Michael Tellier
@michaeltellier.bsky.social
Assistant Professor, University of Leicester (UK). Interested in transcription, RNA processing, and protein phosphorylation.
Group website: https://www.tellierlab.com/
Group website: https://www.tellierlab.com/
Pinned
NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports
Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...
link.springer.com
Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Michael Tellier
meetings.embo.org/event/26-rna3
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!
RNA 3' ends and beyond
Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation es…
meetings.embo.org
March 5, 2026 at 12:22 PM
meetings.embo.org/event/26-rna3
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!
Reposted by Michael Tellier
PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This is open to Home Fee Status candidates only. This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA…
biodtp.norwichresearchpark.ac.uk
March 6, 2026 at 3:06 PM
PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...
Reposted by Michael Tellier
The "publish or perish" culture must perish. Scientists need time to think.
We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science.
Read more and sign here: www.slow-science.com
We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science.
Read more and sign here: www.slow-science.com
February 20, 2026 at 4:11 PM
The "publish or perish" culture must perish. Scientists need time to think.
We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science.
Read more and sign here: www.slow-science.com
We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science.
Read more and sign here: www.slow-science.com
Reposted by Michael Tellier
My PhD work has been published٩( 'ω' )و
Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?
Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?
NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
-> link.springer.com/article/10.1...
-> link.springer.com/article/10.1...
Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
February 21, 2026 at 9:26 AM
My PhD work has been published٩( 'ω' )و
Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?
Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?
Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports
Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...
link.springer.com
February 20, 2026 at 11:09 AM
Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Michael Tellier
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
February 5, 2026 at 12:06 PM
One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry
#postdoc #cryoEM #biochemistry
Reposted by Michael Tellier
Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social
But please more focus on 2 things...
1) Immediate effects (eg funding decisions expected in March)
2) Likely disproportionate effects on early career scientists
www.bbc.co.uk/news/article...
But please more focus on 2 things...
1) Immediate effects (eg funding decisions expected in March)
2) Likely disproportionate effects on early career scientists
www.bbc.co.uk/news/article...
UK’s £8bn research fund faces “hard decisions” as it pauses new grants
UKRI boss Ian Chapman said it had been told by the government to
www.bbc.co.uk
February 5, 2026 at 12:54 PM
Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social
But please more focus on 2 things...
1) Immediate effects (eg funding decisions expected in March)
2) Likely disproportionate effects on early career scientists
www.bbc.co.uk/news/article...
But please more focus on 2 things...
1) Immediate effects (eg funding decisions expected in March)
2) Likely disproportionate effects on early career scientists
www.bbc.co.uk/news/article...
Reposted by Michael Tellier
Opportunity for doing a PhD in my lab under the MRC-DTP programme, working on redefining the role of signal peptidase complex in cellular signalling. warwick.ac.uk/fac/sci/life...
Deadline 2nd March 2026.
www.findaphd.com/phds/program...
Deadline 2nd March 2026.
www.findaphd.com/phds/program...
FindAPhD : Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick
Apply for a PhD: Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick
www.findaphd.com
February 3, 2026 at 4:36 PM
Opportunity for doing a PhD in my lab under the MRC-DTP programme, working on redefining the role of signal peptidase complex in cellular signalling. warwick.ac.uk/fac/sci/life...
Deadline 2nd March 2026.
www.findaphd.com/phds/program...
Deadline 2nd March 2026.
www.findaphd.com/phds/program...
Reposted by Michael Tellier
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
January 15, 2026 at 7:45 AM
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
I am happy to have contributed to this study published in @cp-cellreports.bsky.social and led by @ahellab.bsky.social group, on the interplay between two ADP-ribosylation (ADPr) hydrolases TARG1 and PARG, revealing that PARG regulates TARG1 protein level.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
PARG regulates the proteasomal degradation of TARG1
ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteost…
www.sciencedirect.com
January 8, 2026 at 2:49 PM
I am happy to have contributed to this study published in @cp-cellreports.bsky.social and led by @ahellab.bsky.social group, on the interplay between two ADP-ribosylation (ADPr) hydrolases TARG1 and PARG, revealing that PARG regulates TARG1 protein level.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Michael Tellier
#30DayMapChallenge #30DayMapChallenge2025 #30DayMapChallengeRbanism #30DayMapChallengeR
Day 7: Accessibility.
Access, A Matter of Means.
by @ineszaid.bsky.social
#GeoData #rstats #DataViz #Maps #SpatialViz
Day 7: Accessibility.
Access, A Matter of Means.
by @ineszaid.bsky.social
#GeoData #rstats #DataViz #Maps #SpatialViz
November 7, 2025 at 11:42 AM
#30DayMapChallenge #30DayMapChallenge2025 #30DayMapChallengeRbanism #30DayMapChallengeR
Day 7: Accessibility.
Access, A Matter of Means.
by @ineszaid.bsky.social
#GeoData #rstats #DataViz #Maps #SpatialViz
Day 7: Accessibility.
Access, A Matter of Means.
by @ineszaid.bsky.social
#GeoData #rstats #DataViz #Maps #SpatialViz
Reposted by Michael Tellier
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
We're hiring (again)!
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
September 10, 2025 at 1:34 PM
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Reposted by Michael Tellier
Hi everyone!
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins
August 1, 2025 at 10:44 AM
Hi everyone!
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins
Reposted by Michael Tellier
In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.
Learn more here:
➡️ tinyurl.com/gd352654
Learn more here:
➡️ tinyurl.com/gd352654
July 10, 2025 at 12:52 PM
In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.
Learn more here:
➡️ tinyurl.com/gd352654
Learn more here:
➡️ tinyurl.com/gd352654
Reposted by Michael Tellier
Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!
Taking place on 17-19 September 2025, Transcription and Chromatin UK will showcase cutting-edge research and is a ‘mustattend’ for anyone within the transcription and epigenetics community🧪. Register now: www.eventsforce.net/biochemsoc/2...
June 28, 2025 at 5:27 PM
Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!
Reposted by Michael Tellier
EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.
www.embo.org/press-releas...
#award 🧪
www.embo.org/press-releas...
#award 🧪
EMBO Gold Medal 2025 awarded to Tanmay Bharat and David Bikard – Press releases – EMBO
Every year, EMBO awards the Gold Medal to group leaders in the early stages of their careers for their remarkable contributions to the life sciences in
www.embo.org
June 5, 2025 at 12:05 PM
EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.
www.embo.org/press-releas...
#award 🧪
www.embo.org/press-releas...
#award 🧪
Reposted by Michael Tellier
Nice perspective by Michael Nagel and Dylan Taatjes in @cp-molcell.bsky.social
Regulation of RNA polymerase II transcription through re-initiation and bursting
www.cell.com/molecular-ce...
Regulation of RNA polymerase II transcription through re-initiation and bursting
www.cell.com/molecular-ce...
May 16, 2025 at 5:47 AM
Nice perspective by Michael Nagel and Dylan Taatjes in @cp-molcell.bsky.social
Regulation of RNA polymerase II transcription through re-initiation and bursting
www.cell.com/molecular-ce...
Regulation of RNA polymerase II transcription through re-initiation and bursting
www.cell.com/molecular-ce...
Reposted by Michael Tellier
Built a peer review system that doesn’t take forever.
Spoiler: scientists love it.
Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen.
Read the preprint: bit.ly/4iZ30st
#biologists100 @biologists.bsky.social @biologyopen.bsky.social
Spoiler: scientists love it.
Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen.
Read the preprint: bit.ly/4iZ30st
#biologists100 @biologists.bsky.social @biologyopen.bsky.social
Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal
Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...
bit.ly
March 26, 2025 at 11:52 AM
Built a peer review system that doesn’t take forever.
Spoiler: scientists love it.
Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen.
Read the preprint: bit.ly/4iZ30st
#biologists100 @biologists.bsky.social @biologyopen.bsky.social
Spoiler: scientists love it.
Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen.
Read the preprint: bit.ly/4iZ30st
#biologists100 @biologists.bsky.social @biologyopen.bsky.social
Reposted by Michael Tellier
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
authors.elsevier.com
March 26, 2025 at 1:07 PM
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Reposted by Michael Tellier
Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability
March 2, 2025 at 8:14 PM
Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability
Reposted by Michael Tellier
Interesting idea: get the sick super-rich to pay for clinical trials
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people
Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It’s re...
www.theguardian.com
March 11, 2025 at 8:30 AM
Interesting idea: get the sick super-rich to pay for clinical trials
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
We have an exciting collaborative #PhD project with Dr Catherine Jopling, University of Nottingham, on understanding the role of cancer-associated SF3B1 K700E mutation in microRNA expression and biogenesis.
Application deadline: 10th January 2025.
More information: more.bham.ac.uk/mrc-aim/phd-...
Application deadline: 10th January 2025.
More information: more.bham.ac.uk/mrc-aim/phd-...
PhD Opportunities – MRC AIM
more.bham.ac.uk
December 6, 2024 at 1:47 PM
We have an exciting collaborative #PhD project with Dr Catherine Jopling, University of Nottingham, on understanding the role of cancer-associated SF3B1 K700E mutation in microRNA expression and biogenesis.
Application deadline: 10th January 2025.
More information: more.bham.ac.uk/mrc-aim/phd-...
Application deadline: 10th January 2025.
More information: more.bham.ac.uk/mrc-aim/phd-...
Reposted by Michael Tellier
Excited to share our new paper @genomeresearch.bsky.social about PlatinumCRISPr thanks to @ihaussmann.bsky.social, @roliarnold.bsky.social, @davidmcquarrie.bsky.social & team.
sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs.
genome.cshlp.org/content/earl...
sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs.
genome.cshlp.org/content/earl...
Structure-optimized sgRNA selection with PlatinumCRISPr for efficient Cas9 generation of knockouts
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
December 4, 2024 at 6:35 PM
Excited to share our new paper @genomeresearch.bsky.social about PlatinumCRISPr thanks to @ihaussmann.bsky.social, @roliarnold.bsky.social, @davidmcquarrie.bsky.social & team.
sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs.
genome.cshlp.org/content/earl...
sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs.
genome.cshlp.org/content/earl...
We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression.
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester on FindAPhD.com
PhD Project - Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester, listed on FindAPhD.com
www.findaphd.com
November 21, 2024 at 5:25 PM
We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression.
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Deadline: 16th January 2025.
www.findaphd.com/phds/project...
Reposted by Michael Tellier
What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...
RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription
Independently of the pathways or circuits deregulated in cancer cells, these present altered transcription patterns, often also direct consequence of deregulation of transcription factors. In this sen...
www.biorxiv.org
November 21, 2024 at 10:06 AM
What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...