Whole blood thrombin generation looks like the only promising biomarker of bleeding risk in #cirrhosis
Thrombin is the business end of the hemostatic cascade. Even with ⬇️factors, this is “rebalanced” in cirrhosis. Except when it isn’t. that’s where this test could be helpful #liversky
Thrombin is the business end of the hemostatic cascade. Even with ⬇️factors, this is “rebalanced” in cirrhosis. Except when it isn’t. that’s where this test could be helpful #liversky
December 28, 2024 at 12:55 AM
Whole blood thrombin generation looks like the only promising biomarker of bleeding risk in #cirrhosis
Thrombin is the business end of the hemostatic cascade. Even with ⬇️factors, this is “rebalanced” in cirrhosis. Except when it isn’t. that’s where this test could be helpful #liversky
Thrombin is the business end of the hemostatic cascade. Even with ⬇️factors, this is “rebalanced” in cirrhosis. Except when it isn’t. that’s where this test could be helpful #liversky
May 7, 2025 at 1:46 AM
Love your cum clips, the way you focus on that thrombin pumping action
March 18, 2025 at 3:25 AM
Love your cum clips, the way you focus on that thrombin pumping action
Nephrotic syndrome is associated with excessive thrombin generation and impaired fibrinolysis, increasing risk of thrombosis. kidney.pub/KID0865 #ASNKidney360
July 2, 2025 at 5:25 PM
Nephrotic syndrome is associated with excessive thrombin generation and impaired fibrinolysis, increasing risk of thrombosis. kidney.pub/KID0865 #ASNKidney360
Very cool
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis | PNAS
Neutrophils release neutrophil extracellular traps (NETs) to neutralize infections,
a process that also contributes to immunothrombosis. While bene...
www.pnas.org
July 7, 2025 at 3:12 AM
Very cool
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
🧬 Excessive neutrophil extracellular traps (NETs) cause dangerous clots, but how?
PNAS: single-stranded DNA (ATTCC)n in NETs DIRECTLY BINDS THROMBIN to fuel immunothrombosis
Targeting repeats with antisense LNAs disrupts NET–thrombin binding
New therapy for dysregulated coagulation??
Just an FYI....
PEA, Palmitoylethanolamide increases the risk of thrombin formation in plasma.
The supplement is used for chronic pain.
Glad I caught it, only a few doses in.
PEA, Palmitoylethanolamide increases the risk of thrombin formation in plasma.
The supplement is used for chronic pain.
Glad I caught it, only a few doses in.
January 3, 2025 at 1:22 AM
Just an FYI....
PEA, Palmitoylethanolamide increases the risk of thrombin formation in plasma.
The supplement is used for chronic pain.
Glad I caught it, only a few doses in.
PEA, Palmitoylethanolamide increases the risk of thrombin formation in plasma.
The supplement is used for chronic pain.
Glad I caught it, only a few doses in.
🔪✨️we love sudden, thrombin, immobilizing pain down one leg for no reason✨️🔪 we *love* when this happens
January 4, 2025 at 3:46 AM
🔪✨️we love sudden, thrombin, immobilizing pain down one leg for no reason✨️🔪 we *love* when this happens
You are better off getting injections of hirudin (or a recombinant derivative), a thrombin inhibitor originally isolated from the salivary glands of medicinal leeches (Hirudo medicinalis).
May 25, 2025 at 12:18 AM
You are better off getting injections of hirudin (or a recombinant derivative), a thrombin inhibitor originally isolated from the salivary glands of medicinal leeches (Hirudo medicinalis).
Yeah you need thrombin packs
August 9, 2024 at 3:12 PM
Yeah you need thrombin packs
Mathematical models showed that concizumab enhances thrombin generation by simultaneous inhibition of multiple TFPI anticoagulant activities. #hemophilia #concizumab #TFPI #medsky #hemesky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
November 22, 2024 at 4:27 AM
Mathematical models showed that concizumab enhances thrombin generation by simultaneous inhibition of multiple TFPI anticoagulant activities. #hemophilia #concizumab #TFPI #medsky #hemesky
www.jthjournal.org/article/S153...
www.jthjournal.org/article/S153...
She gets my veins thrombin’!
*gets dragged off of the stage with a shepherds crook*
*gets dragged off of the stage with a shepherds crook*
August 15, 2025 at 1:50 AM
She gets my veins thrombin’!
*gets dragged off of the stage with a shepherds crook*
*gets dragged off of the stage with a shepherds crook*
Shiny apps for reproducible analysis of hemostasis assay data (see JThromb Hemost, doi.org/10.1111/jth....) now have Youtube videos(tinyurl.com/4ywjrr3z). Follow links for clot lysis, clotting and thrombin generation assays on my shiny-clots web page drclongstaff.github.io/shiny-clots/
March 27, 2025 at 4:01 PM
Shiny apps for reproducible analysis of hemostasis assay data (see JThromb Hemost, doi.org/10.1111/jth....) now have Youtube videos(tinyurl.com/4ywjrr3z). Follow links for clot lysis, clotting and thrombin generation assays on my shiny-clots web page drclongstaff.github.io/shiny-clots/
Haven't posted cock in a while. So here's some bear cock that haven't shot a load in while that's thrombin with horniness.
January 7, 2026 at 8:07 PM
Haven't posted cock in a while. So here's some bear cock that haven't shot a load in while that's thrombin with horniness.
The flu vax reduces heart attack rates because all respiratory viruses drive immunothrombosis in the coronary arteries. Don't let anyone tell you that catching colds at work is an acceptable occupational hazard or good for you. That's like saying coal miners' lung is acceptable.
Interferons prime the endothelium for toll-like receptor–mediated thrombin generation
Respiratory infection is associated with microvascular thrombus formation and marked
elevation in cytokine levels. The role of cytokines elaborated by the pulmonary epithelium
in thrombotic responses ...
www.jthjournal.org
April 20, 2025 at 3:40 AM
The flu vax reduces heart attack rates because all respiratory viruses drive immunothrombosis in the coronary arteries. Don't let anyone tell you that catching colds at work is an acceptable occupational hazard or good for you. That's like saying coal miners' lung is acceptable.
She citrate my thrombin til I hyperglobin
December 3, 2024 at 11:46 PM
She citrate my thrombin til I hyperglobin
Oh, absolutely.
Come on thrombin!! Do your job!
Come on thrombin!! Do your job!
May 1, 2026 at 10:33 PM
Oh, absolutely.
Come on thrombin!! Do your job!
Come on thrombin!! Do your job!
Next to the turgid, veiny, thrombin dong.
May 19, 2024 at 11:45 PM
Next to the turgid, veiny, thrombin dong.
Easy bruisability (pancake makeup on a bruise-from smashing his fist, or needing an IV?): he's got A-fib and is on a direct thrombin inhibitor as a guess. I guess that Adderall and tachycardia finally combined to matter. #medsky
August 23, 2025 at 1:39 AM
Easy bruisability (pancake makeup on a bruise-from smashing his fist, or needing an IV?): he's got A-fib and is on a direct thrombin inhibitor as a guess. I guess that Adderall and tachycardia finally combined to matter. #medsky
All respiratory viral illnesses drive immunothrombosis. The more severe the illness, the more MACE you see. The relation between viral illnesses and MACE is causal. @jthjournal.bsky.social @isth.org www.jthjournal.org/article/S153...
May 13, 2025 at 8:30 AM
All respiratory viral illnesses drive immunothrombosis. The more severe the illness, the more MACE you see. The relation between viral illnesses and MACE is causal. @jthjournal.bsky.social @isth.org www.jthjournal.org/article/S153...
This Session Had me GONE......dick thrombin and leaking and I was edging for like a hour in a half......
#DmvBator #DmvB8r #EdgeSession #DmvFreaks #DmvSide #DmvVers
#DmvBator #DmvB8r #EdgeSession #DmvFreaks #DmvSide #DmvVers
August 18, 2026 at 11:04 AM
This Session Had me GONE......dick thrombin and leaking and I was edging for like a hour in a half......
#DmvBator #DmvB8r #EdgeSession #DmvFreaks #DmvSide #DmvVers
#DmvBator #DmvB8r #EdgeSession #DmvFreaks #DmvSide #DmvVers
A naturally occurring factor VIII variant with elevated clotting activity and reduced response to activated protein C may explain severe thrombosis and offers a possible new therapeutic approach for hemophilia A. Learn more: nej.md/45eDMSR
#MedSky #Hematology #CardioSky
#MedSky #Hematology #CardioSky
August 17, 2025 at 1:01 PM
A naturally occurring factor VIII variant with elevated clotting activity and reduced response to activated protein C may explain severe thrombosis and offers a possible new therapeutic approach for hemophilia A. Learn more: nej.md/45eDMSR
#MedSky #Hematology #CardioSky
#MedSky #Hematology #CardioSky
Another episode posted on Unraveled: Understanding Complex Illness.
Please send comments, questions, share and subscribe. Thanks.
youtu.be/DyVlqA0vfHo
Please send comments, questions, share and subscribe. Thanks.
youtu.be/DyVlqA0vfHo
Microclots---Fibrinogen, Thrombin, Fibrin, and their role in the Pathology of Long Covid
YouTube video by Unraveled: Understanding Complex Illness
youtu.be
March 12, 2026 at 4:27 AM
Another episode posted on Unraveled: Understanding Complex Illness.
Please send comments, questions, share and subscribe. Thanks.
youtu.be/DyVlqA0vfHo
Please send comments, questions, share and subscribe. Thanks.
youtu.be/DyVlqA0vfHo
Heparin binds to the cationic areas of thrombin to inhibit coagulation.
March 6, 2026 at 4:49 AM
Heparin binds to the cationic areas of thrombin to inhibit coagulation.