🚨Sneak Peek! I can’t wait for you all to hear @nmercuro.bsky.social & @andrewhaynes.bsky.social discuss IV to PO abx for GP infxns with me for an upcoming @sidpharm.bsky.social #Breakpoints Podcast 🎙️episode. Coming soon… ☺️
#IDsky #AMSsky
#IDsky #AMSsky
October 30, 2026 at 6:41 PM
🚨Sneak Peek! I can’t wait for you all to hear @nmercuro.bsky.social & @andrewhaynes.bsky.social discuss IV to PO abx for GP infxns with me for an upcoming @sidpharm.bsky.social #Breakpoints Podcast 🎙️episode. Coming soon… ☺️
#IDsky #AMSsky
#IDsky #AMSsky
Well, this is scary news for antibiotic stewards.
#AMSSky
#AMSSky
Symptom Misrepresentation to Obtain Antibiotics
This survey study examines the prevalence, reasons for, and characteristics associated with self-reported misrepresentation of symptoms to obtain antibiotics among US adults.
jamanetwork.com
October 31, 2026 at 3:40 PM
Well, this is scary news for antibiotic stewards.
#AMSSky
#AMSSky
This is where the US should invest money for research, not politically motivated research on whether vaccines cause autism.
#AMSSky
www.cidrap.umn.edu/antimicrobia...
#AMSSky
www.cidrap.umn.edu/antimicrobia...
Drug-resistant infections linked to $3.5 trillion in global economic losses in 2021
www.cidrap.umn.edu
October 22, 2026 at 6:58 PM
This is where the US should invest money for research, not politically motivated research on whether vaccines cause autism.
#AMSSky
www.cidrap.umn.edu/antimicrobia...
#AMSSky
www.cidrap.umn.edu/antimicrobia...
Congressman urges medical, dental groups to educate clinicians about antibiotic stewardship
www.cidrap.umn.edu
October 14, 2026 at 9:44 PM
Winter is coming…
#AMSsky
#AMSsky
📣 New #Communicable drops Mon 05 Oct!
Marc Bonten & Emily McDonald are joined by Valentijn Schweitzer & Sylvain Lother to discuss the use of macrolides in community-acquired pneumonia and how the available evidence informs clinical practice. Tune in!
#IDSky #clinmicro
Marc Bonten & Emily McDonald are joined by Valentijn Schweitzer & Sylvain Lother to discuss the use of macrolides in community-acquired pneumonia and how the available evidence informs clinical practice. Tune in!
#IDSky #clinmicro
October 3, 2026 at 10:44 PM
Winter is coming…
#AMSsky
#AMSsky
The OPTIMISE trial aimed to test 7 vs 14 days for treating MDR infections in ICU patients.
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
October 3, 2026 at 10:14 PM
The OPTIMISE trial aimed to test 7 vs 14 days for treating MDR infections in ICU patients.
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Bad news for patients with MDR infections…
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
September 29, 2026 at 11:15 PM
Bad news for patients with MDR infections…
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
So, I think there still is a safe way for cefepime in clinical practice:
✅ Limited to patients with normal renal function.
✅ As empirical treatment for non-severe cases.
✅ As targeted therapy for low-MIC isolates.
Extended-infusion and TDM would probably help in many cases!
🧵(5/5) #IDsky #AMSsky
✅ Limited to patients with normal renal function.
✅ As empirical treatment for non-severe cases.
✅ As targeted therapy for low-MIC isolates.
Extended-infusion and TDM would probably help in many cases!
🧵(5/5) #IDsky #AMSsky
September 20, 2026 at 2:58 AM
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
Cefepime and Mortality
This systematic review with bayesian meta-analysis of randomized clinical trials examined the association of cefepime with all-cause mortality compared with other β-lactam antibiotics.
jamanetwork.com
September 20, 2026 at 2:52 AM
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
We also have the efficacy question.
In my center we use EUCAST for susceptibility testing, whose MIC breakpoints are more restrictive than CLSI’s.
So, we use cefepime just for strains with lower MICs than our american colleagues, probably favoring PK/PD target achievement
🧵 (3/5) #IDsky #AMSsky
In my center we use EUCAST for susceptibility testing, whose MIC breakpoints are more restrictive than CLSI’s.
So, we use cefepime just for strains with lower MICs than our american colleagues, probably favoring PK/PD target achievement
🧵 (3/5) #IDsky #AMSsky
September 20, 2026 at 2:56 AM
Neurotoxicity is definitely an issue for cefepime.
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
Cefepime-induced neurotoxicity: systematic review
AbstractBackground. Cefepime-induced neurotoxicity (CIN) has been well acknowledged among clinicians, although there are no clear diagnostic criteria or sp
academic.oup.com
September 20, 2026 at 2:54 AM
Neurotoxicity is definitely an issue for cefepime.
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
I recently heard from a geriatrician that all the urinary pathogens at a long-term care facility he covers are resistant to nitrofurantoin. Having worked at one, it doesn't surprise me since nurses and families often request antibiotics for assumed UTIs.
#AMSSky
kffhealthnews.org/aging/3-comm...
#AMSSky
kffhealthnews.org/aging/3-comm...
3 Common Drugs Older Adults Might Be Overusing - KFF Health News
Not all older people need benzodiazepines, antibiotics, or daily aspirin — and taking them can carry increased risks.
kffhealthnews.org
September 18, 2026 at 1:31 PM
I recently heard from a geriatrician that all the urinary pathogens at a long-term care facility he covers are resistant to nitrofurantoin. Having worked at one, it doesn't surprise me since nurses and families often request antibiotics for assumed UTIs.
#AMSSky
kffhealthnews.org/aging/3-comm...
#AMSSky
kffhealthnews.org/aging/3-comm...
When will medical schools and residency programs stop teaching trainees that not all hospitalized DFI cases require anti-MRSA and anti-pseudomonal coverage?
#AMSSky
#AMSSky
Five-year trends in antibiotic use and microbiology of hospitalized diabetic foot infections in the Bronx | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core
Five-year trends in antibiotic use and microbiology of hospitalized diabetic foot infections in the Bronx - Volume 6 Issue 1
www.cambridge.org
September 17, 2026 at 9:19 PM
When will medical schools and residency programs stop teaching trainees that not all hospitalized DFI cases require anti-MRSA and anti-pseudomonal coverage?
#AMSSky
#AMSSky
This study should help dispel a common myth that all immunocompromised patients with CAP need empiric broad-spectrum antibiotic therapy over standard therapy because these patients have higher risk of infection with MRSA and Pseudomonas.
#AMSSky
#AMSSky
Risk factors for methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa community-acquired pneumonia at a high-volume transplant center | Antimicrobial Stewardship & Healthcare Epi...
Risk factors for methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa community-acquired pneumonia at a high-volume transplant center - Volume 6 Issue 1
www.cambridge.org
September 12, 2026 at 4:32 PM
This study should help dispel a common myth that all immunocompromised patients with CAP need empiric broad-spectrum antibiotic therapy over standard therapy because these patients have higher risk of infection with MRSA and Pseudomonas.
#AMSSky
#AMSSky
I've experienced the same challenges outlined in this study at my institution. The hardest factor to overcome is the emotions driving the need to order urine testing, such as a clinician's fear of missing a diagnosis or facing potential legal consequences.
#AMSSky
#AMSSky
Retrospective, multicenter evaluation of stricter reflex urine culture criteria and workflow changes in emergency departments across six hospitals and three off-campus sites | Antimicrobial Stewardshi...
Retrospective, multicenter evaluation of stricter reflex urine culture criteria and workflow changes in emergency departments across six hospitals and three off-campus sites - Volume 6 Issue 1
www.cambridge.org
September 12, 2026 at 5:56 PM
I've experienced the same challenges outlined in this study at my institution. The hardest factor to overcome is the emotions driving the need to order urine testing, such as a clinician's fear of missing a diagnosis or facing potential legal consequences.
#AMSSky
#AMSSky
A good guide for stewards who are proposing a business case for a diagnostic stewardship project to their C-suite.
#AMSSky
#AMSSky
A business case for diagnostic stewardship: a practical guide from the Society for Healthcare Epidemiology of America (SHEA) Diagnostic Stewardship Special Interest Group | Antimicrobial Stewardship &...
A business case for diagnostic stewardship: a practical guide from the Society for Healthcare Epidemiology of America (SHEA) Diagnostic Stewardship Special Interest Group - Volume 6 Issue 1
www.cambridge.org
September 9, 2026 at 7:02 PM
A good guide for stewards who are proposing a business case for a diagnostic stewardship project to their C-suite.
#AMSSky
#AMSSky
New publication online in CID describing ceftriaxone serious adverse events (involving CPR or death) in 31 cases across 18 states! 💉
Product testing & trend analysis did not identify evidence of a new safety issue, but needs ongoing vigilance & reporting to Medwatch. #IDSky #AMSsky
Product testing & trend analysis did not identify evidence of a new safety issue, but needs ongoing vigilance & reporting to Medwatch. #IDSky #AMSsky
September 4, 2026 at 12:04 PM
💥🆕“Hospital Strategies to Improve Sepsis Outcomes”
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes
Abstract. Sepsis remains a leading cause of morbidity and mortality in US hospitals despite extensive efforts to improve early recognition and treatment, p
bit.ly
August 29, 2026 at 2:28 PM
💥🆕“Hospital Strategies to Improve Sepsis Outcomes”
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
Excited to see these NHSN AU Case Examples published to CDC’s website! We enjoyed strategizing, building, and distributing these reports to all hospitals with AU data in Colorado!
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
Colorado AU Feedback Reports | NHSN | CDC
www.cdc.gov
August 28, 2026 at 8:40 AM
Excited to see these NHSN AU Case Examples published to CDC’s website! We enjoyed strategizing, building, and distributing these reports to all hospitals with AU data in Colorado!
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
November 16, 2024 at 11:52 PM
November 16, 2024 at 6:36 PM
Yes! Where the stewies at? #StewieSky? #AMSsky?
November 9, 2024 at 3:39 PM
Yes! Where the stewies at? #StewieSky? #AMSsky?
The next #MedEd game for #WAAW2025 is here! Can you find the four groups of four items that belong together? 🧩🤔
Play Infectious Connections today: connections.firstline.org
Discover the engaging educational content crafted by Shaqil Peermohamed, MD! #IDSky #PharmSky #AMSSKy
Play Infectious Connections today: connections.firstline.org
Discover the engaging educational content crafted by Shaqil Peermohamed, MD! #IDSky #PharmSky #AMSSKy
November 17, 2025 at 2:26 PM