Höfer Lab
@hoeferlab.bsky.social
The Höfer lab studies the epitranscriptomic mechanisms of gene regulation based on NAD-capped RNAs in bacteria and bacteriophages. We are located at Marburg University and a member of SYNMIKRO.
Reposted by Höfer Lab
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social !
Deadline: Jan 6, 2027. #Bacdiv27
Deadline: Jan 6, 2027. #Bacdiv27
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027.
Deadline: 6 January 2027
https://meetings.embo.org/event/27-cell-division
#EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪
Deadline: 6 January 2027
https://meetings.embo.org/event/27-cell-division
#EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪
August 25, 2026 at 6:18 AM
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social !
Deadline: Jan 6, 2027. #Bacdiv27
Deadline: Jan 6, 2027. #Bacdiv27
Reposted by Höfer Lab
First up, our keynote speaker Katharina Höfer, wo recently moved to the Leibniz Institute for Immunotherapy in Regensburg. She talks about covalent RNA-Protein networks and their role in phage infection
#Infect-Net #RNA #NAD-RNA #Phages
#Infect-Net #RNA #NAD-RNA #Phages
September 22, 2026 at 11:15 AM
First up, our keynote speaker Katharina Höfer, wo recently moved to the Leibniz Institute for Immunotherapy in Regensburg. She talks about covalent RNA-Protein networks and their role in phage infection
#Infect-Net #RNA #NAD-RNA #Phages
#Infect-Net #RNA #NAD-RNA #Phages
Reposted by Höfer Lab
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪
This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️
Questions? Please reach out! 👩🔬👨🔬
This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️
Questions? Please reach out! 👩🔬👨🔬
New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes.
Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...
Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...
Assistant/Associate Professor in Climate Biophysics
www.biozentrum.unibas.ch
July 3, 2026 at 12:28 AM
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪
This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️
Questions? Please reach out! 👩🔬👨🔬
This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️
Questions? Please reach out! 👩🔬👨🔬
Reposted by Höfer Lab
📢 (1/2) Excited to share the first preprint from my PostDoc! We developed UbSeRP to map co-translational ubiquitination in a translatome-wide, revealing thousands of quality control sites, and how they reshape with aging. www.biorxiv.org/content/10.6... #proteostasis #ribosomes #preprint
Ubiquitin selective ribosome profiling reveals systematic principles of co-translational quality control
Protein biogenesis is a stress- and error-sensitive process that can lead to nascent protein misfolding and aggregation, challenging cellular proteostasis. Co-translational ubiquitination (CTU) is a c...
www.biorxiv.org
June 19, 2026 at 4:47 PM
📢 (1/2) Excited to share the first preprint from my PostDoc! We developed UbSeRP to map co-translational ubiquitination in a translatome-wide, revealing thousands of quality control sites, and how they reshape with aging. www.biorxiv.org/content/10.6... #proteostasis #ribosomes #preprint
Reposted by Höfer Lab
Excited to share the first preprint from the lab! We show that ApeA defends against RNA phage infection by cleaving the phage genome:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 21, 2026 at 5:18 PM
Excited to share the first preprint from the lab! We show that ApeA defends against RNA phage infection by cleaving the phage genome:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Höfer Lab
Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!
We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.
Details & application 👇
Our RNA community in @uniregensburg.bsky.social is set to grow!
We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.
Details & application 👇
March 4, 2026 at 12:21 PM
Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!
We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.
Details & application 👇
Our RNA community in @uniregensburg.bsky.social is set to grow!
We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.
Details & application 👇
Reposted by Höfer Lab
This shows that "abortive infection" phenotypes are not neccessarily in all cases a "last line" of defense, but may be the consequence of mechanisms interferring with early steps in the phage life cycle.
We further show synergy of daunorubicin with RM systems targeting the FST region T5 phages.
We further show synergy of daunorubicin with RM systems targeting the FST region T5 phages.
January 14, 2026 at 8:57 AM
This shows that "abortive infection" phenotypes are not neccessarily in all cases a "last line" of defense, but may be the consequence of mechanisms interferring with early steps in the phage life cycle.
We further show synergy of daunorubicin with RM systems targeting the FST region T5 phages.
We further show synergy of daunorubicin with RM systems targeting the FST region T5 phages.
👇 - #phage
🔬 We're back! Kicking off 2026 with the
23. Industry Academia Panel:
📅 Jan 15, 2026, 4:00 PM CET
💻 Online via Zoom
🦠 Topic "New class of bacteriophage-based antibacterial solutions"
Register: t1p.de/rqk1z
Looking forward to seeing you there! 🎉
#Microbiology #PhageTherapy #VAAM #AMR
23. Industry Academia Panel:
📅 Jan 15, 2026, 4:00 PM CET
💻 Online via Zoom
🦠 Topic "New class of bacteriophage-based antibacterial solutions"
Register: t1p.de/rqk1z
Looking forward to seeing you there! 🎉
#Microbiology #PhageTherapy #VAAM #AMR
January 13, 2026 at 9:34 AM
👇 - #phage
Reposted by Höfer Lab
🚨We are looking for a coordinator located at @uni-wuerzburg.de for our new excellence cluster NUCLEATE - Cluster of Nucleic Acid Sciences and Technologies 👇
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026
www.uni-wuerzburg.de
January 8, 2026 at 1:08 PM
🚨We are looking for a coordinator located at @uni-wuerzburg.de for our new excellence cluster NUCLEATE - Cluster of Nucleic Acid Sciences and Technologies 👇
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026
Reposted by Höfer Lab
Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳:
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
November 18, 2025 at 11:05 AM
Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳:
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
Reposted by Höfer Lab
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
November 15, 2025 at 3:38 PM
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
Reposted by Höfer Lab
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
www.fz-juelich.de
October 8, 2025 at 6:50 AM
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
Reposted by Höfer Lab
Many thanks to Katharina Höfer @hoeferlab.bsky.social for giving an inspiring presentation about RNAylation at our annual "Early-Career Microbiologists Symposium" @johninnescentre.bsky.social. Many thanks also to #EMBO @embo.org for supporting this "Young Investigator Seminar".
September 16, 2025 at 6:45 AM
Many thanks to Katharina Höfer @hoeferlab.bsky.social for giving an inspiring presentation about RNAylation at our annual "Early-Career Microbiologists Symposium" @johninnescentre.bsky.social. Many thanks also to #EMBO @embo.org for supporting this "Young Investigator Seminar".
Reposted by Höfer Lab
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
The advent of system-wide proteomic approaches has largely expanded the number of
RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming
our understanding of biolog...
www.cell.com
September 5, 2025 at 3:49 PM
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Höfer Lab
This demanding fieldwork is coming to an end – we are excited to dig into the collected samples and data!
Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...
#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social
Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...
#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social
August 18, 2025 at 11:21 AM
This demanding fieldwork is coming to an end – we are excited to dig into the collected samples and data!
Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...
#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social
Learn more about the research behind the fieldwork here:
mpi-bremen.de/en/Max-Planc...
#CAPSOLUTION @fischerlab.bsky.social @sumayrasultanji.bsky.social @hoeferlab.bsky.social
Reposted by Höfer Lab
Lac de Louvie (2213 m elevation) was an incredibly stunning place to sample for microbes! Many thanks to altis.swiss for letting us use their maintenance cable car :)
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social
August 12, 2025 at 7:34 PM
Lac de Louvie (2213 m elevation) was an incredibly stunning place to sample for microbes! Many thanks to altis.swiss for letting us use their maintenance cable car :)
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social
#CAPSOLUTION
@mpimarinemicrobio.bsky.social
@erc.europa.eu
@hoeferlab.bsky.social
@maxemilschon.bsky.social
Reposted by Höfer Lab
Switzerland welcomed us with summer weather and beautiful mountains! We started with the Lac de Champex (1467 m) which is influenced by human activity, and then hiked up to the Lacs de Fenêtre (2465 m) the next day.
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social
August 10, 2025 at 3:07 PM
Switzerland welcomed us with summer weather and beautiful mountains! We started with the Lac de Champex (1467 m) which is influenced by human activity, and then hiked up to the Lacs de Fenêtre (2465 m) the next day.
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social
#CAPSOLUTION
@mpimarinemicrobio.bsky.social @erc.europa.eu @hoeferlab.bsky.social
Reposted by Höfer Lab
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
July 14, 2025 at 12:10 PM
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
Reposted by Höfer Lab
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:01 AM
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
Reposted by Höfer Lab
Excited about #ubiquitin and #TPD ?
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...
June 25, 2025 at 9:08 PM
Excited about #ubiquitin and #TPD ?
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...
Reposted by Höfer Lab
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
June 19, 2025 at 8:10 AM
Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵
Reposted by Höfer Lab
Presenting RISoTTo, a molecular context-aware model for RNA sequence design, building on our work with PeSTo (for protein binding interface prediction) and CARBonAra (for protein design).
📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!
#RNAdesign #RNAbiology #AI4Science
📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!
#RNAdesign #RNAbiology #AI4Science
www.biorxiv.org
June 22, 2025 at 9:02 AM
Presenting RISoTTo, a molecular context-aware model for RNA sequence design, building on our work with PeSTo (for protein binding interface prediction) and CARBonAra (for protein design).
📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!
#RNAdesign #RNAbiology #AI4Science
📄 Preprint: www.biorxiv.org/content/10.1...
💻 Code & more coming soon!
#RNAdesign #RNAbiology #AI4Science
Reposted by Höfer Lab
I'm excited to share our new review in Current Opinion in Microbiology: “A solution to the post‑antibiotic era: phages as precision medicine.”
Here, we explore how engineered bacteriophages could be the next generation of anti-bacterials!
Here, we explore how engineered bacteriophages could be the next generation of anti-bacterials!
A solution to the postantibiotic era: phages as precision medicine
Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics th…
www.sciencedirect.com
June 12, 2025 at 12:34 PM
Reposted by Höfer Lab
🔛LOEWE-RobuCop ist online, auch bei proloewe.de !🎯 Ziel von RobuCop @unimarburg.bsky.social ist es, die natürlich Mechanismen d. CO2-Fixierung, Stressantwort-+Resilienz-Mechanismen im Chloroplasten grundleg. zu🔬untersuchen, um robuste Photosynthese zu ermöglichen.
➡️ proloewe.de/de/loewe-vor...
➡️ proloewe.de/de/loewe-vor...
June 10, 2025 at 8:05 AM
🔛LOEWE-RobuCop ist online, auch bei proloewe.de !🎯 Ziel von RobuCop @unimarburg.bsky.social ist es, die natürlich Mechanismen d. CO2-Fixierung, Stressantwort-+Resilienz-Mechanismen im Chloroplasten grundleg. zu🔬untersuchen, um robuste Photosynthese zu ermöglichen.
➡️ proloewe.de/de/loewe-vor...
➡️ proloewe.de/de/loewe-vor...