Jay Hinton
@jayhinton.bsky.social
Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.
Reposted by Jay Hinton
Happy to share that @averynoonan.bsky.social paper “Phylogeny-agnostic strain-level prediction of phage–host interactions from genomes using machine learning”
is now published in @natmicrobiol.nature.com 🎉🎊
👉🏽 rdcu.be/nR2NizD7H5va
is now published in @natmicrobiol.nature.com 🎉🎊
👉🏽 rdcu.be/nR2NizD7H5va
September 29, 2026 at 1:47 PM
Happy to share that @averynoonan.bsky.social paper “Phylogeny-agnostic strain-level prediction of phage–host interactions from genomes using machine learning”
is now published in @natmicrobiol.nature.com 🎉🎊
👉🏽 rdcu.be/nR2NizD7H5va
is now published in @natmicrobiol.nature.com 🎉🎊
👉🏽 rdcu.be/nR2NizD7H5va
Reposted by Jay Hinton
September 17, 2026 at 8:00 AM
Reposted by Jay Hinton
It’s International Microorganism Day! For a third year running, some of our Champions have told us about their favourite microbes and our very talented Champion, Eliza Wolfson, has brought these to life with her illustrations!
@eliza-coli.bsky.social @femsmicro.org
@eliza-coli.bsky.social @femsmicro.org
September 17, 2026 at 8:00 AM
It’s International Microorganism Day! For a third year running, some of our Champions have told us about their favourite microbes and our very talented Champion, Eliza Wolfson, has brought these to life with her illustrations!
@eliza-coli.bsky.social @femsmicro.org
@eliza-coli.bsky.social @femsmicro.org
Reposted by Jay Hinton
Happy international microorganism day!
Deck the halls with vials of agar...
Fa lalalalaa la la la la!
#IntMicroDay 🦠🐡🧪🧬🧫
Deck the halls with vials of agar...
Fa lalalalaa la la la la!
#IntMicroDay 🦠🐡🧪🧬🧫
It’s International Microorganism Day! For a third year running, some of our Champions have told us about their favourite microbes and our very talented Champion, Eliza Wolfson, has brought these to life with her illustrations!
@eliza-coli.bsky.social @femsmicro.org
@eliza-coli.bsky.social @femsmicro.org
September 17, 2026 at 8:08 AM
Happy international microorganism day!
Deck the halls with vials of agar...
Fa lalalalaa la la la la!
#IntMicroDay 🦠🐡🧪🧬🧫
Deck the halls with vials of agar...
Fa lalalalaa la la la la!
#IntMicroDay 🦠🐡🧪🧬🧫
Reposted by Jay Hinton
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
September 4, 2026 at 8:14 AM
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
Contaminated eggs have infected 207 people with Salmonella Enteritidis across the UK, mostly in the last month - killing one and hospitalising 34.
Useful insights into Salmonella infection from @mgibani.bsky.social
www.theguardian.com/society/2026...
Useful insights into Salmonella infection from @mgibani.bsky.social
www.theguardian.com/society/2026...
What is salmonella, how does it spread and are eggs safe to eat?
UKHSA says imported eggs eaten in restaurants are source of outbreak that has infected more than 200 people
www.theguardian.com
August 23, 2026 at 5:41 PM
Contaminated eggs have infected 207 people with Salmonella Enteritidis across the UK, mostly in the last month - killing one and hospitalising 34.
Useful insights into Salmonella infection from @mgibani.bsky.social
www.theguardian.com/society/2026...
Useful insights into Salmonella infection from @mgibani.bsky.social
www.theguardian.com/society/2026...
Reposted by Jay Hinton
Here's the paper! journals.plos.org/plospathogen...
Salmonella effector kinase SteC is activated by phosphorylation at Serine 379
Author summary Salmonella is a bacterium that causes a wide range of human diseases, from gastroenteritis to systemic infection. Blood stream infections are more common in young children or those who ...
journals.plos.org
July 27, 2026 at 5:57 AM
Here's the paper! journals.plos.org/plospathogen...
Reposted by Jay Hinton
Macrophages are known as the immune system’s “scavenger cells”. Yet some pathogens use them as hiding places. Researchers from HIRI & @unimarburg.bsky.social have discovered an lncRNA called SAILR that helps macrophages balance their response to infection: www.helmholtz-hiri.de/en/newsroom/...
(1/3)
(1/3)
July 20, 2026 at 2:23 PM
Macrophages are known as the immune system’s “scavenger cells”. Yet some pathogens use them as hiding places. Researchers from HIRI & @unimarburg.bsky.social have discovered an lncRNA called SAILR that helps macrophages balance their response to infection: www.helmholtz-hiri.de/en/newsroom/...
(1/3)
(1/3)
Reposted by Jay Hinton
We are advertising an exciting PhD opportunity based at Newcastle University. You’ll use epidemiological and genomic data to characterise Campylobacter burden… and work with me on some cool datasets!
Deadline: 28th July 2026 - NB UK Students only due to funding restrictions. Don’t miss out!
Deadline: 28th July 2026 - NB UK Students only due to funding restrictions. Don’t miss out!
NIHR PhD Studentship: Modernising Campylobacter burden assessment using integrated genomics, symptoms and surveillance data at Newcastle University on FindAPhD.com
PhD Project - NIHR PhD Studentship: Modernising Campylobacter burden assessment using integrated genomics, symptoms and surveillance data at Newcastle University, listed on FindAPhD.com
www.findaphd.com
July 17, 2026 at 7:39 PM
We are advertising an exciting PhD opportunity based at Newcastle University. You’ll use epidemiological and genomic data to characterise Campylobacter burden… and work with me on some cool datasets!
Deadline: 28th July 2026 - NB UK Students only due to funding restrictions. Don’t miss out!
Deadline: 28th July 2026 - NB UK Students only due to funding restrictions. Don’t miss out!
Reposted by Jay Hinton
Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools
#phage #phagesky
Trends in Microbiology www.cell.com/trends/micro...
#phage #phagesky
Trends in Microbiology www.cell.com/trends/micro...
Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools
Phages, the most abundant biological entities on Earth, infect bacteria and reprogram
them into ‘virocells’ with altered physiology and ecology. While metagenomic studies
have largely inferred reprogr...
www.cell.com
June 21, 2026 at 4:32 PM
Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools
#phage #phagesky
Trends in Microbiology www.cell.com/trends/micro...
#phage #phagesky
Trends in Microbiology www.cell.com/trends/micro...
Reposted by Jay Hinton
How do dangerous bacteria arm themselves before attack? Scientists from NTU-SCELSE and Imperial College London uncovered a previously unknown mechanism showing how bacteria load toxins into a microscopic weapon system before firing. Nature Microbiology-> rdcu.be/fk0Bq @fillouxlab.bsky.social
May 28, 2026 at 8:17 AM
How do dangerous bacteria arm themselves before attack? Scientists from NTU-SCELSE and Imperial College London uncovered a previously unknown mechanism showing how bacteria load toxins into a microscopic weapon system before firing. Nature Microbiology-> rdcu.be/fk0Bq @fillouxlab.bsky.social
Reposted by Jay Hinton
Great EMBO YIP @embo.org lecture by Teresa Thurston @thurstonlab.bsky.social @ox.ac.uk at "Pathogen Immunity and Signalling" #EMBOpathogenSignalling.
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
See also:
-> link.springer.com/article/10.1...
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
See also:
-> link.springer.com/article/10.1...
June 9, 2026 at 2:23 PM
Great EMBO YIP @embo.org lecture by Teresa Thurston @thurstonlab.bsky.social @ox.ac.uk at "Pathogen Immunity and Signalling" #EMBOpathogenSignalling.
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
See also:
-> link.springer.com/article/10.1...
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs.
See also:
-> link.springer.com/article/10.1...
Reposted by Jay Hinton
Hate to see this happening, but it's a common thing now with all Frontiers journals. Time to stop publishing there people!!! Please read the full thread!
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
June 11, 2026 at 3:27 PM
Hate to see this happening, but it's a common thing now with all Frontiers journals. Time to stop publishing there people!!! Please read the full thread!
Reposted by Jay Hinton
Phage therapy via receptor-constrained evolutionary traps: Trends in Microbiology www.cell.com/trends/micro...
#phage #phagesky
#phage #phagesky
Phage therapy via receptor-constrained evolutionary traps
Phage therapy often fails when bacteria evolve resistance. We argue that phage selection
should begin with receptors whose modification imposes predictable costs, turning
resistance into reduced virul...
www.cell.com
June 11, 2026 at 12:56 PM
Phage therapy via receptor-constrained evolutionary traps: Trends in Microbiology www.cell.com/trends/micro...
#phage #phagesky
#phage #phagesky
Reposted by Jay Hinton
Our paper is now published in eBioMedicine and I'm genuinely thrilled it's out 🎉 🧵 www.thelancet.com/journals/EBI...
Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)
Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)
June 11, 2026 at 12:48 PM
Our paper is now published in eBioMedicine and I'm genuinely thrilled it's out 🎉 🧵 www.thelancet.com/journals/EBI...
Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)
Despite the fact that this is a 2026 paper (such is peer review!), I wanted to write something and take you back to 2023, where the story of this work began. (1/7)
Reposted by Jay Hinton
Monsanto has a patent on glyphosate as an antimicrobial. That explains its deadly impact on our microbiome.
scottcanderson.substack.com/p/the-shocki...
scottcanderson.substack.com/p/the-shocki...
The Shocking Impact of Glyphosate on the Microbiome
Glyphosate, the chemical in Roundup, is also an antibiotic that damages the gut microbiome.
scottcanderson.substack.com
June 5, 2026 at 2:04 PM
Monsanto has a patent on glyphosate as an antimicrobial. That explains its deadly impact on our microbiome.
scottcanderson.substack.com/p/the-shocki...
scottcanderson.substack.com/p/the-shocki...
Reposted by Jay Hinton
Read the short highlight commentary I wrote with @enningalab.bsky.social for @molecularmicro.bsky.social about the latest story by the Humphreys lab onlinelibrary.wiley.com/doi/full/10.... ISG15 and toxins doing cool things during! #Salmonella
ISG15 At the Crossroads of Innate Immunity and Host Survival in Response to Typhoid Toxin
Typhoid toxin, a genotoxin secreted by typhoidal Salmonella serovars, has been implicated in diverse host responses ranging from DNA damage to cellular senescence. In this Research Highlight, we disc...
onlinelibrary.wiley.com
June 3, 2026 at 8:58 AM
Read the short highlight commentary I wrote with @enningalab.bsky.social for @molecularmicro.bsky.social about the latest story by the Humphreys lab onlinelibrary.wiley.com/doi/full/10.... ISG15 and toxins doing cool things during! #Salmonella
Reposted by Jay Hinton
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Researchers say the Trump administration is finding new ways to punish science
Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.
www.npr.org
May 25, 2026 at 5:53 PM
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Reposted by Jay Hinton
"An email from NIH’s National Institute of General Medical Sciences (NIGMS) to research-center grantees, seen by Science, requires their institutions to promise that U.S. authors of papers NIH has flagged because of foreign co-authors will not collaborate with them in the future."
“Units of the NIH are privately directing grantees to request permission in advance for any co-authorship with a scholar affiliated with a foreign institution, even if all the work was done in the United States.”
Grantees also told to remove papers with foreign authors from progress reports.
Grantees also told to remove papers with foreign authors from progress reports.
U.S. researchers face new restrictions on publishing with foreign collaborators
NIH, NASA grantees are confused and concerned amid agencies’ piecemeal communication
www.science.org
May 22, 2026 at 6:32 PM
"An email from NIH’s National Institute of General Medical Sciences (NIGMS) to research-center grantees, seen by Science, requires their institutions to promise that U.S. authors of papers NIH has flagged because of foreign co-authors will not collaborate with them in the future."
Reposted by Jay Hinton
There’s a LOT going on as researchers and public health experts race to respond to the Ebola Bundibugyo outbreak in DRC and Uganda before it grows bigger.
Some really important questions still open, but also a few answers coming into view🧪
My overview in @science.org is here (and thread coming):
Some really important questions still open, but also a few answers coming into view🧪
My overview in @science.org is here (and thread coming):
Scientists play catch-up to startling Ebola outbreak
Testing, sequencing, and clinical trial efforts spring to life as Bundibugyo virus spreads
www.science.org
May 19, 2026 at 7:10 AM
There’s a LOT going on as researchers and public health experts race to respond to the Ebola Bundibugyo outbreak in DRC and Uganda before it grows bigger.
Some really important questions still open, but also a few answers coming into view🧪
My overview in @science.org is here (and thread coming):
Some really important questions still open, but also a few answers coming into view🧪
My overview in @science.org is here (and thread coming):
Reposted by Jay Hinton
As @statnews.com reported yesterday, several Americans in DRC had high-risk exposures to #Ebola in the latest outbreak. One has tested positive. These individuals are being flown to Germany for observation and treatment as needed. www.statnews.com/2026/05/18/c...
U.S. bans entry from Ebola-affected countries as American patient is identified
In response to an Ebola outbreak, the U.S. has banned entry for foreign travelers who have been in the Democratic Republic of the Congo, Uganda, or South Sudan in the past 21 days.
www.statnews.com
May 18, 2026 at 6:52 PM
As @statnews.com reported yesterday, several Americans in DRC had high-risk exposures to #Ebola in the latest outbreak. One has tested positive. These individuals are being flown to Germany for observation and treatment as needed. www.statnews.com/2026/05/18/c...
Reposted by Jay Hinton
BBSRC Early Independence Fellowships had an Outline stage this year to try help with amount of peer review. Turns out they received 586 applications, a 110% increase on 2025, and only typically fund 15 a year. They are cancelling this stage and going straight to full app with an institutional sift.
May 14, 2026 at 4:19 PM
BBSRC Early Independence Fellowships had an Outline stage this year to try help with amount of peer review. Turns out they received 586 applications, a 110% increase on 2025, and only typically fund 15 a year. They are cancelling this stage and going straight to full app with an institutional sift.
Reposted by Jay Hinton
Pathogen genomics is increasingly being implemented in clinical microbiology. Discover the factors that represent barriers to, and potential enablers of, this implementation, including the availability of funding and genomics-trained staff. #ClinMicroRev: asm.social/2VH
May 5, 2026 at 5:08 PM
Pathogen genomics is increasingly being implemented in clinical microbiology. Discover the factors that represent barriers to, and potential enablers of, this implementation, including the availability of funding and genomics-trained staff. #ClinMicroRev: asm.social/2VH