The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
November 30, 2025 at 2:36 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
We have been mapping mRNA modifications for over a decade.
=> Characterizing their functions -- especially on translation -- is a research frontier.
Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine - EMBO Reports
A major goal in epitranscriptomics is to define the diversity of modified nucleotides in mRNA. Most candidate sites are discovered using transcriptome-wide mapping methods that rely on antibody enrich...
link.springer.com
July 5, 2026 at 5:41 PM
Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine
link.springer.com/article/10.1...
link.springer.com/article/10.1...
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 27, 2025 at 1:19 PM
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
RMBase v3.0: decode the landscape, mechanisms & functions of RNA modifications
The Encyclopedia of RNA Epitranscriptome
More than m6A
"73 RNA modifications of 62 species"
bioinformaticsscience.cn/rmbase/
@narjournal.bsky.social 2024
academic.oup.com/nar/article/...
The Encyclopedia of RNA Epitranscriptome
More than m6A
"73 RNA modifications of 62 species"
bioinformaticsscience.cn/rmbase/
@narjournal.bsky.social 2024
academic.oup.com/nar/article/...
July 20, 2025 at 7:06 PM
RMBase v3.0: decode the landscape, mechanisms & functions of RNA modifications
The Encyclopedia of RNA Epitranscriptome
More than m6A
"73 RNA modifications of 62 species"
bioinformaticsscience.cn/rmbase/
@narjournal.bsky.social 2024
academic.oup.com/nar/article/...
The Encyclopedia of RNA Epitranscriptome
More than m6A
"73 RNA modifications of 62 species"
bioinformaticsscience.cn/rmbase/
@narjournal.bsky.social 2024
academic.oup.com/nar/article/...
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks #microsky #rnasky doi.org/10.1093/nar/...
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa
Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di
doi.org
July 28, 2025 at 8:28 PM
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks #microsky #rnasky doi.org/10.1093/nar/...
Fantastic, comprehensive, useful review if you care about RNA modifications in bacteria: @asm.org @csdetweiler.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Compendium of RNA modifications for bacterial stress adaptation | Microbiology and Molecular Biology Reviews
SUMMARYRNA modifications in the tRNA, rRNA, and mRNA constitute a widespread layer of post-transcriptional
gene regulation, commonly known as the epitranscriptome. In bacteria, tRNA and rRNA
modificat...
journals.asm.org
September 23, 2026 at 2:59 AM
Fantastic, comprehensive, useful review if you care about RNA modifications in bacteria: @asm.org @csdetweiler.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Heat stress impacts RNA modification levels in E. coi !🦠 #microsky #rnasky academic.oup.com/nar/article/...
Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress
Abstract. Modifications of RNA, known as the epitranscriptome, affect gene expression, translation, and splicing in eukaryotes, with implications for devel
academic.oup.com
March 24, 2025 at 12:39 PM
Heat stress impacts RNA modification levels in E. coi !🦠 #microsky #rnasky academic.oup.com/nar/article/...
Our new preprint on how in plants ARGONAUT 4 controls RNA cytosine methylation (yes RNA!) which then prevents premature transcription termination
#PlantScience #Epitranscriptome #siRNAs
#PlantScience #Epitranscriptome #siRNAs
April 1, 2026 at 9:37 PM
Our new preprint on how in plants ARGONAUT 4 controls RNA cytosine methylation (yes RNA!) which then prevents premature transcription termination
#PlantScience #Epitranscriptome #siRNAs
#PlantScience #Epitranscriptome #siRNAs
Learn about the regulation of the #transcriptome at the Hybrid EMBO Workshop "The #epitranscriptome" taking place 28–30 October 2025.
Registration deadline: 16 September/13 October (in-person/virtual)
Abstract submission deadline: 5 August
www.embl.org/about/info/c...
#EMBLEpitrans #EMBOevents 🧪
Registration deadline: 16 September/13 October (in-person/virtual)
Abstract submission deadline: 5 August
www.embl.org/about/info/c...
#EMBLEpitrans #EMBOevents 🧪
The epitranscriptome
EMBO Workshop
www.embl.org
May 29, 2025 at 1:52 PM
Learn about the regulation of the #transcriptome at the Hybrid EMBO Workshop "The #epitranscriptome" taking place 28–30 October 2025.
Registration deadline: 16 September/13 October (in-person/virtual)
Abstract submission deadline: 5 August
www.embl.org/about/info/c...
#EMBLEpitrans #EMBOevents 🧪
Registration deadline: 16 September/13 October (in-person/virtual)
Abstract submission deadline: 5 August
www.embl.org/about/info/c...
#EMBLEpitrans #EMBOevents 🧪
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
August 20, 2025 at 12:26 PM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
LncRNAs and the Cancer Epitranscriptome: Mechanisms and Therapeutic Potential
Cancer letters · Maheshwari et al.
doi.org/10.1016/j.canlet.2026.218858
#RNAsky #RNAmods
Cancer letters · Maheshwari et al.
doi.org/10.1016/j.canlet.2026.218858
#RNAsky #RNAmods
LncRNAs and the Cancer Epitranscriptome: Mechanisms and Therapeutic Potential
Cancer letters · Maheshwari C, Nadhan R, Nath K, Shreeshapuranik SK, Isidoro C, Song YS, Dhanasekaran DN.
doi.org
September 29, 2026 at 9:06 PM
LncRNAs and the Cancer Epitranscriptome: Mechanisms and Therapeutic Potential
Cancer letters · Maheshwari et al.
doi.org/10.1016/j.canlet.2026.218858
#RNAsky #RNAmods
Cancer letters · Maheshwari et al.
doi.org/10.1016/j.canlet.2026.218858
#RNAsky #RNAmods
Very excited to be speaking at the @embo.org Epitranscriptome workshop at the @events.embl.org @embl.org Heidelberg this October! I will show some of the newest data from the lab on how ubiquitin signaling drives m6A RNA methylation in the context of neurodevelopment.
The epitranscriptome
www.embl.org
September 18, 2025 at 9:35 AM
Very excited to be speaking at the @embo.org Epitranscriptome workshop at the @events.embl.org @embl.org Heidelberg this October! I will show some of the newest data from the lab on how ubiquitin signaling drives m6A RNA methylation in the context of neurodevelopment.
Epitranscriptome and paper publishing lessons from Prof. Kulkarni @eisg2025.bsky.social #eisg2025
June 11, 2025 at 11:10 AM
Epitranscriptome and paper publishing lessons from Prof. Kulkarni @eisg2025.bsky.social #eisg2025
Interrogating the Escherichia coli epitranscriptome via CRISPR interference and Nanopore native RNA sequencing www.biorxiv.org/content/10.6...
www.biorxiv.org
May 1, 2026 at 4:01 PM
Interrogating the Escherichia coli epitranscriptome via CRISPR interference and Nanopore native RNA sequencing www.biorxiv.org/content/10.6...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 25, 2025 at 7:52 AM
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
🧬 Happy #DNADay!
Celebrate the double helix and the future of genomics 🙌🏼
Catch the latest breakthroughs at upcoming genetics conferences:
🔬 'Gene regulation: one molecule at a time'
💡 'The epitranscriptome'
🔍 'The mobile genome'
...and more!
➡️ https://www.embl.org/events/
#DNA #Genomics
Celebrate the double helix and the future of genomics 🙌🏼
Catch the latest breakthroughs at upcoming genetics conferences:
🔬 'Gene regulation: one molecule at a time'
💡 'The epitranscriptome'
🔍 'The mobile genome'
...and more!
➡️ https://www.embl.org/events/
#DNA #Genomics
April 25, 2025 at 10:06 AM
🧬 Happy #DNADay!
Celebrate the double helix and the future of genomics 🙌🏼
Catch the latest breakthroughs at upcoming genetics conferences:
🔬 'Gene regulation: one molecule at a time'
💡 'The epitranscriptome'
🔍 'The mobile genome'
...and more!
➡️ https://www.embl.org/events/
#DNA #Genomics
Celebrate the double helix and the future of genomics 🙌🏼
Catch the latest breakthroughs at upcoming genetics conferences:
🔬 'Gene regulation: one molecule at a time'
💡 'The epitranscriptome'
🔍 'The mobile genome'
...and more!
➡️ https://www.embl.org/events/
#DNA #Genomics
Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression
www.nature.com/articles/s41...
Coronaviruses reprogram our cells – a new drug could target this vulnerability.
smartup-news.de/gesundheit/h...
www.nature.com/articles/s41...
Coronaviruses reprogram our cells – a new drug could target this vulnerability.
smartup-news.de/gesundheit/h...
Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression - Nature Communications
Coronaviruses use suboptimal codons yet efficiently translate proteins. Here, the authors show that SARS-CoV-2 and HCoV-OC43 infections reprogram four host tRNA modifications, linking stress-induced t...
www.nature.com
March 11, 2026 at 1:10 AM
Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression
www.nature.com/articles/s41...
Coronaviruses reprogram our cells – a new drug could target this vulnerability.
smartup-news.de/gesundheit/h...
www.nature.com/articles/s41...
Coronaviruses reprogram our cells – a new drug could target this vulnerability.
smartup-news.de/gesundheit/h...
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
November 14, 2024 at 9:29 AM
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
Truly inspiring research and people at #EMBOEpitrans. Thanks M Frye, T Suzuki, C Yi for organising this and for inviting me to present our work. Hope to see you all in two years at The epitranscriptome
October 31, 2025 at 5:25 PM
Truly inspiring research and people at #EMBOEpitrans. Thanks M Frye, T Suzuki, C Yi for organising this and for inviting me to present our work. Hope to see you all in two years at The epitranscriptome
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
bit.ly
July 14, 2025 at 4:00 PM
🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation.
@euromedchem.bsky.social
@euromedchem.bsky.social
January 31, 2025 at 9:57 AM
An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation.
@euromedchem.bsky.social
@euromedchem.bsky.social
Our latest preprint is online!
In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome
Do you want to know more? A small thread follows👇
www.biorxiv.org/content/10.1...
In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome
Do you want to know more? A small thread follows👇
www.biorxiv.org/content/10.1...
Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing
RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processin...
www.biorxiv.org
March 14, 2025 at 12:03 PM
Our latest preprint is online!
In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome
Do you want to know more? A small thread follows👇
www.biorxiv.org/content/10.1...
In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome
Do you want to know more? A small thread follows👇
www.biorxiv.org/content/10.1...
⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa
Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di
doi.org
July 28, 2025 at 8:12 AM
⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing #tnasky
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
bit.ly
January 22, 2026 at 7:31 AM
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing #tnasky
This morning, talks by @sblancolab.bsky.social @ciccancer.bsky.social on the epitranscriptome in cancer and @tmarquesbonet.bsky.social @ibe-barcelona.bsky.social on primate genomics
September 15, 2025 at 7:45 AM
This morning, talks by @sblancolab.bsky.social @ciccancer.bsky.social on the epitranscriptome in cancer and @tmarquesbonet.bsky.social @ibe-barcelona.bsky.social on primate genomics