Forget Die Hard vancomycin is a Christmas antibiotic
December 14, 2024 at 12:18 AM
Forget Die Hard vancomycin is a Christmas antibiotic
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology
Genomic and functional analyses of healthcare-associated vancomycin-resistant Enterococcus faecium reveal that bacteriocin T8 is enriched in emergent lineages and provides a competitive advantage in v...
www.nature.com
March 21, 2025 at 1:46 PM
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
you don’t have gram positive cocci growing in your blood stream, your body is just starving for vancomycin
September 20, 2025 at 3:35 PM
you don’t have gram positive cocci growing in your blood stream, your body is just starving for vancomycin
Routine Therapeutic Drug Monitoring Works As Intended; Patient Healthy Without Complications
gonna start breathlessly pitching the Times every time a patient’s vancomycin level comes back with an AUC of 637
gonna start breathlessly pitching the Times every time a patient’s vancomycin level comes back with an AUC of 637
Shocking twist, there is actually some debate about whether the testosterone dose was too high. Overall the kid seems to be doing better with it than without it.
There is literally no story here other than "Father Objects To Son's Happiness."
www.judiciary.uk/wp-content/u...
There is literally no story here other than "Father Objects To Son's Happiness."
www.judiciary.uk/wp-content/u...
December 11, 2025 at 10:54 PM
Routine Therapeutic Drug Monitoring Works As Intended; Patient Healthy Without Complications
gonna start breathlessly pitching the Times every time a patient’s vancomycin level comes back with an AUC of 637
gonna start breathlessly pitching the Times every time a patient’s vancomycin level comes back with an AUC of 637
Estimating GFR from Vancomycin clearance, the mGFR that’s hiding in plane sight
pbfluids.com/2025/08/esti...
pbfluids.com/2025/08/esti...
Estimating GFR with Vancomycin, the measured GFR that’s sitting right in front of us
Vancomycin clearance can approximate GFR offering an alternative to eGFR formulas for estimating kidney function
pbfluids.com
August 3, 2025 at 3:05 PM
Estimating GFR from Vancomycin clearance, the mGFR that’s hiding in plane sight
pbfluids.com/2025/08/esti...
pbfluids.com/2025/08/esti...
peptide antibiotics are made by bacteria and fungi through specialized enzyme systems. These peptides, such as penicillin and vancomycin, effectively treat infections by targeting specific bacterial functions. A newer category, called ribosomally synthesized and post-translationally modified
March 31, 2025 at 4:04 PM
peptide antibiotics are made by bacteria and fungi through specialized enzyme systems. These peptides, such as penicillin and vancomycin, effectively treat infections by targeting specific bacterial functions. A newer category, called ribosomally synthesized and post-translationally modified
Theory: Andrew got handsy and Kate had had ENOUGH so she put her fist right through his ribcage but cut her hand and now she has like eight diseases and she’s in a full-body tank of Vancomycin while the Palace tries to arrange for Andrew to be found in the wreckage of a yacht or something
March 12, 2024 at 1:00 AM
Theory: Andrew got handsy and Kate had had ENOUGH so she put her fist right through his ribcage but cut her hand and now she has like eight diseases and she’s in a full-body tank of Vancomycin while the Palace tries to arrange for Andrew to be found in the wreckage of a yacht or something
Chemists have found that attaching a small quinoline group to vancomycin lets it slip inside the bacteria and reach its target. cen.acs.org/pharmaceutic... #chemsky 🧪
Quinoline tag helps vancomycin breach gram-negative defenses
The work reveals how tiny structural shifts can deliver outsize biological effects
cen.acs.org
December 9, 2025 at 8:35 PM
Chemists have found that attaching a small quinoline group to vancomycin lets it slip inside the bacteria and reach its target. cen.acs.org/pharmaceutic... #chemsky 🧪
So excited to share a new paper from my lab just published in Nature Communications! We showed that vancomycin-resistant enterococci (VRE) occupied distinct intestinal niches in the antibiotic-treated intestine. doi.org/10.1038/s414... Amazing work by first author Olivia King and colleagues!
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation - Nature Communications
Here, the authors show that vancomycin-resistant enterococci grow in the antibiotic-treated gut microbiome by utilising enriched nutrients in the presence of reduced concentrations of inhibitory micro...
doi.org
July 14, 2025 at 9:11 AM
So excited to share a new paper from my lab just published in Nature Communications! We showed that vancomycin-resistant enterococci (VRE) occupied distinct intestinal niches in the antibiotic-treated intestine. doi.org/10.1038/s414... Amazing work by first author Olivia King and colleagues!
This rare autoimmune dermatosis can also be triggered by vancomycin use. I have seen two cases.
www.nejm.org/doi/abs/10.1...
www.nejm.org/doi/abs/10.1...
March 7, 2025 at 2:57 PM
This rare autoimmune dermatosis can also be triggered by vancomycin use. I have seen two cases.
www.nejm.org/doi/abs/10.1...
www.nejm.org/doi/abs/10.1...
One patient, two samples
Weeks apart, E. faecium picked up vancomycin resistance
By sequencing vancomycin-susceptible strains on-site, we caught this early & avoided unnecessary, disruptive interventions #Genomics
Proud to share at #nanoporeconf!
@nanoporetech.com
🖥️🧬💻
#AcademicSky
#MicroSky
🧪🧫🦠
Weeks apart, E. faecium picked up vancomycin resistance
By sequencing vancomycin-susceptible strains on-site, we caught this early & avoided unnecessary, disruptive interventions #Genomics
Proud to share at #nanoporeconf!
@nanoporetech.com
🖥️🧬💻
#AcademicSky
#MicroSky
🧪🧫🦠
May 21, 2025 at 5:27 AM
One patient, two samples
Weeks apart, E. faecium picked up vancomycin resistance
By sequencing vancomycin-susceptible strains on-site, we caught this early & avoided unnecessary, disruptive interventions #Genomics
Proud to share at #nanoporeconf!
@nanoporetech.com
🖥️🧬💻
#AcademicSky
#MicroSky
🧪🧫🦠
Weeks apart, E. faecium picked up vancomycin resistance
By sequencing vancomycin-susceptible strains on-site, we caught this early & avoided unnecessary, disruptive interventions #Genomics
Proud to share at #nanoporeconf!
@nanoporetech.com
🖥️🧬💻
#AcademicSky
#MicroSky
🧪🧫🦠
BABY HAS HER VANCOMYCIN AGAIN. FUCK OFF C DIFF FOR REAL THIS TIME YOU TWATWAFFLE 💪🏼💪🏼💪🏼💪🏼💊💊💊
August 7, 2026 at 10:38 PM
BABY HAS HER VANCOMYCIN AGAIN. FUCK OFF C DIFF FOR REAL THIS TIME YOU TWATWAFFLE 💪🏼💪🏼💪🏼💪🏼💊💊💊
New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile
The glycopeptide antibiotic vancomycin is the frontline treatment for C. difficile infection in the UK. There have been only sporadic reports of resistance in the clinic but testing is rare so the tru...
www.biorxiv.org
August 22, 2025 at 9:39 AM
New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
#OTILT In patients with recurrent C.Diff infection, treatment using a Vancomycin taper showed more sustained symptom resolution compared to a standard vancomycin course.
@bwdionne.bsky.social
@jeffpears0n.bsky.social
@amychun.bsky.social
academic.oup.com/ofid/article...
@bwdionne.bsky.social
@jeffpears0n.bsky.social
@amychun.bsky.social
academic.oup.com/ofid/article...
548. A Randomized, Double-blind, Controlled Trial of Vancomycin Taper/Pulse and Fidaxomicin compared to Vancomycin for Treatment of a First or Second Recurrence of Clostridioides difficile Infection
AbstractBackground. Vancomycin taper followed by pulse and fidaxomicin are two common treatments for recurrent C. difficile infection (rCDI) but they have
academic.oup.com
September 22, 2026 at 4:24 PM
#OTILT In patients with recurrent C.Diff infection, treatment using a Vancomycin taper showed more sustained symptom resolution compared to a standard vancomycin course.
@bwdionne.bsky.social
@jeffpears0n.bsky.social
@amychun.bsky.social
academic.oup.com/ofid/article...
@bwdionne.bsky.social
@jeffpears0n.bsky.social
@amychun.bsky.social
academic.oup.com/ofid/article...
just organically saw a post with a league of legends ship name that i clocked as referring to vancomycin, the med
September 19, 2026 at 4:51 PM
just organically saw a post with a league of legends ship name that i clocked as referring to vancomycin, the med
Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation - Nature Communications
Here, the authors show that vancomycin-resistant enterococci grow in the antibiotic-treated gut microbiome by utilising enriched nutrients in the presence of reduced concentrations of inhibitory micro...
www.nature.com
July 11, 2025 at 1:08 PM
Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
🔥Just published 🔥
TAPER-V RCT
In this RCT of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to a standard 2-week pulse regimen in patients a first episode or first recurrence of CDI
Vanco for 10d is obsolete! #IDSky #EMIMCC
jamanetwork.com/journals/jam...
TAPER-V RCT
In this RCT of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to a standard 2-week pulse regimen in patients a first episode or first recurrence of CDI
Vanco for 10d is obsolete! #IDSky #EMIMCC
jamanetwork.com/journals/jam...
Initial Vancomycin Taper for the Prevention of Recurrent C difficile Infection
This randomized clinical trial tested whether a 4-week pulse and taper vancomycin regimen was superior to a 2-week pulse regimen for preventing recurrence among patients with a first episode or first ...
jamanetwork.com
February 27, 2026 at 4:17 PM
🔥Just published 🔥
TAPER-V RCT
In this RCT of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to a standard 2-week pulse regimen in patients a first episode or first recurrence of CDI
Vanco for 10d is obsolete! #IDSky #EMIMCC
jamanetwork.com/journals/jam...
TAPER-V RCT
In this RCT of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to a standard 2-week pulse regimen in patients a first episode or first recurrence of CDI
Vanco for 10d is obsolete! #IDSky #EMIMCC
jamanetwork.com/journals/jam...
TikTok just showed me a clip of a medical show and a woman with an anaphylactic vancomycin allergy has MRSA bacteremia but linezolid is on backorder so they’re giving vancomycin anyways
ah yes, the only two antibiotics
ah yes, the only two antibiotics
November 1, 2025 at 4:46 PM
TikTok just showed me a clip of a medical show and a woman with an anaphylactic vancomycin allergy has MRSA bacteremia but linezolid is on backorder so they’re giving vancomycin anyways
ah yes, the only two antibiotics
ah yes, the only two antibiotics
Impact of VRE-active perioperative prophylaxis in liver transplant patients colonized by Vancomycin-Resistant Enterococci
VRE infections often complicate liver transplants. Does screening & 🎯 peri-op ppx help?
This multicenter, retrospect. study suggests no
academic.oup.com/cid/advance-... #TxID
VRE infections often complicate liver transplants. Does screening & 🎯 peri-op ppx help?
This multicenter, retrospect. study suggests no
academic.oup.com/cid/advance-... #TxID
Impact of VRE-active perioperative prophylaxis in liver transplant patients colonized by Vancomycin-Resistant Enterococci
Active prophylaxis targeting vancomycin-resistant Enterococci (VRE) did not reduce early VRE infections after liver transplantation (LT) in VRE-colonized p
academic.oup.com
March 17, 2025 at 12:40 PM
Impact of VRE-active perioperative prophylaxis in liver transplant patients colonized by Vancomycin-Resistant Enterococci
VRE infections often complicate liver transplants. Does screening & 🎯 peri-op ppx help?
This multicenter, retrospect. study suggests no
academic.oup.com/cid/advance-... #TxID
VRE infections often complicate liver transplants. Does screening & 🎯 peri-op ppx help?
This multicenter, retrospect. study suggests no
academic.oup.com/cid/advance-... #TxID
🆕💫Small Retrospective matched cohort study #JAC
Ceftaroline was not associated with improved outcomes compared to vancomycin when given as initial treatment for MRSA bacteraemia #idsky
academic.oup.com/jac/advance-...
Ceftaroline was not associated with improved outcomes compared to vancomycin when given as initial treatment for MRSA bacteraemia #idsky
academic.oup.com/jac/advance-...
Ceftaroline versus vancomycin for methicillin-resistant Staphylococcus aureus bacteraemia, a matched cohort study
AbstractBackground. Vancomycin remains the treatment-of-choice in MRSA bacteraemia (MRSAB) despite significant limitations.Objective. To compare the effect
academic.oup.com
January 28, 2025 at 1:19 PM
🆕💫Small Retrospective matched cohort study #JAC
Ceftaroline was not associated with improved outcomes compared to vancomycin when given as initial treatment for MRSA bacteraemia #idsky
academic.oup.com/jac/advance-...
Ceftaroline was not associated with improved outcomes compared to vancomycin when given as initial treatment for MRSA bacteraemia #idsky
academic.oup.com/jac/advance-...
Patient with acute kidney injury following vancomycin treatment for pyelonephritis. Numerous unusual casts (no LC restriction, myo/hemoglobin and chromo negative). EM shows mixture of uromodulin protein and precipitate. C/W vancomycin cast nephropathy. #renalpath #pathsky #nephsky
January 8, 2025 at 1:46 PM
Patient with acute kidney injury following vancomycin treatment for pyelonephritis. Numerous unusual casts (no LC restriction, myo/hemoglobin and chromo negative). EM shows mixture of uromodulin protein and precipitate. C/W vancomycin cast nephropathy. #renalpath #pathsky #nephsky
my antibiotic summer: erythromycin, augmentin, bactrim, vancomycin, neomycin, polymyxin, azithromycin
August 27, 2024 at 9:58 PM
my antibiotic summer: erythromycin, augmentin, bactrim, vancomycin, neomycin, polymyxin, azithromycin
See also dosing vancomycin
It’s hard to moderate the rage. Too little feels like willful ignorance. Too much feels corrosive.
February 4, 2025 at 3:15 AM
See also dosing vancomycin