They also measured a respirometer to compare normal zebrafish vs transgenic zebrafish with ACOD1 and found that these ACOD1 fish produced less energy, consuming less oxygen, and moving less than their counterparts.
September 5, 2025 at 4:30 PM
They also measured a respirometer to compare normal zebrafish vs transgenic zebrafish with ACOD1 and found that these ACOD1 fish produced less energy, consuming less oxygen, and moving less than their counterparts.
#WeekendRead #NeuroimmunologyPower #ImmunometabolismPower #NotOnlyItaconate! Kang &co show Science Advances that #dopamine inhibits ACOD1 upregulation by TLR4/CREB1, preventing ACOD1 (not itaconate) dependent PDL1 induction, protecting against inflammation-induced #immunosuppression during #sepsis!
A neuroimmune pathway drives bacterial infection
Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.
scim.ag
May 17, 2025 at 3:06 PM
#WeekendRead #NeuroimmunologyPower #ImmunometabolismPower #NotOnlyItaconate! Kang &co show Science Advances that #dopamine inhibits ACOD1 upregulation by TLR4/CREB1, preventing ACOD1 (not itaconate) dependent PDL1 induction, protecting against inflammation-induced #immunosuppression during #sepsis!
A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism.
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
A neuroimmune pathway drives bacterial infection
Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.
scim.ag
May 13, 2025 at 6:55 PM
A new #ScienceAdvances study identifies a neuroimmune pathway for treating sepsis, finding that dopamine inhibits expression of a critical regulator of immunometabolism.
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
This suggests that pramipexole, a dopamine agonist, could effectively treat lethal infections. scim.ag/4kfAfrZ
Poor fish also had cardiac failure with ACOD1.
September 5, 2025 at 4:31 PM
Poor fish also had cardiac failure with ACOD1.
They measured fatigue-like symptoms via swimming, and found ~40% reduction in swimming in ACOD1 fish, implying an energy deficit.
September 5, 2025 at 4:28 PM
They measured fatigue-like symptoms via swimming, and found ~40% reduction in swimming in ACOD1 fish, implying an energy deficit.
I see a similar process for ACOD1 inhibition drug discovery in sepsis. 🧪
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
Targeting ACOD1 in Sepsis: A Virtual Screening and Molecular Dynamics Approach
Virtual screening of metabolites (primary metabolites and natural products) against ACOD1 to identify potential inhibitors to treat sepsis. Furthermore, MM-GBSA binding energy, molecular dynamics, an....
chemistry-europe.onlinelibrary.wiley.com
September 5, 2025 at 4:50 PM
I see a similar process for ACOD1 inhibition drug discovery in sepsis. 🧪
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
Unique hyperinflammatory macrophages on the same time slams on the 'brakes' #ACOD1 in #Crohns beautifully presented by Gareth Jones #ECCO2025 in Berlin. #macrophages
Biology is just so interesting @uofgsii.bsky.social @gastrogrj.bsky.social @bainlab.bsky.social
Biology is just so interesting @uofgsii.bsky.social @gastrogrj.bsky.social @bainlab.bsky.social
February 24, 2025 at 5:32 AM
Unique hyperinflammatory macrophages on the same time slams on the 'brakes' #ACOD1 in #Crohns beautifully presented by Gareth Jones #ECCO2025 in Berlin. #macrophages
Biology is just so interesting @uofgsii.bsky.social @gastrogrj.bsky.social @bainlab.bsky.social
Biology is just so interesting @uofgsii.bsky.social @gastrogrj.bsky.social @bainlab.bsky.social
CLYBL and ACOD1 are the two enzymes which govern the process; Phair poses that the ratio of these two (CLYBL: ACOD1) will govern your disease baseline.
September 5, 2025 at 3:55 PM
CLYBL and ACOD1 are the two enzymes which govern the process; Phair poses that the ratio of these two (CLYBL: ACOD1) will govern your disease baseline.
3) Hard evidence linking this proposed mechanism to ME/CFS is lacking. The ACOD1 gene, which plays a key role in the theory, didn’t show a signal in the big DecodeME study.
October 21, 2025 at 3:58 PM
3) Hard evidence linking this proposed mechanism to ME/CFS is lacking. The ACOD1 gene, which plays a key role in the theory, didn’t show a signal in the big DecodeME study.
So, could ACOD1 expression be inhibited and reduce fx?
They tested four compounds that might inhibit ACOD1 and found that there was evidence towards resumed function and increased locomotion in the zebrafish in question.
They tested four compounds that might inhibit ACOD1 and found that there was evidence towards resumed function and increased locomotion in the zebrafish in question.
September 5, 2025 at 4:32 PM
So, could ACOD1 expression be inhibited and reduce fx?
They tested four compounds that might inhibit ACOD1 and found that there was evidence towards resumed function and increased locomotion in the zebrafish in question.
They tested four compounds that might inhibit ACOD1 and found that there was evidence towards resumed function and increased locomotion in the zebrafish in question.
Exciting new preprint from @gastrogrj.bsky.social and @bainlab.bsky.social from @edinuni-irr.bsky.social investigating the role of ACOD1 in #IBD and experimental #colitis
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis https://www.biorxiv.org/content/10.1101/2024.11.15.623347v1
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis https://www.biorxiv.org/content/10.1101/2024.11.15.623347v1
Monocytes are essential for replenishing homeostatic macrophages in the intestine. However, they als
www.biorxiv.org
November 16, 2024 at 8:39 AM
Exciting new preprint from @gastrogrj.bsky.social and @bainlab.bsky.social from @edinuni-irr.bsky.social investigating the role of ACOD1 in #IBD and experimental #colitis
ACOD1 regulates microglial arginine metabolism and inflammatory responses https://www.biorxiv.org/content/10.1101/2025.06.01.657243v1
June 4, 2025 at 12:17 AM
ACOD1 regulates microglial arginine metabolism and inflammatory responses https://www.biorxiv.org/content/10.1101/2025.06.01.657243v1
Do you know if ACOD1 was significant in DecodeME?
October 18, 2025 at 9:57 AM
Do you know if ACOD1 was significant in DecodeME?
6) It's unclear, however, if this model fits ME/CFS. At high expression of ACOD1, the fish also showed a reduced heart rate and signs of cardiac impairment.
October 18, 2025 at 8:07 AM
6) It's unclear, however, if this model fits ME/CFS. At high expression of ACOD1, the fish also showed a reduced heart rate and signs of cardiac impairment.
7) Lastly, they tested multiple ACOD1 inhibitors and found that some restored movement in the zebrafish back to a normal amount. So if the Itaconate shunt model is correct, this could be a potential treatment.
October 18, 2025 at 8:08 AM
7) Lastly, they tested multiple ACOD1 inhibitors and found that some restored movement in the zebrafish back to a normal amount. So if the Itaconate shunt model is correct, this could be a potential treatment.
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis https://www.biorxiv.org/content/10.1101/2024.11.15.623347v1
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis https://www.biorxiv.org/content/10.1101/2024.11.15.623347v1
Monocytes are essential for replenishing homeostatic macrophages in the intestine. However, they als
www.biorxiv.org
November 16, 2024 at 3:16 AM
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis https://www.biorxiv.org/content/10.1101/2024.11.15.623347v1
Heading to #EMDS24 in 🇦🇹 this week?
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
November 27, 2024 at 8:07 AM
Heading to #EMDS24 in 🇦🇹 this week?
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
IL-10/ACOD1 axis regulates catabolism of phagocytosed lipids in trained macrophages https://www.biorxiv.org/content/10.64898/2026.08.18.745517v1
August 24, 2026 at 4:16 AM
IL-10/ACOD1 axis regulates catabolism of phagocytosed lipids in trained macrophages https://www.biorxiv.org/content/10.64898/2026.08.18.745517v1
Hello BlueSky! I run a research lab @notredame.bsky.social focused on the intersection of #celldeath and #metabolism in cancer cells. Excited to connect with this community. Here’s a link to one of our most recent papers: www.cell.com/cell-reports...
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
Schofield et al. report that cancer cells upregulate Acod1 as a survival strategy
in response to αPD-1 therapy. Acod1hi cancer cells secrete inhibitory peptides that
block the activation of naive CD8+...
www.cell.com
November 15, 2024 at 4:25 AM
Hello BlueSky! I run a research lab @notredame.bsky.social focused on the intersection of #celldeath and #metabolism in cancer cells. Excited to connect with this community. Here’s a link to one of our most recent papers: www.cell.com/cell-reports...
2) The hypothesis states that the normal TCA cycle to generate energy is disrupted during an infection. A gene called ACOD1 diverts the metabolites away from the cycle towards the Itaconate pathway, making it less efficient in producing energy.
October 18, 2025 at 8:07 AM
2) The hypothesis states that the normal TCA cycle to generate energy is disrupted during an infection. A gene called ACOD1 diverts the metabolites away from the cycle towards the Itaconate pathway, making it less efficient in producing energy.
4) In tests with lights or vibration as stimuli being turned on and off, the zebrafish with ACOD1 overexpression had approximately a 40% reduction in movement compared to controls.
They also had reduced oxygen consumption.
They also had reduced oxygen consumption.
October 18, 2025 at 8:07 AM
4) In tests with lights or vibration as stimuli being turned on and off, the zebrafish with ACOD1 overexpression had approximately a 40% reduction in movement compared to controls.
They also had reduced oxygen consumption.
They also had reduced oxygen consumption.
5) The gene expression was regulated using heat-shock so the researchers could test different versions of ACOD1 overexpression by increasing the temperature of the water.
The more the gene was expressed, the greater the signs of energy deficits.
The more the gene was expressed, the greater the signs of energy deficits.
October 18, 2025 at 8:07 AM
5) The gene expression was regulated using heat-shock so the researchers could test different versions of ACOD1 overexpression by increasing the temperature of the water.
The more the gene was expressed, the greater the signs of energy deficits.
The more the gene was expressed, the greater the signs of energy deficits.
Protein(s): IRG1/ACOD1 + TCA cycle enzymes
Function: Anti-microbial activity & immunomodulation.
Behaviour: Release of mitochondrial nucleic acids (DAMPs) during infection, which synergise with PAMPs to regulate innate immune response. #Immunometabolism #mitochondria
Function: Anti-microbial activity & immunomodulation.
Behaviour: Release of mitochondrial nucleic acids (DAMPs) during infection, which synergise with PAMPs to regulate innate immune response. #Immunometabolism #mitochondria
🤍 💚
What is your favorite mitochondrial function, protein, or behavior that fascinates you in health or disease?
What is your favorite mitochondrial function, protein, or behavior that fascinates you in health or disease?
August 31, 2025 at 11:41 AM
Protein(s): IRG1/ACOD1 + TCA cycle enzymes
Function: Anti-microbial activity & immunomodulation.
Behaviour: Release of mitochondrial nucleic acids (DAMPs) during infection, which synergise with PAMPs to regulate innate immune response. #Immunometabolism #mitochondria
Function: Anti-microbial activity & immunomodulation.
Behaviour: Release of mitochondrial nucleic acids (DAMPs) during infection, which synergise with PAMPs to regulate innate immune response. #Immunometabolism #mitochondria
Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking @natcomms.nature.com
nature.com/articles/s41...
nature.com/articles/s41...
January 7, 2026 at 10:29 PM
Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking @natcomms.nature.com
nature.com/articles/s41...
nature.com/articles/s41...
FT for that paper can be found here: www.researchgate.net/publication/...
Targeting ACOD1 in Sepsis: A Virtual Screening and Molecular Dynamics Approach | Request PDF
Request PDF | Targeting ACOD1 in Sepsis: A Virtual Screening and Molecular Dynamics Approach | Sepsis treatment has become more challenging than ever due to antimicrobial resistance and the uncontroll...
www.researchgate.net
September 5, 2025 at 4:51 PM
FT for that paper can be found here: www.researchgate.net/publication/...