Cooling fast and slow: Characterising the effects of vitrification in cryo-EM and the subsequent recovery of equilibrium populations www.biorxiv.org/content/10.64898/2026.04.21.720011v1 #cryoem

Just published! at @narjournal.bsky.social . A new example of how gene order in bacterial genomes impacts cell physiology. Inthis episode we messed up with RNA polymerase genes! academic.oup.com/nar/article/...

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

Beautiful #phage structure 🤩
Congrats to the colleagues in Brazil! 🍊🦠

www.biorxiv.org/content/10.6...

#CryoEM #xanthomonas

Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro 🧪 and in vivo 🦠

Thanks for the very fun collaboration! 🤗
#PlantScience 🌾 #TeamTomo 🔬 #LivingPhysics 🧬🧶

❗New Preprint w/ C Bueno (‪@cabb99.bsky.social‬), IE Sánchez (@nachoquique.bsky.social‬), PG Wolynes & DU Ferreiro (@diegulise.bsky.social‬)

We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins

arxiv.org/abs/2508.08109

1/x New story - the structure of the Vault cap, at 2.3Å! Matching a beautiful preprint from @sjorsscheres.bsky.social, we show that the cap of the vault particle has C13 symmetry, in contrast to the 39-fold symmetry of the body. Study lead by talented postdoc @huanli00.bsky.social from my group! ⬇️

I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?

Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells:

www.nature.com/articles/s41...

🚀 #AlphaFold Database update

AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures.

www.ebi.ac.uk/about/news/u...

@pdbeurope.bsky.social

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

Estamos muy contentos de compartir nuestro último trabajo "Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase". doi.org/10.1101/2024...

Let’s hear from our nodes at the CEBEM Annual Meeting #2024!

We are thrilled to learn about the experiences, challenges and achievements from our incredible network nodes 👇

#ImagingTheFuture

🇦🇷 @marianodella.bsky.social shared the facilities and different research lines at #CIBION as well as how they are actively working to develop a Cryo-EM platform in Argentina.
#CEBEM #ImagingTheFuture

"Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors"

#virology #cryoEM

www.nature.com/articles/s41...