Study reveals 2 clades of SARS-CoV-2-related coronaviruses co-circulating in Thai horseshoe bats. One clade binds human ACE2, indicating potential zoonotic risk! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
November 15, 2026 at 7:00 AM
It spreads quickly because it binds much more tightly to human ACE2 receptors, allowing it to infect cells efficiently even when receptor density is low.
November 15, 2026 at 8:52 AM
It spreads quickly because it binds much more tightly to human ACE2 receptors, allowing it to infect cells efficiently even when receptor density is low.
Researchers at Wannan Medical University review evidence that daphnetin may block SARS-CoV-2 entry by reducing ACE2 through HIF-1α and JAK/STAT signaling.
It also targets inflammation, oxidative stress, and immune dysfunction.
www.sciencedirect.com/science/arti...
It also targets inflammation, oxidative stress, and immune dysfunction.
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 11, 2026 at 3:02 PM
Researchers at Wannan Medical University review evidence that daphnetin may block SARS-CoV-2 entry by reducing ACE2 through HIF-1α and JAK/STAT signaling.
It also targets inflammation, oxidative stress, and immune dysfunction.
www.sciencedirect.com/science/arti...
It also targets inflammation, oxidative stress, and immune dysfunction.
www.sciencedirect.com/science/arti...
Hmmmm, Brazil Covid.
PJ.2.1 is following the exact evolutionary blueprint of BA.2.86. Normally, when SARS-CoV-2 mutates to escape antibodies, those mutations damage its ability to bind to human cells. PJ.2.1 has built up an exceptionally strong array of ACE2 binding. It is sweeping the playing field
PJ.2.1 is following the exact evolutionary blueprint of BA.2.86. Normally, when SARS-CoV-2 mutates to escape antibodies, those mutations damage its ability to bind to human cells. PJ.2.1 has built up an exceptionally strong array of ACE2 binding. It is sweeping the playing field
Brazil COVID-19 update
• Cases rising in 19 of 27 states, for 7 straight weeks
• COVID accounts for 8.5% of identified cases and 24.1% of deaths
• Severe cases rising in 5 states
• Children under 2 highest incidence
• 3,479 hospitalisations and 437 deaths in 2026
• 171,369 total cases since January
• Cases rising in 19 of 27 states, for 7 straight weeks
• COVID accounts for 8.5% of identified cases and 24.1% of deaths
• Severe cases rising in 5 states
• Children under 2 highest incidence
• 3,479 hospitalisations and 437 deaths in 2026
• 171,369 total cases since January
November 15, 2026 at 8:51 AM
Hmmmm, Brazil Covid.
PJ.2.1 is following the exact evolutionary blueprint of BA.2.86. Normally, when SARS-CoV-2 mutates to escape antibodies, those mutations damage its ability to bind to human cells. PJ.2.1 has built up an exceptionally strong array of ACE2 binding. It is sweeping the playing field
PJ.2.1 is following the exact evolutionary blueprint of BA.2.86. Normally, when SARS-CoV-2 mutates to escape antibodies, those mutations damage its ability to bind to human cells. PJ.2.1 has built up an exceptionally strong array of ACE2 binding. It is sweeping the playing field
ẞ1-AAK, M2-AAK, AT1(ACE2)-Ak und ß2 AAK.
November 8, 2026 at 7:00 PM
ẞ1-AAK, M2-AAK, AT1(ACE2)-Ak und ß2 AAK.
New research reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats, one showing ability to bind human ACE2. Exciting virological insights! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
November 11, 2026 at 6:00 PM
Le virus pénètre les cellules endothéliales via ACE2, déclenchant une inflammation chronique et état pro-coagulant, micro-caillots, destruction des plus petits vaisseaux. Le tissu pulmonaire peut paraître normal.
« De nombreux patients présentent une dyspnée sévère et une
3/12
« De nombreux patients présentent une dyspnée sévère et une
3/12
November 10, 2026 at 3:06 PM
Le virus pénètre les cellules endothéliales via ACE2, déclenchant une inflammation chronique et état pro-coagulant, micro-caillots, destruction des plus petits vaisseaux. Le tissu pulmonaire peut paraître normal.
« De nombreux patients présentent une dyspnée sévère et une
3/12
« De nombreux patients présentent une dyspnée sévère et une
3/12
昔、ACE2のPVをGEOで眺めていた記憶がある。ゲームはやってない(家にPS2がなかったしあまりゲームを買ってもらえなかった)
November 13, 2026 at 2:10 PM
昔、ACE2のPVをGEOで眺めていた記憶がある。ゲームはやってない(家にPS2がなかったしあまりゲームを買ってもらえなかった)
»Neben den bekannten Zusammenhängen zwischen Virusinfektionen und neurodegenerativen oder neuroinflammatorischen Erkrankungen, wie beispielsweise dem Epstein-Barr-Virus (EBV) bei Multipler Sklerose oder Herpes zoster [Gürtelrose] bei AD,
November 8, 2026 at 2:25 PM
»Neben den bekannten Zusammenhängen zwischen Virusinfektionen und neurodegenerativen oder neuroinflammatorischen Erkrankungen, wie beispielsweise dem Epstein-Barr-Virus (EBV) bei Multipler Sklerose oder Herpes zoster [Gürtelrose] bei AD,
...also class 4 (indirectly but clearly). Even class 1 could be affected by the overall reorganization (allosteric effect). As for ACE2 affinity, although 445G on its own could be detrimental (excessive flexibility), 446T would fit very well with it, allowing it (446T) to form direct hydrogen bonds.
November 11, 2026 at 2:13 PM
...also class 4 (indirectly but clearly). Even class 1 could be affected by the overall reorganization (allosteric effect). As for ACE2 affinity, although 445G on its own could be detrimental (excessive flexibility), 446T would fit very well with it, allowing it (446T) to form direct hydrogen bonds.
New clades of SARS-CoV-2-related coronaviruses are circulating among horseshoe bats in Thailand, with one clade capable of binding human ACE2. Key virological properties explored via cryo-EM and live assays could… PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
November 9, 2026 at 7:00 AM
New clades of SARS-CoV-2-related coronaviruses are circulating among horseshoe bats in Thailand, with one clade capable of binding human ACE2. Key virological properties explored via cryo-EM and live assays could… PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X
Pathophysiological mechanisms of vascular injury #LongCOVID
→ release of pro-thrombotic factors such as vWF
→ transition to a pro-coagulant state...
→ endothelial dysfunction with sustained elevations in biomarkers such as D-dimer, fibrinogen, and C-reactive protein (CRP), ...
#medsky
#radiology
→ release of pro-thrombotic factors such as vWF
→ transition to a pro-coagulant state...
→ endothelial dysfunction with sustained elevations in biomarkers such as D-dimer, fibrinogen, and C-reactive protein (CRP), ...
#medsky
#radiology
![Pathophysiological mechanisms of vascular injury
The endothelial-viral interface and endotheliitis
The vascular endothelium acts as the primary interface between the systemic circulation and the lung parenchyma. SARS-CoV-2 gains entry into host cells primarily via the Angiotensin-Converting Enzyme 2 (ACE2) receptor, which is expressed ubiquitously on the surface of pulmonary endothelial cells [5]. The direct viral infection of these cells precipitates a cascade of endothelial inflammation, termed “endotheliitis,” which is a central driver of the disease’s vascular manifestations [6].
Under homeostatic conditions, the endothelium maintains an anti-thrombotic and anti-inflammatory surface. Virus-mediated injury disrupts this balance, leading to the shedding of the glycocalyx, exposure of the sub-endothelial matrix, and the release of pro-thrombotic factors such as von Willebrand factor (vWF). This transition to a pro-coagulant state promotes the formation of thrombi in situ within the pulmonary microvasculature, a process distinct from classic thromboembolism originating from deep venous thrombosis (DVT) [6]. Radiological studies have correlated this endothelial dysfunction with sustained elevations in biomarkers such as D-dimer, fibrinogen, and C-reactive protein (CRP), even months after the acute infection has resolved [7]. The persistence of these markers suggests that endotheliitis may not be a transient phenomenon limited to the acute phase but a lingering, chronic process in Long COVID, stimulating vascular inflammation and dysfunction [4].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:szc7xq5qv7wg2abye6tlvet2/bafkreifvcap4vzwi4qnkemsjadatlda4647xiz7cfouh7gkr3nkmhb52g4)
November 8, 2026 at 6:46 PM
Pathophysiological mechanisms of vascular injury #LongCOVID
→ release of pro-thrombotic factors such as vWF
→ transition to a pro-coagulant state...
→ endothelial dysfunction with sustained elevations in biomarkers such as D-dimer, fibrinogen, and C-reactive protein (CRP), ...
#medsky
#radiology
→ release of pro-thrombotic factors such as vWF
→ transition to a pro-coagulant state...
→ endothelial dysfunction with sustained elevations in biomarkers such as D-dimer, fibrinogen, and C-reactive protein (CRP), ...
#medsky
#radiology
im a shooter for Ace2 also TBH really replayable game
November 4, 2026 at 2:13 AM
im a shooter for Ace2 also TBH really replayable game
➡️PJ.2.1 can enter cells with low endogenous ACE2 expression more efficiently than the other variants tested. This suggests that increased ACE2 binding may translate into improved infection of target cells with low ACE2 expression.
November 3, 2026 at 10:20 AM
➡️PJ.2.1 can enter cells with low endogenous ACE2 expression more efficiently than the other variants tested. This suggests that increased ACE2 binding may translate into improved infection of target cells with low ACE2 expression.
Key findings:
➡️PJ.2.1 frequency is increasing in North America and Spain.
➡️PJ.2.1 is less susceptible to inhibition by an ACE2-directed antibody as compared to other variants, suggesting increased ACE2 binding.
➡️PJ.2.1 frequency is increasing in North America and Spain.
➡️PJ.2.1 is less susceptible to inhibition by an ACE2-directed antibody as compared to other variants, suggesting increased ACE2 binding.
November 3, 2026 at 10:20 AM
Key findings:
➡️PJ.2.1 frequency is increasing in North America and Spain.
➡️PJ.2.1 is less susceptible to inhibition by an ACE2-directed antibody as compared to other variants, suggesting increased ACE2 binding.
➡️PJ.2.1 frequency is increasing in North America and Spain.
➡️PJ.2.1 is less susceptible to inhibition by an ACE2-directed antibody as compared to other variants, suggesting increased ACE2 binding.
like MUC16 actively sterically hinder the viral spike protein from binding to ACE2. However, if genetic variants alter the structural expression or density of MUC16, the physical shield is compromised. 🦠 bypasses the barrier effortlessly,
November 7, 2026 at 1:18 AM
like MUC16 actively sterically hinder the viral spike protein from binding to ACE2. However, if genetic variants alter the structural expression or density of MUC16, the physical shield is compromised. 🦠 bypasses the barrier effortlessly,
It traps inhaled foreign pathogens and prevents them from physically touching and binding to underlying cellular receptors.
🦠How #SARSCoV2 Made It Worse: To infect a cell, 🦠must reach the ACE2 receptor. Healthy extracellular mucin domains
🦠How #SARSCoV2 Made It Worse: To infect a cell, 🦠must reach the ACE2 receptor. Healthy extracellular mucin domains
November 7, 2026 at 1:18 AM
It traps inhaled foreign pathogens and prevents them from physically touching and binding to underlying cellular receptors.
🦠How #SARSCoV2 Made It Worse: To infect a cell, 🦠must reach the ACE2 receptor. Healthy extracellular mucin domains
🦠How #SARSCoV2 Made It Worse: To infect a cell, 🦠must reach the ACE2 receptor. Healthy extracellular mucin domains
New SC2r-CoVs clades found in Thai horseshoe bats reveal intriguing virological traits, including human ACE2 receptor binding. This highlights ongoing risk of zoonotic spillover! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S009286742600454X
No description available
www.cell.com
November 4, 2026 at 9:00 PM
New SC2r-CoVs clades found in Thai horseshoe bats reveal intriguing virological traits, including human ACE2 receptor binding. This highlights ongoing risk of zoonotic spillover! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Earth drug screens still ask 'does it stick?' Cute. @wyssinstitute.bsky.social FIND on @science.org: DNA nanoswitch, 400 million candidates in one tube, loop = proteins actually hugged. Picked PPAR-gamma agonists plus a spike-ACE2 nanobody. *buuurp* Lab-on-a-molecule, finally.
November 6, 2026 at 11:36 AM
Earth drug screens still ask 'does it stick?' Cute. @wyssinstitute.bsky.social FIND on @science.org: DNA nanoswitch, 400 million candidates in one tube, loop = proteins actually hugged. Picked PPAR-gamma agonists plus a spike-ACE2 nanobody. *buuurp* Lab-on-a-molecule, finally.
