#ATF3
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scinews.bsky.social
Human skin rejuvenation via mRNA
By George M. Church

"ATF3-targeted mRNA treatment effectively reverses the effects of skin aging by modulating specific cellular mechanisms, offering a novel, targeted approach to human skin rejuvenation."

Open Access
www.biorxiv.org/content/10.1...
December 8, 2024 at 3:13 PM
amy-lock.bsky.social
#FluorescenceFriday testing an ATF3 antibody on newly replated immature iPSC-derived sensory neurons. Never get bored of these beautiful images 😍 @denklab.bsky.social
March 7, 2025 at 9:44 PM
haoyin.bsky.social
ATF3 as Anti-Senescence transcription factor (with ATG7 as a direct target gene!) in #SmoothMuscleCell

AAV9-SM22α-shATF3⏫arterial #Senescence & Stiffness in SAMP8🐭

Terazosin, α1AR blocker
⏬YTHDF2-m6A ATF3 mRNA binding
⏬🐭Atherosclerosis

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
July 12, 2025 at 12:27 PM
rantyhighwayman.bsky.social
Absolutely. I was a part time programme manager for some ATF2 and ATF3 work and those were massive issues, plus inflation eroding the budgets too.
January 12, 2025 at 8:12 AM
frezzalab.bsky.social
Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging - Nature Aging 🧪
www.nature.com/articles/s43...
Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging - Nature Aging
Mao, Zhang, Zhuang et al. identified a subclass of endogenous retroviruses that become activated by ATF3 in senescence, generating dsRNAs that activate RIG-I signaling and drive a type I interferon re...
www.nature.com
November 14, 2024 at 2:55 PM
haoyin.bsky.social
Single-cell omics🐭#OvarianAging
scRNAseq scATACseq
12- vs 3-mo

#Aging
1⃣Mesenchymal Phox2B/ESRRγ/HoxB7-TGFβ2➡️ #Fibrosis (steroidogenic stroma, fibroblast, theca, but NOT pericyte)
2⃣Granulosa cell HSPA5 #ATF3 ATF4➡️#ERStress

Any #VascularAging?

#GeroScience 2025
link.springer.com/article/10.1...
March 11, 2025 at 1:09 AM
haoyin.bsky.social
SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging

ATF3 physically sequestrates MDM2 (E3 ligase for p21)

ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs

#AortaEd
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/10.1002/...
January 29, 2025 at 8:06 PM
haoyin.bsky.social
#Senescence-associated #EndogenousRetroVirus

#ATF3 ➡️bidirectional transcription of SA-ERV (ERV1 ERVK ERVL ERVL-MaLR)
➡️⏫ RIG-I/MDA5-MAVS- interferon I & #Senescence

SA-ERV transcripts ⏫in skin nerve muscle adipose & blood during👤#Aging

#NatureAging 2024
www.nature.com/articles/s43...
November 20, 2024 at 1:49 PM
zenlabpasteur.bsky.social
Just published in Development (@biologists.bsky.social):
doi.org/10.1242/dev....
Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells
Highlighted Article: An inducible Cas3*/Cas7* sensor demonstrates that non-apoptotic caspase events occur in zebrafish neural stem cells. In cooperation with the stress-induced transcription factor At...
doi.org
November 24, 2024 at 3:19 PM
haoyin.bsky.social
Integrated Single-Cell Transcriptomic Atlas of Human #PulmonaryHypertension

10 iPAH + 20 SSc-PAH + 4 chronic thromboembolic PH + 30 healthy Ctrl

5 Smooth muscle cell states
Contractile
VCAN-/APOE-hi
FLNA-/XIST-hi
ATF3-/SOCS3-hi
Cox4I2-/TMSB4X-hi

#ATVB 2026
www.ahajournals.org/doi/10.1161/...
May 19, 2026 at 12:12 PM
jiliang-zhou.bsky.social
“ATF3 Deficiency Exacerbates Ageing-Induced Atherosclerosis and Clinical Intervention Strategy”

The title is very odd to me. FYI: Nick Leeper has an ATF3 paper in Cardiovascular Research
July 12, 2025 at 6:11 PM
lizworthey.bsky.social
AP: Eosinophil-specific deletion of ATF3 impairs adipose angiogenesis in vivo - show decreased VEGFA expression and reduced CD31 staining #LorneGenome25
February 17, 2025 at 1:00 AM
dev-journal.bsky.social
Read the #OpenAccess Research Article "Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells " here:
journals.biologists.com/dev/article/...
Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells
Highlighted Article: An inducible Cas3*/Cas7* sensor demonstrates that non-apoptotic caspase events occur in zebrafish neural stem cells. In cooperation with the stress-induced transcription factor At...
journals.biologists.com
November 27, 2024 at 2:23 PM
mikecookson.bsky.social
Totally agree love the Coast and Castles and the C2C, and all the leisure routes that the old railway lines provide.

But still frustrated that my youngest can't cycle to school, because the money awarded to Newcastle City Council in 2022 under ATF3 still hasn't been spent.

@ategov.bsky.social
Screenshot of the ATF3 award.
August 4, 2025 at 6:44 AM
papers-neurodegen.bsky.social
Aβ1‐40 induces venular endothelial cell ferroptosis in cerebral amyloid angiopathy via the ATF3/xCT axis: Insights from single‐cell RNA sequencing #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71858?af=R
September 21, 2026 at 7:02 AM
ericfauman.bsky.social
A daily distraction
This one drawn again from the MVP paper on the value of diversity in genetic studies. Good thing it was published during the last administration

Trait is "Hemoglobin"

Closest genes are ANGEL2,ATF3,BATF3,FLVCR1,GARIN4,NSL1,RPS6KC1,SPATA45,TATDN3,VASH2

Who's that causal gene?
February 7, 2025 at 2:40 PM
haoyin.bsky.social
Bulk transcriptomics of Coarctation of the Aorta
6♀️+15♂️
2 days~7.5 y/r

Coarcted aorta vs proximal/distal aorta
⏫EGR2/3 JUN/FOS ATF3 NR4A1/2 CEBPD
Complement

+Age (3 mo cutoff)/Sex-based analyses

Ductus vs aorta
⏫Centromere-Kinetochore

#AortaEd
JMCC+ 2024
www.sciencedirect.com/science/arti...
February 2, 2025 at 8:04 PM
lizworthey.bsky.social
AP: Suggestion that ATF3 regulates VEGFA - could see enrichment for ATF3 around VEGFA promoter #LorneGenome25
February 17, 2025 at 12:58 AM
mikecookson.bsky.social
democracy.newcastle.gov.uk/mgIssueHisto...

Last seen in January 2024.

Reward for information leading to a decision 😜
Issue details - Heaton Road ATF3 - Funding Agreement | Newcastle City Council
democracy.newcastle.gov.uk
November 22, 2024 at 4:51 PM
sethcheetham.bsky.social
Can #mRNA technology rejuvenate aged skin? George Church's lab identified the AP-1 gene ATF3 as a key regulator of skin ageing. Delivering ATF3 mRNA rejuvenated skin cells, boosting collagen production.

www.biorxiv.org/content/10.1...
Human skin rejuvenation via mRNA
Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induce...
www.biorxiv.org
November 19, 2024 at 3:26 AM
rridrobot.bsky.social
RRID:AB_2234066 from @dshb-antibodies.bsky.social was used by authors in their bioRxiv paper. RRIDs improve reproducibility in scientific research. #methodsmatter #accelerateopenscience #OpenScience
Atf3 Integrates Lipid and Cytoskeletal Remodeling to Drive Macrophage Fusion
Read the full paper: Atf3 Integrates Lipid and Cytoskeletal Remodeling to Drive Macrophage Fusion
doi.org
April 8, 2026 at 7:02 AM
biorxiv-cellbio.bsky.social
Atf3 Integrates Lipid and Cytoskeletal Remodeling to Drive Macrophage Fusion https://www.biorxiv.org/content/10.64898/2026.04.01.715652v1
April 3, 2026 at 1:31 PM
immunoboys.bsky.social
CRISPR screening factors influencing Th1 vs Th2 differentiation, RAMP3 which forms part of a CGRP receptor is a positive regulator of Th1 differention. CGRP acts by increasing intracellular cAMP and ultimately ATF3 activity it induces STAT1 and thereby Th1 differentiation. in 🐭
🧪 ⑂ 1/2
Figure 3 from the paper showing the experimental setup and top hits of Th1 regulators
October 13, 2025 at 12:27 AM
biorxiv-neursci.bsky.social
Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program https://www.biorxiv.org/content/10.64898/2026.02.23.707492v1
February 25, 2026 at 2:15 AM
biorxiv-immuno.bsky.social
Ebola virus exploits host lncRNA LINC01740 to enhance ATF3 and suppress antiviral immune responses https://www.biorxiv.org/content/10.64898/2026.07.06.731958v1
July 10, 2026 at 4:18 AM