Dan
@ltdanpharm.bsky.social
Small-town Hospital Pharmacist interested in ID and Stewardship. Enjoying Colorado living. 🏔 Tennis fan 🎾.
Reposted by Dan
🔥🔥Just published 🔥🔥
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
July 27, 2026 at 4:06 PM
🔥🔥Just published 🔥🔥
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
July 2, 2026 at 8:49 PM
Reposted by Dan
Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?
Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...
accpjournals.onlinelibrary.wiley.com
June 11, 2026 at 12:48 PM
Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Dan
🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
June 9, 2026 at 5:44 PM
🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
Reposted by Dan
Amazing 😍
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky
@shorten2trial.bsky.social
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky
@shorten2trial.bsky.social
May 29, 2026 at 4:27 PM
Amazing 😍
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky
@shorten2trial.bsky.social
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky
@shorten2trial.bsky.social
Reposted by Dan
"If you’re going to give antibiotics to patients who don’t need them, at least do the courtesy of giving them for a brief period of time." @bradspellberg.bsky.social #IDQuotes 🌟 #IDSky #shorterisbetter
May 19, 2026 at 4:22 AM
"If you’re going to give antibiotics to patients who don’t need them, at least do the courtesy of giving them for a brief period of time." @bradspellberg.bsky.social #IDQuotes 🌟 #IDSky #shorterisbetter
Reposted by Dan
🔥Our article in EJHP is now published
We argue that IDSA AMR guidance meropenem dose (2 g IV q8h as 3h EI) for all infections other than uncomplicated cystitis is largely based on PK/PD extrapolation & expert opinion without supporting clinical outcomes data #idsky
ejhp.bmj.com/content/earl...
We argue that IDSA AMR guidance meropenem dose (2 g IV q8h as 3h EI) for all infections other than uncomplicated cystitis is largely based on PK/PD extrapolation & expert opinion without supporting clinical outcomes data #idsky
ejhp.bmj.com/content/earl...
May 14, 2026 at 9:19 PM
🔥Our article in EJHP is now published
We argue that IDSA AMR guidance meropenem dose (2 g IV q8h as 3h EI) for all infections other than uncomplicated cystitis is largely based on PK/PD extrapolation & expert opinion without supporting clinical outcomes data #idsky
ejhp.bmj.com/content/earl...
We argue that IDSA AMR guidance meropenem dose (2 g IV q8h as 3h EI) for all infections other than uncomplicated cystitis is largely based on PK/PD extrapolation & expert opinion without supporting clinical outcomes data #idsky
ejhp.bmj.com/content/earl...
Reposted by Dan
This dogma must stop being taught to clinicians and be put out to pasture as a relic of a bygone era in scientific literature.
I love this 😍
What other dogmas should we retire? #idsky #microsky #EMIMCC
I love this 😍
What other dogmas should we retire? #idsky #microsky #EMIMCC
Static vs. cidal: it’s not complex; it’s simply incorrect
@bradspellberg.bsky.social et Al
Honored to be part of this amazing group who challenges dogmas and debunk ID myths #idsky #microsky
journals.asm.org/doi/10.1128/...
@bradspellberg.bsky.social et Al
Honored to be part of this amazing group who challenges dogmas and debunk ID myths #idsky #microsky
journals.asm.org/doi/10.1128/...
May 6, 2026 at 9:37 PM
Reposted by Dan
Levo with a Cipro Allergy? Check out this week’s KASIC pearl to learn about Quinolone Cross-Reactivity kymdro.org/kasic/?p=8931
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
May 2, 2026 at 2:28 PM
Levo with a Cipro Allergy? Check out this week’s KASIC pearl to learn about Quinolone Cross-Reactivity kymdro.org/kasic/?p=8931
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs
Reposted by Dan
Now this looks like an ep for thee
About a drug that gets into your pee
It’s known to treat crypto and also yeast
It’s time to learn about flucytosine
podcasts.apple.com/gb/podcast/i...
#idsky #microsky #podcast
About a drug that gets into your pee
It’s known to treat crypto and also yeast
It’s time to learn about flucytosine
podcasts.apple.com/gb/podcast/i...
#idsky #microsky #podcast
137. Flucytosine
Podcast Episode · ID:IOTS - Infectious Disease Insight Of Two Specialists · 27 April · 22min
podcasts.apple.com
April 29, 2026 at 7:03 PM
Now this looks like an ep for thee
About a drug that gets into your pee
It’s known to treat crypto and also yeast
It’s time to learn about flucytosine
podcasts.apple.com/gb/podcast/i...
#idsky #microsky #podcast
About a drug that gets into your pee
It’s known to treat crypto and also yeast
It’s time to learn about flucytosine
podcasts.apple.com/gb/podcast/i...
#idsky #microsky #podcast
Reposted by Dan
April 22, 2026 at 11:00 PM
Reposted by Dan
Proud to be part of this great team led by @bradspellberg.bsky.social
🔥Our LTE is now published
“Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.”
A timely discussion on evidence vs eminence in the guidelines development. #IDsky
academic.oup.com/cid/article/...
🔥Our LTE is now published
“Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.”
A timely discussion on evidence vs eminence in the guidelines development. #IDsky
academic.oup.com/cid/article/...
Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate
Brad Spellberg, MD, Bassam Ghanem, PharmD MS BCIDP, Miguel Morante-Ruiz, MD, Émilie Bortolussi-Courval, RN PhD, Anil N Makam, MD MAS, Zeynep Ergenc, MD, Ni
academic.oup.com
April 21, 2026 at 9:06 PM
Proud to be part of this great team led by @bradspellberg.bsky.social
🔥Our LTE is now published
“Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.”
A timely discussion on evidence vs eminence in the guidelines development. #IDsky
academic.oup.com/cid/article/...
🔥Our LTE is now published
“Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.”
A timely discussion on evidence vs eminence in the guidelines development. #IDsky
academic.oup.com/cid/article/...
Reposted by Dan
🔥🔥Just published 🔥🔥
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline | American Journal of Respiratory and Critical Care Medicine | Articles in P...
www.atsjournals.org
July 20, 2025 at 6:45 AM
🔥🔥Just published 🔥🔥
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
ATS CAP guidelines 2025
Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Free access pdf #IDsky#EMIMCC
www.atsjournals.org/doi/10.1164/...
Reposted by Dan
🆕💫 Viewpoint JAMA
Nitrites for Urinary Tract Infection—Time to Say Goodbye?
#idsky #EMIMCC #UTIsky
jamanetwork.com/journals/jam...
Nitrites for Urinary Tract Infection—Time to Say Goodbye?
#idsky #EMIMCC #UTIsky
jamanetwork.com/journals/jam...
Nitrites for Urinary Tract Infection
This Viewpoint examines the urinary nitrite test and questions its effectiveness and relevance in distinguishing between urinary tract infection and asymptomatic bacteriuria.
jamanetwork.com
May 5, 2025 at 8:46 PM
🆕💫 Viewpoint JAMA
Nitrites for Urinary Tract Infection—Time to Say Goodbye?
#idsky #EMIMCC #UTIsky
jamanetwork.com/journals/jam...
Nitrites for Urinary Tract Infection—Time to Say Goodbye?
#idsky #EMIMCC #UTIsky
jamanetwork.com/journals/jam...
Reposted by Dan
Follow us on Bluesky!
April 28, 2025 at 12:05 PM
Follow us on Bluesky!
I've always avoided Cephalexin for Osteomyelitis. But I attended a lecture this weekend and the speaker said they commonly use it for osteo/septic joint. Anyone else doing this? If so, 1g QID? TID? #IDSky
April 21, 2025 at 11:35 PM
I've always avoided Cephalexin for Osteomyelitis. But I attended a lecture this weekend and the speaker said they commonly use it for osteo/septic joint. Anyone else doing this? If so, 1g QID? TID? #IDSky
Anyone at HCA or another Meditech facility and able to share their CAP or Cellulitis order set? I'm trying to increase our use of the sets, but I think our build/layout is the problem... #IDSky
April 20, 2025 at 1:35 PM
Anyone at HCA or another Meditech facility and able to share their CAP or Cellulitis order set? I'm trying to increase our use of the sets, but I think our build/layout is the problem... #IDSky
Reposted by Dan
Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky
April 13, 2025 at 3:38 PM
Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky
Reposted by Dan
Thanks to @absteward.bsky.social for finding 2 RCTs of shorter (1 IM dose) vs. longer (3 weekly IM doses) of PCN for "Early Syphilis"! Added to the Shorter Is Better Table. 23 distinct conditions now reported in the table!
References at
www.bradspellberg.com/shorter-is-b...
References at
www.bradspellberg.com/shorter-is-b...
February 14, 2025 at 5:35 PM
Thanks to @absteward.bsky.social for finding 2 RCTs of shorter (1 IM dose) vs. longer (3 weekly IM doses) of PCN for "Early Syphilis"! Added to the Shorter Is Better Table. 23 distinct conditions now reported in the table!
References at
www.bradspellberg.com/shorter-is-b...
References at
www.bradspellberg.com/shorter-is-b...
Reposted by Dan
🔥A sneak peak on the upcoming IDSA guidelines for cUTI🔥
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
February 19, 2025 at 9:56 PM
🔥A sneak peak on the upcoming IDSA guidelines for cUTI🔥
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
Reposted by Dan
In patients with cUTI (including acute pyelonephritis) treated initially with parenteral therapy who are clinically improving,able to take oral medication,and for whom an effective oral option is available,we suggest transitioning to oral antibiotics rather than continuing IV Abx #idsky #EMIMCC
🔥A sneak peak on the upcoming IDSA guidelines for cUTI🔥
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
Public Comment: IDSA Guideline on Management and Treatment of Complicated Urinary Tract Infections
So it's still not published yet ! #idsky #medsky #utisky
www.idsociety.org/practice-gui...
February 19, 2025 at 10:13 PM
Reposted by Dan
We are delighted to announce that we have begun to assemble a team for Bacteremia WikiGuideline.
Join us to create guidelines with the humility of uncertainty.
Join us to create guidelines with the humility of uncertainty.
Microsoft Forms
forms.office.com
February 10, 2025 at 1:15 AM
We are delighted to announce that we have begun to assemble a team for Bacteremia WikiGuideline.
Join us to create guidelines with the humility of uncertainty.
Join us to create guidelines with the humility of uncertainty.
For diabetic foot osteomyelitis, Amox/clav 875/125, do you typically go with BID or TID? Assuming the patient is not obese nor underweight. #IDSky
January 29, 2025 at 1:38 PM
For diabetic foot osteomyelitis, Amox/clav 875/125, do you typically go with BID or TID? Assuming the patient is not obese nor underweight. #IDSky