Excited to share our recent publications on the role of maternal siRNAs in determining hybridization success in plants: rdcu.be/dZOKw.
Big congrats to Katarzyna Dziasek and everyone who contributed.
Our key findings in short (1/5):
Big congrats to Katarzyna Dziasek and everyone who contributed.
Our key findings in short (1/5):
November 11, 2024 at 12:23 PM
Excited to share our recent publications on the role of maternal siRNAs in determining hybridization success in plants: rdcu.be/dZOKw.
Big congrats to Katarzyna Dziasek and everyone who contributed.
Our key findings in short (1/5):
Big congrats to Katarzyna Dziasek and everyone who contributed.
Our key findings in short (1/5):
New paper in @natplants.nature.com finds that #siRNAs can act as long-distance communication signals from maternal to male tissue in #Capsella with functional role in #pollen development.
Read here: nature.com/articles/s41477-026-02219-6
@claudiakohler11.bsky.social @jiali024.bsky.social
Read here: nature.com/articles/s41477-026-02219-6
@claudiakohler11.bsky.social @jiali024.bsky.social
Long-distance transport of siRNAs with functional roles in pollen development - Nature Plants
This study shows that many small RNAs in Capsella rubella pollen originate from maternal tissues. These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RN...
nature.com
January 28, 2026 at 11:48 AM
New paper in @natplants.nature.com finds that #siRNAs can act as long-distance communication signals from maternal to male tissue in #Capsella with functional role in #pollen development.
Read here: nature.com/articles/s41477-026-02219-6
@claudiakohler11.bsky.social @jiali024.bsky.social
Read here: nature.com/articles/s41477-026-02219-6
@claudiakohler11.bsky.social @jiali024.bsky.social
🔥Fantastic paper!🔥
TE with a role in vegetative phase change and gametogenesis, mediated by 24-nt siRNAs acting in trans to a wide range of genes. Found by GWAS in A. thaliana 🌱. Congratulations to the authors! 👏🏻👏🏻👏🏻
#epigenetics #plantscience
www.pnas.org/doi/10.1073/...
TE with a role in vegetative phase change and gametogenesis, mediated by 24-nt siRNAs acting in trans to a wide range of genes. Found by GWAS in A. thaliana 🌱. Congratulations to the authors! 👏🏻👏🏻👏🏻
#epigenetics #plantscience
www.pnas.org/doi/10.1073/...
March 10, 2026 at 8:33 PM
🔥Fantastic paper!🔥
TE with a role in vegetative phase change and gametogenesis, mediated by 24-nt siRNAs acting in trans to a wide range of genes. Found by GWAS in A. thaliana 🌱. Congratulations to the authors! 👏🏻👏🏻👏🏻
#epigenetics #plantscience
www.pnas.org/doi/10.1073/...
TE with a role in vegetative phase change and gametogenesis, mediated by 24-nt siRNAs acting in trans to a wide range of genes. Found by GWAS in A. thaliana 🌱. Congratulations to the authors! 👏🏻👏🏻👏🏻
#epigenetics #plantscience
www.pnas.org/doi/10.1073/...
New OA Article: "Long-distance transport of siRNAs with functional roles in pollen development" rdcu.be/e1pxk
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
January 30, 2026 at 1:51 AM
New OA Article: "Long-distance transport of siRNAs with functional roles in pollen development" rdcu.be/e1pxk
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
Our new preprint on how in plants ARGONAUT 4 controls RNA cytosine methylation (yes RNA!) which then prevents premature transcription termination
#PlantScience #Epitranscriptome #siRNAs
#PlantScience #Epitranscriptome #siRNAs
April 1, 2026 at 9:37 PM
Our new preprint on how in plants ARGONAUT 4 controls RNA cytosine methylation (yes RNA!) which then prevents premature transcription termination
#PlantScience #Epitranscriptome #siRNAs
#PlantScience #Epitranscriptome #siRNAs
maternal siRNAs. IYKYK 🪱🧬
April 22, 2025 at 1:18 PM
maternal siRNAs. IYKYK 🪱🧬
How does human AGO2 distinguish cleavable from non-cleavable RNA targets?
Our cryo-EM structures reveal that central guide–target pairing pries open AGO2’s central cleft, driving AGO2 into the preactive state required for target cleavage.
www.pnas.org/doi/10.1073/...
#RNAi #CryoEM #siRNA
Our cryo-EM structures reveal that central guide–target pairing pries open AGO2’s central cleft, driving AGO2 into the preactive state required for target cleavage.
www.pnas.org/doi/10.1073/...
#RNAi #CryoEM #siRNA
Central guide–target pairing activates human Argonaute2 by uncoupling the N-PAZ and MID–PIWI lobes | PNAS
Small interfering RNAs (siRNAs) are widely used to repress gene expression. For human
Argonaute2 (AGO2) to cleave target RNA, siRNAs must be almost...
www.pnas.org
August 10, 2026 at 7:22 PM
How does human AGO2 distinguish cleavable from non-cleavable RNA targets?
Our cryo-EM structures reveal that central guide–target pairing pries open AGO2’s central cleft, driving AGO2 into the preactive state required for target cleavage.
www.pnas.org/doi/10.1073/...
#RNAi #CryoEM #siRNA
Our cryo-EM structures reveal that central guide–target pairing pries open AGO2’s central cleft, driving AGO2 into the preactive state required for target cleavage.
www.pnas.org/doi/10.1073/...
#RNAi #CryoEM #siRNA
Phased, secondary siRNAs in plant reproduction
Blake Meyers
University of California, Davis
@ucdavisplants.bsky.social
More questions than anthers 🤣
#icar2026
Blake Meyers
University of California, Davis
@ucdavisplants.bsky.social
More questions than anthers 🤣
#icar2026
June 25, 2026 at 1:37 AM
Phased, secondary siRNAs in plant reproduction
Blake Meyers
University of California, Davis
@ucdavisplants.bsky.social
More questions than anthers 🤣
#icar2026
Blake Meyers
University of California, Davis
@ucdavisplants.bsky.social
More questions than anthers 🤣
#icar2026
A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR -
Yikey Yikes! BTW, similar concerns apply to siRNAs/ASOs that are sometimes suspected to affect RT and/or PCR . So nice somebody looked into this! rdcu.be/RUYFaGa649va
Yikey Yikes! BTW, similar concerns apply to siRNAs/ASOs that are sometimes suspected to affect RT and/or PCR . So nice somebody looked into this! rdcu.be/RUYFaGa649va
rdcu.be
September 1, 2026 at 12:11 PM
A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR -
Yikey Yikes! BTW, similar concerns apply to siRNAs/ASOs that are sometimes suspected to affect RT and/or PCR . So nice somebody looked into this! rdcu.be/RUYFaGa649va
Yikey Yikes! BTW, similar concerns apply to siRNAs/ASOs that are sometimes suspected to affect RT and/or PCR . So nice somebody looked into this! rdcu.be/RUYFaGa649va
I love the siRNAs if only for the convenience of their dosing.
January 31, 2026 at 2:42 PM
I love the siRNAs if only for the convenience of their dosing.
I’m thrilled to share my latest research with @claudiakohler11.bsky.social in @mpi-mp-potsdam.bsky.social, now published in @natplants.nature.com ! In this work, we reveal that long-distance transported siRNAs from maternal sporophytic tissues are functional in pollen development and reproduction.
New OA Article: "Long-distance transport of siRNAs with functional roles in pollen development" rdcu.be/e1pxk
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
...These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RNAs are crucial for successful plant reproduction.
February 2, 2026 at 11:02 AM
I’m thrilled to share my latest research with @claudiakohler11.bsky.social in @mpi-mp-potsdam.bsky.social, now published in @natplants.nature.com ! In this work, we reveal that long-distance transported siRNAs from maternal sporophytic tissues are functional in pollen development and reproduction.
Transposable element-derived siRNAs control viral disease in Arabidopsis https://www.biorxiv.org/content/10.64898/2026.02.06.704401v1
February 7, 2026 at 11:02 AM
Transposable element-derived siRNAs control viral disease in Arabidopsis https://www.biorxiv.org/content/10.64898/2026.02.06.704401v1
ps what you have against miRNAs and siRNAs?!?
November 2, 2025 at 1:43 AM
ps what you have against miRNAs and siRNAs?!?
Excited to be at #ISMPMI2025! Come visit poster P-257 to learn about the role of siRNAs in symptom recovery during viral infection @ibmp-cnrs.bsky.social
July 14, 2025 at 2:05 PM
Excited to be at #ISMPMI2025! Come visit poster P-257 to learn about the role of siRNAs in symptom recovery during viral infection @ibmp-cnrs.bsky.social
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...
www.science.org
December 20, 2024 at 5:14 PM
In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...
Things I learned in grad school:
- How to use siRNAs for targeted gene suppression
- Protocols for Northern, Southern, & Western blots
Things I did not learn in grad school:
- How to run a lab when the government is falling apart
- How to get funding for "woke science"
- How to use siRNAs for targeted gene suppression
- Protocols for Northern, Southern, & Western blots
Things I did not learn in grad school:
- How to run a lab when the government is falling apart
- How to get funding for "woke science"
January 28, 2025 at 4:08 PM
Things I learned in grad school:
- How to use siRNAs for targeted gene suppression
- Protocols for Northern, Southern, & Western blots
Things I did not learn in grad school:
- How to run a lab when the government is falling apart
- How to get funding for "woke science"
- How to use siRNAs for targeted gene suppression
- Protocols for Northern, Southern, & Western blots
Things I did not learn in grad school:
- How to run a lab when the government is falling apart
- How to get funding for "woke science"
And while plants don’t do adaptive immunity based on B- and T-cells, they DO do it with siRNAs.
March 28, 2024 at 3:23 PM
And while plants don’t do adaptive immunity based on B- and T-cells, they DO do it with siRNAs.
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @voslab.org and @bartellab.bsky.social with @amohamed98.bsky.social
Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
The structural basis for RNA slicing by human Argonaute2
Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.
tinyurl.com
January 1, 2025 at 6:31 PM
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @voslab.org and @bartellab.bsky.social with @amohamed98.bsky.social
My co-founded company, Silvec, gets nice write up in Wall Street Journal for our solution to citrus greening using benign virus delivery of anti-bacterial peptides. Good field trials and EPA approval for technology. Virus delivery of siRNAs & peptides is finally here!
www.wsj.com/business/rac...
www.wsj.com/business/rac...
The Race to Save Florida Orange Industry From Total Collapse
After groves were ravaged for decades by a disease, new EPA-approved genetic technologies are giving citrus growers a chance to rebuild.
www.wsj.com
September 20, 2026 at 1:08 AM
My co-founded company, Silvec, gets nice write up in Wall Street Journal for our solution to citrus greening using benign virus delivery of anti-bacterial peptides. Good field trials and EPA approval for technology. Virus delivery of siRNAs & peptides is finally here!
www.wsj.com/business/rac...
www.wsj.com/business/rac...
Artık kalkın muhterem cemaat. Aranızda hala yorganla sırnaş olanları görüyorum 👀
January 23, 2024 at 6:37 AM
Artık kalkın muhterem cemaat. Aranızda hala yorganla sırnaş olanları görüyorum 👀
Here are my favourite facts from the @gensocuk.bsky.social Medal Talk and Balfour lecture. Of course much more fascinating information was also included!
1) siRNAs cause the triploid block which kills triploid maize progeny, which are bad
2) Alternative approached to getting ancient omics sequencing
1) siRNAs cause the triploid block which kills triploid maize progeny, which are bad
2) Alternative approached to getting ancient omics sequencing
November 21, 2024 at 5:51 PM
Here are my favourite facts from the @gensocuk.bsky.social Medal Talk and Balfour lecture. Of course much more fascinating information was also included!
1) siRNAs cause the triploid block which kills triploid maize progeny, which are bad
2) Alternative approached to getting ancient omics sequencing
1) siRNAs cause the triploid block which kills triploid maize progeny, which are bad
2) Alternative approached to getting ancient omics sequencing
1/n So, this is out in NAR, finally. The longest, the most expensive and the most challenging project in the lab. Sparked by controversy concerning mammalian antiviral RNAi and our identification of Dicer variant, which is sufficient to increase RNAi.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Enhanced RNAi does not provide efficient innate antiviral immunity in mice
Abstract. In RNA interference (RNAi), long double-stranded RNA is cleaved by the Dicer endonuclease into small interfering RNAs (siRNAs), which guide degra
doi.org
January 21, 2025 at 2:05 PM
1/n So, this is out in NAR, finally. The longest, the most expensive and the most challenging project in the lab. Sparked by controversy concerning mammalian antiviral RNAi and our identification of Dicer variant, which is sufficient to increase RNAi.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Distinct regulation of mRNA decay pathways by ABA enhances Nitrate Reductase 1/2-derived siRNAs production and stress adaptation
www.sciencedirect.com/science/arti...
#plantscience
www.sciencedirect.com/science/arti...
#plantscience
April 21, 2025 at 9:41 AM
Distinct regulation of mRNA decay pathways by ABA enhances Nitrate Reductase 1/2-derived siRNAs production and stress adaptation
www.sciencedirect.com/science/arti...
#plantscience
www.sciencedirect.com/science/arti...
#plantscience