Wiep Klaas Smits (ExpBac/CMAT)
@smitslab.bsky.social
Assoc. prof. at LUMC/@unileiden. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath Steering committee. Education officer ESGCD. Previously: @unigroningen and @mitofficial. https://sites.google.com/view/expbac-lumc/homepage
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
When genus deserves to be a family 🦠🔬
Recent phylogenomic analyses showed that the genus Methanobrevibacter is severely underclassified. We propose reclassifying it into a family, Methanobrevibacteraceae consisting of 11 genera.
@microbiologysociety.org
#MicroSky #Archaea
doi.org/10.1099/ijse...
Recent phylogenomic analyses showed that the genus Methanobrevibacter is severely underclassified. We propose reclassifying it into a family, Methanobrevibacteraceae consisting of 11 genera.
@microbiologysociety.org
#MicroSky #Archaea
doi.org/10.1099/ijse...
September 18, 2026 at 7:54 AM
When genus deserves to be a family 🦠🔬
Recent phylogenomic analyses showed that the genus Methanobrevibacter is severely underclassified. We propose reclassifying it into a family, Methanobrevibacteraceae consisting of 11 genera.
@microbiologysociety.org
#MicroSky #Archaea
doi.org/10.1099/ijse...
Recent phylogenomic analyses showed that the genus Methanobrevibacter is severely underclassified. We propose reclassifying it into a family, Methanobrevibacteraceae consisting of 11 genera.
@microbiologysociety.org
#MicroSky #Archaea
doi.org/10.1099/ijse...
Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut | Science Signaling www.science.org/doi/10.1126/...
Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut
A coordinated response to low iron and bacitracin enables Clostridioides difficile to survive in the gut.
www.science.org
September 17, 2026 at 8:26 AM
Clostridioides difficile couples responses to host nutritional immunity and a commensal-derived antibiotic to enable growth in the gut | Science Signaling www.science.org/doi/10.1126/...
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
The Tube
#MedSky
#UKSky
#MedSky
#UKSky
September 15, 2026 at 4:57 AM
The Tube
#MedSky
#UKSky
#MedSky
#UKSky
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
Why did some #viruses evolve to be #giants while others did not? Our perspective piece on this topic with Eugene Koonin. www.pnas.org/doi/10.1073/...
Why did some viruses evolve to be giants while others did not? | PNAS
Viruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The ...
www.pnas.org
September 11, 2026 at 5:10 PM
Why did some #viruses evolve to be #giants while others did not? Our perspective piece on this topic with Eugene Koonin. www.pnas.org/doi/10.1073/...
It's a wrap! #ICDS2026 has come to an end. As usual, flawless execution, great crowd. There will be another ICDS in two years - but not organised by Maja Rupnik anymore. Lots of respect and appreciation for what she has done over the past decades for the #cdiff community.
September 11, 2026 at 8:31 AM
How is your day going so far? My trip to #ICDS2026 starts with an overbooked flight resulting me to arrive half a day later (if all goes "well") than expected... #mondayblues
September 7, 2026 at 11:07 AM
How is your day going so far? My trip to #ICDS2026 starts with an overbooked flight resulting me to arrive half a day later (if all goes "well") than expected... #mondayblues
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
Thrilled our latest paper out @natureportfolio.nature.com Nature Comms, lead author @microberamon.bsky.social, who developed P-FLO, a urine-flowing human micro-bladder model in collab with Oxford & Leicester to understand #UTI biology & treatment failure 1/4
#UTISky
www.nature.com/articles/s41...
#UTISky
www.nature.com/articles/s41...
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications
Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...
www.nature.com
September 4, 2026 at 10:11 AM
Thrilled our latest paper out @natureportfolio.nature.com Nature Comms, lead author @microberamon.bsky.social, who developed P-FLO, a urine-flowing human micro-bladder model in collab with Oxford & Leicester to understand #UTI biology & treatment failure 1/4
#UTISky
www.nature.com/articles/s41...
#UTISky
www.nature.com/articles/s41...
This is a great study by @joeyzacks.bsky.social et al on "asymptomatic" carriage of Cdiff in infants. Must read! Early-life colonization with Clostridioides difficile remodels the developing gut | Science www.science.org/doi/10.1126/...
Early-life colonization with Clostridioides difficile remodels the developing gut
Clostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...
www.science.org
September 4, 2026 at 9:00 AM
This is a great study by @joeyzacks.bsky.social et al on "asymptomatic" carriage of Cdiff in infants. Must read! Early-life colonization with Clostridioides difficile remodels the developing gut | Science www.science.org/doi/10.1126/...
Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection | Infection and Immunity journals.asm.org/doi/10.1128/...
Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection | Infection and Immunity
Clostridioides difficile infection (CDI) is responsible for approximately 25% of all antibiotic-associated
diarrhea (1, 2). In the United States, over 223,900 CDI cases occur annually, with a mortalit...
journals.asm.org
September 3, 2026 at 2:03 PM
Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection | Infection and Immunity journals.asm.org/doi/10.1128/...
Multi-strain Clostridioides difficile infection: Increased detection and clinical implications. www.sciencedirect.com/science/arti...
Multi-strain Clostridioides difficile infection: Increased detection and clinical implications
Clostridioides difficile infection (CDI) is an antibiotic-associated diarrheal disease. Mixed infection has been previously reported. However, its cli…
www.sciencedirect.com
September 3, 2026 at 2:02 PM
Multi-strain Clostridioides difficile infection: Increased detection and clinical implications. www.sciencedirect.com/science/arti...
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social!
#ProudPI #MicroSky #AMR #SubtiWiki
In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
#ProudPI #MicroSky #AMR #SubtiWiki
In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
September 2, 2026 at 6:28 PM
Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social!
#ProudPI #MicroSky #AMR #SubtiWiki
In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
#ProudPI #MicroSky #AMR #SubtiWiki
In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧵 below for more details.
Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...
Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man | Antimicrobial Age...
Fidaxomicin is a macrocyclic antibiotic recommended as the preferred antimicrobial
treatment for Clostridioides difficile infection (CDI) when available (1, 2). Fidaxomicin is as effective as oral van...
journals.asm.org
September 3, 2026 at 9:38 AM
Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a Clostridioides difficile isolate with reduced fidaxomicin susceptibility in an elderly man | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...
AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review www.sciencedirect.com/science/arti...
www.sciencedirect.com
September 1, 2026 at 7:10 AM
AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review www.sciencedirect.com/science/arti...
Very interesting! Novel surveillance design exploiting network analysis for efficient, rapid detection of emerging Clostridioides difficile strains www.nature.com/articles/s41...
Novel surveillance design exploiting network analysis for efficient, rapid detection of emerging Clostridioides difficile strains - Nature Communications
Using network analysis for inter-hospital spread and algorithmically optimising sentinel site selection, the authors design a surveillance system to rapidly detect emerging nosocomial pathogen strains...
www.nature.com
August 28, 2026 at 3:04 PM
Very interesting! Novel surveillance design exploiting network analysis for efficient, rapid detection of emerging Clostridioides difficile strains www.nature.com/articles/s41...
Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B–specific CD4+ T cell responses academic.oup.com/jimmunol/art...
Validate User
academic.oup.com
August 27, 2026 at 10:45 AM
Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B–specific CD4+ T cell responses academic.oup.com/jimmunol/art...
Reposted by Wiep Klaas Smits (ExpBac/CMAT)
As a component of aseptic technique, Bunsen burners do not universally decrease deposition of microbe-containing particles journals.asm.org/doi/full/10.... #jcampubs
August 18, 2026 at 10:44 PM
As a component of aseptic technique, Bunsen burners do not universally decrease deposition of microbe-containing particles journals.asm.org/doi/full/10.... #jcampubs
Elucidating the pleiotropic effects of clpC deletion in Clostridioides difficile: proteomic and phenotypic insights www.sciencedirect.com/science/arti...
www.sciencedirect.com
August 17, 2026 at 11:00 AM
Elucidating the pleiotropic effects of clpC deletion in Clostridioides difficile: proteomic and phenotypic insights www.sciencedirect.com/science/arti...
A TcdB-Targeting
Antivirulence Compound Preserves
Gut Homeostasis and Ameliorates Clostridioides difficile Infection pubs.acs.org/jafcau/artic...
Antivirulence Compound Preserves
Gut Homeostasis and Ameliorates Clostridioides difficile Infection pubs.acs.org/jafcau/artic...
A TcdB-Targeting Antivirulence Compound Preserves Gut Homeostasis and Ameliorates Clostridioides difficile Infection
Abstract. Clostridioides difficile (C. difficile) is a leading cause
of antibiotic-associated
diarrhea and colitis, with hypervirulent or resistant strains
pubs.acs.org
August 12, 2026 at 8:50 AM
A TcdB-Targeting
Antivirulence Compound Preserves
Gut Homeostasis and Ameliorates Clostridioides difficile Infection pubs.acs.org/jafcau/artic...
Antivirulence Compound Preserves
Gut Homeostasis and Ameliorates Clostridioides difficile Infection pubs.acs.org/jafcau/artic...
Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria www.nature.com/articles/s41... #mecA #clostridia
Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria - Nature Communications
Cephamycin antibiotics inhibit sporulation of the pathogenic bacterium Clostridioides difficile by targeting the spore protein SpoVD. Here, the authors show that isolates carrying the resistance gene ...
www.nature.com
August 12, 2026 at 7:43 AM
Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria www.nature.com/articles/s41... #mecA #clostridia
A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation: dx.plos.org/10.1371/jour...
A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation
Author summary Most bacteria use orphan DNA methyltransferases to modify their genomes and alter their gene expression. While these modifications lead to changes in a bacterium’s phenotype, the specif...
dx.plos.org
August 10, 2026 at 11:39 AM
A single DNA methylation site regulates cell fate during Clostridioides difficile sporulation: dx.plos.org/10.1371/jour...
Balancing act of cytokines in controlling the severity of Clostridioides difficile infection | Infection and Immunity journals.asm.org/doi/10.1128/...
Balancing act of cytokines in controlling the severity of Clostridioides difficile infection | Infection and Immunity
Clostridioides difficile is the most common cause of health care-associated gastrointestinal infections and
is responsible for approximately half a million infections and 30,000 deaths in the
United S...
journals.asm.org
August 10, 2026 at 10:45 AM
Balancing act of cytokines in controlling the severity of Clostridioides difficile infection | Infection and Immunity journals.asm.org/doi/10.1128/...
Strain-level ecological filtering governs microbial colonization of the human gut www.sciencedirect.com/science/arti...
Strain-level ecological filtering governs microbial colonization of the human gut
Microbial colonization of the human gut is typically inferred from species-level profiling, yet durable establishment operates at the strain level. He…
www.sciencedirect.com
August 7, 2026 at 10:32 AM
Strain-level ecological filtering governs microbial colonization of the human gut www.sciencedirect.com/science/arti...
Pyocyanin produced by Pseudomonas aeruginosa creates legacy effects that promote antibiotic resistance evolution in enterococci | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/... from @lizscurious.bsky.social 's team
Pyocyanin produced by Pseudomonas aeruginosa creates legacy effects that promote antibiotic resistance evolution in enterococci | Antimicrobial Agents and Chemotherapy
Bacterial infections may consist of different species that together form a polymicrobial
community, as is the case in urinary tract infections (UTIs) (1–3). The response to antibiotic treatment of suc...
journals.asm.org
August 5, 2026 at 12:56 PM
Pyocyanin produced by Pseudomonas aeruginosa creates legacy effects that promote antibiotic resistance evolution in enterococci | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/... from @lizscurious.bsky.social 's team
A hierarchical regulatory cascade defines the temporal window of natural transformation in Staphylococcus aureus www.biorxiv.org/content/10.6...
A hierarchical regulatory cascade defines the temporal window of natural transformation in Staphylococcus aureus
Natural transformation (NT), a major mechanism of horizontal gene transfer, promotes bacterial genome plasticity and contributes to the dissemination of antibiotic resistance. NT requires the developm...
www.biorxiv.org
August 5, 2026 at 10:25 AM
A hierarchical regulatory cascade defines the temporal window of natural transformation in Staphylococcus aureus www.biorxiv.org/content/10.6...
🚨publication alert: Collateral effects of antibiotic resistance in Campylobacter jejuni - academic.oup.com/femsle/artic...
Collateral effects of antibiotic resistance in Campylobacter jejuni
Collateral effects in antibiotic sensitivity related to antibiotic resistance in Campylobacter jejuni.
academic.oup.com
August 3, 2026 at 8:14 AM
🚨publication alert: Collateral effects of antibiotic resistance in Campylobacter jejuni - academic.oup.com/femsle/artic...