date: 16th October
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Associate: ALS Protein Interactions
Postdoc at King's College London using NMR, SAXS and cell biology to map Annexin A11 interactions and how ALS mutations drive protein aggregation.
www.dementiaresearcher.nihr.ac.uk
September 26, 2026 at 9:42 PM
Postdoc vacancy at King's College London using NMR, SAXS and cell biology to map Annexin A11 interactions and how ALS mutations drive protein aggregation. Closing date: 16th October
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
New preprint from Pozzo group demonstrating SAXS analysis of very large multi-protein assemblies using Monte Carlo sampling.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
February 3, 2025 at 5:42 AM
New preprint from Pozzo group demonstrating SAXS analysis of very large multi-protein assemblies using Monte Carlo sampling.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Production on this is amazing- the saxs sound like cigarette smoke coiling up to sky (like on cover)
January 24, 2026 at 5:09 PM
Production on this is amazing- the saxs sound like cigarette smoke coiling up to sky (like on cover)