#serosal
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ravimadan.bsky.social
Important to distinguish #serosal findings on #PSMA 🩻vs. #parenchymal

Serosal lesions are better seen on #PSMA vs CT/MRI in #ProstateCancer but likely have an indolent course even with no 🚫therapy (even on the liver!)

Dr. Melissa Abel at el @natrevurol.nature.com

rdcu.be/eBwPs
Ominous-appearing serosal findings on PSMA imaging might belie indolent clinical course
Nature Reviews Urology - Understanding of metastatic prostate cancer is mainly defined by macroscopic findings, but prostate-specific membrane antigen (PSMA) PET has increased sensitivity. PSMA+...
rdcu.be
August 21, 2025 at 12:02 PM
robrichards.bsky.social
Part of this consortium www.cell.com/cell/fulltex...
Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever
Familial Mediterranean fever (FMF) is a recessively inherited disorder characterized by dramatic episodes of fever and serosal inflammation. This report describes the cloning of the gene likely to cau...
www.cell.com
January 29, 2025 at 3:39 AM
magicmel.bsky.social
Small vessel lymphovascular invasion and serosal surface involvement (pT4a).
Microscopic image stained with haematoxylin and eosin showing lymphatic invasion by goblet cell adenocarcinoma. Microscopic image stained with haematoxylin and eosin showing goblet cell adenocarcinoma on the serosal surface of the appendix.
November 26, 2024 at 10:01 AM
magicmel.bsky.social
Staging of these can be tricky. Lucky for me, acellular mucin involving the serosal surface (pT4a) was obvious in the first block. Not so lucky for the patient, of course.
Low power microscopic image stained with haematoxylin and eosin showing appendiceal wall with mucin on the serosal surface. High power microscopic image stained with haematoxylin and eosin showing appendiceal wall with mucin on the serosal surface.
December 24, 2024 at 8:41 AM
nkwhiteman.bsky.social
Delighted a panel from our collaborative paper was in the hallway of the Biological Research Centre in Szeged…the dapi-stained nuclei are of the serosal cells of parasitoid wasp embryos extracted from Drosophila larvae and in green is the antibody against the humoral FusionB toxin secreted by fly…
May 25, 2026 at 7:20 AM
ravimadan.bsky.social
Not the first example of indolent serosal findings on #PSMA in #ProstateCancer

This pt with findings in 2018
tinyurl.com/29tpcddy
@ascocancer.bsky.social

This patient with serosal findings on the liver remains without parenchymal Mets in 2025. Went most of the 7 years without treatment.
August 21, 2025 at 12:27 PM
magicmel.bsky.social
It’s Christmas Eve so of course one of my “gifts” was a low grade appendiceal mucinous neoplasm (LAMN). Our practice is to embed the entire appendix so this ran to 36 blocks. #Pathsky #Medsky
Macroscopic image of an appendix with attached mesoappendix. The mid portion is dilated and the serosal surface in this area is grey/white. Microscopic image stained with haematoxylin and eosin showing appendiceal lumen lined by mucinous epithelium with low grade dysplasia.
December 24, 2024 at 8:41 AM
jama.com
Systemic lupus erythematosus (SLE) is a chronic systemic #autoimmune disease characterized by inflammation and immune-mediated injury to multiple organ systems.

This Review summarizes the diagnosis and treatment of SLE.

🔖 Bookmark it for your citations:
ja.ma/48gtnX0
Systemic Lupus Erythematosus review from JAMA, outlining diagnostic criteria. Key points include initial criteria, summation of clinical & immunologic domains, constitutional symptoms (fever), mucocutaneous signs, serosal issues, renal, hematologic, & neuropsychiatric aspects.
November 30, 2025 at 4:00 PM
jpeacejpeace.bsky.social
Don't forget the impact on the mesothelium of the serosal cavities and the subarachnoid space.

"Proteomic profiling identifies biomarkers of COVID-19 severity"
www.sciencedirect.com/science/arti...
Increased Mesothelin protein expression corresponding to severity of CV-19 disease.
November 14, 2024 at 11:24 PM
virussucks.com
A patient with confirmed asymptomatic #COVID19 (negative initial PCR but positive serology) presented with acute chest pain due to large circumferential pericardial effusion, confirmed by echocardiography. The effusion resolved after pericardiocentesis and anti-inflammatory therapy.

#LongCOVID
Case Reports Symptomatic pericardial effusion in the setting of asymptomatic COVID-19 infection: A case report Behzad Amoozgar et al. Medicine (Baltimore). 2020. Rationale: Infection with the severe acute respiratory coronavirus disease 2019 (COVID-19) has been shown to cause multi-organ involvement including cardiopulmonary serosal layers infection and inflammation. As a result, pericarditis and pericardial effusion may occur with or without COVID-19 related respiratory signs. Due to limitations in sensitivity and specificity of current COVID-19 diagnostic studies, cases that trigger high clinical intuition, even with negative serologic and polymerase chain reaction testing results, may necessitate further diagnostic workup to discover the underlying etiology. Patient concerns: Here we present a rare case of pericardial effusion in the setting of asymptomatic COVID-19 infection manifesting with the chief complaint of chest pain. Diagnosis: While undergoing diagnostic workup, the patients first 2 sets of COVID 19 reverse transcription-polymerase chain reaction (RT-PCR) were negative while a latter RT-PCR test, as well as serology, were positive, leading to the diagnosis of COVID-19 reinfection or subacute presentation of viral infection with pericardial effusion. Echocardiogram depicted large circumferential pericardial effusion with mildly thickened pericardium. Interventions: The patient underwent pericardial window placement followed by ibuprofen administration and discharged from the hospital. Outcomes: During the follow-up visit patient had no symptoms and echocardiogram demonstrated complete resolution of the effusion. Lessons: Due to the possible establishment of pericardial effusions and consecutively tamponade even without any COVID-19 related clinical presentation, it is crucial for clinicians to trust their intuition, conduct the appropriate diagnostic tests, find the underlying diagnosis and prevent the devastating consequences.
February 15, 2026 at 6:24 PM
tarnopol.bsky.social
We found that the FusionB toxin was secreted from the fat body to the host hemolymph, where it targetec the serosal tissue of parasitoids and led to increased wasp mortality by 72 hpi. To our knowledge, it is the first toxic humoral anti-parasitoid factor described in Drosophila. (5/n)
Immunofluorescence images of L. boulardi neonate wasps stained with DAPI (white) and anti-Fusion antibodies (green). The Fusion signal targets a tissue called the serosa, characterized by large polyploid nuclei. We found that D. melanogaster expressing fusionB from immune tissues phenocopies the native D. ananassae system.
December 20, 2024 at 5:58 PM
traffic-journal.bsky.social
Just published onlinelibrary.wiley.com/doi/10.1111/...
TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...
onlinelibrary.wiley.com
June 6, 2025 at 6:55 AM
ravimadan.bsky.social
In short. Yes. I do think #serosal lesions on #PSMA in #BCR do not present an urgent clinical threat. We are evaluating this further on our ongoing study of Prospective PSMAs in BCR #ProstateCancer

www.clinicaltrials.gov/study/NCT055...
ClinicalTrials.gov
www.clinicaltrials.gov
September 18, 2025 at 4:11 PM
leahshape.bsky.social
Hang on let me copy the exact wording.
"The middle and upper portions of the vagina are naturally lined by peritoneum and the smooth lining of the capsule of the prostate and serosal layer of the bowel."
April 21, 2025 at 9:51 PM
auntminnie.bsky.social
FIGO classification helps categorize uterine fibroids based on their relationship to endometrial and serosal surfaces #radiology #MRI #fibroids
FIGO classification from MRI leads to moderate agreement among rads
FIGO classification of uterine fibroids on MRI led to moderate overall interobserver agreement among radiologists.
buff.ly
October 11, 2025 at 9:23 AM
robrichards.bsky.social
Part of this consortium that identified the gene causing Familial Mediterranean Fever. Vast majority of this research was done within the NIH itself by Dan Kastner & colleagues www.cell.com/cell/fulltex...
Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever
Familial Mediterranean fever (FMF) is a recessively inherited disorder characterized by dramatic episodes of fever and serosal inflammation. This report describes the cloning of the gene likely to cau...
www.cell.com
January 29, 2025 at 1:11 PM
ucpath.bsky.social
Here's a case you don’t see every day! A hepatic sarcoma in a rat caused by tapeworm larvae. Taenia taeniaformis infestation with chronic inflammation and spindle-cell proliferation paves the way for neoplastic transformation.

Nature is weird sometimes!

#skypath #vetpath #parasites
This is a subgross image of liver with a large tumor containing a blood filled cavity that has multiple sections of tapeworm larvae. A bit of the hepatic parenchyma is on the upper right. H&E-stained section. Here are cross sections of the degenerate tapeworm larvae from the previous image. They lack detail but the calcareous corpuscles are still visible. These appear to be strobilocerci. As I understand it, this tapeworm initially forms cysticerci in the rat which then metamorphose into strobilocerci. H&E-stained section. This image demonstrates the fibrosarcoma on the right and the interface with the extant hepatic parenchyma on the left. The neoplasm is well demarcated in this section. In others it was more directly invasive and widespread metastases were all through the abdomen. This seemed to be a case of true sarcomatosis. Implantation of bits of neoplasia directly on the serosal surfaces of the abdomen, leading to additional tumors. A high magnification image of this neoplasm. Neoplastic cells have significant variability in size. They are generally oval to round. Mitotic figures and apoptotic cells are occasionally seen.
March 18, 2025 at 11:51 PM
drmohammadvaziri.bsky.social
Familial Mediterranean Fever (FMF) mohammadvazirimedicaleducation.wordpress.com/2026/04/10/f...
Familial Mediterranean Fever (FMF)
Familial Mediterranean Fever (FMF) represents the prototype of a group of inherited disorders characterized by recurrent episodes of fever accompanied by serosal, synovial, or cutaneous inflammatio…
mohammadvazirimedicaleducation.wordpress.com
April 10, 2026 at 5:28 PM
longtail-news.bsky.social
Feed: "STITCHES"
By: STITCHES Newsletter on Friday, October 24, 2025
Serosal Invasion Drastically Impacts Survival in Cholangiocarcinoma
Tumor serosal invasion (si) significantly worsens outcomes in perihilar cholangiocarcinoma (pcca).37.7% of 725 patients had si, linked to 34.1% postoperative peritoneal dissemination versus 12.8% in non-si.Overall recurrence rates were 81.0% for si vs. 58.6% for non-si (p
www.stitches.today
October 25, 2025 at 4:39 AM
epsteinweb.bsky.social
Parts 1-2/2 — EFTA00137976.jpg
#epsteinweb #efta00137976
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00137914 | EFTA00137976 OFFICE OF CHIEF MEDICAL EXAMINER CITY OF NEW YORK REPORT OF AUTOPSY CASE NO. M-19-019432 I hereby certify that I, Kristin Roman, M.D., City Medical Examiner - ll, have performed an autopsy on the body of Jeffrey Edward Epstein, on the 11 of August 2019, commencing at 9:21 AM in the Manhattan Mortuary of the Office of Chief Medical Examiner of the City of New York. EXTERNAL EXAMINATION: The body is received in a sealed, labeled, plastic body bag (seal #152384). The body is of a well-developed, thin, muscular, light skinned, 5'10", 196 lb man whose appearance is consistent with the given age of 66 years. The scalp hair is wavy, predominantly grey with interspersed dark hairs, has slight male pattern balding, and measures up to 3". The facial hair is cleanly shaven. The eyes have light irides. The oral cavity has intact teeth in good repair. The tongue is free of natural disease. The finger and toenails are well groomed and free of polish. Striae are on the shoulders. The genitalia are atraumatic and of a normal, circumcised man. The anus is atraumatic. POSTMORTEM CHANGES: There is moderate, symmetric rigor mortis of the upper and lower extremities and the jaw. Lividity is fixed, purple, and unevenly distributed on the posterior surfaces of the body. The body is cool. SCARS: On the back of the left shoulder is an oblique, 1-1/2", well healed, linear scar. On the right lower quadrant of the abdomen is an oblique, 2", well healed, linear appendectomy scar. THERAPEUTIC PROCEDURES: An endotracheal tube is in the mouth, extending into the upper airway. On the lips are multiple, focal, red abrasions. A cervical collar encircles the neck. Electrocardiogram electrodes are on the torso. An intravascular catheter is in the left antecubital fossa. An intraosseous line is in the right shin. A blood pressure cuff encircles the upper, right arm. On the chest between the nipples is a 3" x r, irregular, yellow abrasion. Internally, there are minimally hemorrhagic, parasternal, rib fractures of right ribs #4-6 and left ribs # 5-6, approximately 60 ml of liquid blood thinly coating the serosal SU\V LIUDIC6.3 EFTA00137976 Epstein Web iOS app on the App Store.
April 22, 2026 at 11:34 AM
epsteinweb.bsky.social
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#epsteinweb #efta00133075
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00132684 | EFTA00133075 OFFICE OF CHIEF MEDICAL EXAMINER CITY OF NEW YORK REPORT OF AUTOPSY CASE NO. M-19-019432 City Medical Examiner - If, have performed I hereby certify that an autopsy on the body of Jeffrey Edward Epstein, on the 11 of August 2019, commencing at 9:21 AM in the Manhattan Mortuary of the Office of Chief Medical Examiner of the City of New York. EXTERNAL EXAMINATION: The body is received in a sealed, labeled, plastic body bag (seal #152384). The body is of a well-developed, thin, muscular, light skinned, 5'10", 196 lb man whose appearance is consistent with the given age of 66 years. The scalp hair is wavy, predominantly grey with interspersed dark hairs, has slight male pattern balding, and measures up to 3". The facial hair is cleanly shaven. The eyes have light irides. The oral cavity has intact teeth in good repair. The tongue is free of natural disease. The finger and toenails are well groomed and free of polish. Striae are on the shoulders. The genitalia are atraumatic and of a normal, circumcised man. The anus is atraumatic. POSTMORTEM CHANGES: There is moderate, symmetric rigor mortis of the upper and lower extremities and the jaw. Lividity is fixed, purple, and unevenly distributed on the posterior surfaces of the body. The body is cool. SCARS: On the back of the left shoulder is an oblique, 1-1/2", well healed, linear scar. On the right lower quadrant of the abdomen is an oblique, 2", well healed, linear appendectomy scar. THERAPEUTIC PROCEDURES: An endotracheal tube is in the mouth, extending into the upper airway. On the lips are multiple, focal, red abrasions. A cervical collar encircles the neck. Electrocardiogram electrodes are on the torso. An intravascular catheter is in the left antecubital fossa. An intraosseous line is in the right shin. A blood pressure cuff encircles the upper, right arm. On the chest between the nipples is a 3" x 3", irregular, yellow abrasion. Internally, there are minimally hemorrhagic, parasternal, rib fractures of right ribs #4-6 and left ribs # 5-6, approximately 60 ml of liquid blood thinly coating the serosal EFTA00133075 Epstein Web iOS app on the App Store.
April 22, 2026 at 8:04 AM
epsteinweb.bsky.social
Parts 1-2/2 — EFTA00130078.jpg
#epsteinweb #efta00130078
https://epsteinweb.org
Available in the iOS app store now!
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EFTA00130065 | EFTA00130078 Az. OFFICE OF CHIEF MEDICAL EXAMINER CITY OF NEW YORK REPORT OF AUTOPSY CASE NO. M-19-019432 I hereby certify that I, M, M.D., City Medical Examiner - II, have performed an autopsy on the body of Jeffrey Edward Epstein, on the 11 of August 2019, commencing at 9:21 AM in the Manhattan Mortuary of the Office of Chief Medical Examiner of the City of New York. EXTERNAL EXAMINATION: The body is received in a sealed, labeled, plastic body bag (seal #152384). The body is of a well-developed, thin, muscular, light skinned, 5'10", 196 lb man whose appearance is consistent with the given age of 66 years. The scalp hair is wavy, predominantly grey with interspersed dark hairs, has slight male pattern balding, and measures up to 3". The facial hair is cleanly shaven. The eyes have light irides. The oral cavity has intact teeth in good repair. The tongue is free of natural disease. The finger and toenails are well groomed and free of polish: Striae are on the shoulders. The genitalia are atraumatic and of a normal, circumcised man. The anus is atraumatic. POSTMORTEM CHANGES: There is moderate, symmetric rigor mortis of the upper and lower extremities and the jaw. Lividity is fixed, purple, and unevenly distributed on the posterior surfaces of the body. The body is cool. SCARS: On the back of the left shoulder is an oblique, 1-1/2", well healed, linear scar. On the right lower quadrant of the abdomen is an oblique, 2", well healed, linear appendectomy scar. THERAPEUTIC PROCEDURES: An endotracheal tube is in the mouth, extending into the upper airway. On the lips are multiple, focal, red abrasions. A cervical collar encircles the neck. Electrocardiogram electrodes are on the torso. An intravascular catheter is in the left antecubital fossa. An intraosseous line is in the right shin. A blood pressure cuff encircles the upper, right arm. On the chest between the nipples is a 3" x 3", irregular, yellow abrasion. Internally, there are minimally hemorrhagic, parasternal, rib fractures of right ribs #4-6 and left ribs # 5-6, approximately 60 ml of liquid blood thinly coating the serosal EFTA00130078
April 22, 2026 at 5:52 AM
epsteinweb.bsky.social
Parts 1-2/2 — EFTA00063521.jpg
#epsteinweb #efta00063521
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00063517 | EFTA00063521 OFFICE OF CHIEF MEDICAL EXAMINER CITY OF NEW YORK REPORT OF AUTOPSY CASE NO. I hereby certify that I, Kristin Roman, M.D., City Medical Examiner - II, have performed an autopsy on the body of Jeffrey Edward Epstein, on the 11 of August 2019, commencing at 9:21 AM in the Manhattan Mortuary of the Office of Chief Medical Examiner of the City of New York. EXTERNAL EXAMINATION: The body is received in a sealed, labeled, plastic body bag (seal #152384). The body is of a well-developed, thin, muscular, light skinned, 5'10", 196 lb man whose appearance is consistent with the given age of 66 years. The scalp hair is wavy, predominantly grey with interspersed dark hairs, has slight male pattern balding, and measures up to 3". The facial hair is cleanly shaven. The eyes have light irides. The oral cavity has intact teeth in good repair. The tongue is free of natural disease. The finger and toenails are well groomed and free of polish. Striae are on the shoulders. The genitalia are atraumatic and of a normal, circumcised man. The anus is atraumatic. POSTMORTEM CHANGES: There is moderate, symmetric rigor mortis of the upper and lower extremities and the jaw. Lividity is fixed, purple, and unevenly distributed on the posterior surfaces of the body. The body is cool. SCARS: On the back of the left shoulder is an oblique, 1-1/2", well healed, linear scar. On the right lower quadrant of the abdomen is an oblique, 2", well healed, linear appendectomy scar. THERAPEUTIC PROCEDURES: An endotracheal tube is in the mouth, extending into the upper airway. On the lips are multiple, focal, red abrasions. A cervical collar encircles the neck. Electrocardiogram electrodes are on the torso. An intravascular catheter is in the left antecubital fossa. An intraosseous line is in the right shin. A blood pressure cuff encircles the upper, right arm. On the chest between the nipples is a 3" x 3", irregular, yellow abrasion. Internally, there are minimally hemorrhagic, parasternal, rib fractures of right ribs #4-6 and left ribs # 5-6, approximately 60 ml of liquid blood thinly coating the serosal EFTA00063521 Epstein Web iOS app on the App Store.
April 20, 2026 at 3:13 AM
epsteinweb.bsky.social
Parts 1-2/2 — EFTA00049617.jpg
#epsteinweb #efta00049617
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00048963 | EFTA00049617 OFFICE OF CHIEF MEDICAL EXAMINER CrTY OF NEW YORK REPORT OF AUTOPSY CASE NO. M-19-019432 I hereby certify that t, Kristin Roman, M.D., City Medical Examiner - ii, have performed an autopsy on the body of Jeffrey Edward Epstein, on the 11 of August 2019, commencing at 9:21 AM in the Manhattan Mortuary of the Office of Chief Medical Examiner of the City of New York. EXTERNAL EXAMINATION: The body is received in a sealed, labeled, plastic body bag (seal #152384). The body is of a well-developed, thin, muscular, light skinned, 5110", 196 lb man whose appearance is consistent with the given age of 66 years. The scalp hair is wavy, predominantly grey with interspersed dark hairs, has slight male pattern balding, and measures up to 3". The facial hair is cleanly shaven. The eyes have light irides. The oral cavity has intact teeth in good repair. The tongue is free of natural disease. The finger and toenails are well groomed and free of polish. Striae are on the shoulders. The genitalia are atraumatic and of a normal, circumcised man. The anus is atraumatic. POSTMORTEM CHANGES: There is moderate, symmetric rigor mortis of the upper and lower extremities and the jaw. Lividity is fixed, purple, and unevenly distributed on the posterior surfaces of the body. The body is cool. SCARS: On the back of the left shoulder is an oblique, 1-1/2", well healed, linear scar. On the right lower quadrant of the abdomen is an oblique, 2", well healed, linear appendectomy scar. THERAPEUTIC PROCEDURES: An endotracheal tube is in the mouth, extending into the upper airway. On the lips are multiple, focal, red abrasions. A cervical collar encircles the neck. Electrocardiogram electrodes are on the torso. An intravascular catheter is in the left antecubital fosse. An intraosseous line is in the right shin. A blood pressure cuff encircles the upper, right arm. On the chest between the nipples is a 3" x 3", irregular, yellow abrasion. Internally, there are minimally hemorrhagic, parasternal, rib fractures of right ribs #4-6 and left ribs # 5-6, approximately 60 ml of liquid blood thinly coating the serosal EFTA00049617
April 19, 2026 at 5:44 PM