Cesar Valades-Cruz
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cessvala.bsky.social
Cesar Valades-Cruz
@cessvala.bsky.social
47 followers 98 following 11 posts
BioImage Analyst • Associate Researcher at Institute of Hydrobiology, Chinese Academy of Sciences

https://cessvala.github.io/
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cessvala.bsky.social
Happy to share 4polar3D #SMOLM @natcomms.nature.com! Great collab with S. Brasselet, @charitra.bsky.social,M. Sison, @agvesga.bsky.social,J. Rey-Barroso,V. Curcio,L. Alemán-Castañeda,M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis @institutfresnel.bsky.social @france-bioimaging.bsky.social CAS
4polar3D single molecule imaging of 3D orientation in dense actin networks using ratiometric polarization splitting - Nature Communications
This article presents a method capable of imaging the 3D orientation and lateral positions of fluorescent single-molecule labels in cells. It is applied to the 3D organization of actin filaments withi...
www.nature.com
May 13, 2026 at 6:42 AM
cessvala.bsky.social
Amazing work from our lab at the Institute of Hydrobiology, CAS! 🎉 Congrats to Q. Sun and all coauthors! 👏 Work led by Prof. Zhang Cheng-Cai and Dr. Zeng Xiaoli 🔬 @plosbiology.org #cyanobacteria #microbiology
plosbiology.org PLOS Biology @plosbiology.org · Apr 10
Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @plosbiology.org 🧪 plos.io/3QubUVG
Top: Micrographs of Anabaena filaments of WT, ΔcdgSpICT-all1219 strains (left), and Δ8DGC-1 strain (right) cultured in BG11 medium with (+) or without (−) Cu2+ and theophylline at the indicated time points. Scale bars represent 15 µm. Bottom: Schematic of the proposed dual-threshold c-di-GMP regulatory system that governs cell growth and survival in Anabaena.
April 13, 2026 at 5:32 AM
cessvala.bsky.social
A nice perspective article led by Prof. Cheng-Cai Zhang, Prof. Wei Miao & Prof. Kaiyao Huang from IHB, CAS, on the shift from “gene editing” to “cell editing.” 🧬 Published in The Innovation Life, it highlights how synthetic biology may move beyond DNA editing toward engineering cellular systems. 🔬📖
theinnovation.bsky.social The Innovation @theinnovation.bsky.social · Mar 13
Deng et al. propose cell editing—a technology inspired by endosymbiosis—for implementing complex functions into a host chassis that are currently difficult or impossible to achieve.
doi.org/10.59717/j.x...
#LifeSciences #syntheticbiology #cellediting #biotechnology
March 23, 2026 at 7:56 AM
cessvala.bsky.social
Happy to contribute to the analysis of α5β1 integrin using @the.3i.social LLSM
@natcomms.nature.com

rdcu.be/eNeNh

@ludovicleconte.bsky.social M. Shafaq-Zadah @christianwunder.bsky.social J. Salamero, Johannes team
@institutcurie.bsky.social #inria @france-bioimaging.bsky.social @inserm.fr @cnrs.fr
October 29, 2025 at 8:39 AM
cessvala.bsky.social
Great work from our lab (Zhang Cheng-Cai’s group at IHB-CAS) uncovering how carbon metabolism shapes FtsZ levels and cell division in Anabaena PCC 7120. Communications Biology @commsbio.nature.com :
www.nature.com/articles/s42...
October 14, 2025 at 7:13 AM
cessvala.bsky.social
Very interesting paper from our lab (Zhang Cheng-Cai’s group at IHB-CAS)! Functional dissection of the CRP-family transcription factor DevH and its interplay with NtcA in a cyanobacterium. Published in Cell Reports (@cp-cellreports.bsky.social)
www.cell.com/cell-reports...
Functional dissection of the CRP-family transcription factor DevH and its interplay with NtcA in a cyanobacterium
Xu et al. uncovered how duplicated transcription factors DevH and NtcA achieve functional specialization in Anabaena. Unlike NtcA, DevH operates at higher cellular levels with broader regulatory capac...
www.cell.com
October 14, 2025 at 7:11 AM
cessvala.bsky.social
Great review by S. Brasselet & M.D. Lew in @natphoton.nature.com on single-molecule orientation & localization microscopy ( #SMOLM ). These methods resolve both the 3D position of single molecules and their orientation/wobble.
@institutfresnel.bsky.social @lewlab.com

www.nature.com/articles/s41...
Single-molecule orientation and localization microscopy - Nature Photonics
The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.
www.nature.com
September 10, 2025 at 8:08 AM
cessvala.bsky.social
Happy to share our work on polarized super-res imaging: 4polar3D in bioRxiv!

Great collab with S. Brasselet, @charitra.bsky.social , M. Sison, @agvesga.bsky.social , J. Rey-Barroso, V. Curcio, L. Alemán-Castañeda, M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis
www.biorxiv.org/content/10.1...
July 19, 2025 at 1:56 PM
Reposted by Cesar Valades-Cruz
spirochrome.com
Highly impressive LLSM imaging of PKmito Orange stained cells using DeepCristae, a newly published mitochondrial cristae restoration convolutional neural network.

PKMito Orange: spirochrome.com/product/pkmi...

Source Article: doi.org/10.1038/s420...

Happy #FluorescenceFriday
February 28, 2025 at 9:54 AM
Reposted by Cesar Valades-Cruz
lreymond.bsky.social
That's some badass 4D imaging!
🧪
spirochrome.com Spirochrome @spirochrome.com · Feb 28
Highly impressive LLSM imaging of PKmito Orange stained cells using DeepCristae, a newly published mitochondrial cristae restoration convolutional neural network.

PKMito Orange: spirochrome.com/product/pkmi...

Source Article: doi.org/10.1038/s420...

Happy #FluorescenceFriday
February 28, 2025 at 10:05 AM
Reposted by Cesar Valades-Cruz
ludovicleconte.bsky.social
Excited to announce our new paper: DeepCristae, a CNN for the restoration of mitochondria cristae
@commsbio.bsky.social
@cessvala.bsky.social, S. Papereux, @JeanSalamero, C. Kervrann, A. Badoual
@the.3i.social @PKU1898 @france-bioimaging.bsky.social @Inria_Rennes @PKU1898
February 28, 2025 at 1:59 PM
cessvala.bsky.social
Happy to share DeepCristae😀, a CNN for mitochondria restoration, now in @commsbio.bsky.social y.social

rdcu.be/ebrAQ

S.Papereux, @ludovicleconte.bsky.social, @zhixingchen2.bsky.social, J.Salamero, C.Kervrann, A.Badoual
@the.3i.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social
February 28, 2025 at 12:13 AM
Reposted by Cesar Valades-Cruz
france-bioimaging.bsky.social
Congratulations, Cesar, on your publication! 👏

Discover Cesar’s research on Lattice Light Sheet imaging and image analysis, conducted in collaboration with Ludger Johannes’ team at Institut Curie ⤵️
February 26, 2025 at 1:47 PM
Reposted by Cesar Valades-Cruz
aforrester.bsky.social
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
February 23, 2025 at 1:03 PM
Reposted by Cesar Valades-Cruz
christianwunder.bsky.social
Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis.

=> A proton pump driven glycoswitch @naturecellbiology.bsky.social :

rdcu.be/eaLM9

#glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
"Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis" An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.
February 22, 2025 at 10:31 PM
cessvala.bsky.social
February 22, 2025 at 10:58 AM
cessvala.bsky.social
Happy to contribute to the analysis of β1integrin endocytosis using @the.3i.social LLSM, now in @naturecellbiology.bsky.social
rdcu.be/eaLM9
L. Leconte @christianwunder.bsky.social @aforrester.bsky.social @ewanmacdonald.bsky.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social
February 22, 2025 at 9:01 AM
Reposted by Cesar Valades-Cruz
christlet.bsky.social
Some microscopy reading 🔬📰 Single-molecule orientation-localization microscopy: Applications and approaches www.cambridge.org/core/journal...
Single-molecule orientation-localization microscopy: Applications and approaches | Quarterly Reviews of Biophysics | Cambridge Core
Single-molecule orientation-localization microscopy: Applications and approaches - Volume 57
www.cambridge.org
December 23, 2024 at 3:15 PM