In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...
#plantscience
#plantscience
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 13, 2026 at 9:43 AM
In @science.org this week, thermospermine affects ribosome methylation, which in turn regulates translation of xylem development proteins www.science.org/doi/10.1126/...
#plantscience
#plantscience
Happy to share our last paper published in Developmental Cell. Amazing work by Anna Sole-Gil. Great co-supervision with Miguel Blázquez and equally great collaboration with the labs of @liamdolanlab.bsky.social, Barbara Ambrose and Kimitsune Ishizaki.
www.cell.com/developmenta...
www.cell.com/developmenta...
Divergent evolution of a thermospermine-dependent regulatory pathway in land plants
Solé-Gil et al. report that the thermospermine-dependent genetic circuit controlling
vascular proliferation in tracheophytes is not fully connected but divided into two
modules in the bryophyte Marcha...
www.cell.com
January 12, 2025 at 4:12 PM
Happy to share our last paper published in Developmental Cell. Amazing work by Anna Sole-Gil. Great co-supervision with Miguel Blázquez and equally great collaboration with the labs of @liamdolanlab.bsky.social, Barbara Ambrose and Kimitsune Ishizaki.
www.cell.com/developmenta...
www.cell.com/developmenta...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 12, 2026 at 7:19 PM
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
🌱🧬 VIEWPOINT 🧬🌱
The recruitment of thermospermine to OVERACHIEVER-modified ribosomes represents a substantive advance in understanding how polyamines regulate vascular differentiation during plant development - Silva et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
The recruitment of thermospermine to OVERACHIEVER-modified ribosomes represents a substantive advance in understanding how polyamines regulate vascular differentiation during plant development - Silva et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
September 18, 2026 at 10:00 AM
🌱🧬 VIEWPOINT 🧬🌱
The recruitment of thermospermine to OVERACHIEVER-modified ribosomes represents a substantive advance in understanding how polyamines regulate vascular differentiation during plant development - Silva et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
The recruitment of thermospermine to OVERACHIEVER-modified ribosomes represents a substantive advance in understanding how polyamines regulate vascular differentiation during plant development - Silva et al.
🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪
New Science paper out! 🚀
The @starmorph-syg.bsky.social team contributed to a Science paper revealing a completely new mechanism that plants use to develop vascular tissue. Amazing teamwork with colleagues from Cambridge, Helsinki & beyond. 🌱✨
www.science.org/doi/10.1126/...
The @starmorph-syg.bsky.social team contributed to a Science paper revealing a completely new mechanism that plants use to develop vascular tissue. Amazing teamwork with colleagues from Cambridge, Helsinki & beyond. 🌱✨
www.science.org/doi/10.1126/...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 12, 2026 at 7:40 PM
New Science paper out! 🚀
The @starmorph-syg.bsky.social team contributed to a Science paper revealing a completely new mechanism that plants use to develop vascular tissue. Amazing teamwork with colleagues from Cambridge, Helsinki & beyond. 🌱✨
www.science.org/doi/10.1126/...
The @starmorph-syg.bsky.social team contributed to a Science paper revealing a completely new mechanism that plants use to develop vascular tissue. Amazing teamwork with colleagues from Cambridge, Helsinki & beyond. 🌱✨
www.science.org/doi/10.1126/...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 14, 2026 at 9:40 AM
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
#new_paper: Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
@science.org
Interantional cooperation by University of Cambridge, University of Helsinki, Palacký University Olomouc and Institute of Experimental botany CAS.
doi.org/10.1126/scie...
@science.org
Interantional cooperation by University of Cambridge, University of Helsinki, Palacký University Olomouc and Institute of Experimental botany CAS.
doi.org/10.1126/scie...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
doi.org
February 16, 2026 at 12:25 PM
#new_paper: Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
@science.org
Interantional cooperation by University of Cambridge, University of Helsinki, Palacký University Olomouc and Institute of Experimental botany CAS.
doi.org/10.1126/scie...
@science.org
Interantional cooperation by University of Cambridge, University of Helsinki, Palacký University Olomouc and Institute of Experimental botany CAS.
doi.org/10.1126/scie...
📜 Thermospermine is an evolutionarily ancestral phytohormone required for organ development and stress responses in Marchantia polymorpha
🧑🔬 Takuya Furumoto, Taku Takahashi, et al.
📔 Plant & Cell Physiology
🔗 academic.oup.com/pcp/advance-...
#️⃣ (Feeds) #PlantScience #PlantEvoDevo #Phytohormones
🧑🔬 Takuya Furumoto, Taku Takahashi, et al.
📔 Plant & Cell Physiology
🔗 academic.oup.com/pcp/advance-...
#️⃣ (Feeds) #PlantScience #PlantEvoDevo #Phytohormones
Thermospermine is an evolutionarily ancestral phytohormone required for organ development and stress...
Abstract. Thermospermine suppresses auxin-inducible xylem differentiation, whereas its structural isomer, spermine, is involved in stress responses in angiosper
academic.oup.com
January 12, 2024 at 8:16 AM
📜 Thermospermine is an evolutionarily ancestral phytohormone required for organ development and stress responses in Marchantia polymorpha
🧑🔬 Takuya Furumoto, Taku Takahashi, et al.
📔 Plant & Cell Physiology
🔗 academic.oup.com/pcp/advance-...
#️⃣ (Feeds) #PlantScience #PlantEvoDevo #Phytohormones
🧑🔬 Takuya Furumoto, Taku Takahashi, et al.
📔 Plant & Cell Physiology
🔗 academic.oup.com/pcp/advance-...
#️⃣ (Feeds) #PlantScience #PlantEvoDevo #Phytohormones
Lost in Translation...
Nishii et al show that thermospermine-dependent thiolation of tRNA is important for #xylem development as it influences upstream open reading frame (uORF)-mediated translational control of key developmental regulators
doi.org/10.1093/pcp/...
#PlantDevelopment
#PlantScience
Nishii et al show that thermospermine-dependent thiolation of tRNA is important for #xylem development as it influences upstream open reading frame (uORF)-mediated translational control of key developmental regulators
doi.org/10.1093/pcp/...
#PlantDevelopment
#PlantScience
September 25, 2026 at 12:27 PM
Lost in Translation...
Nishii et al show that thermospermine-dependent thiolation of tRNA is important for #xylem development as it influences upstream open reading frame (uORF)-mediated translational control of key developmental regulators
doi.org/10.1093/pcp/...
#PlantDevelopment
#PlantScience
Nishii et al show that thermospermine-dependent thiolation of tRNA is important for #xylem development as it influences upstream open reading frame (uORF)-mediated translational control of key developmental regulators
doi.org/10.1093/pcp/...
#PlantDevelopment
#PlantScience
🚨 A subtle ribosome tweak can reshape plant tissues—methylation enables #thermospermine to bind and both boost and suppress protein production, fine-tuning xylem development.
#PlantBiology #Ribosome #Translation #Xylem #RNAmodification
#PlantBiology #Ribosome #Translation #Xylem #RNAmodification
May 1, 2026 at 1:26 PM
🚨 A subtle ribosome tweak can reshape plant tissues—methylation enables #thermospermine to bind and both boost and suppress protein production, fine-tuning xylem development.
#PlantBiology #Ribosome #Translation #Xylem #RNAmodification
#PlantBiology #Ribosome #Translation #Xylem #RNAmodification
New findings show that thermospermine regulates plant vascular development by binding to methylated ribosomes, influencing the balance between woody xylem and fleshy storage tissues.
How plants balance woody xylem and fleshy tissues: Thermospermine targets methylated ribosomes
Scientists have identified a crucial mechanism that allows plants to shape their vascular systems, determining whether they grow soft edible storage organs or develop the rigid woody tissue characteristic of trees.
phys.org
February 12, 2026 at 7:00 PM
New findings show that thermospermine regulates plant vascular development by binding to methylated ribosomes, influencing the balance between woody xylem and fleshy storage tissues.
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SU...
www.science.org
February 16, 2026 at 12:11 PM
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate | Science www.science.org/doi/10.1126/...
The research concludes that thermospermine is a bifunctional translational regulator for SAC51 and LHW, but requires a specific methylation, m3U2952, for its bifunctional regulation. It acts by promoting SACLs translation while inhibiting that of LHW.
February 13, 2026 at 12:02 PM
The research concludes that thermospermine is a bifunctional translational regulator for SAC51 and LHW, but requires a specific methylation, m3U2952, for its bifunctional regulation. It acts by promoting SACLs translation while inhibiting that of LHW.
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate www.sciencemagazinedigital.org/sciencemagaz...
Science Magazine - Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
The intricate chemical landscape of the ribosome has been brought into focus at a structurally high resolution (1-8).
www.sciencemagazinedigital.org
February 13, 2026 at 3:53 PM
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate www.sciencemagazinedigital.org/sciencemagaz...
Thermospermine guides xylem fate in Arabidopsis by promoting SAC51 translation on methylated 25S ribosomes via OVERACHIEVER enzyme. PMID:41678627, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx2867 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1126/science.adx2867
No description available
doi.org
May 8, 2026 at 2:10 AM
Thermospermine guides xylem fate in Arabidopsis by promoting SAC51 translation on methylated 25S ribosomes via OVERACHIEVER enzyme. PMID:41678627, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx2867 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Researchers from Alan Warren’s lab at the Cambridge Institute for Medical Research and Finn Kirpekar’s lab at the University of Southern Denmark analysed chemical modifications and the structure of the Arabidopsis ribosome to see how it functions as a signalling sensor.
February 13, 2026 at 12:02 PM
Researchers from Alan Warren’s lab at the Cambridge Institute for Medical Research and Finn Kirpekar’s lab at the University of Southern Denmark analysed chemical modifications and the structure of the Arabidopsis ribosome to see how it functions as a signalling sensor.
New study: spraying thermospermine (T-Spm) helps #wucai beat the cold: maintains photosynthesis, strengthens antioxidant defenses, and balances metabolism.
Result: greener, healthier plants under low temps. Check out the research!
doi.org/10.1016/j.pl... #plantscience #horticulture #climatechange
Result: greener, healthier plants under low temps. Check out the research!
doi.org/10.1016/j.pl... #plantscience #horticulture #climatechange
August 18, 2025 at 2:10 PM
New study: spraying thermospermine (T-Spm) helps #wucai beat the cold: maintains photosynthesis, strengthens antioxidant defenses, and balances metabolism.
Result: greener, healthier plants under low temps. Check out the research!
doi.org/10.1016/j.pl... #plantscience #horticulture #climatechange
Result: greener, healthier plants under low temps. Check out the research!
doi.org/10.1016/j.pl... #plantscience #horticulture #climatechange
Read the Spotlight “Thermospermine drives dual-action ribosomes to shape plant xylem development” from Wu Hsin-Yen (Larry) and Polly Yingshan Hsu: authors.elsevier.com/a/1n1EL3S6Gf...
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authors.elsevier.com
May 1, 2026 at 1:26 PM
Read the Spotlight “Thermospermine drives dual-action ribosomes to shape plant xylem development” from Wu Hsin-Yen (Larry) and Polly Yingshan Hsu: authors.elsevier.com/a/1n1EL3S6Gf...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Science, Volume 391, Issue 6786 , Page 694-699, February 2026.
www.science.org
February 12, 2026 at 9:01 PM
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate