Gonzalo Villanueva Martin
@gonzalovm.bsky.social
PhD in biomedicine. Computational genomics and transcriptomics postdoc. Postdoctoral researcher at the @bsci-lab.bsky.social
Reposted by Gonzalo Villanueva Martin
🛬 Welcome Gonzalo @gonzalovm.bsky.social to the lab!
He joins us as a computational postdoc to investigate how blood stem cells remodel their transcriptome and epigenome across different tissue sources and during ex vivo culture. 🖥️🩸
He joins us as a computational postdoc to investigate how blood stem cells remodel their transcriptome and epigenome across different tissue sources and during ex vivo culture. 🖥️🩸
August 5, 2026 at 1:06 PM
🛬 Welcome Gonzalo @gonzalovm.bsky.social to the lab!
He joins us as a computational postdoc to investigate how blood stem cells remodel their transcriptome and epigenome across different tissue sources and during ex vivo culture. 🖥️🩸
He joins us as a computational postdoc to investigate how blood stem cells remodel their transcriptome and epigenome across different tissue sources and during ex vivo culture. 🖥️🩸
Reposted by Gonzalo Villanueva Martin
How do genetic #riskvariants translate into cellular dysfunction in #autoimmunedisease?
Excited to share our latest preprint “Variant-to-function mapping in lupus links IL12A to the expansion of disease-associated B cells with a cytotoxic program”
www.medrxiv.org/content/10.6...
Excited to share our latest preprint “Variant-to-function mapping in lupus links IL12A to the expansion of disease-associated B cells with a cytotoxic program”
www.medrxiv.org/content/10.6...
Variant-to-function mapping in lupus links IL12A to the expansion of disease-associated B cells with a cytotoxic program
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by over 200 risk variants identified through genome-wide association studies. While the majority of these are non-codin...
www.medrxiv.org
July 31, 2026 at 2:12 PM
How do genetic #riskvariants translate into cellular dysfunction in #autoimmunedisease?
Excited to share our latest preprint “Variant-to-function mapping in lupus links IL12A to the expansion of disease-associated B cells with a cytotoxic program”
www.medrxiv.org/content/10.6...
Excited to share our latest preprint “Variant-to-function mapping in lupus links IL12A to the expansion of disease-associated B cells with a cytotoxic program”
www.medrxiv.org/content/10.6...
🚀A few weeks ago, I joined @bsci-lab.bsky.social It’s an amazing group advancing blood stem cell biology at @carrerasijc.bsky.social in Barcelona🩸
I’m thrilled to be back in Spain doing exciting science. Thanks to Vincenzo for this opportunity—I look forward to contributing to the lab’s research!
I’m thrilled to be back in Spain doing exciting science. Thanks to Vincenzo for this opportunity—I look forward to contributing to the lab’s research!
August 3, 2026 at 7:47 AM
🚀A few weeks ago, I joined @bsci-lab.bsky.social It’s an amazing group advancing blood stem cell biology at @carrerasijc.bsky.social in Barcelona🩸
I’m thrilled to be back in Spain doing exciting science. Thanks to Vincenzo for this opportunity—I look forward to contributing to the lab’s research!
I’m thrilled to be back in Spain doing exciting science. Thanks to Vincenzo for this opportunity—I look forward to contributing to the lab’s research!
🎓 Today is my last day at Boston Children’s Hospital and Harvard Medical School.
Grateful for an incredible experience filled with great science, wonderful colleagues, and invaluable lessons. Thank you to @mariagtac.bsky.social and the Immunology Division 💙
🚀 On to new adventures!
#Postdoc
Grateful for an incredible experience filled with great science, wonderful colleagues, and invaluable lessons. Thank you to @mariagtac.bsky.social and the Immunology Division 💙
🚀 On to new adventures!
#Postdoc
June 5, 2026 at 2:15 PM
🎓 Today is my last day at Boston Children’s Hospital and Harvard Medical School.
Grateful for an incredible experience filled with great science, wonderful colleagues, and invaluable lessons. Thank you to @mariagtac.bsky.social and the Immunology Division 💙
🚀 On to new adventures!
#Postdoc
Grateful for an incredible experience filled with great science, wonderful colleagues, and invaluable lessons. Thank you to @mariagtac.bsky.social and the Immunology Division 💙
🚀 On to new adventures!
#Postdoc
🧬 Excited to share our new preprint!
We characterized CD4+ T cells in #SystemicSclerosis using #SingleCellRNAseq, revealing IFN-driven activation, Treg dysregulation, and Th2/Th17 expansion in disease.
📄 www.biorxiv.org/content/10.6...
#scRNAseq #Immunology #SSc
We characterized CD4+ T cells in #SystemicSclerosis using #SingleCellRNAseq, revealing IFN-driven activation, Treg dysregulation, and Th2/Th17 expansion in disease.
📄 www.biorxiv.org/content/10.6...
#scRNAseq #Immunology #SSc
www.biorxiv.org
March 19, 2026 at 1:33 PM
🧬 Excited to share our new preprint!
We characterized CD4+ T cells in #SystemicSclerosis using #SingleCellRNAseq, revealing IFN-driven activation, Treg dysregulation, and Th2/Th17 expansion in disease.
📄 www.biorxiv.org/content/10.6...
#scRNAseq #Immunology #SSc
We characterized CD4+ T cells in #SystemicSclerosis using #SingleCellRNAseq, revealing IFN-driven activation, Treg dysregulation, and Th2/Th17 expansion in disease.
📄 www.biorxiv.org/content/10.6...
#scRNAseq #Immunology #SSc
Reposted by Gonzalo Villanueva Martin
Sobre nuestro último estudio de metilación del ADN en arterias de pacientes de arteritis de células gigantes!! 👇🏼👇🏼
Descubren señales moleculares en el ADN que explican la inflamación crónica de las arterias a partir de los 50 años
El @ipblncsic.bsky.social identifica también células inmunitarias “agotadas” que podrían explicar por qué la inflamación persiste en la arteritis de células gigantes
t.ly/tTyjB
El @ipblncsic.bsky.social identifica también células inmunitarias “agotadas” que podrían explicar por qué la inflamación persiste en la arteritis de células gigantes
t.ly/tTyjB
October 30, 2025 at 10:34 AM
Sobre nuestro último estudio de metilación del ADN en arterias de pacientes de arteritis de células gigantes!! 👇🏼👇🏼
#ACR2025 is over! Grateful for the chance to dive deep into rheumatology, present Liyoung Kim’s poster, and meet so many inspiring scientists. Thanks to Maria Gutierrez-Arcelus for the support! See you next time! 👋
#Rheumatology #Immunology #ACR
#Rheumatology #Immunology #ACR
October 29, 2025 at 2:05 PM
#ACR2025 is over! Grateful for the chance to dive deep into rheumatology, present Liyoung Kim’s poster, and meet so many inspiring scientists. Thanks to Maria Gutierrez-Arcelus for the support! See you next time! 👋
#Rheumatology #Immunology #ACR
#Rheumatology #Immunology #ACR
Reposted by Gonzalo Villanueva Martin
October 2, 2025 at 6:57 AM
Reposted by Gonzalo Villanueva Martin
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...
doi.org
August 28, 2025 at 10:40 AM
New paper just out (online first) in Arthritis & Rheumatology! 🎉
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵
Read: doi.org/10.1002/art....
cc @ipblncsic.bsky.social
Reposted by Gonzalo Villanueva Martin
I’m excited to share my latest work with Marcella Franco, @mariagtac.bsky.social, and an amazing team. We used multi-omics to dissect key pathways of B cell activation, exploring gene programs, splicing, cell fates, and disease heritability in activated B cells.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
May 28, 2025 at 4:00 PM
I’m excited to share my latest work with Marcella Franco, @mariagtac.bsky.social, and an amazing team. We used multi-omics to dissect key pathways of B cell activation, exploring gene programs, splicing, cell fates, and disease heritability in activated B cells.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Gonzalo Villanueva Martin
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
May 28, 2025 at 3:13 PM
Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Huge thanks to the committee, I’m truly honored!
Hope to see you in Barcelona! #EMEUNET #EULAR2025
Reposted by Gonzalo Villanueva Martin
If I had an habit of terribly procrastinating writing, I’d totally recommend this feature from @naturebiotech.bsky.social. But, you know, for other people
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology
Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write
www.nature.com
March 25, 2025 at 8:51 AM
If I had an habit of terribly procrastinating writing, I’d totally recommend this feature from @naturebiotech.bsky.social. But, you know, for other people
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gonzalo Villanueva Martin
#StandUpForScience👩🔬👨🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration.
@standupforscience.bsky.social @maxplanck.de
@standupforscience.bsky.social @maxplanck.de
March 7, 2025 at 12:08 PM
#StandUpForScience👩🔬👨🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration.
@standupforscience.bsky.social @maxplanck.de
@standupforscience.bsky.social @maxplanck.de
Reposted by Gonzalo Villanueva Martin
Inolvidables los diálogos que escribía Asimov
March 4, 2025 at 3:46 PM
Inolvidables los diálogos que escribía Asimov
🧬 New preprint by good friend @goboru.bsky.social!
DNA methylation profiling in giant cell arteritis (GCA) reveals altered inflammatory & vascular pathways, plus exhausted T cells (SLAMF6, HAVCR2). New insights into GCA pathogenesis!
📄 Read more in: www.biorxiv.org/content/10.1...
#Vasculitis #GCA
DNA methylation profiling in giant cell arteritis (GCA) reveals altered inflammatory & vascular pathways, plus exhausted T cells (SLAMF6, HAVCR2). New insights into GCA pathogenesis!
📄 Read more in: www.biorxiv.org/content/10.1...
#Vasculitis #GCA
www.biorxiv.org
March 4, 2025 at 4:03 PM
🧬 New preprint by good friend @goboru.bsky.social!
DNA methylation profiling in giant cell arteritis (GCA) reveals altered inflammatory & vascular pathways, plus exhausted T cells (SLAMF6, HAVCR2). New insights into GCA pathogenesis!
📄 Read more in: www.biorxiv.org/content/10.1...
#Vasculitis #GCA
DNA methylation profiling in giant cell arteritis (GCA) reveals altered inflammatory & vascular pathways, plus exhausted T cells (SLAMF6, HAVCR2). New insights into GCA pathogenesis!
📄 Read more in: www.biorxiv.org/content/10.1...
#Vasculitis #GCA
Reposted by Gonzalo Villanueva Martin
A few years ago, we started a fun 'Plot of the Month' competition. Each member made a plot with their data and shared the code to learn ggplot2 together. At the end of the month, we’d vote for the best one, and the winner kept a cute trophy for the next month. It made plotting way more fun!
February 13, 2025 at 3:36 PM
A few years ago, we started a fun 'Plot of the Month' competition. Each member made a plot with their data and shared the code to learn ggplot2 together. At the end of the month, we’d vote for the best one, and the winner kept a cute trophy for the next month. It made plotting way more fun!
Reposted by Gonzalo Villanueva Martin
A great example to start this section is Mal-ID (MAchine Learning for Immunological Diagnosis). A cool acronym for the method presented in this paper that uses machine learning to predict disease status from BCR & TCR repertoires. A great name for an impressive work! www.science.org/doi/10.1126/...
February 21, 2025 at 8:56 AM
A great example to start this section is Mal-ID (MAchine Learning for Immunological Diagnosis). A cool acronym for the method presented in this paper that uses machine learning to predict disease status from BCR & TCR repertoires. A great name for an impressive work! www.science.org/doi/10.1126/...
Reposted by Gonzalo Villanueva Martin
Single-cell RNA sequencing is very important when studying gene expression. I found scDotPlot package developed by @laufer.bsky.social, and I think it could be a very useful tool to analyze and plot scRNA-seq data using R.
You can find more information in bioconductor.org/packages/rel...
You can find more information in bioconductor.org/packages/rel...
January 30, 2025 at 3:52 AM
Single-cell RNA sequencing is very important when studying gene expression. I found scDotPlot package developed by @laufer.bsky.social, and I think it could be a very useful tool to analyze and plot scRNA-seq data using R.
You can find more information in bioconductor.org/packages/rel...
You can find more information in bioconductor.org/packages/rel...
Reposted by Gonzalo Villanueva Martin
New paper 🚨
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways
AbstractObjectives. COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and
academic.oup.com
January 31, 2025 at 10:26 AM
New paper 🚨
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔
In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇
academic.oup.com/rheumatology...
Reposted by Gonzalo Villanueva Martin
It's always good to begin with a friendly reminder 📊
January 13, 2025 at 3:29 PM
It's always good to begin with a friendly reminder 📊
Reposted by Gonzalo Villanueva Martin
And final bonus fact: as a total nerd project, @javiml221098.bsky.social and I made a R package to use color palettes based on movies from Studio Ghibli in your plots 🔥
github.com/goboru/Ghibl...
github.com/goboru/Ghibl...
January 13, 2025 at 4:30 PM
And final bonus fact: as a total nerd project, @javiml221098.bsky.social and I made a R package to use color palettes based on movies from Studio Ghibli in your plots 🔥
github.com/goboru/Ghibl...
github.com/goboru/Ghibl...