One of my favourite papers about Trypanosoma parasites is this study where researchers infect zebra fish larvae (which are transparent) with Trypanosoma carassii and were able to observe how these single-celled parasites move through their host's body. 🧪
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
March 4, 2026 at 1:32 AM
One of my favourite papers about Trypanosoma parasites is this study where researchers infect zebra fish larvae (which are transparent) with Trypanosoma carassii and were able to observe how these single-celled parasites move through their host's body. 🧪
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Em um 14.04 como hoje, pelos idos de 1909, o médico brasileiro Carlos Chagas descobria a doença de Chagas: uma doença parasitária tropical causada pelo Trypanosoma cruzi.
#efemérides
#efemérides
April 14, 2026 at 11:57 PM
Em um 14.04 como hoje, pelos idos de 1909, o médico brasileiro Carlos Chagas descobria a doença de Chagas: uma doença parasitária tropical causada pelo Trypanosoma cruzi.
#efemérides
#efemérides
Polybia wasps: bioengineers with pharmaceutical potential
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
April 5, 2025 at 12:14 AM
Polybia wasps: bioengineers with pharmaceutical potential
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Going on a date with a single trypanosoma cruzi tonight. taking it to chili’s. kinda nervous
May 3, 2026 at 4:45 PM
Going on a date with a single trypanosoma cruzi tonight. taking it to chili’s. kinda nervous
"Like Monarez, O’Neill is not a physician" is a fascinating sentence. It seems like it might be relevant that Susan Monarez has a PhD (dissertation: "Macrophage regulation by trypanosome GIP-SVSG during trypanosoma brucei rhodesiense infection ") while Jim O'Neill is a venture capitalist with an MA.
Breaking news: The White House selected Jim O’Neill, a top deputy to RFK Jr., to serve as acting head of the CDC after a clash over vaccine policy ended in the departure of several agency leaders.
White House taps top RFK Jr. deputy as acting CDC director
The decision comes a day after Trump fired Susan Monarez, the Senate-confirmed CDC director, prompting a series of resignations of other top officials there.
wapo.st
August 28, 2025 at 10:29 PM
"Like Monarez, O’Neill is not a physician" is a fascinating sentence. It seems like it might be relevant that Susan Monarez has a PhD (dissertation: "Macrophage regulation by trypanosome GIP-SVSG during trypanosoma brucei rhodesiense infection ") while Jim O'Neill is a venture capitalist with an MA.
Então menina você não sabe né o Trypanosoma cruzi entra no nosso corpo já falando "inhaí bicha" e o macrófago já no "quem é você??" e engole tudo (lá ele) mas aí o bicho faz um banheirão dentro da célula explode e sai invadindo tudo o sistema imune todo ficando acrílico com a situação
estagiário: "hoje eu tenho prova na faculdade né. daí eu coloquei todo o resumo que minha amiga me passou no chat gpt e pedir pra ele me explicar a matéria como se fosse uma fofoca. daí eu li e eu entendi. eu entendi a matéria da prova"
June 24, 2026 at 1:16 AM
Então menina você não sabe né o Trypanosoma cruzi entra no nosso corpo já falando "inhaí bicha" e o macrófago já no "quem é você??" e engole tudo (lá ele) mas aí o bicho faz um banheirão dentro da célula explode e sai invadindo tudo o sistema imune todo ficando acrílico com a situação
@marquescata.bsky.social @uofgsii.bsky.social presenting new findings on stable polyploid Trypanosoma brucei at @microbiologysociety.org #Eukaryotes25
September 12, 2025 at 4:41 PM
@marquescata.bsky.social @uofgsii.bsky.social presenting new findings on stable polyploid Trypanosoma brucei at @microbiologysociety.org #Eukaryotes25
@scotomorph.bsky.social @uofgsii.bsky.social presenting new insights into Trypanosoma congolense at #Eukaryotes25 @microbiologysociety.org
September 12, 2025 at 4:43 PM
@scotomorph.bsky.social @uofgsii.bsky.social presenting new insights into Trypanosoma congolense at #Eukaryotes25 @microbiologysociety.org
Flagellum structures of Trypanosoma parasite reveal how molecular motors drive the movement. Incredible back to back papers in Science by @alanbrownhms.bsky.social & @ruizhangmt.bsky.social, Hong Zhou & Kent Hill.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 14, 2025 at 1:49 AM
Flagellum structures of Trypanosoma parasite reveal how molecular motors drive the movement. Incredible back to back papers in Science by @alanbrownhms.bsky.social & @ruizhangmt.bsky.social, Hong Zhou & Kent Hill.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Trypanosoma cruzi
Protozoário name so fire I almost got doença de chagas
Protozoário name so fire I almost got doença de chagas
August 1, 2026 at 6:31 PM
Trypanosoma cruzi
Protozoário name so fire I almost got doença de chagas
Protozoário name so fire I almost got doença de chagas
Scientists tested how the body processes acoziborole, a potential single-dose cure for sleeping sickness. It’s well absorbed and slowly cleared via the gut. A step forward in the fight against this deadly neglected disease. ⤵️ journals.asm.org/doi/10.1128/...
Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans |...
Acoziborole (SCYX-7158) is a first-in-class oxaborole 6-carboxamide derivative active
against Trypanosoma brucei (T.b.) gambiense and rhodesiense, the parasites responsible for human African trypanoso...
journals.asm.org
September 30, 2025 at 9:10 AM
Scientists tested how the body processes acoziborole, a potential single-dose cure for sleeping sickness. It’s well absorbed and slowly cleared via the gut. A step forward in the fight against this deadly neglected disease. ⤵️ journals.asm.org/doi/10.1128/...
Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...
Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex - Nature Communications
Bernhard et al. reveal the architecture of the tetrameric Trypanosoma brucei nuclear cap-binding complex. Using cryo-electron microscopy and biochemical assays, the researchers characterize its bindin...
www.nature.com
January 21, 2025 at 10:14 AM
Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...
DAY 345
SPECIES 345 - Trypanosoma cruzi
MEDIUM: Arches Paper. Chromatek & QoR watercolor, Sakura pen
T. cruzi is a parasitic protozoan that causes Chagas disease, a potentially life threatening infection transmitted primarily by kissing bugs
#sciart #art #paint #protist #eukaryotic #protistsonsky
SPECIES 345 - Trypanosoma cruzi
MEDIUM: Arches Paper. Chromatek & QoR watercolor, Sakura pen
T. cruzi is a parasitic protozoan that causes Chagas disease, a potentially life threatening infection transmitted primarily by kissing bugs
#sciart #art #paint #protist #eukaryotic #protistsonsky
May 16, 2026 at 7:36 AM
DAY 345
SPECIES 345 - Trypanosoma cruzi
MEDIUM: Arches Paper. Chromatek & QoR watercolor, Sakura pen
T. cruzi is a parasitic protozoan that causes Chagas disease, a potentially life threatening infection transmitted primarily by kissing bugs
#sciart #art #paint #protist #eukaryotic #protistsonsky
SPECIES 345 - Trypanosoma cruzi
MEDIUM: Arches Paper. Chromatek & QoR watercolor, Sakura pen
T. cruzi is a parasitic protozoan that causes Chagas disease, a potentially life threatening infection transmitted primarily by kissing bugs
#sciart #art #paint #protist #eukaryotic #protistsonsky
Our collaboration with @mbonhivers.bsky.social is now out in @plosbiology.org! 🎉Using U-ExM, we mapped the formation of the flagellar pocket collar in T. brucei. Huge thanks to everyone involved — one step closer to #PhDone!
#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
October 10, 2025 at 6:47 PM
Our collaboration with @mbonhivers.bsky.social is now out in @plosbiology.org! 🎉Using U-ExM, we mapped the formation of the flagellar pocket collar in T. brucei. Huge thanks to everyone involved — one step closer to #PhDone!
#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
Nature research paper: DNA damage drives antigen diversification in Trypanosoma brucei
go.nature.com/3PQ8tZo
go.nature.com/3PQ8tZo
DNA damage drives antigen diversification in Trypanosoma brucei - Nature
An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.
go.nature.com
April 13, 2026 at 3:36 PM
Nature research paper: DNA damage drives antigen diversification in Trypanosoma brucei
go.nature.com/3PQ8tZo
go.nature.com/3PQ8tZo
Krasiļņikova assembled a T2T genome of Trypanosoma congolense, comparing it with T. brucei to reveal shared and divergent architecture, and provided preliminary evidence for differing strategies for antigenic variation via a common antigen
🔗 academic.oup.com/gbe/article/...
#societyjournal #genome
🔗 academic.oup.com/gbe/article/...
#societyjournal #genome
De Novo Assembly of the Trypanosoma congolense Genome Reveals an Organization Influenced by Antigenic Variation but Distinct from Trypanosoma brucei
Abstract. Antigenic variation allows pathogens to evade mammalian adaptive immunity through the continuous change in exposed antigens. In African trypanoso
academic.oup.com
September 8, 2026 at 11:45 AM
Krasiļņikova assembled a T2T genome of Trypanosoma congolense, comparing it with T. brucei to reveal shared and divergent architecture, and provided preliminary evidence for differing strategies for antigenic variation via a common antigen
🔗 academic.oup.com/gbe/article/...
#societyjournal #genome
🔗 academic.oup.com/gbe/article/...
#societyjournal #genome
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 6, 2025 at 3:36 PM
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
“In the heart of Illinois, while researching wildlife disease, I made a discovery that stunned me: More than half of the raccoons I sampled were infected with Trypanosoma cruzi, the parasite that causes Chagas’ disease… It’s here, in the United States, spreading silently in wildlife.”
A ‘tropical’ disease is spreading in American wildlife
This neglected tropical disease is no longer confined to the tropics. It’s here, in the United States, spreading silently in wildlife.
www.statnews.com
August 8, 2025 at 11:44 AM
“In the heart of Illinois, while researching wildlife disease, I made a discovery that stunned me: More than half of the raccoons I sampled were infected with Trypanosoma cruzi, the parasite that causes Chagas’ disease… It’s here, in the United States, spreading silently in wildlife.”
La bacterióloga Muriel Robertson (1883-1973) falleció un
14 de junio.
Investigó sobre el Trypanosoma gambiense, el parásito que causa la enfermedad del sueño.
14 de junio.
Investigó sobre el Trypanosoma gambiense, el parásito que causa la enfermedad del sueño.
Muriel Robertson, bacterióloga - Mujeres con ciencia
Muriel Robertson. Bacteriología. Protozoología. Trypanosoma gambiense. Enfermedad del sueño. Clostridium perfringens. Gangrena.
mujeresconciencia.com
June 14, 2025 at 11:07 AM
La bacterióloga Muriel Robertson (1883-1973) falleció un
14 de junio.
Investigó sobre el Trypanosoma gambiense, el parásito que causa la enfermedad del sueño.
14 de junio.
Investigó sobre el Trypanosoma gambiense, el parásito que causa la enfermedad del sueño.
🧪 Trypanosoma evansi infection in Tunisia: current situation
Infection à Trypanosoma evansi en Tunisie : situation actuelle
مرض الدباب (الجُفَار) في تونس: الوضع الراهن
doi.org/10.1051/para...
Infection à Trypanosoma evansi en Tunisie : situation actuelle
مرض الدباب (الجُفَار) في تونس: الوضع الراهن
doi.org/10.1051/para...
October 9, 2025 at 1:10 PM
🧪 Trypanosoma evansi infection in Tunisia: current situation
Infection à Trypanosoma evansi en Tunisie : situation actuelle
مرض الدباب (الجُفَار) في تونس: الوضع الراهن
doi.org/10.1051/para...
Infection à Trypanosoma evansi en Tunisie : situation actuelle
مرض الدباب (الجُفَار) في تونس: الوضع الراهن
doi.org/10.1051/para...
Don't respect the hard work. Respect the expertise.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
August 30, 2025 at 9:23 PM
Don't respect the hard work. Respect the expertise.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
Monarez has microbiology&immunology PhD
Her research prevents, diagnoses, & treats infectious diseases (trypanosome GIP-sVSG regulation of macrophages during Trypanosoma brucei rhodesiense infection).
Calling her Ms. denies the science.
Here's a short summary of our most recent paper, published today on @commsbio.bsky.social:
We want to understand how Trypanosoma congolense cytoadheres, or sequesters, to the vascular endothelium because sequestration determines clinical outcome and disease severity.
(1/7)
We want to understand how Trypanosoma congolense cytoadheres, or sequesters, to the vascular endothelium because sequestration determines clinical outcome and disease severity.
(1/7)
Bioengineered 3D microvessels and complementary animal models reveal mechanisms of Trypanosoma congolense sequestration
Communications Biology - Organ-specific bioengineered microvessels and animal models reveal that Trypanosoma congolense sequestration depends on the endothelial cell bed, parasite strain, cyclic...
rdcu.be
February 27, 2025 at 9:53 AM
Here's a short summary of our most recent paper, published today on @commsbio.bsky.social:
We want to understand how Trypanosoma congolense cytoadheres, or sequesters, to the vascular endothelium because sequestration determines clinical outcome and disease severity.
(1/7)
We want to understand how Trypanosoma congolense cytoadheres, or sequesters, to the vascular endothelium because sequestration determines clinical outcome and disease severity.
(1/7)
How do you interpret a positive test that has 99.98% specificity?
With caution if you screen lots of low risk individuals.
49 of 89k military 🩸 donors screened ➕ for T cruzi antibodies.
0 met diagnostic criteria for Chagas’ disease
#IDSky
academic.oup.com/ofid/advance...
With caution if you screen lots of low risk individuals.
49 of 89k military 🩸 donors screened ➕ for T cruzi antibodies.
0 met diagnostic criteria for Chagas’ disease
#IDSky
academic.oup.com/ofid/advance...
Outcomes of Military Blood Donors at Joint Base San Antonio with Reactive Trypanosoma cruzi Antibody Screening
AbstractBackground. Blood donors in the United States are universally screened once for Trypanosoma cruzi antibodies to prevent transfusion-transmitted Cha
academic.oup.com
August 30, 2025 at 9:48 PM
How do you interpret a positive test that has 99.98% specificity?
With caution if you screen lots of low risk individuals.
49 of 89k military 🩸 donors screened ➕ for T cruzi antibodies.
0 met diagnostic criteria for Chagas’ disease
#IDSky
academic.oup.com/ofid/advance...
With caution if you screen lots of low risk individuals.
49 of 89k military 🩸 donors screened ➕ for T cruzi antibodies.
0 met diagnostic criteria for Chagas’ disease
#IDSky
academic.oup.com/ofid/advance...