A U.S. Food and Drug Administration advisory panel voted in favor of recommending that the agency approve a blood test for multiple cancers on Wednesday. The assay, called the Galleri test, is design...

Artificial chemical synapses are promising for diagnosis applications. Here, the authors develop an artificial chemical synapse in which biomarker recognition switches ionic conductance between excita...

Discover the future of cancer treatment with Cancer Cell Reprogramming - turning the tide by converting cancer cells back to normal.

Attempting to eliminate funding for certain kinds of “woke” studies, the Trump administration erased hundreds of millions of dollars being used for cancer research.

ACS CAN is the leading cancer advocacy organization that is working every day to make cancer issues a national priority.

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Paper raises questions about safety of food and other products as early onset breast cancer rates surge worldwide

Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1–4. Glypican-3 (GPC3) is expressed in a group of solid cancers5–10, and here we report the evaluation in humans of the effects of IL-15 co-expression on GPC3-expressing CAR T cells (hereafter GPC3 CAR T cells). Cohort 1 patients ( NCT02905188 and NCT02932956 ) received GPC3 CAR T cells, which were safe but produced no objective antitumour responses and reached peak expansion at 2 weeks. Cohort 2 patients ( NCT05103631 and NCT04377932 ) received GPC3 CAR T cells that co-expressed IL-15 (15.CAR), which mediated significantly increased cell expansion and induced a disease control rate of 66% and antitumour response rate of 33%. Infusion of 15.CAR T cells was associated with increased incidence of cytokine release syndrome, which was controlled with IL-1/IL-6 blocka

Summary:. NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-...

Scientists have discovered a sugar compound from deep-sea bacteria that can destroy cancer cells in a dramatic way. This natural substance, produced by microbes living in the ocean, causes cancer cells to undergo a fiery form of cell death, essentially making them self-destruct. In lab tests and in mice with liver cancer, the compound not only stopped tumors from growing, but also activated the immune system to fight back. This finding could pave the way for entirely new cancer treatments based on sugars from marine organisms.

Overexpression of c-MYC regulates tumor metabolism in pancreatic ductal adenocarcinoma (PDAC). Here the authors identify ELOVL6, a fatty acid elongase regulated by c-MYC, as a potential therapeutic ta...

Scientific Reports - Extracorporeal shock waves effectively suppress colorectal cancer proliferation and growth

From makeshift classrooms in Uganda to postdoctoral research in Chicago, MOSAIC scholar Elizabeth Kaweesa builds a legacy in women’s health.