Neuroscientists are incredible and insane (in a great way). Is this really single cell resolution?
This stuff is amazing. I cant wrap my head around this, I'll stick to molbio and structbio
This stuff is amazing. I cant wrap my head around this, I'll stick to molbio and structbio
Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint.bsky.social!
Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social
Paper: doi.org/10.64898/202...
Wiki: miniscope.org/wiki/Minisco...
Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social
Paper: doi.org/10.64898/202...
Wiki: miniscope.org/wiki/Minisco...
September 15, 2026 at 12:16 PM
Neuroscientists are incredible and insane (in a great way). Is this really single cell resolution?
This stuff is amazing. I cant wrap my head around this, I'll stick to molbio and structbio
This stuff is amazing. I cant wrap my head around this, I'll stick to molbio and structbio
July 22, 2026 at 12:07 PM
I’ve been really excited by conferences that aim to combine techniques across scales, as I think it’s what’s current and future for #structbio. If you get excited by the same, here is an upcoming structural biology/computation/imaging conference at Keystone 👇🏾
May 24, 2026 at 11:40 AM
I’ve been really excited by conferences that aim to combine techniques across scales, as I think it’s what’s current and future for #structbio. If you get excited by the same, here is an upcoming structural biology/computation/imaging conference at Keystone 👇🏾
Anyone working on #protein #evolution or #orphan #pfam please hmu. DM here or google me and email me. I need advice, discussion, software testing?
#FoldSeek #AlphaFold #AlphaFind #BLAST #homology #biology #structbio #structuralbiology #bioinformatics #hps
#FoldSeek #AlphaFold #AlphaFind #BLAST #homology #biology #structbio #structuralbiology #bioinformatics #hps
April 20, 2026 at 12:59 PM
Anyone working on #protein #evolution or #orphan #pfam please hmu. DM here or google me and email me. I need advice, discussion, software testing?
#FoldSeek #AlphaFold #AlphaFind #BLAST #homology #biology #structbio #structuralbiology #bioinformatics #hps
#FoldSeek #AlphaFold #AlphaFind #BLAST #homology #biology #structbio #structuralbiology #bioinformatics #hps
I failed! I got an offer to stay in academics that sounds a lot more supportive. Also, found a day care that is more reliable and somehow doesn't cost my entire salary (but does prevent me from getting my #subaru, rn)
Coming back to #virology and maybe some #structbio
Coming back to #virology and maybe some #structbio
April 14, 2026 at 3:17 PM
I failed! I got an offer to stay in academics that sounds a lot more supportive. Also, found a day care that is more reliable and somehow doesn't cost my entire salary (but does prevent me from getting my #subaru, rn)
Coming back to #virology and maybe some #structbio
Coming back to #virology and maybe some #structbio
...assess the strength of presented data based on analysis of the figures. E.g. if I was a reviewer for this paper, I would look at this fig and dismiss the paper out of hand, because the maps are nonsense. This is an extreme example, but similar principles apply to analysis of most #structbio data.
October 16, 2025 at 4:00 PM
...assess the strength of presented data based on analysis of the figures. E.g. if I was a reviewer for this paper, I would look at this fig and dismiss the paper out of hand, because the maps are nonsense. This is an extreme example, but similar principles apply to analysis of most #structbio data.
🎙 Moderní technologie a brilantní adepti vědecké dráhy jsou nejlepší investicí výzkumných ústavů.
Že se na tom nevyplatí šetřit, říká v #podcastCHEmic zástupkyně ředitele Pavlína M. Řezáčová.
#podcast #chemic #chemie #iocb #uochb #iocbprague #akademievedcr #cryoem #mikroskopie #structbio
Že se na tom nevyplatí šetřit, říká v #podcastCHEmic zástupkyně ředitele Pavlína M. Řezáčová.
#podcast #chemic #chemie #iocb #uochb #iocbprague #akademievedcr #cryoem #mikroskopie #structbio
Podcast CHEmic #63 – Aby se vědecký ústav dostal na špičku, musí dát šanci mladým talentům
Moderní technologie a brilantní adepti vědecké dráhy jsou nejlepší investicí výzkumných ústavů. Že se na tom nevyplatí šetřit, říká v podcastu CHEmic zástupkyně ředitele ÚOCHB Pavlína M. Řezáčová.
www.uochb.cz
September 5, 2025 at 12:25 PM
🎙 Moderní technologie a brilantní adepti vědecké dráhy jsou nejlepší investicí výzkumných ústavů.
Že se na tom nevyplatí šetřit, říká v #podcastCHEmic zástupkyně ředitele Pavlína M. Řezáčová.
#podcast #chemic #chemie #iocb #uochb #iocbprague #akademievedcr #cryoem #mikroskopie #structbio
Že se na tom nevyplatí šetřit, říká v #podcastCHEmic zástupkyně ředitele Pavlína M. Řezáčová.
#podcast #chemic #chemie #iocb #uochb #iocbprague #akademievedcr #cryoem #mikroskopie #structbio
🦾🧬 bionics BSc, medical biotech MSc
🧠🧲 structbio PhD topic on PSD proteins - I believe NMR and protein dynamics are the future ♥️
🌎🦠 Fulbrightee, worked on NMR investigation of an antibiotic resistance enzyme
💬🤓 I love scicomm
👺🎨 secretly a manga artist
📍🇭🇺➡️🇦🇹
🧠🧲 structbio PhD topic on PSD proteins - I believe NMR and protein dynamics are the future ♥️
🌎🦠 Fulbrightee, worked on NMR investigation of an antibiotic resistance enzyme
💬🤓 I love scicomm
👺🎨 secretly a manga artist
📍🇭🇺➡️🇦🇹
July 18, 2025 at 7:32 PM
🦾🧬 bionics BSc, medical biotech MSc
🧠🧲 structbio PhD topic on PSD proteins - I believe NMR and protein dynamics are the future ♥️
🌎🦠 Fulbrightee, worked on NMR investigation of an antibiotic resistance enzyme
💬🤓 I love scicomm
👺🎨 secretly a manga artist
📍🇭🇺➡️🇦🇹
🧠🧲 structbio PhD topic on PSD proteins - I believe NMR and protein dynamics are the future ♥️
🌎🦠 Fulbrightee, worked on NMR investigation of an antibiotic resistance enzyme
💬🤓 I love scicomm
👺🎨 secretly a manga artist
📍🇭🇺➡️🇦🇹
When I arrived to NYC as a postdoc, NYSBDG was my first local meeting, and I was blown way by the world-class quality of the science.
It's a great opportunity to meet the local #structbio & #cryoem community, and it's coming up in two weeks, so register now at the eventbrite link below!
It's a great opportunity to meet the local #structbio & #cryoem community, and it's coming up in two weeks, so register now at the eventbrite link below!
July 7, 2025 at 2:13 PM
When I arrived to NYC as a postdoc, NYSBDG was my first local meeting, and I was blown way by the world-class quality of the science.
It's a great opportunity to meet the local #structbio & #cryoem community, and it's coming up in two weeks, so register now at the eventbrite link below!
It's a great opportunity to meet the local #structbio & #cryoem community, and it's coming up in two weeks, so register now at the eventbrite link below!
The external speakers are set and ready to navigate the intersection of #AI & #StructBio for the Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology.
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz
June 17, 2025 at 1:15 PM
The external speakers are set and ready to navigate the intersection of #AI & #StructBio for the Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology.
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz
This is an excellent meeting for #structbio folks in the northeast & tristate area! Great lineup 🤩
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
March 18, 2025 at 11:09 AM
This is an excellent meeting for #structbio folks in the northeast & tristate area! Great lineup 🤩
The free and open and INGENIOUS format (which dates back to the 70’s) of the PDB file and associated analysis code for #structbio is completely under appreciated. PDB predates Genbank by a decade! People dedicated their working lives to overnight shifts at the synchrotron to collect these data.
His Nobel should have gone to the people who built the PDB.
February 8, 2025 at 9:12 AM
The free and open and INGENIOUS format (which dates back to the 70’s) of the PDB file and associated analysis code for #structbio is completely under appreciated. PDB predates Genbank by a decade! People dedicated their working lives to overnight shifts at the synchrotron to collect these data.
Finally put together a script that scrapes arxiv/biorxiv/pubmed and emails the relevant structbio/ml papers from there every morning github.com/delalamo/Pub... I have it running on Heroku cloud for $7/mo, but it can also run locally for free on a raspberry pi or whatever
February 4, 2025 at 5:48 PM
Finally put together a script that scrapes arxiv/biorxiv/pubmed and emails the relevant structbio/ml papers from there every morning github.com/delalamo/Pub... I have it running on Heroku cloud for $7/mo, but it can also run locally for free on a raspberry pi or whatever
Using Federal funding, we described for the first time, the architecture of the Pentameric subunits of the HIV capsid and how they differ in binding to the rest of the capsid which is important for nuclear entry and drug binding, and we show this structurally. #structbio #FundScience
January 29, 2025 at 6:58 PM
Using Federal funding, we described for the first time, the architecture of the Pentameric subunits of the HIV capsid and how they differ in binding to the rest of the capsid which is important for nuclear entry and drug binding, and we show this structurally. #structbio #FundScience
Next September, I will be going to Colombia taking part of this workshop in Structural Bioinformatics. If you are interesting in discovering and designing peptides using structural bioinformatics, check this out#PeptideDrugs #StructuralBioinformatics
ubmc-pecet.udea.edu.co/structbio/
ubmc-pecet.udea.edu.co/structbio/
December 13, 2024 at 10:42 AM
Next September, I will be going to Colombia taking part of this workshop in Structural Bioinformatics. If you are interesting in discovering and designing peptides using structural bioinformatics, check this out#PeptideDrugs #StructuralBioinformatics
ubmc-pecet.udea.edu.co/structbio/
ubmc-pecet.udea.edu.co/structbio/
Friendly reminder, a model does not have a resolution; a map has a resolution. A model has spatial variance, rotamers, populations, etc. The map has resolution(s), threshold, density falloff, any number of correlation coefficients, etc.
Please, do not assign a resolution to your model.
#structbio
Please, do not assign a resolution to your model.
#structbio
December 2, 2024 at 12:25 AM
Friendly reminder, a model does not have a resolution; a map has a resolution. A model has spatial variance, rotamers, populations, etc. The map has resolution(s), threshold, density falloff, any number of correlation coefficients, etc.
Please, do not assign a resolution to your model.
#structbio
Please, do not assign a resolution to your model.
#structbio
Good to see you again! We should talk at sometime. Hope things are well. Would be good to link you to this: australian-structural-biology-computing.github.io/website/
StructBio Computing
Example of ELIXIR toolkit theme as a remote jekyll theme
australian-structural-biology-computing.github.io
October 20, 2024 at 9:23 PM
Good to see you again! We should talk at sometime. Hope things are well. Would be good to link you to this: australian-structural-biology-computing.github.io/website/
And we're live! This was actually the first project I started in my PhD, a little over 3 years ago when I joined the Pornillos lab for #HIV #StructBio in February of 2021. Shifted focus to a more high profile project, but methods were developed specifically because this mutant was so weird! #cryoEM
Arg18 Substitutions Reveal the Capacity of the HIV-1 Capsid Protein for Non-Fullerene Assembly
In the fullerene cone HIV-1 capsid, the central channels of the hexameric and pentameric capsomers each contain a ring of arginine (Arg18) residues that perform essential roles in capsid assembly and ...
www.mdpi.com
June 27, 2024 at 1:42 PM
And we're live! This was actually the first project I started in my PhD, a little over 3 years ago when I joined the Pornillos lab for #HIV #StructBio in February of 2021. Shifted focus to a more high profile project, but methods were developed specifically because this mutant was so weird! #cryoEM
Second paper from my thesis work is live on biorxiv.
Allosteric regulation of quaternary structure in the HIV capsid. Mutational analysis of a binding site may have long range effects on a protein even if the tertiary structure is seemingly unchanged, but seeing is believing. #structbio #cryoEM
Allosteric regulation of quaternary structure in the HIV capsid. Mutational analysis of a binding site may have long range effects on a protein even if the tertiary structure is seemingly unchanged, but seeing is believing. #structbio #cryoEM
Arg18 substitutions reveal the capacity of the HIV-1 capsid protein for non-fullerene assembly
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
March 5, 2024 at 8:58 PM
Second paper from my thesis work is live on biorxiv.
Allosteric regulation of quaternary structure in the HIV capsid. Mutational analysis of a binding site may have long range effects on a protein even if the tertiary structure is seemingly unchanged, but seeing is believing. #structbio #cryoEM
Allosteric regulation of quaternary structure in the HIV capsid. Mutational analysis of a binding site may have long range effects on a protein even if the tertiary structure is seemingly unchanged, but seeing is believing. #structbio #cryoEM
A well written introduction to Mixture-of-experts from last summer. This technique ensembles multiple ML models with distinct "specialties". As far as I know if has not yet popped up in the structbio/ml subfield, please correct if wrong
Mixture-of-Experts Explained: Why 8 smaller models are better than 1 gigantic one
GPT-4 is rumored to be a Mixture-of-Experts, totaling 1.76T parameters. How does MoE work and why is it so powerful?
alexandrabarr.beehiiv.com
February 16, 2024 at 9:32 AM
A well written introduction to Mixture-of-experts from last summer. This technique ensembles multiple ML models with distinct "specialties". As far as I know if has not yet popped up in the structbio/ml subfield, please correct if wrong
Gonna stop curating structbio/ML preprint & papers for a few weeks. The colab notebook below should mostly do the trick (except arxiv) for anyone interested in catching up on whats going on
colab.research.google.com/drive/17e0pD...
colab.research.google.com/drive/17e0pD...
Google Colaboratory
colab.research.google.com
January 26, 2024 at 10:11 AM
Gonna stop curating structbio/ML preprint & papers for a few weeks. The colab notebook below should mostly do the trick (except arxiv) for anyone interested in catching up on whats going on
colab.research.google.com/drive/17e0pD...
colab.research.google.com/drive/17e0pD...
Structbio/ML preprints and publications for 26 Jan 2024 🧪🧶🧬
January 26, 2024 at 6:09 AM
Structbio/ML preprints and publications for 26 Jan 2024 🧪🧶🧬
Structbio/ML preprints and publications for 25 Jan 2024 🧪🧶🧬
January 25, 2024 at 6:14 AM
Structbio/ML preprints and publications for 25 Jan 2024 🧪🧶🧬
Structbio/ML preprints and publications for 24 Jan 2024 🧪🧶🧬
January 24, 2024 at 6:36 AM
Structbio/ML preprints and publications for 24 Jan 2024 🧪🧶🧬
Structbio/ML preprints and publications for 23 Jan 2024 🧪🧶🧬
January 23, 2024 at 6:09 AM
Structbio/ML preprints and publications for 23 Jan 2024 🧪🧶🧬