Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high-yielding, scalable reaction that proceeds under mild, catalyst-free conditions. It operates via a multi-....

Abstract. Herein, we report a photoredox-enabled catalytic transamination strategy that enables direct amine-to-amine interconversion without prefunctional

Driving non-photoresponsive transformations out of equilibrium with light requires transducing light energy into a different stimulus. Here, we demons…

All-perovskite tandem solar cells are emerging at a fast rate because of their potential to exceed efficiencies of Si-perovskite tandems, in combination with faster manufacturing, lower cost and the ....

The incorporation of nitrogen in steroidal glycoalkaloids is hypothesized to occur through a transamination reaction. Here, the authors show that GLYCOALKALOID METABOLISM12 appears to evolve from the ...

"Swiss Crypto bank Seba now 'Amina'. The new name taken from 'transamination', symbolizes fusion of different banking types. #CryptoBanking #GlobalExpansion" According to Cointelegraph.

Protein is important for keeping the muscles, bones, and tissues healthy. Protein plays a role in many bodily processes, such as blood clotting, fluid balance, immune system responses, vision, hormone...

PDF | Thioesters, such as acetyl-coenzyme A and succinyl-coenzyme A, play a crucial role in Biochemistry. The energy stored within thioester bonds is... | Find, read and cite all the research you need...

The Front Cover illustrates the systematic optimization and evaluation of reaction parameters in the transaminase-catalyzed amination of 5-(hydroxymethyl)furfural (HMF) for subsequent upscaling of the biocatalytic synthesis from small-scale experiments (2 mL) to preparative reaction volumes (20 and 200 mL). More information can be found in the Research Article by T. Heinks and co-workers (DOI: 10.1002/cctc.70939). Artwork designed by the team of INMYWORK Studio.

Oxidative stress is a major driver of cardiovascular disease; however, the fast changes in cellular metabolism caused by short-lived reactive oxygen species (ROS) remain ill-defined. Here, we characterized changes in the endothelial cell metabolome in response to acute oxidative challenges and identified novel redox-sensitive metabolic enzymes. H2O2 selectively increased the amount of α-ketoglutaramate (αKGM), a largely uncharacterized metabolite produced by glutamine transamination and an unrecognized intermediate of endothelial glutamine catabolism. In addition, H2O2 impaired the catalytic activity of nitrilase-like 2 ω-amidase (NIT2), the enzyme that converts αKGM to α-ketoglutarate (αKG), by the reversible oxidation of specific cysteine residues. Moreover, a NIT2 gene variant exhibited decreased expression in humans and was associated with increased plasma αKGM concentration. Endothelial-specific knockout of NIT2 in mice increased cellular αK

Read the full paper: Biocatalytic Carboxylic Acid Reduction and Transamination in Cell-Free Lysates at High Substrate Loading

High-yield summary of U01.01.112. Understand the inter-organ exchange between muscle and liver, the role of pyruvate transamination, and how the body maintains blood glucose during exercise.

Nature Communications - Direct conversion of amines to corresponding alcohols is challenging even under harsh reaction conditions. Inspired by enzymatic transamination, the authors present a...