Scientific Reports - Sperm sncRNA networks are synchronized by a coordination between adverse childhood experiences (ACE) and current stress

Small noncoding RNAs (sncRNAs) are subject to 3’-end trimming and tailing activities that impact maturation versus degradation decisions during biogenesis. To investigate the dynamics of human sncRNA ...

Cell Death Discovery - The sperm survival switch: circRNA-mediated regulatory loops control apoptotic signalling in human spermatozoa

A valuable approach to understanding small non-coding RNA (sncRNA) function is to regulate their expression. However, inducible expression of sncRNAs can be challenging. Here, we present a protocol to express sncRNAs in Saccharomyces cerevisiae using a two-plasmid inducible tet-on system. We describe the steps for generating plasmids and inducing and assessing sncRNA expression. This protocol can be used to express and elucidate the function of tRNA introns and has the potential to identify func...

Chronic kidney disease risk and response to SGLT2 inhibitors in type 2 diabetes are associated with circulating small non-coding RNAs, particularly SNORD12C and SNORD105B. These findings uncover a previously unrecognized small non-coding RNA axis and provide new insight into mechanisms underlying kidney disease progression and renoprotective therapy.

saguetan, estaltze unean aitaren dietak eragina duela ondorengo arren osasun metabolikoan eta eragin hori maila epigenetikoan gertatzen dela

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