Carl von Hallerstein
@jchvh.bsky.social
DPhil Student in Biophysics, Rauschenbach & Robinson groups, University of Oxford. Interested in the combo of Mass Spec and Electron Microscopy, at times with MD. I throw proteins at a wall and then take pictures of them.
Really chuffed that this has finally made it out after so many years in the making.
TLDR: we chased down the mechanism behind an extremely steep and unusual structure-activity cliff at a class A GPCR. It’s a bit different from my current work on Mass Spec+EM, but I thought I’d do a little 🧵 anyway:
TLDR: we chased down the mechanism behind an extremely steep and unusual structure-activity cliff at a class A GPCR. It’s a bit different from my current work on Mass Spec+EM, but I thought I’d do a little 🧵 anyway:
Congratulations to @jchvh.bsky.social as his part II simulation work in @oxfordbiochemistry.bsky.social appears, Carl's simulations nicely revealed the dynamic connection between binding and biased signalling in GPR84. www.nature.com/articles/s41.... With Russell, Tikhonova, Zhang and Milligan labs
Steric control of signaling bias in the immunometabolic receptor GPR84 - Nature Communications
This study reveals how subtle changes in ligand structure control signaling bias at the immunometabolic receptor GPR84, providing structural details for the rational design of drugs with tailored sign...
www.nature.com
September 28, 2026 at 4:19 PM
Really chuffed that this has finally made it out after so many years in the making.
TLDR: we chased down the mechanism behind an extremely steep and unusual structure-activity cliff at a class A GPCR. It’s a bit different from my current work on Mass Spec+EM, but I thought I’d do a little 🧵 anyway:
TLDR: we chased down the mechanism behind an extremely steep and unusual structure-activity cliff at a class A GPCR. It’s a bit different from my current work on Mass Spec+EM, but I thought I’d do a little 🧵 anyway:
Reposted by Carl von Hallerstein
Big thanks to @arnemoeller.bsky.social , @djanuliene.bsky.social, all speakers, and everyone who made the #WEHeraeusSeminar - Cryo-EM on the Move such an amazing event! It was a blast!
#cryoEM #StructuralBiology #Microscopy
#cryoEM #StructuralBiology #Microscopy
September 17, 2025 at 11:46 AM
Big thanks to @arnemoeller.bsky.social , @djanuliene.bsky.social, all speakers, and everyone who made the #WEHeraeusSeminar - Cryo-EM on the Move such an amazing event! It was a blast!
#cryoEM #StructuralBiology #Microscopy
#cryoEM #StructuralBiology #Microscopy